2型糖尿病合并牙周病患者脂联素水平与颈动脉内膜-中膜厚度的关系

目的 探讨2型糖尿病合并牙周病脂联素的变化及与颈动脉内膜-中膜厚度的关系.方法 60例2型糖尿病合并牙周病患者(T2DM+牙周病),50例无牙周病的糖尿病患者(T2DM),测定两组人群空腹血糖(FPG)、空腹胰岛素(FINS)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、脂联素水平,并测量颈动脉内膜-中膜厚度(IMT).同时计算体重指数(BMI)、胰岛素抵抗指数(HOMA-IR),分析2型糖尿病合并牙周病IMT与FPG、FINS、血脂、脂联素的关系.结果 2型糖尿病合并牙周病患者FPG、FINS、TG、IMT、HOMA-IR水平高于无牙周病的糖尿病患者,而HDL-C、脂联素水平低于无牙周病的糖尿病组,差异有统计学意义(P＜ 0.05或P＜0.01).且IMT与年龄、糖尿病病程、FPG、TC、TG、LDL-C、FINS、HOMA-IR、BMI呈正相关(P＜0.05或P＜0.01),与HDL-C、脂联素呈负相关(P＜0.01).结论 2型糖尿病合并牙周病患者血清脂联素水平低于无牙周病的糖尿病组,且低脂联素水平与2型糖尿病合并牙周病患者IMT密切相关.     

2型糖尿病合并非酒精性脂肪肝患者脂联素与胰岛素抵抗关系的研究

目的 探讨2型糖尿病(T2DM)合并非洒精性脂肪肝(NAFLD)血清脂联素与胰岛素抵抗的关系.方法 选取30例T2DM合并NAFLD患者(观察1组)、30例T2DM无NAFLD患者(观察2组)和30例健康体检者(对照组),测定三组的身高、体重、腰围、臀围、血压、空腹血糖、血脂、空腹胰岛素和脂联素水平,计算体重指数、腰臀比和胰岛素抵抗指数(HOMA-IR).结果 观察1组BMI、WHR、血清脂联素、SBP、DBP、FBG、FINS、TG、TC、HOMA-IR明显高于对照组;观察1组BMI、WHR、血清脂联素、FINS、TG、HOMA-IR明显高于观察2组;BMI、WHR、TG、脂联素与T2DM合并NAFLD发生IR密切相关.结论 T2DM合并NAFLD患者血清脂联素水平降低,并与胰岛素抵抗密切相关,脂联素可能在T2DM合并NAFLD患者胰岛素抵抗的发生、发展中起重要的作用.     

新诊断2型糖尿病患者血清骨膜蛋白及脂联素水平变化与胰岛素抵抗相关性研究

目的:探讨新诊断2型糖尿病(n T2DM)患者空腹血清骨膜蛋白与脂联素表达水平的变化及其与胰岛素抵抗(IR)的关系及意义。方法:选取n T2DM肥胖患者30例为T2DM肥胖组(BMI≥25 kg/m2),非肥胖的n T2DM患者30例作为T2DM非肥胖组(BMI 25 kg/m2),另选取糖耐量正常者(BMI 25 kg/m2) 30例为对照组。采用ELISA法检测各组受检者空腹血清骨膜蛋白及脂联素水平,应用改良的稳态模型公式分别计算出各组的胰岛素抵抗指数(HOMA-IR)、胰岛素敏感性指数(ISI)和胰岛β细胞功能指数(HOMA-β),比较各组间数值的相关性。结果:(1) T2DM肥胖组血清骨膜蛋白水平较T2DM非肥胖组升高(P=0. 001),且两组均明显高于正常对照组(P=0. 000);而正常对照组、T2DM非肥胖组、T2DM肥胖组的脂联素水平依次降低(P0. 05)。(2) Pearson相关分析表明血清骨膜蛋白与BMI、空腹血糖(FPG)、甘油三酯(TG)、胆固醇(TC)、低密度脂蛋白(LDL-C)、糖化血红蛋白(Hb A1C)、空腹胰岛素(FINS)及HOMA-IR呈正相关(P 0. 05),与高密度脂蛋白(HDL-C)、ISI、HOMA-β及脂联素呈负相关(P 0. 01)。(3)以骨膜蛋白作为因变量,进行多元逐步回归分析发现,TG、HOMA-IR为骨膜蛋白的独立影响因素(P 0. 05)。结论:n T2DM患者血清骨膜蛋白水平升高可能参与了肥胖、糖脂代谢功能紊乱、IR及T2DM的发生与发展,并且骨膜蛋白与脂联素之间存在相关性。     

血清趋化素、瘦素、脂联素浓度与学龄前单纯性肥胖儿童糖脂代谢的关系

目的 研究血清趋化素、瘦素、脂联素水平与3~6岁学龄前期儿童单纯性肥胖及代谢的关系,为学龄前单纯性肥胖儿童临床监测及治疗效果提供依据。方法 选取2019年1月—2020年5月于大连市妇幼保健院儿童保健门诊体检的3~6岁儿童为研究对象,获取单纯性肥胖儿童41例作为研究组,另获取同年龄、同时期儿童43例作为对照组。测量其身高和体重,并计算身高别体重;测定血清趋化素、瘦素、脂联素、空腹血糖(FPG)、空腹胰岛素(FINS)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-c)、低密度脂蛋白胆固醇(LDL-c),同时计算胰岛素抵抗指数。结果 单纯性肥胖组的FINS、胰岛素抵抗指数(HOMA-IR),LDL-c,血清趋化素,瘦素明显高于对照组,差异有统计学意义(t=3.288、2.927、4.939、3.078、5.456,P＜0.05),HDL-c,脂联素明显低于对照组,差异有统计学意义(t=-5.179、-3.145,P＜0.05)。而两组FPG、TG、TC差异无统计学意义(t=0.391、0.768、-0.266,P＞0.05); 趋化素与身高别体重、FINS、HOMA-IR、 LDL-c、瘦素呈正相关(r=0.339、0.416、0.227、0.376、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.410、-0.309,P＜0.05)。瘦素与身高别体重、FINS、HOMA-IR、 LDL-c、趋化素呈正相关(r=0.492、0.375、0.279、0.269、0.266,P＜0.05),与HDL-c、脂联素呈负相关(r=-0.467、-0.326,P＜0.05)。脂联素与身高别体重、FINS、HOMA-IR,LDL-c、趋化素、瘦素呈负相关(r=-0.296、-0.351、-0.278、-0.229、-0.309、-0.326,P＜0.05),与HDL-c呈正相关(r=0.234,P=0.032)。结论 血清趋化素、瘦素、脂联素水平与学龄前单纯性肥胖儿童糖脂代谢密切相关,这些指标对于识别、监测、干预学龄前单纯性肥胖儿童有着重要意义。     

早期2型糖尿病患者血清内脂素与瘦素的变化及相关性分析

目的 了解初诊断2型糖尿病患者血清内脂素、瘦素水平变化,探讨内脂素与各项代谢指标之间的相关性.方法 选取新诊断或患病时间短的2型糖尿病者(n=57)与健康人群(n=61例)进行对比,根据BMI分为超重亚组和正常体重亚组,检测内脂素和瘦素水平,并检测胰岛素、血糖、糖化血红蛋白等相关生化指标,测量人体腰臀比、体重指数等参数,分析内脂素与上述指标的关系.结果 糖尿病组FPG HbA1C HOMA-IR TC TG WHR较健康对照组升高,两者差异有统计学意义(P＜0.01),Fins LDL-C HDL-C BMI两组差异无统计学意义(P＞0.05);糖尿病组检测的内脂素、瘦素较NGT稍高,但差异无统计学意义(P＞0.05);每组中超重亚组瘦素较体重正常亚组间升高,差异有统计学意义(P＜0.01);而内脂素虽升高但差异无统计学意义(P＞0.05);内脂素与瘦素以及其他临床指标相关分析提示糖尿病组内脂素与WHR HbA1C呈负相关(r=-0.34,和r=-0.26),与瘦素及其他参数包括BMI、HOMA-IR无明显相关.结论 内脂素的升高与脂肪组织分布特点(如女性下半身肥胖)的关系更密切;并推测内脂素可能是糖尿病病理生理中的一种代偿机制.瘦素仅与体重状态有关,非糖尿病发病独立因素.     

妊娠期糖尿病孕妇血中内脂素、IL-18的相关性研究

目的:分析妊娠期糖尿病(GDM)孕妇血中内脂素、IL-18的水平差异及与胰岛素抵抗的相关性.方法:选取该科2013～2014年行产前检查并住院足月分娩的GDM患者40例(GDM组),同时选取同期血糖正常的孕妇40例作为对照组.对比两组一般情况和血糖、血脂、内脂素、白介素-18 (IL-18)和稳态模型胰岛素抵抗指数(HOMA-IR)水平.分析GDM组血清内脂素、IL-18和其他变量之间的相关性.结果:GDM组的空腹血糖(FPG)、餐后2h血糖(2hPG)、空腹胰岛素(FINS)、糖化血红蛋白(HbA1C)、体重指数(BMI)、甘油三酯(TG)、低密度脂蛋白(LDL)、内脂素、IL-18和HOMA-IR显著高于对照组,P＜0.05.GDM组孕妇的内脂素分别与FPG、2hPG、FINS和HOMA-IR呈正相关,P＜0.05;IL-18分别与FPG、2hPG、FINS和HOMA-IR呈正相关,P＜0.05.结论:GDM孕妇血清内脂素、IL-18可影响患者胰岛素抵抗的程度.     

多囊卵巢综合征患者内脂素水平变化及分析

目的 探讨内脂素水平变化与多囊卵巢综合征之间的相互关系.方法 选取2010年1月～2011年12月期间在某院检查确诊的128例多囊卵巢综合征患者(PCOS组),其中肥胖组52例及非肥胖组76例,随机选取门诊同期体检妇女120例作为对照组,观察各组体重指数(BMI)、腰臀比(WER)、血清卵泡刺激素(FSH)、黄体生成素(LH)、雌二醇(E2)、孕酮(P)、睾酮(T)、泌乳素(PRL)、内脂素、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)变化情况.结果 PCOS组BMI、WER、LH、T、FINS、HOMA-IR水平高于对照组,PCOS组内脂素水平(32.27±16.62) ng/ml,对照组(18.83±12.21) ng/ml,两组之间比较差异有统计学意义(P＜0.05);肥胖组患者BMI、FINS、HOMA-IR水平明显高于非肥胖组患者,肥胖组内脂素水平(34.86±17.14) ng/ml,非肥胖组(27.76±12.27)ng/ml,两组之间比较差异有统计学意义(P＜0.05).结论 多囊卵巢综合征患者血浆内脂素水平较正常人群明显升高,并且在肥胖患者中升高更为明显.     

PCOS患者血清瘦素、鸢尾素、胰岛功能及生殖激素的变化与BMI变化的关系

目的探讨多囊卵巢综合征(PCOS)患者血清瘦素、鸢尾素(irisin)、胰岛功能及生殖激素水平的变化及与体质量指数(BMI)间的关系。方法选取我院2016年6月至2017年3月确诊的90例PCOS妇女作为PCOS组、另选取对应的90例健康体检妇女作为对照组。检测两组的血清瘦素、irisin、雄激素(T)、雌激素(E2)、泌乳素(PRL)、黄体生成素(LH)、空腹血糖(FPG)、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)。结果 PCOS组的血清瘦素、irisin、FPG、FINS及HOMA-IR均显著的高于对照组,(P0.05);PCOS组的血清T、LH均显著的高于对照组,(P0.05);BMI≥25 kg/m~2的PCOS患者血清瘦素、Irisin、FINS及HOMA-IR均显著的高于BMI25 kg/m~2的PCOS患者,(P0.05)。结论 PCOS患者存在生殖激素水平紊乱、瘦素及irisin水平升高、不同程度的胰岛素抵抗,并且肥胖的PCOS患者瘦素、irisin及生殖激素水平紊乱及胰岛素抵抗更加突出。     

糖调节受损患者血清脂联素和瘦素水平的变化

目的探讨糖调节受损患者血清脂联素、瘦素的变化及其意义。方法采用ELISA法测定40例IGR患者（IGR组）和35例健康体检者（对照组）的血清脂联素、瘦素水平,并分析两者与体质指数（BMI）、腰臀（WHR）、血脂、血糖（FBG）、胰岛素抵抗指数（HOMA-IR）之间的关系。结果 IGR组的BMI、WHR、SBP、FINS、TC、HbA1c、HOMA-IR、TG、LDL-C及Leptin均明显高于对照组（P〈0.05）。IGR患者血清脂联素与BMI、HOMA-IR、LDL-C、瘦素呈显著负相关（P〈0.05）,与HDL-C呈显著正相关（P〈0.05）;血清瘦素与WHR、FBG、HOMA-IR、TG、LDL-C呈显著正相关（P〈0.05）,与HDL-C呈显著负相关（P〈0.05）。结论 IGR患者体内存在高瘦素血症和低脂联素血症,且脂联素与瘦素表达具有显著相关性,共同参与了IGR的发生发展。     

多囊卵巢综合征患者血清内脂素、超敏C反应蛋白、单核细胞趋化蛋白-1水平的变化

目的 研究多囊卵巢综合征(PCOS)患者血清中内脂素、超敏C反应蛋白(CRP)、单核细胞趋化蛋白-1(MCP-1)水平,为阐明PCOS的发病机制提供基础.方法 将94例PCOS患者和100例年龄与体重指数(BMI)相匹配的健康对照组,按BMI≥25 kg/m2或<25 kg/m2分为肥胖亚组和非肥胖亚组,采用酶联免疫吸附法(ELISA)和全自动生化分析仪检测其血清内脂素、CRP、MCP-1水平,并采用化学发光分析法检测其性激素水平以及内分泌代谢指标.结果 (1)PCOS组睾酮(T)、黄体生成素(LH)以及泌乳素(PRL)水平高于健康对照组(P<0.05～0.01),而卵泡刺激素(FSH)水平低于健康对照组(P<0.01).(2)PCOS肥胖亚组和非肥胖亚组内脂素、CRP、MCP-1、空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IR)均分别高于健康对照组的肥胖亚组和非肥胖亚组(P<0.01).(3)PCOS组和健康对照组血清内脂素、CRP、MCP-1水平均与BMI、FINS、HOMA-IR呈正相关(r=0.323～0.675,P<0.01);在控制BMI后的偏相关分析显示,PCOS组血清内脂素水平与HOMA-IR呈正相关(r=0.491,P<0.01),PCOS组的MCP-1水平与LH呈正相关(r=0.267,P<0.05).结论 PCOS患者存在较高的内脂素、CRP和MCP-1水平,且内脂素水平与P-COS的胰岛素抵抗相关联.肥胖可能加重了PCOS的慢性炎症过程.     

多囊卵巢综合征患者血清irisin水平测定及其意义

目的：Irisin能够提高胰岛素敏感性,改善胰岛素抵抗。本研究测定多囊卵巢综合征（polycystic ovary syndrome,PCOS）患者血清irisin水平,初步探讨其临床意义。方法：选择2014年7月-2016年2月于湖北医药学院附属东风医院（我院）中医科就诊的80例PCOS患者（PCOS组）和同期于我院体检中心体检的60例月经周期规律的健康体检者（对照组）作为研究对象。2组研究对象均接受体格检查以及血脂、性激素各项指标及血清irisin水平检测,对以上指标进行组间比较及相关性分析。此外,根据体质量指数（BMI）将PCOS患者分为肥胖组和非肥胖组,并进一步比较2组间上述指标的差异。结果：①PCOS组irisin、睾酮（T）、黄体生成激素（LH）、总胆固醇（TC）水平以及BMI、腰臀比（WHR）高于对照组,高密度脂蛋白胆固醇（HDL-c）、雌二醇（E2）水平低于对照组,差异有统计学意义（均P＜0.05）;在剔除其他指标影响后,PCOS患者血清irisin水平与雄激素水平、BMI呈正相关（r=0.476,P＜0.001;r=0.329,P=0.041）。②PCOS肥胖组三酰甘油（TG）水平高于PCOS非肥胖组,差异有统计学意义（P=0.028）;PCOS肥胖组irisin水平虽略高于PCOS非肥胖组,但差异无统计学意义（P=0.087）。结论：PCOS患者血清irisin水平较正常女性显著升高,且与雄激素、BMI呈正相关;提示irisin可能与PCOS发生相关。     

肥胖2型糖尿病患者血浆内脂素水平的变化

目的探讨肥胖2型糖尿病患者血浆内脂素水平的变化。方法采用ELISA法检测106例我院内分泌科住院T2DM患者（T2DM组）和100例本院门诊健康体检者（对照组）的血浆内脂素水平,同时检测两组患者血糖、血脂代谢参数水平。结果T2DM组非肥胖亚组与肥胖亚组的血浆内脂素水平分别高于对照组肥胖亚组与非肥胖亚组（P〈0．01）;T2DM肥胖亚组血浆内脂素水平高于非肥胖亚组,差异有统计学意义（P〈0．01）。多元线性逐步回归分析显示WHRD=3．412,P〈0．01）和FPG（t=2．245,P〈0．01）是影响血浆内脂素水平的独立相关因素。结论血浆内脂素水平变化与糖脂代谢关系密切,它可能在T2DM的发病机制中起着一定作用。     

Abnormal signal-averaged electrocardiogram (SAECG) in obesity

OBJECTIVE: The occurrence of small high-frequency electrocardiogram (ECG) potentials (1 to 20 microV) seen at the end of the QRS complex and into the ST segment have been correlated with increased risk for ventricular arrhythmias and sudden cardiac death. Computer-assisted analysis of these "late potentials" by signal-averaged electrocardiography (SAECG) has been studied and utilized to predict the likelihood of ventricular arrhythmias in various clinical states. Obesity is associated with significant cardiovascular morbidity and sudden death. Ventricular arrhythmias are postulated causes. We studied the occurrence of late potentials in a randomly selected group of obese patients and healthy volunteers. RESEARCH METHODS AND PROCEDURES: We performed SAECG on 105 subjects. Of these, 62 were obese ambulatory patients with body mass index (BMI) of >30 kg/m2, whereas 43 were healthy asymptomatic volunteers with a BMI of <30 kg/m2. Patients with a history of clinical heart disease and pulmonary disease, electrolyte abnormalities, recent hospitalizations, or abnormal screening ECG or taking medications known to alter the QRS interval were excluded. At least 250 beats were analyzed with a noise level of <0.50 microV. Criteria of a late potential include QRS duration >114 ms, high-frequency low amplitude >38 ms, and root-mean-square voltage <20 microV. Patients were divided into four subgroups based on BMI values. The prevalence of SAECG abnormalities in each BMI subgroup was studied. We utilized multiple logistic regression analysis to study the effect of obesity, hypertension, and diabetes mellitus on abnormal SAECG results. RESULTS: Compared to age- and sex-matched healthy volunteers with BMI of <30 kg/m2, obese patients with BMI of >30 kg/m2 had significantly more abnormalities on SAECG (4.6% vs. 55%). In the obese group, the prevalence and number of abnormalities increased with increase in BMI (35% in the BMI 31 to 40 kg/m2 subgroup, 86% in the BMI 41 to 50 kg/m2 subgroup, and 100% in patients with BMI of >50 kg/m2). Multiple logistic regression analysis shows that BMI is an independent predictor variable of abnormal SAECG results in obese patients (n = 62) with BMI of >30 kg/m2 as well as in all study subjects (n = 105). BMI also predicts abnormality of each abnormal SAECG criterion in both obese and all subjects. Hypertension was found to influence the QRS duration alone in obese and all subjects. DISCUSSION: Obesity is associated with increased occurrence of abnormal SAECG results. These abnormalities are found both in obese patients with and without hypertension and/or diabetes. Obesity is an independent predictor variable of abnormal SAECG results. A history of hypertension predicts abnormality of QRS duration only.     

Associations between combinations of body mass index plus non-alcoholic fatty liver disease and diabetes mellitus among Korean adults

The purpose of this study was to investigate associations between combinations of body mass index (BMI) categories plus non-alcoholic fatty liver disease (NAFLD) and diabetes mellitus (DM) among Korean adults. We prepared the data of 5665 subjects aged 20 years and over who had visited a health promotion center. We excluded 582 subjects as they had a viral or alcoholic liver disease. According to BMI-NAFLD status, the subjects were categorized as non-obese (BMI<25 kg/m2) without NAFLD (n=2568), obese (BMI≥25 kg/m2) without NAFLD (n=572), non-obese with NAFLD (n=748), or obese with NAFLD (n=1195). The prevalence of NAFLD was highest in the obese subjects with DM (87.9%). In non-obese and non-DM subjects, the prevalence of NAFLD was lowest (18.4%). After adjustment of age, gender, waist circumference, smoking status, alcohol drinking, regular exercise, the odd ratios for DM or DM plus impaired fasting glucose (IFG) of subjects with mild NAFLD regardless of obesity were almost 2-fold compared to non-obese subjects without NAFLD. Moreover, those of subjects with moderate or severe NAFLD regardless of obesity were about 4- fold. Clinicians and investigators need to pay attention to non-obese patients with fatty liver.     

The interrelationship between insulin secretion and action in type 2 diabetes mellitus with different degrees of obesity: evidence supporting central obesity

This paper investigates the relative role of the impairment of insulin secretion and action in the pathogenesis of Type 2 diabetes mellitus (T2DM). The parameters indicating insulin secretion and action were calculated from the data obtained during oral glucose tolerance test (OGTT), in 156 age- and sex-matched T2DM patients divided in 4 groups according to their body mass index (BMI, I = 20.0-24.9, II = 25.0-29.9, III = 30.0-39.9 and IV > 40.0 kg/m2). After obtaining baseline biomedical parameters (plasma glucose, serum insulin, cholesterol, HDL-cholesterol, triglycerides, BMI, and amount of fat tissue), the rates of insulin secretory capacity and insulin action were obtained from OGTT and compared between the T2DM patients with normal body weight and different grades of obesity. Beta-cell secretory capacity of the participants was found to be proportionally and significantly higher in graded obese than that of the normal body weight patients. The rates of hepatic as well as peripheral insulin resistance in obese groups proportionally and significantly rise in comparison with that of non-obese diabetics. In addition, these parameters are shown to be related to the body fat, presumably visceral in origin. In conclusion, hyperglycemia-hyperinsulinemia observed in obese and T2DM patients might be due, in part, to increased capacity of insulin secretion, and to exaggerated hepatic glucose production because of hepatic insulin resistance, respectively.     

老年男性2型糖尿病患者骨质疏松相关因素分析

目的 探讨与老年男性2型糖尿病（type 2 diabetes mellitus,T2DM）骨质疏松（osteoporosis,OP）发生相关的因素。方法 选取老年男性T2DM患者288例,根据OP诊断标准分为骨量正常组（72例）、骨量减少组（118例）和骨质疏松组（98例）。测量身高、体重,计算体质指数（body mass index,BMI）;测定空腹血糖（fasting blood glucose,FBG）、糖化血红蛋白（glycosylated hemoglobinA1c,HbA1c）、甲状旁腺素（parathyroid hormone,PTH）、血清钙（serum calcium,Ca）、血清磷（serum phosphonium,P）、25羟维生素D （serum 25-hydroxyvitamin D,25-OH-VD）及尿白蛋白/肌酐（urinary albumin/creatinine ratio,ACR）,记录患者病程、降糖药物使用和糖尿病慢性并发症情况。结果 与骨量正常组比较,骨质疏松组和骨量减少组病程较长和HbA1c较高,BMI减低,差异均有统计学意义（均有P<0.05）。相关分析显示股骨颈、三角区、大转子、腰椎（lumbar vertebrae,L）2-4节骨密度（bone mineral density,BMD）与BMI均呈正相关（均有P<0.05）,但与HbA1C均呈负相关（均有P<0.05）。骨质疏松组糖尿病肾病、糖尿病视网膜病变发生率均高于骨量正常组、骨量减少组（均有P<0.05）;骨质疏松组糖尿病神经病变发生率高于骨量正常组（χ2=6.168,P=0.013）。Logistic回归分析显示BMI、HbA1c及糖尿病肾病与糖尿病骨质疏松发生相关（均有P<0.05）。结论 低BMI,血糖控制不佳和糖尿病肾病是老年男性T2DM患者OP发生的危险因素。     

Lipoprotein oxidation and plasma vitamin E in nondiabetic normotensive obese patients

OBJECTIVE: To correlate the susceptibility of low-(LDL) and very-low-density lipoprotein to oxidation in vitro and the concentrations of serum antibodies against malondialdehyde-modified LDL and plasma vitamin E with the anthropometric and laboratory characteristics of obesity. RESEARCH METHODS AND PROCEDURES: A total of 75 nondiabetic, normotensive obese patients were assigned to one of four groups according to their body mass index (BMI): moderately obese (30 50 kg/m(2), n = 15). RESULTS: The oxidation lag time for LDL from patients with a BMI >or=35 kg/m(2) was shorter than that for LDL from non-obese controls (n = 13), whereas very-low-density lipoprotein oxidation lag times were not significantly different. The serum antibodies against modified LDL were similar in all groups, whereas the plasma vitamin E concentrations of obese patients were decreased (p 相似文献   

绝经后女性2型糖尿病患者发生骨质疏松性骨折的危险因素分析

目的探讨绝经后女性2型糖尿病(T2DM)患者发生骨质疏松性骨折的危险因素。方法采用回顾性研究方法,选取绝经后女性T2DM骨质疏松患者220例,根据有无骨折分为骨折组(n=100)和无骨折组(n=120),记录患者的一般资料,收集其空腹血样本用于血糖、血脂、尿酸、HbA_1c等检测。结果骨折组BMI、TG、FBG、HbA_1c水平高于无骨折组(P <0.05);Logistic回归分析提示,BMI、TG、FBG和HbA_1c是绝经后女性T2DM骨质疏松患者发生骨折的独立危险因素;分别根据BMI、TG、FBG和HbA_1c三分位数将绝经后女性T2DM骨质疏松患者分成3组,结果提示随着BMI、TG、FBG和HbA_1c水平的升高,骨折的发生率逐渐升高。结论在绝经后女性T2DM骨质疏松患者中,BMI、TG、FBG和HbA_1c是其发生骨折的独立危险因素。     

Resting metabolic rate in severely obese diabetic and nondiabetic subjects

OBJECTIVES: To compare the resting metabolic rate (RMR) between diabetic and nondiabetic obese subjects and to develop a predictive equation of RMR for these subjects. RESEARCH METHODS AND PROCEDURES: Obese adults (1088; mean age = 44.9 +/- 12.7 years) with BMI > or = 35 kg/m2 (mean BMI = 46.4 +/- 8.4 kg/m2) were recruited. One hundred forty-two subjects (61 men, 81 women) were diagnosed with type 2 diabetes (DM), giving the prevalence of DM in this clinic population as 13.7%. RMR was measured by indirect calorimetry, and several multivariate linear regression models were performed using age, gender, weight, height, BMI, fat mass, fat mass percentage, and fat-free mass as independent variables. RESULTS: The severely obese patients with DM had consistently higher RMR after adjustment for all other variables. The best predictive equation for the severely obese was RMR = 71.767 - 2.337 x age + 257.293 x gender (women = 0 and men = 1) + 9.996 x weight (in kilograms) + 4.132 x height (in centimeters) + 145.959 x DM (nondiabetic = 0 and diabetic = 1). The age, weight, and height-adjusted least square means of RMR between diabetic and nondiabetic groups were significantly different in both genders. DISCUSSION: Severely obese patients with type 2 diabetes had higher RMR than those without diabetes. The RMR of severely obese subjects was best predicted by an equation using age, gender, weight, height, and DM as variables.