硫酸亚铁和叶酸防治山区孕妇盆血的效果观察

目的 为防治山区孕妇贫血制定合理用药剂量。方法 在分别只给予硫酸亚铁０．３ｇ／ｄ或叶酸５ｍｇ／ｄ观察结果的基础上，分组观测每日、分组观测每日、隔日及隔２日顿服铁剂和叶酸对孕妇血清叶酸、血清铁蛋白水平及血红蛋白浓度的影响。结果 每日给药组可以有效地防治贫血的发生，隔日给药及隔２日给药均未能完全防治贫血的发生，而３种给药组均完全消除了叶酸缺乏症的出现。结论 每日服硫酸亚铁０．３ｇ，每３日蜉叶酸５ｍｇ可     

不同剂量复方硫酸亚铁叶酸片对贫血孕妇的疗效及影响

目的 探讨不同剂量的复方硫酸亚铁叶酸片对贫血孕妇的治疗效果。方法 366例缺铁性贫血的孕妇随机分为2组,A组给予200mg(常规剂量)复方硫酸亚铁叶酸片,3次/d;B组给予100mg(低剂量)复方硫酸亚铁叶酸片,3次/d。治疗一个月后检测两组红细胞计数(RBC)、血红蛋白(Hb)、和血清铁蛋白(SF)水平的变化。结果 两组治疗前后无论轻度还是中重度贫血孕妇RBC、Hb及SF指标增长均有统计学差异(P均<0.05)。但轻度贫血患者治疗总有效率在两组之间比较无统计学差异(χ²=0.589,P>0.05);对于中重度贫血患者治疗总有效率在两组之间比较有统计学差异(χ²=4.48,P<0.05);不良反应方面B组低于A组,差异有统计学意义（(χ²=4.446,P=0.035)。结论 复方硫酸亚铁叶酸片治疗孕妇缺铁性贫血效果显著。对轻度贫血患者可采用低剂量进行治疗,可以达到治疗效果并降低不良反应的发生。     

叶酸及维生素B12强化促红细胞生成素防治早产儿贫血疗效观察

【目的】 观察叶酸及维生素B₁₂在强化促红细胞生成素(erythropoietin, EPO)在早产儿贫血中的防治作用。 【方法】 将2006年1月—2010年5月间在本院新生儿科住院的早产儿69例,首先按出生体重分为两组;1 000 g≤出生体重<1 500 g的极低出生体重儿48例为第一组,再随机分为治疗组Ⅰ26例,对照组Ⅰ22例;出生体重<1 000 g的超低出生体重儿21例为第二组,并随机分为治疗组Ⅱ11例,对照组Ⅱ10例,两组均于生后第7天给予EPO 250 U/(kg·d),3次/周,共6周,同时加服铁剂[元素铁3~5 mg/(kg·d)]。治疗组在此基础上加服叶酸[200 μg/(kg·d)],以及维生素B₁₂[30 μg／(kg·周)]。对照组未予强化叶酸及维生素B₁₂。 【结果】 6周后治疗组外周血血红蛋白,红细胞计数,红细胞压积均显著高于对照组,红细胞平均体积显著低于对照组。且超低出生体重儿组的疗效较极低出生体重儿组更显著。 【结论】 叶酸及维生素B₁₂可加强EPO防治早产儿贫血的疗效,且出生体重愈低,疗效愈显著。     

抗贫血胶囊改善缺铁性贫血效果的初步观察

目的:观察抗贫血胶囊改善缺铁性贫血的效果。方法:选用150 g左右的雄性SD大鼠,用低铁饲料喂养法制备缺铁性贫血模型后,将大鼠随机分为5组,一组为对照组,一组为硫酸亚铁组(补充铁20.0 mg/kg),其余为高、中、低剂量血红素铁组,分别补充2.7、5.41、6.0 mg/kg的血红素铁。分别于补充前、补充35 d后,测定各组大鼠体重、血液学指标、血清铁、铁蛋白、红细胞游离原卟啉水平。结果:补铁前后,大鼠体重均有所增长,但各组之间均无显著差异。补充硫酸亚铁、抗贫血胶囊后,硫酸亚铁组和低、中、高剂量血红素铁组大鼠血红蛋白、红细胞计数、红细胞压积均明显高于对照组。硫酸亚铁组和低、中、高剂量血红素铁组大鼠红细胞游离原卟啉均明显低于对照组,硫酸亚铁组和中、高剂量血红素铁组大鼠的血清铁水平,中、高剂量血红素铁组大鼠血清铁蛋白明显高于对照组。结论:抗贫血胶囊有改善缺铁性贫血的作用。     

不同剂量铁剂治疗缺铁性贫血的疗效观察比较

缺铁性贫血是最常见的贫血性疾病,多见于生育年龄妇女、婴幼儿及儿童,本病经铁剂治疗可获痊愈,近年来遂宁市妇幼保健院使用不同剂量铁剂治疗缺铁性贫血,收到较好效果,现报道如下。1对象与方法1.1病例来源及分组100例缺铁性贫血患者系1999年至2001年经临床和实验室确诊的住院和门诊病人。其中男44例,女56例,年龄6～65岁。自出现贫血症状至确诊时间最短7天,最长20年。按每日给予硫酸亚铁不同剂量随机分为3组,分别为0.3g组:硫酸亚铁0.3g/天,早餐后口服;0.9g组:硫酸亚铁0.9g/天,分3次饭后口服,以上2组均同时口服维生素C0.6g/天,分3次口服;控释…     

妊娠期妇女贫血状况调查分析

本文对259名正常初孕妇女的营养性贫血状况进行了调查分析。于不同孕期取血测定血清铁蛋白,红细胞原卟啉,血红蛋白,血清叶酸及血清维生素B_(12)含量。结果发现,孕妇体内铁缺乏、叶酸及维生素B_(12)不足随孕周增加日趋明显,至孕后期血清铁蛋白<12μg/L者达72.0％;红细胞原卟啉>500μg/L(全血)者占25.9％;血清叶酸<3μg/L者占32.1％;血清维生素B_(12)<150μg/L者为25.6％。259名孕妇中89名患有贫血,总患病率为34.4％。对89名贫血孕妇按缺铁性、叶酸缺乏,及铁和叶酸双缺进行分类,以缺铁性贫血为主,为61例(68.5％),叶酸缺乏贫血22例(28.1％),双缺者3例(3.4％)。不同孕期贫血的分类结果表明,缺铁性贫血随孕周增加所占比例逐渐下降;而叶酸缺乏贫血所占比例随孕周增加逐渐增高。     

促红细胞生成素加服铁剂防治早产儿贫血临床疗效探讨

目的：探讨促红细胞生成素加服铁剂防治早产儿贫血疗效。方法：选择胎龄耋35周、出生体重1100-1950g的早产儿50例,生后7d病情稳定后取末梢血查血红蛋白（Hb）、红细胞压积（Hct）、网织红细胞（Ret）,并随机分成两组,对照组（n=25）于生后1周常规服雏生素VC、COB、叶酸。治疗组（n=25）在对照组的基础上皮下注射重组人类促红细胞生成素250u／（kg·次）,隔日一次,共4周。并同时加服铁剂,元素铁按第1周：2mg／（kg·d）,第2周：3mg／（kg·d）,第3周：4rag（kg·d）,第4周5rag（kg·d）,两组均于生后21和42d复查Hb、Hct、Ret。结果：治疗组的Hb、Hct、Net明细高于对照组。结论：促红细胞生成素加服铁剂治疗早产儿贫血安全有效。     

5569例米非司酮药物流产回顾分析

目的:回顾性分析抗早孕药物米非司酮不同给药方法药物流产的临床效果.方法:对5569例自愿要求药物流产的孕妇(孕周≤7w),随机分为甲、乙、丙三组,分别按不同的服药方法服用米非司酮片剂.甲组给米非司酮50mg口服,1次/12h,共3次.乙组刺量加倍,即给米非司酮50mg口服,2次/d,共3d.均于用完药次晨一次性口服米索前列醇600μg;丙组给药方法同甲组,但在胎囊排出后加服米非司酮50μg,1次/d,共用3d.观察完全流产率、阴道出血量及阴道出血持续时间、不良反应.结果:甲、乙、丙组完全流产率73%、74.5%、95%.甲、乙组无统计学显著差异(P＞0.05).丙组与甲组、乙组均具有统计学显著差异(P＜0.05).结论:丙组用药完全流产率高,阴道出血量少、阴道出血持续时间短.且不良反应较小.     

贫困山区孕妇营养不良性贫血发病调查

妊娠期由于孕妇对铁、叶酸的需要量增加,容易发生铁和(或)叶酸缺乏及相应的贫血。国内外一些研究显示,不同的国家、地区,孕妇出现铁和(或)叶酸缺乏症及贫血的发生率明显不同。因此,有必要根据地区特点做具体调查,以便指导孕妇预防性补充用药,减少各类缺乏症及贫血的发生。我们对张家口市区及沽原县坝上山区的孕妇,进行了血清铁、叶酸、血红蛋白量的测定,报告如下。     

每周1次补铁治疗婴幼儿缺铁性贫血疗效观察

目的:观察每周1次补铁方法对婴幼儿缺铁性贫血的治疗效果。方法:75例缺铁性贫血患儿随机分为两组,观察组40例,每周1次给琥珀酸亚铁6 mg/kg(按所含元素铁计2 mg/kg),早餐前1次服;对照组35例,每日给药剂量同观察组,分早、晚两次餐前服。主要观察指标:血红蛋白(Hb)、平均红细胞体积(MCV)、网织红细胞(Ret)、血清铁蛋白(SF)、红细胞内游离原卟啉(FEP)等。结果:两组治疗12周后,血红蛋白均有升高,与治疗前比较有显著差异(P<0.05),Hb、MCV、Ret、SF、FEP两组比较无显著差异。结论:每周1次给药与每天给药两种方法治疗缺铁性贫血效果相似。     

Concomitant supplemental vitamin A enhances the response to weekly supplemental iron and folic acid in anemic teenagers in urban Bangladesh.

BACKGROUND: Iron deficiency is the most common micronutrient deficiency and affects >2 billion persons worldwide, leading to anemia in >40% of women of reproductive age in the developing world. OBJECTIVE: The objective was to determine whether weekly supplementation with iron and folate would reduce the frequency of anemia in teenage women in urban Bangladesh before they became pregnant. DESIGN: Participants with a hemoglobin concentration of 80-120 g/L were entered into a randomized, double-blind, placebo-controlled trial and received supplements of placebo, vitamin A, iron + folic acid, or iron + folic acid + vitamin A weekly for 12 wk. The supplements contained 2.42 mg vitamin A (retinol) as retinyl palmitate, 120 mg elemental Fe as ferrous sulfate, and 3.5 mg folic acid. RESULTS: Hemoglobin concentrations increased significantly more after supplementation with iron + folic acid or iron + folic acid + vitamin A than after either the placebo or vitamin A alone. There was a significantly greater increase in hemoglobin after iron + folic acid + vitamin A than after iron + folic acid, but the additional effect disappeared after adjustment for baseline hemoglobin, serum vitamin A, and ferritin and the number of supplements taken. Those with the lowest baseline hemoglobin had the greatest increase in hemoglobin. Compared with the placebo, iron + folic acid + vitamin A reduced anemia by 92%, iron deficiency by 90%, and vitamin A deficiency by 76%. CONCLUSION: There may be significant health benefits from a program that enhances the nutritional status of iron, folate, and vitamin A in poor urban young women before they become pregnant.     

Effect of time of initiation and dose of prenatal iron and folic acid supplementation on iron and folate nutriture of Korean women during pregnancy

BACKGROUND: In Korea, it is customary to prescribe iron and folic acid supplements to pregnant women after the 20th wk of gestation; however, little evidence exists to support this practice. OBJECTIVE: The objective was to determine the effects of time of initiation and dose of prenatal iron and folic acid supplementation on the iron and folate nutriture of Korean women during pregnancy. DESIGN: A total of 131 pregnant women were placed into 1 of 5 experimental groups, either the control group or 1 of 4 supplemented groups. The supplemented groups varied by time of initiation, which was either during the first trimester or at week 20 of gestation, and by dose of iron and folic acid supplements provided, which consisted of either 30 mg Fe plus 175 microg folic acid or 60 mg Fe plus 350 microg folic acid. All supplemented groups continued supplementation until delivery. RESULTS: Improvements in iron and folate nutriture were highly dependent on when the supplement program was initiated, but both supplement doses were equally effective. In contrast, the influence of folic acid supplementation on maternal folate status was not as pronounced as was the influence of iron supplementation on iron status. CONCLUSION: In pregnant Korean women, initiating iron and folic acid supplementation earlier during pregnancy may prevent the deterioration of iron and folate nutriture more than does increasing supplement doses in later stages of pregnancy.     

Treatment and prevention of anemia with ferrous sulfate plus folic acid in children attending daycare centers in Goiânia, Goiás State, Brazil: a randomized controlled trial

The objective of this study was to assess the prevalence of anemia and the therapeutic and prophylactic response to ferrous sulfate and folic acid. A double-blind, randomized, controlled clinical trial was conducted with 196 children 6 to 24 months of age enrolled in municipal daycare centers in Goiania, Goiás State, Brazil. The children were assigned to two treatment groups that received a daily dose (5 times a week) of either 4.2mg/kg/day of ferrous sulfate + folic acid (50microg) or 4.2mg/kg/day of ferrous sulfate + folic acid placebo. One of the prevention groups received 1.4mg/kg/day of ferrous sulfate + folic acid (50microg/day) and the other 1.4mg/kg/day of ferrous sulfate + folic acid placebo. Supplementation lasted approximately three months. Baseline anemia prevalence was 56.1% (95%CI: 48.9-63.1). After treatment, anemia prevalence in the folic acid group (14%) was lower than in the placebo group (34.9%) (p = 0.02). After prophylaxis in the non-anemic children, the incidence of anemia did not differ between the groups, but there was an increase in hemoglobin level in the folic acid group (p = 0.003). Iron plus folic acid was effective for the treatment of anemia and improvement of hemoglobin level in non-anemic children.     

Daily iron supplementation is more effective than twice weekly iron supplementation in pregnant women in Pakistan in a randomized double-blind clinical trial

In the context of limited effectiveness of iron supplementation programs, intermittent iron supplementation is currently under debate as a possible alternative strategy that may enhance the effectiveness of operational programs. This field-based trial assessed the outcome of twice weekly iron supplementation compared to daily in Pakistan. A double-blind, randomized, clinical trial was conducted in Northern Pakistan. Anemic pregnant women (n = 191) were assigned to receive daily (200 mg ferrous sulfate) or twice weekly (2 x 200 mg ferrous sulfate) iron supplementation. Hemoglobin was measured at baseline and at 4-wk intervals for up to 12 wk. Serum ferritin was measured at baseline and 8 or 12 wk. Analysis was by intention to treat. The two groups did not differ in age, parity, sociodemographic characteristics, hemoglobin or serum ferritin concentrations at baseline. Women who received iron daily had a greater rise in hemoglobin compared with women who received iron twice weekly (17.8 +/- 1.8 vs. 3.8 +/- 1.2 g/L, P < 0.001). The serum ferritin concentrations increased by 17.7 +/- 3.9 microgram/L (P < 0.001) in the daily supplemented group and did not change in the twice weekly group. Daily iron supplementation remained superior to twice weekly supplementation after controlling initial hemoglobin Z-scores and duration of treatment. The body mass index (BMI) modified the effect of daily versus twice weekly iron supplementation. For every unit increase in BMI, the difference between the two treatment groups was reduced by 0.0014 (final hemoglobin Z-score; P = 0.027). We recommend continuation of daily iron supplementation as opposed to intermittent iron supplementation in pregnant women in developing countries.     

妊娠期补充微量元素及维生素对妊娠高血压疾病的预防作用

目的探讨孕妇妊娠期补充微量元素(铁和锌)及维生素(叶酸和维生素D)对妊娠高血压疾病的预防作用。方法以2014年1月到2016年3月期间在海南省三亚市妇幼保健医院妇产科就诊经医学检查确认怀孕的768例育龄期女性为研究对象,随机平均分为A、B、C三组,其中A组补充适量的维生素(包括叶酸和维生素D)和微量元素(包括铁和锌);B组补充适量铁和锌两种微量元素,而不补充维生素;C组既不补充维生素也不补充微量元素。考察在经过补充微量元素和维生素后,三组血中铁、锌含量,叶酸及维生素含量,24小时动态血压指标和妊娠高血压发病率上的差异。结果 A、B组血液中的铁、锌含量较C组有明显提高;通过口服补充维生素,A组血液中的叶酸和维生素D含量较B、C两组有明显提高。经24小时动态血压检测比较发现,A、B、C三组在收缩压和舒张压存在显著差异,三组在妊娠高血压总发病率、1级高血压发病率和2级高血压发病率比较上也存在显著差异,C组B组A组,差异均有统计学意义。结论孕妇妊娠期补充微量元素(铁和锌)和维生素(叶酸和维生素D)相比不补充的孕妇,妊娠高血压综合征的发生率明显下降,妊娠期补充微量元素(铁和锌)和维生素(叶酸和维生素D)对预防妊娠高血压疾病具有一定的作用。     

Moderate NaFeEDTA and ferrous sulfate supplementation can improve both hematologic status and oxidative stress in anemic pregnant women

Iron is important general well being, to prevent or treat anemia, and is a cofactor of many enzymes in the anti-oxidant process. Effect of sodium iron ethylenediaminetetraacetate (NaFeEDTA) and ferrous sulfate on iron bioavailability and oxidative stress in anemic pregnant women was evaluated. A 2-month randomized controlled trial was conducted on 153 anemic pregnant women, with 80 <= Hb <110 g/L. They were randomly allocated to three groups: group C (n=51) was the placebo control group, group I (n=51) was supplemented daily with 60 mg iron as ferrous sulfate, and group IE (n=51) with 60 mg iron as NaFeEDTA. Blood samples were collected before and at the end of the intervention for measurements of hematological indices and oxidative stress parameters. Considerable increases of hematologic indicators were observed: 20.5 and 21.8 g/L for Hb (both p values <0.001); 4.81 and 7.19 μmol/L for plasma iron (both p values <0.001), 2.63 and 8.99 μg /L for ferritin (both p values <0.05) in I and IE groups, respectively, compared with the control group. Glutathione peroxidase (GSH-Px) activities increased by 32.6 and 75.3 IU/ml, and malondialdehyde (MDA) levels decreased by 0.70 and 1.12 μmol/L in I and IE groups, compared with the C group (p values <0.05). Moreover, differences of plasma iron, ferritin and GSH-Px activity were 2.38 μmol/L, 6.36 μg /L and 42.7 IU/ml were also significantly greater in the IE group than in the I group. Moderate iron supplementation may be beneficial to improving iron deficiency and oxidative stress, and NaFeEDTA is better than ferrous sulfate.     

Community Mobilization and Social Marketing to Promote Weekly Iron-Folic Acid Supplementation: A New Approach Toward Controlling Anemia Among Women of Reproductive Age in Vietnam

Community-based social marketing and mobilization increased knowledge and participation in preventive weekly iron-folic acid supplementation among women of reproductive age in Vietnam. Rates of buying and taking the weekly supplement containing 60 mg elemental iron and 3.5 mg folic acid among non-pregnant women of reproductive age was between 55% and 92%. Free distribution to pregnant women of the weekly supplement containing 120 mg iron and 3.5 mg folic acid covered almost all pregnant women during the project. In developing countries where community women's groups and health networks are strong, preventive supplementation can be successfully promoted to encourage active participation in the prevention and control of iron-deficiency anemia.     

武汉地区孕妇同型半胱氨酸水平与妊娠结局的相关性研究

目的 探讨武汉地区孕妇同型半胱氨酸、叶酸水平与妊娠结局的相关性。方法 选取在某院就诊的先兆流产孕妇200例作为观察组,健康孕妇200例为对照组,比较2组Hcy和叶酸水平之间差异,同时比较2组妊娠结局之间的差异。结果 观察组Hcy水平高于对照组,叶酸水平低于对照组,差异具有统计学意义(t = 34.895,P＜0.001;t = 12.152,P＜0.001)。经相关性分析,观察组和对照组血清Hcy与叶酸水平均呈负相关(r = - 0.91,P＜0.05; r = - 0.842,P＜0.05)。观察组自然分娩率低于对照组,早产率和流产率高于对照组,2组的妊娠结局差异有统计学意义(P＜0.05)。观察组妊娠结局中流产组Hcy水平高于早产组和自然分娩组(F = 271.800,P＜0.001)。同时,流产组叶酸水平明显低于早产组和自然分娩组,差异具有统计学意义(F = 5.192,P = 0.006)。对孕妇进行个体规范化补充叶酸,2组中规范补充叶酸组叶酸水平高于未按医嘱规范补充叶酸组(t = 5.243,P＜0.05;t = 6.095, P＜0.05),相应的,规范组Hcy水平低于不规范组,差异有统计学意义(t = 11.341,P＜0.05;t = 10.552, P＜0.05)。结论 在先兆流产孕妇体内血清Hcy增高,叶酸低表达,且Hcy和叶酸水平与孕妇的妊娠结局有关。     

神经管畸形高、低发区农村孕早期妇女血液叶酸水平比较研究

目的 了解神经管畸形高发区与低发区农村孕早期妇女血液叶酸状况。方法 采用现况调查方法对2003年神经管畸形高发与低发两个地区共688名农村孕早期妇女的血浆叶酸与红细胞叶酸水平进行研究。结果 高发区农村孕早期妇女血浆叶酸浓度（10．53nmol／L）与红细胞叶酸浓度（389．2nmol／L）中位数明显低于低发区妇女（血浆叶酸30．39nmol/L，红细胞叶酸926．0nmol／L），差异有统计学意义；高发区妇女血浆叶酸缺乏率约为50％，红细胞叶酸缺乏率约为43％，远高于低发区妇女（血浆叶酸6％，红细胞叶酸4％），差异有统计学意义；高、低发区服用叶酸组妇女血浆叶酸水平约为不服用组的2倍，红细胞叶酸水平是不服用组的1．4倍，差异有统计学意义；高、低发区服用叶酸组孕早期妇女的血浆缺乏率均低于不服用组，相对危险度（RR）值分别为0．60（95％CI：0．36～1．01）与0．16（95％CI：0．06～0．44），差异均有统计学意义；高、低发区服用叶酸组与不服用组红细胞叶酸缺乏率之间的RR值分别为0．64（95％CI：0．36～1．13）与0．39（95％CI：0．13～1．13），差异无统计学意义；服用叶酸的孕早期妇女中，低发区血浆叶酸水平约为高发区的1．7～1．9倍，红细胞叶酸水平约为高发区的2倍，差异有统计学意义；服用叶酸的孕早期妇女中，高发区血浆叶酸与红细胞叶酸缺乏率约为低发区的10～14倍，差异有统计学意义。结论 神经管畸形高发区农村孕早期妇女血液叶酸水平很低，增补叶酸可有效提高妇女血液叶酸水平、降低妇女叶酸缺乏率，高发区育龄妇女怀孕前后每日服用0．4mg叶酸的剂量可能不足，建议增加服用剂量。     

Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements

In rural China, many pregnant women in their third trimester suffer from anemia (48%) and iron deficiency (ID; 42%), often with coexisting deficiencies of retinol and riboflavin. We investigated the effect of retinol and riboflavin supplementation in addition to iron plus folic acid on anemia and subjective well-being in pregnant women. The study was a 2-mo, double-blind, randomized trial. Subjects (n = 366) with anemia [hemoglobin (Hb) 相似文献