老年阵发性房颤患者衰弱水平与抗凝治疗依从性的关系研究

目的探讨老年阵发性房颤患者衰弱水平与抗凝治疗依从性的关系。方法选取2018年6月-2020年6月接受治疗的79例老年阵发性房颤患者,依据患者抗凝治疗依从性评估结果,分为依从性良好组与依从性低下组。所有患者均接受衰弱水平评估,分析老年阵发性房颤患者衰弱水平与抗凝治疗依从性的关系。结果79例老年阵发性房颤患者中,依从性良好患者45例,占比56.96%,依从性低下患者34例,占比43.04%;TFI评分与抗凝治疗依从性有关,差异有统计学意义(P<0.05);经Logistic回归分析结果显示,TFI评分高是老年阵发性房颤患者抗凝治疗依从性低下的影响因素(OR>1,P<0.05);绘制ROC曲线显示,TFI评分预测老年阵发性房颤患者抗凝治疗依从性情况的AUC为0.985,预测价值较高。结论老年阵发性房颤患者衰弱水平与抗凝治疗依从性密切相关,衰弱水平严重是诱发患者抗凝治疗依从性低下的影响因素,临床可根据此研究结果,及时制定并实施合理的预防措施,有利于提升患者的治疗依从性。     

老年心房颤动122例临床分析

目的分析老年心房颤动患者的病因和治疗等相关情况。方法对我院2002—2006年8月住院的122例65岁以上老年房颤患者的临床资料进行回顾分析。结果阵发性房颤、持续性房颤和持久性房颤分别为27.9%,18.3%,54.8%。93.44%的老年患者存在器质性心脏病,其中冠心病49.18%、高血压病18.85%、风心病17.21%、肺心病3.28%。心功能Ⅰ~Ⅱ级者50.82%,Ⅲ~Ⅳ级者49.18%。结论本组分析表明,冠心病、高血压病、风心病是老年人房颤的主要原因。心房颤动患者抗凝率低,抗凝治疗应得到重视。     

达比加群酯治疗高龄女性非瓣膜性心房纤颤的安全性和有效性分析

目的探讨达比加群酯抗凝治疗高龄女性患者非瓣膜性心房纤颤(房颤)的疗效及安全性。方法选取解放军210医院2014年9月至2015年4月收治的非瓣膜性房颤高龄老年女性(年龄≥80岁)患者9例,给予达比加群酯110 mg,每日2次,观察其抗凝疗效及药物安全性。结果本组9例患者均获得6个月随访。末次随访时,9例患者均无新发脑梗死,无脑出血。药物不良反应方面,2例(22.2%)消化不良,1例(11.1%)上腹痛,患者为空腹服药,纠正为餐后服药后上腹痛缓解;2例(22.2%)皮下瘀斑,1例(11.1%)牙龈出血。无严重出血事件,血红蛋白、血小板、肝功能、肾功能无变化。结论达比加群酯抗凝治疗高龄老年女性患者非瓣膜性房颤安全、有效。     

伴房颤的大面积脑梗死51例临床分析

目的探讨伴有房颤的大面积脑梗死的临床特征、治疗及预后。方法对2006年1月～2008年12月期间我科收治的51例伴有房颤的大面积脑梗死患者资料进行临床分析。结果老年伴有房颤的大面积脑梗死患者房颤主要由冠心病引起。高龄、意识障碍、病变面积大、并发症多是死亡的主要因素。结论非风湿性心脏病房颤引起的大面积脑梗死在老年人中较风湿性多见,抗凝治疗及控制血压、血糖等危险因素可减少大面积脑梗死的发生及复发。     

Carto三维标测系统指导导管射频消融治疗心房纤颤6例

心房纤颤（房颤）是最常见的心律失常之一,其发生率随年龄而增加,常可导致心悸、心力衰竭、脑卒中和肢体栓塞等。治疗房颤的理想目标是恢复窦性心律,这是防范继发心血管事件和血栓并发症的最佳手段。 最常见的复律方法是药物复律,有时还会采用电复律。但许多房颤患者常难以通过药物或直流电恢复窦性心律而只能控制室率,这些患者常因不能耐受或依从而使用抗凝药物,成为并发栓塞的高危患者。近10年来,有关房颤电生理机制和治疗手段的研究取得了令人鼓舞的成果。     

心房颤动188例临床分析

目的探讨心房颤动（房颤）的基础疾病、并发症及抗凝治疗情况。方法选取1993年1月到2006年12月期间在我院住院的房颤患者188例，采用回顾性分析方法对其进行研究。结果与房颤相关的病因谱发生明显变化：风湿性瓣膜疾病已由第1位下降，而高血压、冠心病等心血管疾病成为房颤的主要相关疾病；栓塞性疾病是房颤的严重并发症；华法林使用比率很低。结论房颤的防治应引起临床关注，尤其应加强对房颤诱因的监测和治疗，以及房颤的抗凝治疗。     

重视心房颤动的非药物干预

心房颤动 (以下简称房颤 )是临床上最常见的心律失常之一 ,其发生率在普通人群为 0 .4 %～ 2 % ,在 6 5岁人群为 5 %左右。最近Ｃａｍｐｂｅｌｌ指出 ,房颤可分为 3种类型 :阵发型房颤 ,持续型房颤和永久型房颤。但阵发型或持续型房颤可最终导致永久型房颤。以往认为 ,对大多数房颤可不必转律治疗 ,而仅需用药物 (例如地高辛或 β受体阻滞剂 )控制心率。临床医生认为 ,房颤持续 <6个月可能是复律的指征。对永久型房颤患者而言 ,治疗策略围绕着控制心率和预防血栓这两个环节。在房颤的药物治疗方面 ,口服抗凝药的开发 ,加大了药效 不良反应…     

老年和非老年急性肺栓塞患者临床特点比较

 目的 比较分析老年和非老年急性肺栓塞患者(acute pulmonary embolism,APE)的临床特点。方法 对医院近7年来119例APE患者进行回顾性分析,根据年龄分为两组,即老年 (年龄≥65岁) 组53例和非老年(年龄<65岁)组66例,对两组的易患因素、临床表现、辅助检查、诊断及治疗等进行分析比较。结果 (1)老年组合并高血压(49.1%)、房颤(28.3%)、消化道溃疡或出血(9.8%)明显高于非老年组合并高血压(25.8%)、房颤(10.6%)、消化道溃疡或出血(0);(2)老年组下肢肿胀痛(15.1%)比非老年组下肢肿胀痛(4%)更常见;(3)老年组ST、T改变(90.5%)、房颤(17.0%)明显高于非老年组ST、T改变(63.2%)、房颤(1.5%),非老年组窦速、右束支传导阻滞(84.2%)明显高于老年组(52.4%)。(4)老年组PCO₂＜35 mmHg(65.8%)明显高于非老年组(40.9%);非老年组PO₂＜80 mmHg(95.5%)明显高于老年组(76.3%)。(5)APE较易误诊为心内科疾病,老年组误诊率(30.1%)明显高于非老年组(15.1%)。老年组更多采用抗凝治疗,非老年组更多采用抗凝+溶栓治疗。两组住院期间病死率无明显差异。结论 老年与非老年APE合并的基础疾病、临床表现及治疗方式有所不同,老年组误诊率较高。对有下肢肿胀痛,低碳酸血症及心电图表现为ST-T改变、房颤的老年患者应警惕 APE,以减少漏诊及误诊。     

三维标测系统指导下射频消融治疗房颤的护理观察

目的：探讨三维标测系统指导下射频消融治疗房颤的护理。方法对172例房颤患者行三维标测系统指导下射频消融治疗的观察和护理。结果手术顺利完成,手术并发症发生率低。结论三维标测系统指导下射频消融治疗房颤安全有效,有针对性的观察及有预见性的护理配合是治疗成功的重要保障。     

房间隔缺损封堵术后成功植入LAmbre左心耳封堵器1例

心房颤动(房颤)是一种心律失常性疾病,临床发病率高,心源性血栓栓塞所致中风是房颤的一项临床常见并发症,轻则致残,重则死亡.既往研究证实,与口服抗凝治疗相比,对于具有高血栓栓塞和出血风险的非瓣膜性房颤患者,左心耳封堵(LAAC)治疗是一种安全有效的替代方法[1].房间隔穿刺是行LAAC的一个关键步骤,也是一项技术难点,既...     

Knee injury and Osteoarthritis Outcome Score (KOOS) - validation of a Swedish version

The Knee injury and Osteoarthritis Outcome Score (KOOS) is a self-administered instrument measuring outcome after knee injury at impairment, disability, and handicap level in five subscales. Reliability, validity, and responsiveness of a Swedish version was assessed in 142 patients who underwent arthroscopy because of injury to the menisci, anterior cruciate ligament, or cartilage of the knee. The clinimetric properties were found to be good and comparable to the American version of the KOOS. Comparison to the Short Form-36 and the Lysholm knee scoring scale revealed expected correlations and construct validity. Item by item, symptoms and functional limitations were compared between diagnostic groups. High responsiveness was found three months after arthroscopic partial meniscectomy for all subscales but Activities of Daily Living.     

Endovascular management of carotid-cavernous fistulas

Objective To investigate endovascular treatment of traumatic direct carotid-cavernous fistulas （CCF） and their complications such as pseudoaneurysms. Methods： Over a five-year period, 22 patients with traumatic direct CCFs were treated endovascularly in our institution. Thirteen patients were treated once with the result of CCF occluded, 8 twice and 1 three times. Treatment modalities included balloon occlusion of the CCF, sacrifice of the ipsilateral internal carotid artery with detachable balloon, coll embolization of the cavernous sinus and secondary pseudoaneurysms, and covered-stem management of the pseudoaneurysms. Results All the direct CCFs were successfully managed endovascularly. Four patients developed a pseudoaneurysm after the occlusion of the CCF with an incidence of pseudoaneurysm formation of 18.2% （4/22）. A total number of 8 patients experienced permanent occlusion of the ICA with a rate of ICA occlusion reaching 36.4% （8/22）. Followed up through telephone consultation from 6 months to 5 years, all did well with no recurrence of CCF symptoms and signs. Conclusion Traumatic direct CCFs can be successfully managed with endovascular means. The pseudoaneurysms secondary to the occlusion of the CCFs can be occluded with stent-assisted coiling and implantation of covered stents.     

The acutely limping child

Acute limping may be the result of multiple pathologies in children. The differential diagnosis varies based on the age of the child. Irrespective of age, the initial imaging work-up includes AP and frog leg radiographs of the pelvis and ultrasound; MRI may sometimes be helpful. In children less than 3 years, infections and trauma are most frequent. MRI is the imaging modality of choice when osteomyelitis is clinically suspected. Between the ages of 3 and 10 years, transient synovitis of the hip and Legg-Calvé-Perthes disease are main considerations but infection, inflammation and focal bony lesions are also considered. In children over 10 years, slipped capital femoral epiphysis also is considered.     

Do Balance Board Training Programs Reduce the Risk of Ankle Sprains in Athletes?

Introduction Ankle sprains are the most common musculo-skeletal injury that occurs in athletes,particularly in sports that require jumping and landing on one foot such as soccer,and basketball(1-4).These injuries often result in significant time loss from participation,long-term disability,and have a major impact on health care costs and resources(5-8).     

High Intensity Interval Training:New Insights

KEY POINTS ·High-intensity interval training(HIT)is characterized by repeated sessions of relatively brief，intermittent exercise.often performed with an“a11 out”effort or at an intensity close to that which elicits peak oxygen uptake(i.e.，≥90%of VO2 peak).     

Developmental validation of the PowerPlex(®) ESI 16 and PowerPlex(®) ESI 17 Systems: STR multiplexes for the new European standard

In response to the ENFSI and EDNAP groups’ call for new STR multiplexes for Europe, Promega^® developed a suite of four new DNA profiling kits. This paper describes the developmental validation study performed on the PowerPlex^® ESI 16 (European Standard Investigator 16) and the PowerPlex^® ESI 17 Systems. The PowerPlex^® ESI 16 System combines the 11 loci compatible with the UK National DNA Database^®, contained within the AmpFlSTR^® SGM Plus^® PCR Amplification Kit, with five additional loci: D2S441, D10S1248, D22S1045, D1S1656 and D12S391. The multiplex was designed to reduce the amplicon size of the loci found in the AmpFlSTR^® SGM Plus^® kit. This design facilitates increased robustness and amplification success for the loci used in the national DNA databases created in many countries, when analyzing degraded DNA samples. The PowerPlex^® ESI 17 System amplifies the same loci as the PowerPlex^® ESI 16 System, but with the addition of a primer pair for the SE33 locus. Tests were designed to address the developmental validation guidelines issued by the Scientific Working Group on DNA Analysis Methods (SWGDAM), and those of the DNA Advisory Board (DAB). Samples processed include DNA mixtures, PCR reactions spiked with inhibitors, a sensitivity series, and 306 United Kingdom donor samples to determine concordance with data generated with the AmpFlSTR^® SGM Plus^® kit. Allele frequencies from 242 white Caucasian samples collected in the United Kingdom are also presented. The PowerPlex^® ESI 16 and ESI 17 Systems are robust and sensitive tools, suitable for the analysis of forensic DNA samples. Full profiles were routinely observed with 62.5 pg of a fully heterozygous single source DNA template. This high level of sensitivity was found to impact on mixture analyses, where 54–86% of unique minor contributor alleles were routinely observed in a 1:19 mixture ratio. Improved sensitivity combined with the robustness afforded by smaller amplicons has substantially improved the quantity of data obtained from degraded samples, and the improved chemistry confers exceptional tolerance to high levels of laboratory prepared inhibitors.