50. Mutagenicity Study of Meloxicam

The Meloxicam is a drug for diminishing inflammation and contraining ache, and has good curative effect on clinic. In order to ascertain the safety of it, mutagenicity of Meloxicam was studied by using Ames test、 chromosome test and micronuclus test. ①Ames test: Meloxicam at six concentrations of 5 000、2 000、200、20、2、0.2 μg/plate were studied by using TA97、TA98、TA100、TA102 bacterial plant     

A pooled analysis of case–control studies of thyroid cancer. IV. Benign thyroid diseases

Objective: To obtain more precise estimates of the association between thyroid cancer and benign thyroid diseases and to elucidate the role of potential confounders or effect modifiers.Methods: The original data from 12 case–control studies from the United States, Asia, and Europe were pooled. Based on 2094 women and 425 men with cancer of the thyroid and, respectively, 3248 and 928 control subjects, odds ratios (ORs) and the corresponding 95% confidence intervals (CIs) were obtained by conditional regression models, conditioning on study and age at diagnosis, and adjusting for age and radiotherapy.Results: A history of hypothyroidism was not associated with cancer risk (pooled ORs=0.9, 95% confidence interval, CI: 0.7–1.3 in women and 1.7, 95% CI: 0.3–11.7 in men). ORs for hyperthyroidism were 1.4 (95% CI: 1.0–2.1) in women and 3.1 (95% CI: 1.0–9.8) in men. In women, however, risk was lower in the absence of or after allowance for history of goiter. Pooled ORs for a history of goiter were 5.9 (95% CI: 4.2–8.1) in women and 38.3 (95% CI: 5.0–291.2) in men. Risk for a history of benign nodules/adenomas was especially high (OR=29.9, 95% CI: 14.5–62.0, in women; 18 cases versus 0 controls in men). The excess risk for goiter and benign nodules/adenomas was greatest within 2–4 years prior to thyroid cancer diagnosis, but an elevated OR was present 10 years or more before cancer.Conclusions: Goiter and benign nodules/adenomas are the strongest risk factors for thyroid cancer, apart from radiation in childhood.     

A Pooled Analysis of Case–Control Studies of Thyroid Cancer. VI. Fish and Shellfish Consumption

Objective: To better understand the role of fish and shellfish on thyroid cancer risk, we systematically re-analyzed the original data from 13 case–control studies conducted in the US, Japan, China, and Europe. Methods: A total of 2497 cases (2023 women, 474 men) and 4337 controls (3268 women, 1069 men) were considered. Odds ratio (OR) and corresponding 95% confidence interval (CI) were estimated for each study by logistic regression models, conditioned on age and sex, and adjusted for history of goiter, thyroid nodules or adenomas, and radiation. Combined ORs were computed as the weighted average of the estimates from each study. Results: The ORs for the highest level of total fish consumption (three or more times per week) as compared to the lowest one (less than once per week) was above unity in Hawaii, Connecticut, Japan, Norway, Tromsø, and Vaud. Conversely, the ORs for the studies in Los Angeles, Shanghai, southeastern Sweden, Uppsala, northern Sweden, northern Italy, and Athens were below one. The pattern of risk for salt water fish and shellfish was not substantially different from that of total fish. Fish was not associated with thyroid cancer risk in all studies combined (OR=0.99, 95% CI 0.85–1.2 for moderate, and OR=0.88, 95% CI 0.71–1.1 for high total fish consumption), but there was a suggestion of a protective effect in endemic goiter areas (OR=0.65, 95% CI 0.48–0.88). Conclusion: This combined analysis indicates that relatively elevated fish consumption does not appreciably increase thyroid cancer risk, and may have a favorable influence in areas where iodine deficiency is, or was, common.     

57. Effects of Light and Temperature on the Antimutigenicity of Chlorophyllin

Chlorophyllin (Sodium-Copper Salt, Chln), a derivative of chlorophyll, has been showed to be antimutagenic to certain chemical mutagens, carcinogens, and environmental mixes such as B(a)P, MNNG, AFB1, Trp-p-1, airborne particles, in many researches. But these results were obtained under common laboratory situation, that is to say, Chln was not treated with high temperature and/or exposed to light. In the     

Solicit for Subscriptions of The Chinese.German Journal of Clinical Oncology

The Chinese-German Journal of Clinical Oncology,a medical academic periodical superintended by Chinese Educa-tional Ministry,sponsored by Huazhong University of Science and Technology and cooperatively published by China-Ger-many,is issued and published as a united journal of Chinese-German Medical Association in China and German-ChineseMedical Association in Germany.     

A pooled analysis of case-control studies of thyroid cancer¶ I. Methods

Objective: Because the etiology of thyroid cancer is not well described, we conducted a pooled analysis of all published case- control studies, as well as two identified unpublished studies. This paper describes the major characteristics of the 14 studies included in the analysis, as well as the statistical methods employed. Four studies were conducted in the United States (1 each in Washington State, California, Connecticut and Hawaii), 8 in Europe (3 in Sweden, 2 in Norway, 1 in Switzerland, 1 in Italy and 1 in Greece), and 2 in Asia (1 in China and 1 in Japan).Methods: The original datasets were obtained and restructured in a uniform format. Data on socio-demographic characteristics, anthropometric measures, smoking and alcohol consumption, history of benign thyroid diseases and of other selected medical conditions and treatments, family history of cancer and of benign thyroid conditions, occupation, residence in endemic goitre areas, and dietary habits were analyzed. For women, we also analyzed menstrual and reproductive factors and use of female hormones. Radiotherapy and, in Japan, exposure to the A-bombs were considered as potential confounding factors.Results: A total of 2,725 cases (2,247 females and 478 males) and 4,776 controls (3,699 females and 1,077 males) were included in this study. Of the cases, 79% were classified as papillary thyroid carcinomas, 14% as follicular, 2% medullary, 1% anaplastic, 1% other histologies, and 3% histological type unknown. Each of the datasets was checked for outliers and consistency. Data were analysed separately by study center, gender, and the two major histologic types (papillary, follicular). Frequency tables and simple statistics were computed for each variable under study. Conditional logistic regression was used to compute odds ratios. For matched studies, the original matching was preserved, whereas, for unmatched ones, five-year age groups were used for matching. Study-specific analyses were computed, and then the data from all the studies were pooled conditioning on study. Heterogeneity between studies, geographic areas and study designs was assessed, and the modifying effect of age was also evaluated.     

51. Mutagenicity Study of Cyclophoshpamide on Human Sperm

Whether Cyclophoshpamide(CP) has mutagenicity on germ cell or not is paid close attention to. This paper studied the mutagenicity of CP on germ cell by adopting human sperm chromosome and micronuclus in two-cell embryo. Semen samples obtained from healthy male were liquefied、dealed with Ca2+, and exposed to four     

Metastatic involvement of the Meckel‘s cave and trigeminal nerve. A case report.

The case of a patient with a right atypical trigeminal neuralgiacaused by a metastatic tumor involving the Meckels cave is reported. His medical history was significant for colon-rectaladenocarcinoma. The preoperative diagnosis of Meckels cave neoplasmwas made by MR. The patient underwent surgery, consisting oftotal removal of tumor and peeling of the ganglion and of the branches of the nerve, obtaining a histological diagnosis anda resolution of pain. The clinical, radiological findings and the treatment of this rare entity are discussed.