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1.
Jince Mary Joseph 《Journal of ethnopharmacology》2010,131(1):216-219
Aim of the study
This study was aimed to evaluate the antiulcer activity of the whole plants of Hedyotis puberula (G. Don) R. Br. ex Arn.Materials and methods
Gastroprotective potential of the Hedyotis puberula methanol extract (200 and 400 mg/kg body weight) was studied on indomethacin (IND), ethanol and pyloric ligation (PL)-induced gastric ulcer models in rats.Results
The treatment with Hedyotis puberula extract at 400 mg/kg p.o. protected the rats against the ulceration which was comparable to the reference drug omeprazole. Pretreatment with extract protected rats from gastric lesion development by way of increased pH and decreased volume, acidity and pepsin content of gastric secretion. Furthermore, total carbohydrate: protein ratio of the gastric juice were noticeably increased in pretreated rats.Conclusion
Results of our study showed that Hedyotis puberula possess significant gastroprotective activity and validate the folklore claim. 相似文献2.
Pinheiro BG Silva AS Souza GE Figueiredo JG Cunha FQ Lahlou S da Silva JK Maia JG Sousa PJ 《Journal of ethnopharmacology》2011,138(2):479-486
Ethnopharmacological relevance
Peperomia serpens (Piperaceae), popularly known as “carrapatinho”, is an epiphyte herbaceous liana grown wild on different host trees in the Amazon rainforest. Its leaves are largely used in Brazilian folk medicine to treat inflammation, pain and asthma.Aim of the study
This study investigated the effects of essential oil of Peperomia serpens (EOPs) in standard rodent models of pain and inflammation.Materials and methods
The antinociceptive activity was evaluated using chemical (acetic acid and formalin) and thermal (hot plate) models of nociception in mice whereas the anti-inflammatory activity was evaluated by carrageenan- and dextran-induced paw edema tests in rats croton oil-induced ear edema, as well as cell migration, rolling and adhesion induced by carrageenan in mice. Additionally, phytochemical analysis of the EOPs has been also performed.Results
Chemical composition of the EOPs was analyzed by gas chromatography and mass spectrometry (GC/MS). Twenty-four compounds, representing 89.6% of total oil, were identified. (E)-Nerolidol (38.0%), ledol (27.1%), α-humulene (11.5%), (E)-caryophyllene (4.0%) and α-eudesmol (2.7%) were found to be the major constituents of the oil. Oral pretreatment with EOPs (62.5-500 mg/kg) significantly reduced the writhing number evoked by acetic acid injection, with an ED50 value of 188.8 mg/kg that was used thereafter in all tests. EOPs had no significant effect on hot plate test but reduced the licking time in both phases of the formalin test, an effect that was not significantly altered by naloxone (0.4 mg/kg, s.c.). EOPs inhibited the edema formation induced by carrageenan and dextran in rats. In mice, EOPs inhibited the edema formation by croton oil as well as the leukocyte and neutrophil migration, the rolling and the adhesion of leukocytes.Conclusions
These data show for the first time that EOPs has a significant and peripheral antinociceptive effect that seems unrelated to interaction with the opioid system. EOPs also displays a significant anti-inflammatory effect in acute inflammation models. This effect seems to be related to components which inhibit the production of several inflammatory mediators. These results support the widespread use of Peperomia serpens in popular medicine to treat inflammation and pain. 相似文献3.
Ethnopharmacological relevance
Cnestis ferruginea Vahl ex DC (Connaraceae) is a shrub widely used in traditional African Medicine (TAM) for the treatment of various painful and inflammatory conditions.Aim of the study
The objective of this study was to investigate the analgesic and anti-inflammatory properties of the methanolic root extract of Cnestis ferruginea.Materials and methods
Analgesic activity was evaluated using the acetic acid-induced writhing, formalin, tail clip, and hot plate tests in mice. The carrageenan- and egg albumin-induced rat paw oedema, formaldehyde-induced arthritis inflammation, and xylene-induced ear oedema tests were used to investigate the anti-inflammatory actions of Cnestis ferruginea.Results
The methanolic root extract of Cnestis ferruginea (100, 200, and 400 mg/kg; p.o.) produced significant (P < 0.05) dose-dependent inhibition of pain response elicited by acetic acid and formalin while also increasing the nociceptive reaction latency in the tail clip and hot plate tests. In respect of anti-inflammatory activity, Cnestis ferruginea caused significant (P < 0.05) dose-dependent inhibition of oedema development in the carrageenan, egg albumin, formaldehyde, and xylene-induced inflammation tests. The effects of the extract in the various models were generally comparable to those of the standard drugs used.Conclusion
The findings in this study suggest that the methanolic root extract of Cnestis ferruginea possesses analgesic and anti-inflammatory activities possibly mediated through peripheral and central mechanisms involving inhibition of release and/or actions of vasoactive substances (histamine, serotonin and kinins) and prostaglandins. The results justify the use of the extract in TAM for the treatment of painful and inflammatory conditions. 相似文献4.
Bayir Y Halici Z Keles MS Colak S Cakir A Kaya Y Akçay F 《Journal of ethnopharmacology》2011,138(2):408-414
Ethnopharmacological relevance
Since ancient times, various herbal preparations have been used in treatment of urolithiasis, which is basically formation of calcium oxalate stones in kidney. The aim of our study is to assess the effects of Helichrysum plicatum DC. subsp. plicatum (HP) as a preventive agent in experimentally induced urolithiasis model in rats.Materials and methods
The efficacy of 125, 250, and 500 mg/kg HP extract was studied in 1% ethylene glycol and 1% ammonium chloride-induced urolithiasis for 21 days in rats. The weight difference and the levels of calcium, magnesium, phosphorus, urea nitrogen, creatinine and uric acid in both serum and 24 h-urine were measured. The calcium oxalate (CaOx) and pH were defined in urine. Histo-pathological analyses in kidneys were also performed.Results
The rats’ weights were higher in HP groups than urolithiasis group. Urolithiasis caused a significant increase in both serum and urine biochemical parameters compared to healthy rats. HP extract decreased levels of these parameters. Urine CaOx level was high in urolithiasis rats, whereas it was decreased by HP extract. Histopathological examinations revealed extensive intratubular crystal depositions and degenerative tubular structures in urolithiasis group, but not in HP treatment groups.Conclusion
More studies will be necessary to elucidate the antiurolithiatic activity of HP. Nonetheless, having a beneficial effect in preventing and eliminating CaOx deposition into kidneys, HP extract may be a potential drug for urolithiasis treatment. 相似文献5.
Yogesh HS Chandrashekhar VM Katti HR Ganapaty S Raghavendra HL Gowda GK Goplakhrishna B 《Journal of ethnopharmacology》2011,134(2):334-338
Ethnopharmacological relevance
Traditionally Berberis aristata is employed for its supposed properties in treatment of joint pain and also used in alleviating symptoms of menopause.Aim of the study
The aim of the present study is to evaluate the antiosteoporotic effect of Berberis aristata in ovariectomized (OVX) rats.Materials and methods
Sprague-Dawley rats were divided into sham and OVX groups. The OVX rats were further divided into four groups, which received standard estrogen (0.0563 mg/kg) and 100, 300, and 500 mg/kg aqueous-methanol extract of Berberis aristata, daily for 42 days. The uterine weight, bone loss, ash content, biomechanical, biochemical and histopathological observation were carried out for antiosteoporotic activity.Results
The experimental animals treated with Berberis aristata aqueous-methanol extract showed dose dependent activity. The significant increase in uterine weight, femur BMD, ash content and lumbar hardness were observed. In addition, increased levels of calcium and phosphorus in serum and significant decreased in urine were observed as compared to control OVX group. The histopathological results also confirm the protective effect of extract.Conclusion
The present findings strongly suggest that Berberis aristata possess the potent antiosteoporosis activity in ovariectomized rats and substantiates the ethnic use in treatment of postmenopausal osteoporosis. 相似文献6.
Cui XY Cui SY Zhang J Wang ZJ Yu B Sheng ZF Zhang XQ Zhang YH 《Journal of ethnopharmacology》2012,139(3):796-800
Ethnopharmacological relevance
Ganoderma lucidum (Ling Zhi) is a basidiomycete white-rot macrofungus that has been used as a tranquilizing agent (i.e., An-Shen effect) for the treatment of restlessness, insomnia, and palpitation in China for hundreds of years.Aim of the study
The present study aimed to investigate whether Ganoderma lucidum extract (GLE) influences the sleep of freely moving rats and the potential mechanism.Materials and methods
Ganoderma lucidum extract was extracted from fruiting bodies of Ganoderma lucidum. Rats were treated with GLE orally for 3 days, and on the third day, electroencephalographic and electromyographic recordings were made for 6 h from 9:00 p.m. to 3:00 a.m. in freely moving rats. Sleep parameters were analyzed using SleepSign software. Tumor necrosis factor-α (TNF-α) levels were measured using the enzyme-linked immunosorbent assay.Results
Three-day administration of GLE significantly increased total sleep time and non-rapid eye movement (NREM) sleep time at a dose of 80 mg/kg (i.g.) without influencing slow-wave sleep or REM sleep in freely moving rats. TNF-α levels were significantly increased concomitantly in serum, the hypothalamus, and dorsal raphe nucleus. The hypnotic effect of GLE (80 mg/kg, i.g.) was significantly inhibited by intracerebroventricular injection of TNF-α antibody (2.5 μg/rat). Co-administration of GLE (40 mg/kg, i.g.) and TNF-α (12.5 ng/rat, i.c.v.), both at ineffective doses, revealed an additive hypnotic effect.Conclusion
These results suggest that GLE has hypnotic effects in freely moving rats. The mechanism by which the extract promoted sleep remains unclear, but this effect appears to be primarily related to the modulation of cytokines such as TNF-α. Furthermore, these data at least partially support the ethnomedical use of Ganoderma lucidum. 相似文献7.
Charles PD Ambigapathy G Geraldine P Akbarsha MA Rajan KE 《Journal of ethnopharmacology》2011,134(1):55-61
Aim of the study
To examine the effect of Bacopa monniera leaf ethanolic extract (BMEE) on the serotonergic system of postnatal rats with reference to learning and memory.Materials and methods
From postnatal day (PND)-15-29, rats were treated with BMEE (40 mg/kg BW + 0.5% gum acacia) by oral gavage. Behavioural tests (Y-maze, hole-board and passive avoidance) were used to evaluate their learning (PND-32-37) and retention of memory (PND-47-53). Effect of BMEE on neurotransmitter system was analyzed by ELISA and semi-quantitative polymerase chain reaction (PCR).Results
Oral administration of BMEE improved learning and retention of memory significantly in all behavioural tasks. Following BMEE treatment, the level of serotonin (5-HT) increased while dopamine (DA) decreased significantly. We also found variation in the level of acetylcholine (ACh). However, no significant changes were observed in the level of ACh and glutamate (Glu). The level of 5-HT was significantly elevated up to PND-37 and was then restored to normal level on PND-53. Interestingly, concomitant up-regulation was recorded in the mRNA expression of serotonin synthesizing enzyme tryptophan hydroxylase-2 (TPH2) and serotonin transporter (SERT) on PND-29 and PND-37, which was restored on PND-53.Conclusions
The results suggest that BMEE treatment significantly enhances the learning and retention of memory in postnatal rats possibly through regulating the expression of TPH2, 5-HT metabolism and transport. 相似文献8.
G.I. Anuja S.R. Suja S. Shyamal V.J. Shine S. Sini S. Pradeep P. Shikha S. Rajasekharan 《Journal of ethnopharmacology》2010,132(2):456-460
Ethnopharmacological relevance
Drynaria quercifolia (L.) J. Smith (Polypodiaceae), has been widely used by ethnic groups of India to treat inflammation, rheumatism, headache, bone fracture, jaundice, etc.Aim of the study
To evaluate the anti-inflammatory and analgesic properties of the ethanolic extract of rhizome of Drynaria quercifolia (DQ) and its phytochemical profile.Materials and methods
DQ was used to evaluate the anti-inflammatory and analgesic effects using carrageenan-induced paw oedema/cotton pellet-induced granuloma in Wistar rats and acetic acid-induced writhing/formalin-induced paw licking test in Swiss albino mice respectively.Results
Oral administration of DQ produced significant inhibition of carrageenan-induced paw oedema and granuloma formation in rats, almost comparable to that caused by indomethacin. DQ significantly attenuated acute and delayed phases of formalin-induced pain and acetic acid-induced writhing episodes in mice. The analgesia was comparable to that produced by sodium salicylate and aspirin respectively. Phytochemical analysis gave positive tests for catechin, coumarins, flavonoids, phenolics, saponin, steroids, tannins, and triterpenes. The total phenolics in DQ was 244 mg/g and naringin content was 0.048%.Conclusion
The results suggest the presence of potent anti-inflammatory and analgesic principles in DQ that justifies its use for alleviating painful inflammatory conditions. 相似文献9.
Mohammad Arfan Nematullah Khan Muhammad Saeed Fazal-ur-Rehman 《Journal of ethnopharmacology》2010,131(2):502-504
Aims of the study
Current study was designed to explore the analgesic and anti-inflammatory effects of a constituent isolated from Mallotus philippinensis, in order to validate its folk use.Materials and methods
11-O-galloylbergenin was isolated from ethanolic extract of Mallotus philippinensis. Analgesic and anti-inflammatory activities of the test compound were assessed using formalin test and carrageenan-induced paw edema models.Results
11-O-galloylbergenin showed significant analgesic activity at doses of 20 and 40 mg/kg against formalin test in rats. Similarly, 11-O-galloylbergenin exhibited significant anti-inflammatory activity in carrageenan-induced paw edema model at doses of 10, 20 and 30 mg/kg.Conclusion
11-O-galloylbergenin has demonstrated its significant potential to be further investigated for its discovery as a new lead compound for management of pain and inflammation. 相似文献10.
Geraghty DP Ahuja KD Pittaway J Shing C Jacobson GA Jager N Jurković S Narkowicz C Saunders CI Ball M Pinkard A Vennavaram RR Adams MJ 《Journal of ethnopharmacology》2011,134(1):97-103
Ethnopharmacological relevance
Carpobrotus rossii (CR) has a history of use as a food and therapeutic agent by Australian indigenous peoples and early European settlers and is believed to contain a number of pharmacologically active polyphenolic compounds.Aims of the study
Oxidation of low density lipoprotein (LDL), platelet aggregation, and inflammation contribute to the development and progression of atherosclerosis. The aim of the present study was to investigate the antioxidant, antiplatelet and anti-inflammatory activity of CR extract using human blood components.Materials and methods
An assay employing in vitro copper-induced oxidation of serum lipids was used to assess antioxidant activity of CR extract (and tannin, flavonoid and pre- and post-flavonoid fractions). The effects of CR extract on ADP- and collagen-induced platelet aggregation, and on basal (unstimulated) and lipopolysaccharide (LPS)- and phytohaemagglutinin A (PHA)-stimulated cytokine release from peripheral blood mononuclear cells (PBMC) were also investigated.Results
CR extract increased the lag time of serum oxidation (maximum of ∼4-fold at 20 μg/ml) in a concentration-dependent manner. The antioxidant activity resided only in the tannin and post-flavonoid fractions. CR had no effect on ADP-induced platelet aggregation, but significantly decreased collagen-induced platelet aggregation. LPS, but not PHA, significantly increased the release of IL-1β and TNF-α from PBMC. CR extract alone inhibited monocyte chemoattractant protein (MCP)-1 release and in the presence of LPS, inhibited IL-10, TNF-α and MCP-1 release compared to LPS alone.Conclusion
CR has significant in vitro antioxidant, antiplatelet and, potentially, anti-inflammatory activity. 相似文献11.
Di Viesti V Carnevale G Zavatti M Benelli A Zanoli P 《Journal of ethnopharmacology》2011,134(2):514-517
Aim of the study
To evaluate the influence of Humulus lupulus extract on sexual behavior in female rats.Materials and methods
Ovariectomized rats hormonally primed with estradiol benzoate (1.5 μg/rat) and progesterone (500 μg/rat) were acutely treated by oral gavage with Humulus lupulus extract dosed at 5, 10 and 25 mg/kg and then tested for partner preference and sexual receptivity.Results
The administration of Humulus lupulus extract at the highest dose significantly increased the preference for the stimulus male during the partner preference test and the number of proceptive behaviors during the receptivity test, without affecting the lordosis response.Conclusions
Humulus lupulus extract increased sexual motivation in hormone-primed female rats. 相似文献12.
Huh JE Lee WI Seo BK Baek YH Lee JD Choi DY Park DS 《Journal of ethnopharmacology》2011,137(2):1011-1017
Ethnopharmacological relevance
The dried flowers of Lonicera japonica, also known as Japanese honeysuckle, and the dried root of Anemarrhena asphodeloides, the component herbs of WIN-34B, are traditionally used in Eastern medicine to treat various inflammatory conditions including arthritis.Objective
To study the acute and chronic toxicities of WIN-34B and to compare its effects on gastric mucosa with those of diclofenac, a widely used NSAID, and celecoxib, a selective COX-2 inhibitor.Materials and methods
To investigate acute toxicity, we orally administered a single dose of 5000 mg/kg WIN-34B to rats. To investigate chronic toxicity, we orally administered 500, 1000 or 2000 mg/kg WIN-34B to rats daily for 13 weeks. To assess its effects on gastric mucosa, rats received either a single dose or repeated doses of WIN-34B (400, 1000, or 2000 mg/kg), diclofenac (10, 40, or 80 mg/kg), celecoxib (100 or 1000 mg/kg), or vehicle, after which samples of gastric mucosa were assessed grossly and histologically. We also measured tissue activity of myeloperoxidase and synthesis of eicosanoids, including prostaglandin E2 (PGE2) and leukotriene B4 (LTB4). To further assess its effects, we administered WIN-34B to rats either intraperitoneally or orally, measured gastric injury scores using a rat model of diclofenac-induced gastric injury, and measured eicosanoid synthesis.Results
WIN-34B showed no signs of acute or chronic toxicity in terms of general behavior, gross appearance of the internal organs, blood chemistry, or mortality. WIN-34B did not cause significant gastric mucosal damage after single or repeated doses. In contrast, diclofenac and celecoxib both caused gastric damage. In terms of eicosanoid synthesis, WIN-34B significantly suppressed LTB4 synthesis while both diclofenac and celecoxib increased LTB4 synthesis. WIN-34B slightly reduced PGE2 production, while both diclofenac and celecoxib significantly reduced PGE2 production. In a rat model of diclofenac-induced gastric injury, WIN-34B significantly suppressed LTB4 synthesis and restored PGE2 release.Conclusions
These results demonstrate that WIN-34B did not cause acute or chronic toxicity in male or female rats. In addition, WIN-34B did not cause significant gastric mucosal damage, instead appearing to protect the mucosa from diclofenac-induced gastric damage through the regulation of PGE2 and LTB4. 相似文献13.
Ethnopharmacological relevance
The dried flower buds of Magnolia biondii Pamp (Magnoliaceae) possesses significant anti-inflammatory activities.Aim of the study
Volatile oil in Magnolia biondii Pamp (VOMbP) is considered to be important pharmacologically active individuals against acute inflammation, but its exact anti-inflammatory mechanism remains elusive. In this study, we aimed to investigate the intervention of VOMbP on rats with acute inflammation and explore the possible anti-inflammatory mechanisms of VOMbP with metabonomic strategy.Materials and methods
Acute inflammation was induced by subcutaneously injection of carrageenan in the rats. Plasma was analyzed using gas chromatography-mass spectrometry (GC-MS), based on which the principal component analysis (PCA) and partial least squares-discriminate analysis (PLS-DA) models were established for metabonomic analysis.Results
It was revealed that the pretreatment of VOMbP in acute inflammatory rats induces a substantial and characteristic change in their metabolic profiles. Some significantly changed metabolites, including hexadecanoic acid, linoleic acid, oleic acid, stearic acid, and cholesterol, were found to be reasonable in explaining the anti-inflammatory mechanism of VOMbP.Conclusions
In all, it is likely that VOMbP intervenes the metabolic process of inflammatory rats by affecting the fatty acid and cholesterol metabolism. Our work also indicated that the metabonomics method is a promising tool for performing intervention and mechanism research of traditional Chinese medicines. 相似文献14.
Aim of study
The aim of this study was to establish the anti-inflammatory activity of the methanolic extract of Dregea volubilis leaves (MEDV) with its fractions and to delineate the possible mechanism of action for MEDV.Materials and methods
The anti-inflammatory activities of MEDV along with its petroleum ether and chloroform fractions were evaluated in a carrageenan induced model of acute inflammation. The effect of MEDV on lipopolysaccharide induced production of nitric oxide (NO) in macrophages was also studied.Results
MEDV (100, 200 and 400 mg/kg body weight) significantly reduced carrageenan induced paw edema; chloroform fraction was most potent (66%, p < 0.001). MEDV was non-toxic up to 125 μg/ml in mouse peritoneal macrophages wherein it (0-100 μg/ml) reduced lipopolysaccharide induced NO production.Conclusion
MEDV possesses significant anti-inflammatory activity. Chloroform fraction of MEDV showed best anti-inflammatory activity. 相似文献15.
Ethnopharmacological relevance
Rhizoma Pinelliae Praeparatum is the product of raw Rhizoma Pinellia processed with alkaline solution and Licorice, which had been widely used for treatment of insomnia in traditional Chinese medicine. The present study aimed to investigate the sedative, hypnotic and anticonvulsant activities of ethanol fraction from Rhizoma Pinelliae Praeparatum (EFRP) and to determine whether these effects were related to GABAergic mechanism.Materials and methods
The sedative, hypnotic and anticonvulsant activities of EFRP were investigated with locomotion activity, pentobarbital-induced sleeping and nikethamide (NKTM)-induced convulsion tests, respectively. Additionally, the effects of flumazenil (an antagonist of GABAA receptor) and l-malic acid (blocker of synthetic enzyme for GABA) on the hypnotic activity of EFRP were evaluated.Results
EFRP at dose of 12 g/kg significantly inhibited the locomotion activity of mice. EFRP showed synergic effect on pentobarbital-induced sleeping by increased numbers of mice falling asleep, reduced the sleep latency and prolonged the sleeping time. l-malic acid and flumazenil inhibited the augment effects of EFRP on pentobarbital-induced sleeping. EFRP promoted a significant protection to NKTM-induced convulsion, by prolonged the death latency and decreased mortality.Conclusion
EFRP possessed sedative, hypnotic and anticonvulsant activities and these activities may be related to the GABAergic system. 相似文献16.
Freitas PC Pucci LL Vieira MS Lino RS Oliveira CM Cunha LC Paula JR Valadares MC 《Journal of ethnopharmacology》2011,134(2):501-503
Aim of the study
Palicourea coriacea (Cham.) K Schum, is an endemic plant used in the Midwestern Region of Brazil, popularly known as “douradinha do campo” and “congonha do campo”. This plant has been used in traditional medicine for several ailments, especially to treat kidney diseases. Since no formal studies on the biological activities and medicinal properties of the ethanolic extract of Palicourea coriacea (PCEE) have been carried out previously, the present study represents the first research into the efficacy of this plant as a diuretic agent employing laboratory rats as test animals.Materials and methods
For diuretic activity evaluation we assayed three doses of PCEE (20, 40 and 80 mg/kg) and measurement of the urinary volume and electrolytes (Na+, K+) concentration were taken. The acute oral toxicity of PCEE was investigated according to OECD Guideline 423.Results
The oral administration of a single dose of PCEE significantly increased the urinary volume in 24 h. Additionally, the treatment with PCEE increased, in a dose-dependent manner, the excretion of both, Na+ and K+. No sign of toxicity was observed in the animals.Conclusions
The present study confirmed the ethnopharmacological use of Palicourea coriacea as a diuretic agent in the experimental condition tested here. Additionally, this work supports the importance of the preservation of local knowledge as well as the conservation of Brazilian biodiversity. 相似文献17.
Stefanova NA Fursova AZh Sarsenbaev KN Kolosova NG 《Journal of ethnopharmacology》2011,138(2):624-632
Ethnopharmacological relevance
Cistanche deserticola (СD) has been traditionally used in the Chinese medicine as a tonic, vasodilator and neuroprotective agent.Aim of the study
To investigate the effect of CD on the age-related behavior decline and cataract and retinopathy development in senescent accelerated OXYS rats.Materials and methods
OXYS and Wistar (control) rats were supplemented with 15 mg CD on kg of body weight during 2 months from the age of 12 months. Behavioral responses of animals were assessed in the elevated plus-maze (EPM), open field (OF) and in a Morris water maze (MWM). Before and after CD treatment OXYS rats were examined by an ophthalmologist.Results
14-month-old OXYS rats had demonstrated considerably reduced activities in OF, increased anxiety in EPM, and manifestly impaired learning abilities in the MWM as compared to Wistar rats. Supplementation of CD had no effect on motor and exploratory activity of Wistar and OXYS rats in the OF, but it reduced their anxiety in the EPM compared to age-matched controls. CD significantly improved visual ability of the rats, reducing the severity of the developed signs of retinopathy and cataract while having no impact on OXYS rats’ spatial memory in the MWM. CD-treated Wistar rats exhibited slower learning ability in the MWM task comparison to the control group. The effect of CD on the learning ability in OXYS and Wistar rats may be associated with differences in their redox homeostasis.Conclusion
All in all, the findings suggest that CD improves the age-related behavioral decline, which makes it an attractive candidate for treatment of various neurodegenerative disorders. Primarily it demonstrated its ability to slow development and to reduce to some extent severity of pathological manifestations of cataract and retinopathy in OXYS rats, which makes it an attractive candidate for treatment of age-related eye diseases too. 相似文献18.
19.
Santa-Cecília FV Vilela FC da Rocha CQ Dias DF Cavalcante GP Freitas LA dos Santos MH Giusti-Paiva A 《Journal of ethnopharmacology》2011,133(2):467-473
Aim of the study
In Brazilian folk medicine, the leaves of Garcinia brasiliensis are used to treat tumors, inflammation of the urinary tract and arthritis as well as to relieve pain. Nevertheless, scientific information regarding Garcinia brasiliensis is limited; there are no reports related to its possible anti-inflammatory and antinociceptive effects. This study employed in vivo inflammatory and nociceptive models to evaluate the scientific basis for the traditional use of Garcinia brasiliensis.Materials and methods
Carrageenan-induced paw edema, peritonitis and fibrovascular tissue growth induced by s.c. cotton pellet implantation were used to investigate the anti-inflammatory activity of Garcinia brasiliensis ethanolic extract (GbEE) in rats. Formalin and acetic acid-induced writhing tests were used to investigate the antinociceptive activity in mice.Results
GbEE at test doses of 30-300 mg/kg p.o. clearly demonstrated anti-inflammatory effects by reduced paw edema induced by carrageenan, inhibited leukocyte recruitment into the peritoneal cavity, and in the model of chronic inflammation using the cotton pellet-induced fibrovascular tissue growth in rats, the GbEE significantly inhibited the formation of granulomatous tissue.The extracts at test doses of 30-300 mg/kg, p.o., clearly demonstrated antinociceptive activity, except for the first phase of the formalin test.Conclusion
GbEE markedly demonstrated anti-inflammatory action in rats and antinociceptive activity in mice, which supports previous claims of the traditional use of species of the Garcinia genus for inflammation and pain. 相似文献20.
Barua CC Pal SK Roy JD Buragohain B Talukdar A Barua AG Borah P 《Journal of ethnopharmacology》2011,134(1):62-66