中药毒性的再认识

我们的祖先在临床实践过程中认识到一些药物对人体有毒,将中药毒性分为大毒、有毒、小毒3级,并认为中药毒性有广义之毒和狭义之毒之分。近代,人们对有毒中药的毒性成分及中毒机制有了进一步的认识,特别是中药肾毒性的认识。影响中药毒性的因素较多,主要有品种、炮制、剂量、配伍及环境等因素。要防止中药的毒性作用,一方面需加强药政管理,另一方面要提高医务人员的业务素质,加强医务人员对中药毒性的认识,同时要让患者掌握正确的煎煮及服药方法。     

中医古籍疑难字考辨例释

中医古籍中的疑难字是今人阅读和理解中医古籍、传承优秀中医药文化的障碍,同时也不利于中医古籍的数字化加工和中医药信息知识元的提取和标引.文章通过形音义互求、文献比勘等方法,对中医古籍中的"(儧)""(滃)""(施)""(斘)""(鍤)""(鬞)""(帶)""(舔)""(蟜)"等9个疑难字进行了考辨,明确了形音义信息,沟通了相关字际关系,并对《汉语大词典》《汉语方言大词典》等大型辞书中的部分释义内容进行了辨正.     

Current Basic Research on Traditional Chinese Herbal Drugs

Ｃｕｒｒｅｎｔ　Ｂａｓｉｃ　Ｒｅｓｅａｒｃｈ　ｏｎ　Ｔｒａｄｉｔｉｏｎａｌ　Ｃｈｉｎｅｓｅ　Ｈｅｒｂａｌ　ＤｒｕｇｓＬＩＵＧａｎｚｈｏｎｇ（Ｃｈｉｎａ－ＪａｐａｎＦｒｉｅｎｄｓｈｉｐＩｎｓｔｉｔｕｔｅｏｆＣｌｉｎｉｃａｌＭｅｄｉｃａｌＳｃｉｅｎｃｅｓ...     

中药药性与蛋白质含量相关性研究

目的:初步探讨中药寒热药性与蛋白质含量的相关性。方法:采用考马斯亮蓝法测定20味中药的蛋白质含量,以蛋白质含量为指标,确定中药药性与蛋白质含量的相关关系。结果:中药的寒热药性与蛋白质含量没有统计学意义,但10种热性药蛋白质平均含量为12.6670mg/g,10种寒性药蛋白质平均含量为6.5036mg/g,热性药蛋白质含量是寒性药的1.9倍。结论:蛋白质含量与中药寒热药性有一定的相关性。     

Experimental study on anti-acute leukemia with Chinese traditional drugs

This paper deals with the experimental study on L7212 leukemic model of mice with Chinese medicine Liushenwan, Zhijinding and Xihuangwan for the treatment. This study proved that these drugs possessed the effect of inhibiting and killing L7212 leukemic cells of the experimental leukemic mice (P less than 0.05-0.001). They affected the S stage of the cell multiplication cycle time mainly (P less than 0.01). They could relieve the infiltration of leukemic cells in the liver and spleen of L7212 mice (P less than 0.001) and obviously prolong the survival time of the mice (P less than 0.01-0.001).     

中药治疗变态反应性疾病研究进展

变态反应是机体受抗原性物质刺激引起的组织损伤或生理功能紊乱,即病理性的免疫反应.近年来,变态性疾病的发病率逐年增加,随着免疫学研究的进展,中药抗变态反应的研究已越来越受到重视,并发现多种单味中药、中药复方及中药提取物具有抗变态反应作用,临床上也取得了较好的疗效,并且无严重不良反应发生.     

中药指纹图谱在药用植物开发中的应用初探

中药指纹图谱是指中药材经过适当的处理后,采用一定的分析手段和仪器检测得到的,能够标识其中各种组分群体特征的共有峰的图谱[1]。主要用以鉴别真伪,区分植物药材的不同部位,评价原料药材、半成品和成品质量的均一性和稳定性。中药指纹图谱具备“整体性”和“模糊性”的特点。     

基于本体推理的中西药物相互作用自动发现研究

目的:通过构建中西药物相互作用本体,利用本体推理工具自动发现中西药物相互作用.方法:基于用药安全规则及药物相互作用原理,利用本体语言构建疾病治疗的中西药物相互作用本体.设计本体推理工具的自定义规则,实现从药物相互作用到药物使用风险的推理.结果:药物相互作用本体构建及推理方法可用于发现中西药物联用可能发生的风险和风险预警...     

中药基原性状与寒热药性相关性研究工作的要点和注意事项分析

认为中药基原性状与寒热药性相关性研究的主要目的是探寻相同或相近四性属性中药组群可能存在的基原性状共性特征要素及其表达的规律性;探寻古人基于基原性状推理中药药性属性的主要规则;探寻中药基原性状要素影响寒热药性属性的共性特征及其规律性。研究要点包括品种、药用部位、生态环境与道地性、采收时节、性状特征等。研究过程中应着重注意如下事项:取样应均衡、充足、有代表性;严格选取研究中药;原植物鉴定研究;根据研究需要制备相应显微分析用切片;系统比较,综合分析。     

Application of traditional Chinese drugs in comprehensive treatment of primary liver cancer

The present paper is a summary for treating 50 cases of Stage II primary liver cancer by the Integrated method of traditional Chinese and Western medicine. It was found by comparative observation that the average survival time of the Spleen-Deficiency (SD) type patients was markedly longer than that of Phlegm-Dampness-Stagnancy (PDS), Qi- and Blood-Stagnancy (QBS) and Liver-Kidney-Yin-Deficiency (LKYD) types, indicating that the SD type patients might have a better prognosis, and that the Chinese herbal medicine was an alternative for treating intermediate and late carcinoma.     

Prospective on the Development of Traditional Chinese Drugsin the New Century

ＰｒｏｓｐｅｃｔｉｖｅｏｎｔｈｅＤｅｖｅｌｏｐｍｅｎｔｏｆＴｒａｄｉｔｉｏｎａｌＣｈｉｎｅｓｅＤｒｕｇｓｉｎｔｈｅＮｅｗＣｅｎｔｕｒｙＺＨＯＵＪｉｎ－ｈｕａｎｇ（周金黄）ＭＤ（ＤｅｐａｒｔｍｅｎｔｏｆＴＣＤＰｈａｒｍａｃｏｌｏｇｙ，Ａｃａｄｅｍｙｏｆ...     

Treatment of ulcerative colitis by traditional Chinese medicine and dynamic study of immune functions

The effect of the traditional Chinese medicinal herbs enema and enteric-coated capsules in the treatment of ulcerative colitis (UC) were compared in 260 cases. The immune complexes and the dynamic change of autoantibodies were monitored in 28 out of the 260 cases before and after treatment. The following results were observed. (1) There was no significant difference in the total effective rate between the enema group and the oral capsule group (93.3% and 87.5% respectively), but the recovery rates of purulent hemafecia, mucusfecia and erosion accompanying colitis, etc. in the former group were higher than those in the latter (P less than 0.01). (2) The circulating immune complexes were found 43 times above the normal range in 17 cases with positive rate 60.7%, and tended to decrease as the condition became better after treatment. Antinuclear antibodies were determined by the indirect fluorescent immune method and the indirect enzyme labelling method and the positive rates were 53.6% and 64.7% respectively, both being much higher than those in the controls (P less than 0.01).     

血管性认知损害的中医证候与认知功能的关系

目的：探讨血管性认知损害（vascular cognitive i mpairment,VCI）患者的认知功能与中医证候的相关性,为VCI的中医辨证治疗提供依据。方法：2006年12月~2010年3月从北京东直门医院老年病科和社区居民中招募774名患者,筛选出认知正常组251例,VCI组107例。采用海金斯基缺血量表（Hachinski ischemic scale,HIS）、汉密尔顿抑郁评定量表（Hamilton depression scale,HAMD）、简易精神状态检查（mini-mental state examination,MMSE）中文版、临床痴呆评定量表（clinical dementia ratingscale,CDR）、画钟试验（clock drawing test,CDT）及日常生活能力量表（ability of dailyliving,ADL）评价患者认知功能、日常生活能力和痴呆的严重程度等,采用偏相关分析法分析VCI患者认知功能与中医证候的相关性。结果：VCI组中医证候与量表成绩的相关性分析显示,MMSE总分、CDT得分均与痰浊蒙窍证呈负相关（r=-0.525,r=-0.321;P=0.000,P=0.001）,ADL与痰浊蒙窍证呈正相关（r=0.424,P=0.000）,与肾精亏虚证呈正相关（r=0.216,P=0.028）。VCI组的认知功能与中医证候的偏相关分析显示,MMSE中总定向力以及时间和空间定向力得分均与痰浊蒙窍证呈负相关（r=-0.451,r=-0.448,r=-0.392;P=0.001,P=0.000,P=0.004）,单词即刻记忆和单词延迟回忆得分与痰浊蒙窍证呈负相关（r=-0.355,r=-0.225;P=0.000,P=0.021）,计算力/注意力、语言功能及执行功能得分均与痰浊蒙窍证呈负相关（r=-0.379,r=-0.448,r=-0.321;P=0.000,P=0.000,P=0.013）。痰浊蒙窍证患者的MMSE中总定向力、时间定向力、空间定向力、注意力/计算力均显著低于无痰浊蒙窍证患者（P〈0.01）,痰浊蒙窍证患者语言功能及单词延迟回忆得分均显著低于无痰浊蒙窍证患者（P〈0.05）。结论：VCI的主要中医证候为肾精亏虚、痰浊蒙窍和瘀阻脑络,其中痰浊与患者定向力、记忆力、注意力/计算力、语言功能关系密切,故化痰开窍法可用于防治血管性认知损害。