一次性包皮切割缝合器在包皮环切术中的应用

目的 探讨一次性包皮切割缝合器在包皮环切术中的应用.方法 选择2008年1月至2016年2月在我院行包皮环切术的1200例患者作为研究对象,按手术方式分为传统组和研究组各600例,传统组行传统包皮环切术,研究组行一次性包皮切割缝合器包皮环切术.比较两组手术时间、伤口愈合时间、术中出血发生率、术中及术后伤口开裂发生率、术后明显水肿发生率、术后感染率.结果 研究组手术时间和并发症发生率低于传统组(P＜0.05).结论 一次性包皮切割缝合器应用于包皮环切术,优势明显,值得临床推广.     

小儿包皮环套术与环切术的临床分析

目的探讨小儿包皮过长、包茎的手术较佳方式。方法对1997年至2005年826例(随机分为环套术631例、环切术195例)小儿包茎、包皮过长进行回顾性分析,采用x2检验。结果手术时间分别为(4±1)min和(20±5)min(P<0．01);总并发症发生率分别为5．23％(33／631)和18．97％(37／195)(P< 0．01);术后护理工作量:环套术组明显简单于环切术组。结论小儿包皮过长、包茎以包皮环套术为优。     

包皮环切缝合器与传统包皮环切术在小儿包皮手术中的临床效果比较研究

目的在小儿包皮手术中分析比较应用包皮环切缝合器和传统包皮环切术治疗的效果。方法选取2015年1月~2016年7月在医院接受包皮手术的90例包茎或包皮过长小儿作为研究对象,根据手术方式进行分组,其中45例患儿应用传统包皮环切术治疗,命名为传统组,另外45例患儿应用包皮环切缝合器进行手术治疗,命名为研究组,比较两组患者手术治疗效果。结果研究组患者手术时间、伤口愈合所需时间均明显比传统组要短,患者术中出血量、术后VAS评分均低于传统组,并发症总发生率明显低于传统组。结论在小儿包皮手术中应用包皮环切吻合器治疗,疗效确切,值得临床推广。     

商环包皮环切术和一次性包皮环切缝合器行包皮环切的临床疗效对比研究

目的比较使用商环包皮环切术和一次性包皮环切缝合器行包皮环切的临床疗效。方法应用商环包皮环切术手术(A组)、一次性包皮环切缝合器环切术(B组)200例(每组100例)包皮过长、包茎患者手术治疗,通过观察术中出血量、手术时间和术中、术后24h疼痛评分、术口愈合时间,术口愈合满意度,术口感染、出血或血肿、包皮水肿等并发症对比分析。结果 A组和B组比较,术口感染、包皮水肿较多,术口愈合时间较长,术后包皮外观满意度较低,术后24h疼痛评分高,术中出血量、手术时间、出血或血肿无差异。结论一次性包皮环切缝合器作为一项新技术,其优越性明显,并发症少,患者满意度高,可以取代传统的包皮环切术。     

A note on sufficiency in binary panel models

Consider estimating the slope coefficients of a fixed‐effect binary‐choice model from two‐period panel data. Two approaches to semiparametric estimation at the regular parametric rate have been proposed: one is based on a sufficiency requirement, and the other is based on a conditional‐median restriction. We show that, under standard assumptions, both conditions are equivalent.     

A note on concordance correlation coefficient

In this note, we first review some recent developments about measures of agreement, which are often required in medicine and other sciences, with focus on differences between these methods. In the last part, we mention five important concerns when using a newly developed concordance correlation coefficient. Our conclusion is that we need to be especially careful when using existing correlation methods and a new correlation method needs to be developed in the future.     

A note on ethnic sensitivity studies

In this article, we propose a similarity criterion for ethnic sensitivity studies in pharmacokinetic variables. We present how this criterion can be used in the context of different dose-exposure models and how sample size and power calculations can be done. Examples for the planning and analysis of ethnic sensitivity studies are provided.     

Infant circumcision.

A prospective one year study of a birth cohort of 1262 infants indicates that the rate of infant circumcision has decreased substantially and is now about 25 percent. Most are performed at parental request and for family and traditional reasons rather than medical indications.     

包皮环切手术对男性性功能的影响

目的了解包皮环切手术对男性性功能的影响.方法选择年龄22～45岁,性功能正常的35例男性作为调查对象,采用性功能问卷调查并进行评分,将包皮环切术前,术后的性功能评分进行统计学检验.结果35例男性性功能问卷调查分六个方面进行评分,其评分结果统计性检验显示手术前、后无显著性差异.结论包皮环切手术对男性性功能没有显著影响.     

A note on variance estimation in random effects meta-regression

For random effects meta-regression inference, variance estimation for the parameter estimates is discussed. Because estimated weights are used for meta-regression analysis in practice, the assumed or estimated covariance matrix used in meta-regression is not strictly correct, due to possible errors in estimating the weights. Therefore, this note investigates the use of a robust variance estimation approach for obtaining variances of the parameter estimates in random effects meta-regression inference. This method treats the assumed covariance matrix of the effect measure variables as a working covariance matrix. Using an example of meta-analysis data from clinical trials of a vaccine, the robust variance estimation approach is illustrated in comparison with two other methods of variance estimation. A simulation study is presented, comparing the three methods of variance estimation in terms of bias and coverage probability. We find that, despite the seeming suitability of the robust estimator for random effects meta-regression, the improved variance estimator of Knapp and Hartung (2003) yields the best performance among the three estimators, and thus may provide the best protection against errors in the estimated weights.     

A note on poly-L-lysine-mediated gene transfer in HeLa cells

Poly-L-lysines of chain lengths varying from 70 to 300 residues are shown to bring about luciferase pRSVL DNA uptake and expression in HeLa cells. Transfection was approximately 50% that of the cationic liposome DOTAB. Expression was higher in the presence of chloroquine. Of interest was the fact that luciferase activity depended on the polysine/DNA charge ratio (+/ -). Maximum activity occurred at a charge ratio (+/ -) of 3, while at a charge ratio of 1 (conjugate electrically neutral) activity was much lower. At the higher charge ratios (+/ -) of 4 and 5, luciferase activity decreased. The results obtained are discussed.