近端胰岛素瘤的腹腔镜切除

目的:探讨近端胰岛素瘤切除术的技术要点、可行性及安全性。方法:回顾分析2003年3月至2010年2月行腹腔镜手术治疗38例胰岛素瘤患者的临床资料,按肿瘤位置分为近端组和远端组,探讨两组的技术要点,分析两组的手术方式、手术时间、出血量及并发症发生率。结果:2例未找到病灶终止手术,36例顺利完成手术,其中近端组16例,远端组21例(1例为颈、体多发肿瘤同时计入两组)。近端组均行肿瘤切除术,远端组包括肿瘤切除术6例,胰体尾切除术15例(其中保脾7例)。近端组与远端组相比,手术中转率(18.8%vs.14.3%)、并发症发生率(56.3%vs.28.6%)、手术时间[(205±66.7)minvs.(202±90.0)min]差异无统计学意义(P0.05),出血量较少[(68.7±49.4)ml vs.(118.0±98.3)ml,P0.05)],术后住院时间明显延长[(14.4±8.2)d vs.(7.6±1.7)d,P0.05)]。结论:近端胰岛细胞瘤的腹腔镜切除总体是安全可行的,但与远端胰腺胰岛素瘤相比技术难度较大,需要谨慎选择合适的病例。     

腹腔镜多发胰岛素瘤切除术1例报告

目的:探讨腹腔镜切除多发胰岛素瘤的可行性.方法:2010年7月2日为1例多发胰岛素瘤患者(胰体尾部各一)施行腹腔镜切除术.结果:手术顺利,手术时间52min,出血约15ml,术中放置引流管,术后各项指标恢复正常,症状完全缓解,术后第2天进食,1周出院,2周拔除引流管,无其他并发症发生.结论:位于表浅部位的胰岛素瘤或其他...     

腹腔镜胰岛素瘤切除一例

患者女，35岁。2个月前晨起时突发性意识丧失、呼之不应，四肢无抽搐，持续1 h后清醒，感觉轻微头晕、心慌，无头育。之后每天晨起均有发作，有时伴口吐白沫、大、小便失禁、大汗淋漓，进食后缓解，以胰岛素瘤收入院。CT示胰尾处圆形明显强化，静脉期强化稍减退，中心呈点状无强化区，     

腹腔镜下胰岛素瘤切除13例

【摘要】 目的 探讨完全腹腔镜下胰岛素瘤手术切除的可行性、安全性。方法 我科2008年1月~2012年9月住院的对13例胰岛素瘤患者行完全腹腔镜下肿瘤切除的临床资料进行回顾性分析,并总结其主要技术环节。结果 13例患者在腹腔镜超声指导下成功实施镜下胰岛素瘤切除术,其中行单纯肿瘤切除术7例,胰体尾+脾切除4例,保留脾脏胰体尾切除术2例,过程顺利,血糖监测提示手术效果满意,术后胰漏3例,保守治疗痊愈,术后无严重腹腔感染和大出血发生。随访无复发。结论 腹腔镜下行胰岛素瘤切除安全、微创、可行,尤其是结合腹腔镜术中超声可有助于胰岛素瘤的的准确定位及选择合适的手术方式。     

腹腔镜胰岛素瘤摘除术一例

患者　女性 ,35岁 ,未婚 ,主因“乏力 9个月 ,晨起不能唤醒 1个月”入院。9个月前因劳累后自觉乏力 ,休息及进食后症状缓解 ,1个月来患者晨起不能唤醒 ,先后发作 4次 ,进食后症状缓解。空腹血糖 2 9mg/dl。Ins/Glu比值为0 6 6。腹部增强CT示 :胰体高密度病灶 ,脾囊肿 8cm× 7cm大小。DSA示胰体尾部类圆形多血管染色 ,由胰大动脉供血 ,符合胰岛素瘤的DSA表现。术前诊断 :胰岛素瘤 ,脾囊肿。于 2 0 0 2年 7月 3日全麻下行腹腔镜胰岛素瘤摘除术。取仰卧截石位 ,腹部取五个戳口 ,分别位于脐部、左右腹部旁正中、左中腹腋前线及上腹旁正中戳…     

胰岛细胞瘤的诊断与治疗（附21例报告）

胰腺内分泌肿瘤的发生率较低,其中最常见的是胰岛细胞瘤,分为功能性和非功能性两类,多为良性,定位诊断较难,处理较为棘手。本院2000年7月—2011年10月收治胰岛细胞瘤患者21例,其中5例合并胰腺癌,总结分析如下。     

腹腔镜阑尾切除术540例临床体会

目的:探讨腹腔镜阑尾切除术(laparoscopic appendectomy,LA)阑尾残端及系膜的处理方法和可靠性。方法:回顾分析2004年至2009年我院为540例患者施行LA的临床资料,总结阑尾残端及系膜的处理方法。结果:使用钛夹处理阑尾残端及系膜,术后无残端漏及腹腔出血等并发症发生。结论:使用钛夹处理阑尾残端及系膜安全可靠,且费用低,手术时间短,有应用价值。     

胰岛细胞瘤21例临床分析

目的:探讨胰岛细胞瘤的临床特征、治疗效果。方法:回顾分析我院近5年诊治胰岛细胞瘤21例的经验,总结胰岛细胞瘤的临床特征、诊治方法及其效果。结果:本组病例中,无功能性胰岛细胞瘤9例,胰岛素瘤12例,其中2例为多发性内分泌腺瘤。前者恶变率为55.6％(5/9),平均年龄为40岁;后者恶变率为8.3％(1/12),平均年龄为39岁。肿瘤位子胰头9例,胰体6例,胰尾6例。术前影像诊断明确肿瘤定位16例(占76.2％),其余5例经术中触摸探查和超声检查得到定位。肿瘤行局部切除术12例,胰体尾切除+胰空肠吻合术6例,肿瘤+脾脏切除术2例,Whipple手术1例。术后胰瘘发生率为33.3％(7/21),其是最常见的并发症,本组无手术死亡。结论:无功能胰岛细胞瘤恶变率显著高于胰岛素瘤(P相似文献   

Ultrasound-guided laparoscopic resection of pancreatic islet cell tumors

Pancreatic islet cell tumors represent a diverse group of neuroendocrine lesions. These tumors may be singular or multiple, benign or malignant, sporadic, or part of the constellation of multiple endocrine neoplasia type 1. Tumors such as insulinomas and gastrinomas produce gastrointestinal peptides that lead to diagnosis. Nonfunctioning lesions may be found incidentally or by screening patients at high risk for such tumors. Successful management of patients with pancreatic islet cell tumors relies on accurate localization and sound operative technique. With proper preoperative localization, advanced laparoscopic methods can be used to manage patients with these pancreatic neoplasms. Preoperative localization of pancreatic islet cell tumors was difficult in the past. Standard imaging and localizing modalities, such as computed tomography scanning, magnetic resonance imaging, angiography, transabdominal sonography, and portal venous sampling, yield only 24% to 75% accuracy. Consequently, many biochemically suspected lesions cannot be imaged with current techniques. Decreased tactile sensation of laparoscopy adds complexity to intraoperative identification. Endoscopic sonography and laparoscopic sonography provide accurate preoperative and intraoperative localization to enhance laparoscopic and open resection. The authors treated two patients with islet cell neoplasms using endoscopic sonography to preoperatively visualize the tumors and laparoscopic sonography to guide laparoscopic enucleation. Their approach and difficulties are discussed.     

Laparoscopic enucleation of a pancreatic insulinoma

Insulinoma is the most common functional neuroendocrine tumor of the pancreas [2]. In most cases the lesions are benign, solitary, and located within the pancreatic parenchyma. Because of these characteristics, the majority of these lesions can be treated with simple enucleation [2]. Advances in laparoscopic techniques have recently enabled the safe resection of pancreatic islet cell tumors [1] and may provide patients with the benefits of minimally invasive surgery. This video demonstrates the technique of laparoscopic enucleation of a pancreatic insulinoma. The case presentation is that of a 40-year-old man who had symptoms of neuroglycopenia and was found to have elevated proinsulin levels during a 72-hour fast. Further evaluation included a CT scan, which revealed a 1.5 cm lesion on the posterior surface of the midbody of the pancreas. The video shows the operative technique of enucleation of the lesion, including positioning and trocar placement, performance of intraoperative ultrasound for tumor localization, and the use of specialized instruments (laparoscopic freer-elevator with a spatulated tip) that allowed enucleation of the lesion without excess handling of the tumor itself. The operation was performed in 105 minutes with minimal blood loss. The patient was fed clear liquid diet on the day after surgery and was discharged home on the third postoperative day. He had an uneventful recovery and has experienced no further symptoms. This multimedia article (video) has been published online and is available for viewing at http://www.springerlink.com. Its abstract is presented here. As a subscriber to Surgical Endoscopy you have access to our SpringerLink electronic service, including Online First.     

全腹腔镜下胰岛素瘤切除术18例单中心经验总结

目的:总结全腹腔镜下胰岛素瘤的诊断和治疗经验。方法:回顾分析2002年6月至2009年10月北京协和医院为18例患者施行全腹腔镜下胰岛素瘤切除术的临床资料,分析全腹腔镜胰岛素瘤切除术的安全性、可行性及主要技术环节。结果:18例中1例胰岛素瘤位于胰颈外,余均位于胰体/尾部,肿瘤直径平均(1.77±0.57)cm;7例行肿瘤切除术,7例行保留脾脏的胰腺远端切除术,4例中转开腹,中转开腹率22.2%。术后平均随访48个月,无低血糖症状复发。结论:全腹腔镜胰岛素瘤切除术安全可行,尤其肿瘤位于胰头表面或胰体尾部,更优于经典的开腹手术。     

腹腔镜远端胰腺切除的临床应用

目的 总结腹腔镜远端胰腺切除术的临床应用与手术技巧.方法 回顾性分析腹腔镜远端胰腺切除术治疗胰体尾肿瘤10例的临床资料.结果 10例胰体尾肿瘤中8例成功完成腹腔镜远端胰腺切除术,其中1例为保脾远端胰腺切除术,中转开腹手术2例,1例因胰腺癌侵及周围脏器,1例因术中出血.腹腔镜远端胰腺切除术平均手术时间为141±35 min(95～195 min),平均出血263±151 ml(100～600 ml),术后平均住院7±1 d(5～9 d),全部患者均治愈.术后病理诊断实性假乳头状瘤4例、黏液性囊腺瘤3例、胰岛细胞瘤1例,胰腺导管腺癌2例.结论 腹腔镜远端胰腺切除术最佳适应证是胰腺体尾部良性肿瘤及早期恶性肿瘤,具有创伤小、恢复快、并发症少的优点,是治疗胰体尾良性肿瘤及早期恶性肿瘤的安全有效的微创疗法.

Abstract：

Objective To summarize the clinical applications and surgical technique of laparoscopic distal pancreatectomy (LDP). Method The clinical data of 10 cases of pancreatic body and tail tumors undergoing laparoscopic distal pancreatectomy were retrospectively analyzed.Results Laparoscopic distal pancreatectomy (LDP) was successfully undertaken in 8 cases (including spleen preserving distal pancreatectomy in one case ). Intraoperatively two cases were converted to open surgery because of peripancreatic organs involvement by cancer in one case and massive bleeding in another case during laparoscopic procedures. The average operation time of LDP was 141 ± 35 min (95 -195 min),mean blood loss was 263 ± 151 ml( 100 -600 ml), average postoperative hospital stay was 7 ± 1 days (5 -9 days ). There was no major postoperative complications and no mortality. Final pathology was solid psedopapillary tumor in 4 cases, mucinous cystadenoma in 3 cases and islet cell tumor in 1 case, pancreatic ductal adenocarcinoma in 2 cases, hence 80% of tumors were benign. Conclusions LDP is indicated for benign body and tail pancreatic tumors and early malignant tumor of pancreatic body and tail. Being less traumatic, and fewer complications, LDP is a safe, effective and minimally invasive therapy.     

Laparoscopic resection of the pancreatic tail with splenic preservation

OBJECTIVE: Evaluation of feasibility and efficacy of left resection of the pancreas with preservation of the splenic vessels and spleen as a laparoscopic procedure. BACKGROUND: Laparoscopic technique is used less often on the pancreas than on other organs. The most common indications are enucleation of endocrine-active tumors and distal resections for benign primary pancreatic lesions. An important premise of these operations is atraumatic removal of as little of the pancreas as possible and the preservation of the spleen and its main vessels. METHODS: Five patients aged 16 to 56 years, all female, underwent laparoscopic left resection of the pancreas with preservation of the splenic vessels and the spleen. There were 4 cases of benign epithelial tumors of the pancreas and 1 case of a left-sided adrenal cyst, which pre- and intraoperatively gave the impression of a pancreatic cystadenoma. RESULTS: In all 5 cases, the laparoscopic procedure was completed with preservation of the splenic vessels and the spleen itself. No patient required blood transfusion, and there was only 1 postoperative fluid collection at the site of the tumor resection, which was drained percutaneously on the fourth postoperative day. CONCLUSION: Distal pancreas resection can be performed as a laparoscopic procedure, with the usual advantages that this techniques has for the patient. Optimal closure of the cut edge of the pancreas and the preservation of the spleen and its main vessels are the most important aspects of this operation.     

胰岛细胞肿瘤35例诊治分析

目的探讨胰岛细胞肿瘤的诊断和治疗，对胰岛细胞肿瘤发病情况进行分析。方法回顾性分析1953～2003年浙江大学医学院附属第二医院收治的胰岛细胞肿瘤35例，并结合国内有关文献报道进行诊治分析。结果35例胰岛细胞肿瘤经手术切除病理证实33例，其中胰岛紊瘤24例（72，7％，24／33），无功能胰岛细胞瘤7例（21．2％，7／33），胰高糖素瘤、胃泌素瘤各1例。国内同期文献报道胰岛细胞肿瘤2785例。结论胰岛细胞瘤主要是胰岛素瘤和无功能胰岛细胞瘤，其他肿瘤少见。对良性者宜行单纯肿瘤切除或胰腺部分切除，对恶性肿瘤应采用扩大范围的根治性肿瘤切除术为主的综合治疗，预后好于其他腹腔内脏器肿瘤。     

胰岛素瘤腹腔镜外科治疗体会

目的 评估腹腔镜胰岛素瘤切除术的可行性和安全性。方法 2002年6月至2004年6月25例胰岛素瘤患者,分别行腹腔镜胰岛素瘤切除术（腹腔镜组,10例）和开腹胰岛素瘤切除术（开腹手术组,15例）,比较2组手术时间、术中出血量、术后住院天数和并发症发生率差异是否有统计学意义。结果 肿瘤发生部位、大小差异无统计学意义,手术时间、术中出血量和术后平均住院天数等差异均无统计学意义（P〉0．05）。并发症发生率方面,腹腔镜手术组仅1例并发胰瘘,开腹手术组3例并发胰瘘、2例并发腹腔感染、5例并发胸腔积液,开腹手术组并发症发生率显著高于腹腔镜手术组（P〈0．01）。结论 位于胰体或尾部的胰岛素瘤行腹腔镜下胰岛素瘤切除术是安全可行的,并且并发症发生率低于经典的开腹手术。     

腹腔镜胃间质瘤切除56例体会

目的：总结腹腔镜胃间质瘤切除术的治疗体会。方法：回顾分析56例腹腔镜胃间质瘤切除术的手术方法、术中处理要点及术后治疗效果。结果：56例手术均顺利完成,平均手术时间1.5h,平均出血60ml,术后平均住院5d,术后复发1例。结论：腹腔镜胃间质瘤切除术患者创伤小,术后康复快,是治疗胃间质瘤最佳的手术方式。