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1.
Cheng-Bin Cui Qing-Chun Zhao Bing Cai Xin-Sheng Yao Hiroyuki Osadsa 《Journal of Asian natural products research》2013,15(4):243-252
Two new polyphenolics, rubuphenol (1) and sanguiin H-2 ethyl ester (2), were isolated together with ellagic acid (3), ethyl gallate (4), 1,2,3,4,6-penta-O-galloyl-g -D-glucopyranose (5) and 1,2,3,6-tetra-O-galloyl-g -D-glucopyranose (6) as new cell-cycle inhibitors from Rubus aleaefolius by bioassay-guided separation procedure and the structures of 1 and 2 were elucidated by spectroscopic method. Compounds 1 - 6 inhibited the cell cycle progression of tsFT210 cells at the G0/G1 phase with the MIC values of 14.6 w M (1), 22.1 w M (2), 10.3 w M (3), 7.8 w M (4), 7.9 w M (5) and 6.6 w M (6). 相似文献
2.
Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1 - 5 showed growth inhibitory activity (1, IC50 25 μg/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 μg/ml) and apoptosis inducing (2, MIC 1.56 μg/ml; 3, MIC 25 μg/ml; 4, MIC 20 μg/ml; 5, MIC 30 μg/ml) activities on mouse tsFT210 cells, respectively, and 2 - 5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers. 相似文献
3.
Cheng-Bin Cui Shao-Yu Yan Bing Cai Xin-Sheng Yao 《Journal of Asian natural products research》2013,15(4):233-241
Carbazole alkaloids, 3-methylcarbazole (1), murrayafoline A (2), girinimbine (3), mahanimbine (4) and bicyclomahanimbine (5), were isolated for the first time from Clausena dunniana Levl. by bioassay-guided separation procedure and were identified by spectroscopic methods. Compounds 1 - 5 showed growth inhibitory activity (1, IC50 25 w g/ml) on human fibrosarcoma HT-1080 cells and cell cycle M-phase inhibitory (2, MIC 0.78 w g/ml) and apoptosis inducing (2, MIC 1.56 w g/ml; 3, MIC 25 w g/ml; 4, MIC 20 w g/ml; 5, MIC 30 w g/ml) activities on mouse tsFT210 cells, respectively, and 2 - 5 provided the first examples of carbazole alkaloids as new cell cycle inhibitors and apoptosis inducers. 相似文献