Dendritic cells as a pharmacological target of traditional Chinese medicine

Dendritic cells （DCs） represent a heterogeneous population of professional antigen-presenting cells （APCs） that play a central role in the initiation and regulation of immune responses. There is considerable evidence that DCs can be used as therapeutic targets for pharmacological modulation of immune responses. Traditional Chinese medicine （TCM） has a long-standing history of using herbal medicine in the treatment of variety of human diseases. Many of the clinical effects of TCM have reportedly been attributed to the up- or down-regulation of immune responses. Accumulating evidence indicates that TCM and its components can interfere with immune responses at the earliest stage by targeting key functions of DCs. Here, we review those published studies of TCM with respect to their effects on immunobiological functions of DCs. Investigations based on both chemical entities derived from TCM as well as TCM herbal mixtures are presented. These studies suggest that various TCM herbal medicines have the capacity to inhibit or promote major functions of DCs, such as differentiation, maturation, cytokine production, survival, antigen uptake and presentation as well as trafficking. These studies have revealed novel biological effects of TCM and documented the utility of this approach to discover novel biological modifier of DC functions derived from natural sources.     

中西医结合治疗胎儿宫内发育迟缓

目的 探讨胎儿宫内发育迟缓(IUGR)的治疗方法。方法 分别采用硫酸镁加中药治疗胎儿宫内发育迟缓67例,硫酸镁治疗61例,利用彩色超声多普勒对其临床疗效进行观察。结果 硫酸镁加中药的有效率高于硫酸镁,其差异具有显著性意义(P<0.05)。结论 硫酸镁加中药是治疗IUGR的有效方法之一。     

中医诊断仪器的研发思路

本文分析了中医诊断仪器的研发现状与问题,从中医理论和科学方法指导的层面上提出了一个创新型的研发思路,将“系统、辨证”和“整体观”的中医理论运用到中医诊断仪器的研发中,并举例说明了该研发思路的可行性。     

中医药类数据库建设的回顾与分析

以文献计量的方法，按学科主题、数据库类型，对1984年到2003年中医药类数据库进行分析。结果显示：大型的、复合的、基于互联网的医药数据库是目前主流。预计了今后中医药类数据库建设的趋势，认为数据库建设的关键在于借用先进计算机技术，有效利用地域资源，及延揽医学信息学专业人员。     

中药复方S-抗毒合剂对传染性喉气管炎的防治作用

目的 探讨中药复方S-抗毒合剂对传染性喉气管炎的防治作用。方法 将患有传染性喉气管炎的孔雀30只随机分为三组，每组10只，S-抗毒合剂组饲喂含中药的基础日粮；西药组饲喂含西药(阿莫西林 利巴韦林)的基础日粮；对照组为基础日粮，连续饲养二周；观察治疗期患有传染性喉气管炎孔雀的发病与死亡情况。结果 中药复方S-抗毒合剂对传染性喉气管炎防治的有效率达98％以上，西药及对照组有效率分别仅为20％、50％。结论 中药复方S-抗毒合剂对防治传染性喉气管炎效果良好。     

中药与西药对照治疗偏头痛的Meta分析

目的评价中药治疗偏头痛的临床疗效和安全性。方法计算机检索中国期刊全文数据库、维普中文期刊数据库、万方学术期刊全文数据库、中国生物医学文献服务系统（CBM）、中国生物医学期刊引文数据库（CMCI/CMCC整合版）、中医药在线数据库,检索2000年1月—2009年12月10年间的相关文献,收集中药治疗偏头痛的随机对照试验（RCTs）。按纳入排除标准筛选试验、评价研究质量、提取有效数据,并采用RevMan5.0进行统计分析。结果最终纳入20个RCT评价中药与西药在偏头痛疗效方面的差异,Meta分析显示：有效率[RR=1.22,95%CI（1.15,1.29）,P〈0.01],差异有统计学意义。敏感性分析表明评价结果稳定。漏斗图显示不对称,提示纳入评价的文献存在发表性偏倚。结论中药治疗偏头痛有效,但由于本系统评价纳入研究的方法学质量较低,尚需开展更多设计合理、执行严格的多中心大样本且随访时间足够长的随机对照试验验证其疗效及安全性。     

中西医结合治疗青春期功能性子宫出血78例临床分析

目的探讨中西医结合治疗青春期功能性子宫出血的临床效果.方法将我院2000年～2004年收治的76例青春期功能性子宫出血病例分成A、B两组,A组(治疗组)38例根据B超下子宫内膜厚度采用中药配合补佳乐或妇康片治疗,B组(对照组)40例,只采中药治疗.结果 A组38例,治愈23例(60.5%),好转12例(31.6%),未愈3例(7.9%),总有效率为92.1%;B组40例,治愈12例(30%),好转19例(47.5%),未愈9例(22.5%),总有效率77.5%,两组总有效率相比差异有显著性(P＜0.05),说明治疗组疗效优于对照组.结论以中药配合补佳乐或妇康片治疗青春期功能性子宫出血临床效果更显著.     

人工智能在中医诊断中的应用进展

本研究立足于各类人工智能算法的数学原理,阐述了人工智能在中医诊断中的应用现状及问题。其中传统机器学习算法,如支持向量机、贝叶斯算法等因其小样本学习的特性,在闻诊、问诊等场景具备较高的精度与稳健性;而近年来新兴的深度学习算法则可以处理如图像、音频信号、文本等非结构化数据,与望诊、切诊等场景相契合;多模态深度学习则可以充分挖掘望闻问切数据中的信息,并在特征空间中进行隐式的四诊合参。人工智能的引入可以进一步推动中医的客观化、定量化发展,但其数据驱动的特性要求进一步规范现行的中医数据库建立流程。     

中西医结合治疗青春期功能性子宫出血78例临床分析

目的探讨中西医结合治疗青春期功能性子宫出血的临床效果.方法将我院2000～2004年收治的78例青春期功能性子宫出血病例分成A、B两组,A组(治疗组)38例,根据B超下子宫内膜厚度采用中药配合补佳乐或妇康片治疗,B组(对照组)40例,只采用中药治疗.结果A组38例,治愈23例(60.5%),好转12例(31.6%),未愈3例(7.9%),总有效率为92.1%;B组40例,治愈12例(30%),好转19例(47.5%),未愈9例(22.5%),总有效率77.5%,两组总有效率相比差异有显著性(P＜0.05),说明治疗组疗效优于对照组.结论以中药配合补佳乐或妇康片治疗青春期功能性子宫出血效果更显著.     

中医脉象发生仪的研制

目的利用工程学方法形象客观地模拟人体各种脉象。方法构建了一个符合人体构造的运动的流体模型，在此基础上开发了一套针对中医诊断教学的模拟系统——中医脉象发生仪。该系统将中医学与仿生学、机械学、传感技术及计算机技术等工程学方法结合起来。结果它成功模拟了人体常见的26种脉象，体现了各种脉象的指下特征，适用于课堂教学、教学测试和科学研究等方面。结论借助于这种模型，研究人员可以深入进行血液流变学、脉诊学、脉象特征提取等方面的研究。     

Clinical characteristics and impacts of traditional Chinese medicine treatment on the convalescents of COVID-19

Objectives: A significant proportion of discharged COVID-19 patients still have some symptoms. Traditional Chinese medicine (TCM) has played an important role in the treatment of COVID-19, but whether it is helpful for discharged patients is still unknown. The aim of this study was to retrospectively analyze the impacts of TCM treatment on the convalescents of COVID-19.Methods: A total of 372 COVID-19 convalescents from February 21 to May 3 in Shenzhen, China were retrospectively analyzed, 291 of them accepted clinically examined at least once and 191 convalescents accepted TCM.Results: After retrospective analysis of the clinical data of convalescents accepted TCM treatment or not, we found that the white blood cell count, as well as serum interleukin-6 and procalcitonin decreased in TCM group. Serum γ-glutamyl transpeptidase was significantly decreased, while prealbumin and albumin increased in TCM group. Red blood cell, hemoglobin, and platelet count increased in TCM group. The mechanisms of TCM treatment might be the overall regulations, including balanced immune response, improved hematopoiesis and coagulation systems, enhanced functions of liver and heart, increased nutrient intake and lipid metabolism.Conclusions: This study suggested that TCM treatment would be beneficial for discharged COVID-19 patients. However, long-term medical observation and further study with randomized trial should be done to confirm this result. Besides, the potential molecular mechanisms of TCM treatment should be further revealed.     

中西医结合治疗多囊卵巢综合征不孕症63例分析

目的多囊卵巢综合征(PCOS),以持续不排卵和高雄性激为根本特征的一种常见妇科内分泌疾病。临床表现为月经不调、不孕、多毛、肥胖和卵巢囊性增大的综合征。方法本文将在本院妇科门诊患者分成两组,对照组37例,采用纯西医治疗,治疗组63例,在上基础上配合中药治疗。结果对照组受孕率29.73%,治疗组受孕率66.67%,差异有显著性意义。结论采用中西医结合方法治疗多囊卵巢不孕症能提高患者的妊娠率。     

大学生疲劳与中医体质的相关性研究

目的探讨中医体质与大学生疲劳发生的相关性。方法整群抽样抽取广州某大学6029名大学生,进行问卷调查了解疲劳状况及中医体质分型,进行卡方检验、多分类Logistic回归分析。结果疲劳发生情况为“总是”占3．3％（196）、“经常”占19．7％（1187）。男、女大学生发生疲劳的差异有统计学意义（X2=44．725,P=O．000）。多分类Logistic回归分析显示,“总是”发生疲劳时平和质为保护因素,气虚质、瘀血质及湿热质为危险因素;“经常”发生疲劳时平和质为保护因素,气虚质、瘀血质为危险因素;“有时”发生疲劳时只有平和质密切相关。为保护因素：“很少”发生疲劳时各体质对模型无贡献。结论气虚质、瘀血质和湿热质是大学生发生疲劳的危险因素,而平和质是保护因素。     

Potential therapeutic effect and methods of traditional Chinese medicine on COVID-19-induced depression: A review

COVID-19 (coronavirus) has spread all over the world with a high infection rate. Currently, there are no targeted therapeutic drugs for COVID-19 as well as for stress induced by COVID-19. The unpredictable events of COVID-19 can trigger feelings of fear, worry, or unease in people, leading to stress-related disorders such as depression and anxiety. It has been reported that individuals, including COVID-19 patients, medical staff, and ordinary people, are under both physical and psychological pressure, and many of them have developed depression or anxiety during this pandemic. Traditional Chinese medicine (TCM) has been widely used in treating depression with relatively better safety and efficacy and may have an important role in treating stress-related disorders induced by COVID-19. In this review, we collected the common TCM treatment methods including Qigong, Acupuncture, Five Elements Musical Therapy, Five Elements Emotional Therapy, and Chinese herbal medicine from the databases of PubMed and the China National Knowledge Internet to illustrate the effect of TCM on depression. The better knowledge of TCM and implementation of TCM in COVID-19 clinics may help to effectively improve depression induced by COVID-19, may assist people to maintain a healthy physical and mental quality, and may alleviate the current shortage of medical resources.     

复方S-抗毒合剂治疗传染性喉气管炎的血液学影响

目的 探讨中药复方S-抗毒合剂治疗传染性喉气管炎(ILT)后血液细胞和血液化学的变化。方法以孔雀为实验对象，将中药按每日每只2g拌饲料投喂ILT孔雀进行治疗，并于治疗前后取翅静脉血做血细胞和化学检测。结果该药能提高ILT孔雀的RBC、HGB和PCT数，降低肝功酶谱活性．改善损伤的肾功指标，且在用中药2周内使血清IgM升高；4周时IgA显著升高。结论中药复方S-抗毒合剂对孔雀具有止血和抗贫血，恢复肝肾功能，提高机体免疫功能和防治ILT病的作用。     

良性甲状腺结节的中西医研究进展

甲状腺结节是指各种原因导致甲状腺内出现一个或多个组织结构异常的团块,近年来发病率不断上升.目前西医治疗手段有甲状腺激素抑制治疗、放射性131I治疗、超声引导下经皮酒精注射及手术等.临床上虽有一定疗效但存在不良反应和风险.中医药在治疗甲状腺结节方面有着独特的优势,不仅疗效确切,而且安全简便.现通过查阅大量文献,就良性甲状腺结节的中西医研究进展进行综述.     

三黄汤、茵栀黄联合西药治疗新生儿黄疸168例临床观察

目的探讨中药三黄汤、茵栀黄联合西药、蓝光照射等联合治疗新生儿黄疸的临床疗效。方法轻度:三黄汤加鲁米那、强的松口服治疗三天,中重度:茵栀黄加白蛋白、强的松、维生素、鲁米那、蓝光照射等。结果 31例轻度患儿给予三黄汤加鲁米那治疗后黄疸消退时间3-4天23例,5-6天8例,血清总胆红素平均6天降到正常值;137例中重症患儿,茵栀黄加白蛋白、强的松、维生素、鲁米那、蓝光照射后嗜睡、呕吐消失,二便正常,皮肤及巩膜黄染6-20天消退,血清总胆红素平均6-8天(105例)、8-10天(24例)、10-18天(8例)降到正常。结论早期发现并早期应用中药配合西药综合治疗新生儿黄疸,可以明显缩短病程并预防核黄疸发生。