共查询到20条相似文献,搜索用时 31 毫秒
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Donald L Bissett PhD Larry R Robinson PhD Patricia S Raleigh BS Kukizo Miyamoto PhD Tomohiro Hakozaki PhD Jim Li MS MA Gary R Kelm PhD 《Journal of Cosmetic Dermatology》2009,8(4):260-266
Objectives N‐undecyl‐10‐enoyl‐l ‐phenylalanine (Sepiwhite®, N‐undecylenoyl phenylalanine), a reported alpha‐melanocyte‐stimulating hormone (MSH) receptor antagonist, has been observed to reduce melanin production in cultured melanocytes. In other testing, niacinamide has been found to inhibit melanosome transfer in cultured cells and to reduce the appearance of hyperpigmented spots in clinical studies. Since these two agents function by different mechanisms, we conducted two studies to determine if their combination is more effective than niacinamide alone in reducing facial hyperpigmentation. Methods Two double‐blind, 10‐week (2‐week washout + 8‐week treatment), left‐right randomized, split‐face clinical studies were conducted. In one, two groups of Japanese women applied one of two pairs of test emulsion formulations: a vehicle control and a 5% niacinamide formulation (n= 40), or a 5% niacinamide and a 5% niacinamide plus 1%N‐undecylenoyl phenylalanine formulation (n = 40). Each formulation was applied to the randomly assigned side of the face. In the second study, Caucasian women applied one of three emulsions: vehicle control, 5% niacinamide formulation, or combination 5% niacinamide plus 1%N‐undecylenoyl‐phenylalanine formulation to the randomly assigned side of the face (n = ~60 treatment sites per formulation). In both studies, hyperpigmented spots were evaluated at weeks 4 and 8 by quantitative image analysis. Results In both studies, the combination formulation was significantly more effective than the vehicle and the 5% niacinamide formulation in reducing the appearance of hyperpigmentation after 8 weeks. Conclusions The combination of 5% niacinamide and 1%N‐undecylenoyl phenylalanine is an effective anti‐aging technology for use on facial skin. 相似文献
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Treatment of psychodermatological conditions, particularly body‐focused repetitive behavior disorders, is often unsatisfactory. Various psychopharmacological and non‐pharmacological treatments have been used to ameliorate the symptoms of these disorders. N‐Acetylcysteine (NAC) is a newer modality in the treatment of these disorders. This short review focuses on pharmacology, mode of action, and use of NAC in common body‐focused repetitive disorders such as trichotillomania, skin‐picking disorders, and onychotillomania (nail biting). Current research and literature review have been evaluated and will be discussed. 相似文献
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Rhododendrol‐induced leukoderma accompanied by allergic contact dermatitis caused by a non‐rhododendrol skin‐lightening agent, 5,5′‐dipropylbiphenyl‐2,2′‐diol
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Akiko Yagami Kayoko Suzuki Akiyo Sano Masayuki Takahashi Tsukane Kobayashi Yusuke Morita Aki Ando Yohei Iwata Kayoko Matsunaga 《The Journal of dermatology》2015,42(7):739-740
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EunJin Bang Eun Kyeong Lee Sang‐Gyun Noh Hee Jin Jung Kyoung Mi Moon Mi Hwa Park Yeo Jin Park Min Kyung Hyun A Kyoung Lee Su Jeong Kim Jungho Yang Yujin Park Pusoon Chun Hyung Ryong Moon Hae Young Chung 《Experimental dermatology》2019,28(6):734-737
Tyrosinase is a key enzyme that catalyses the initial rate‐limiting steps of melanin synthesis. Due to its critical role in melanogenesis, various attempts were made to find potent tyrosinase inhibitors although many were not safe and effective in vivo. We evaluated tyrosinase inhibitory activity of six compounds. Among them, (Z)‐5‐(3‐hydroxy‐4‐methoxybenzylidene)‐2‐thioxothiazolidin‐4‐one (5‐HMT) had the greatest inhibitory effect and potency as the IC50 value of 5‐HMT was lower than that of kojic acid, widely‐known tyrosinase inhibitor. Based on in silico docking simulation, 5‐HMT had a greater binding affinity than kojic acid with a different binding conformation in the tyrosinase catalytic site. Furthermore, its skin depigmentation effect was confirmed in vivo as 5‐HMT topical treatment significantly reduced UVB‐induced melanogenesis in HRM2 hairless mice. In conclusion, our study demonstrated that 5‐HMT has a greater binding affinity and inhibitory effect on tyrosinase and may be a potential candidate for a therapeutic agent for preventing melanogenesis. 相似文献
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4‐Hexyl‐1,3‐phenylenediol,a nuclear factor‐κB inhibitor,improves photodamaged skin and clinical signs of ageing in a double‐blinded,randomized controlled trial
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S. Kaur M. Kizoulis J. Fantasia T. Oddos N. Bigot P. Galera S. Tucker‐Samaras J.J. Leyden M.D. Southall 《The British journal of dermatology》2015,173(1):218-226
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Shunsuke Iriyama Haruyo Yamanishi Naomi Kunizawa Tetsuji Hirao Satoshi Amano 《Experimental dermatology》2019,28(3):247-253
Daily exposure to sunlight is known to affect the structure and function of the epidermal basement membrane (BM), as well as epidermal differentiation and epidermal barrier function. The aim of this study is to clarify whether the inhibition of BM‐degrading enzymes such as heparanase and matrix metalloproteinase 9 (MMP‐9) can improve the epidermal barrier function of facial skin, which is exposed to the sun on a daily basis. 1‐(2‐hydroxyethyl)‐2‐imidazolidinone (HEI) was synthesized as an inhibitor of both heparanase and MMP‐9. HEI inhibited not only the BM damage at the DEJ but also epidermal proliferation, differentiation, water contents and transepidermal water loss abnormalities resulting from ultraviolet B (UVB). This was determined in this study by the use of UVB‐induced human cultured skins as compared with the control without HEI. Moreover, topical application of HEI improved epidermal barrier function by increasing water content and decreasing transepidermal water loss in daily sun‐exposed facial skin as compared with non‐treated skins. These results suggest that the inhibition of both heparanase and MMP‐9 is an effective way to care for regularly sun‐exposed facial skin by protecting the BM from damage. 相似文献