1996年6月份全国疫情监测点35种法定传染病疫情动态简介

１９９６年６月份全国疾病监测点３５种法定传染病疫情动态简介１９９６年６月份全国疾病监测点甲、乙、丙类传染病疫情（１／１０万）１９９６年６月份全国疾病监测点３５种法定传染病疫情动态简介...     

1996年10月份全国疫情监测点35种法定传染病疫情动态简介

１９９６年１０月份全国疾病监测点３５种法定传染病疫情动态简介１９９６年１０月全国疾病监测点３５种法定报告传染病疫情（１／１０万）中国预防医学科学院流研所疾病监测组１９９６年１０月份全国疾病监测点３５种法定传染病疫情动态简介...     

1996年11月份全国疫情监测点35种法定传染病疫情动态简介

１９９６年１１月份全国疾病监测点３５种法定传染病疫情动态简介中国预防医学科学院研所疾病监测组１９９６年１１月份全国疾病监测点３５种法定传染病疫情动态简介...     

1996年2月份全国疾病监测点35种法定传染病疫情动态简介

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1996年4月份全国疾病监测点35种法定传染病疫情动态简介

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1996年9月份全国疾病监测点35点种法定传染病疫情动态简介

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1996年1月份全国疾病监测点35种法定传染病疫情动态简介

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1996年5月份全国疾病监测点35种法定传染病疫情动态简介

１９９６年５月份全国疾病监测点３５种法定传染病疫情动态简介中国预防医学科学院流研所疾病监测组１９９６年５月份全国疾病监测点３５种法定传染病疫情动态简介$中国预防医学科学院流研所疾病监测组...     

1994年8月份全国疾病监测点35种法定传染病疫情动态简介

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1994年4月份全国疾病监测点35种法定传染病疫情动态简介

１９９４年４月份全国疾病监测点３５种法定传染病疫情动态简介１９９４年４月份全国疾病监测点３５种法定传染病疫情动态简介...     

NO and HNO donors,nitrones, and nitroxides: Past,present, and future

The biological effects attributed to nitric oxide (^?NO) and nitroxyl (HNO) have been extensively studied, propelling their array of putative clinical applications beyond cardiovascular disorders toward other age‐related diseases, like cancer and neurodegenerative diseases. In this context, the unique properties and reactivity of the N‐O bond enabled the development of several classes of compounds with potential clinical interest, among which ^?NO and HNO donors, nitrones, and nitroxides are of particular importance. Although primarily studied for their application as cardioprotective agents and/or molecular probes for radical detection, continuous efforts have unveiled a wide range of pharmacological activities and, ultimately, therapeutic applications. These efforts are of particular significance for diseases in which oxidative stress plays a key pathogenic role, as shown by a growing volume of in vitro and in vivo preclinical data. Although in its early stages, these efforts may provide valuable guidelines for the development of new and effective N‐O‐based drugs for age‐related disorders. In this report, we review recent advances in the chemistry of NO and HNO donors, nitrones, and nitroxides and discuss its pharmacological significance and potential therapeutic application.     

Lipid messenger, diacylglycerol, and its regulator, diacylglycerol kinase, in cells, organs, and animals: history and perspective

Diacylglycerol kinase (DGK) metabolizes diacylglycerol (DG), a glycerolipid containing two acyl chains, to convert phosphatidic acid. DG is produced through phosphoinositide turnover within the membrane and is well known to act as a second messenger that modulates the activity of protein kinase C in the cellular signal transduction. Recent studies have revealed that DG also activates several proteins, including Ras guanine-nucleotide releasing protein and ion channels such as transient receptor potential proteins. Therefore, DGK is thought to participate in a number of signaling cascades by modulating levels of DG. Previous studies have disclosed that DGK is composed of a family of the isozymes, which differ in the structure, enzymological property, gene expression and localization, subcellular localization, and binding molecules. The present review focuses on the stories of phosphoinositide turnover and DG, including historical views, structural features, metabolism, and relevant cellular phenomena, together with the characteristics of DGK isozymes and the pathophysiological findings on animal studies using knockout mice and models for human diseases. Now it is being revealed that the structural and functional diversity and heterogeneity of and around DGK support the proper arrangement of the complex signal transduction machinery.     

Heat, cold, noise, and vibration

Exposure to a cold environment induces a number of physiological alterations, the most serious being hypothermia. This state can occur in all individuals, but the very young and the elderly are more susceptible. Environmental and industrially generated high ambient temperature can place further stress on aged individuals and workers, resulting in a complex symptom picture. Morbidity and death may result from such exposures. Causative factors have been identified. Noise exposure induces hearing losses above those secondary to the aging process. Psychophysiological effects during noise exposure are considered to result from the sympathetic activity secondary to a general stress reaction. Vibration from the use of power tools results in Raynaud's phenomenon. However, modification of power tools has reduced the symptoms associated with vibration exposure. Termination of exposure to vibration appears eventually to reduce symptoms related to white-finger spasms. Interaction between these stressors has not been clarified because of the complex effects of each. The need for additional information about the response to these stressors is evident.