伊曲康唑联合希尔生洗剂治疗头皮脂溢性皮炎的疗效观察

收集我院2011年7月~2013年7月诊治的头皮脂溢性皮炎患者230例作为研究对象,以抛硬币的方式分为试验组与对照组各115例。对照组患者单纯采用希尔生洗剂治疗,试验组采用伊曲康唑联合希尔生洗剂治疗,对两组患者的治疗效果和一年复发率进行分析对比。结果试验组中有70例治愈,30例显效,10例有效,5例无效,总有效率为95.65%;对照组中有52例治愈,34例显效,13例有效,16例无效,总有效率为86.09%,试验组患者的治疗效果明显优于对照组(P0.05)。通过对患者实施为期一年的随访发现,试验组中有8例患者复发,复发率为6.96%,对照组中有26例患者复发,复发率为22.61%,试验组复发率明显低于对照组(P0.05)。伊曲康唑联合希尔生洗剂治疗头皮脂溢性皮炎具有良好的临床疗效,能有效提高治疗效果,降低复发率,值得在临床应用上推广。     

中药联合酮康唑洗剂治疗头皮脂溢性皮炎42例

［摘要］目的：观察中药抑脂汤联合酮康唑洗剂治疗头皮脂溢性皮炎的疗效。方法：对照组45例,采用2％酮康唑洗剂治疗,联合组42例,在对照组的基础上加自拟中药抑脂汤口服。观察两组治疗前后的疗效。结果：联合组的有效率为85.7%,对照组的有效率为62.2%,两组比较有统计学意义（χ2=6.16,P<0.05）。结论：中药抑脂汤联合酮康唑洗剂治疗头皮脂溢性皮炎疗效确切,值得推广使用。     

伊曲康唑治疗皮肤真菌病疗效研究

目的研究伊曲康唑治疗皮肤真菌病疗效.方法 100例皮肤浅部真菌感染者应用伊曲康唑治疗,观察疗效.结果 100例中痊愈92例,显效4例,有效1例,无效0例,治愈率92%,有效率97%,真菌镜检治疗前阳性100例,治疗后转阴95例,真菌清除率95%.结论伊曲康唑是治疗前皮肤真菌病较为理想的药物.     

伊曲康唑治疗深部真菌感染疗效观察

目的：探讨伊曲康唑治疗深部真菌感染的临床疗效。方法：23例深部真菌感染患者采用伊曲康唑针剂静脉滴注（症状好转后改为口服）治疗，疗程15-20d。结果：可评价病例22例中17例有效，其中治愈12例（54．5％），显效5例（22．7％），无效5例（22．7％），有效率为77．3％。结论：伊曲康唑治疗深部真菌感染疗效较好，不良反应轻，患者耐受好，可作为临床治疗深部真菌感染的首选。     

伊曲康唑胶囊联合联苯苄唑乳膏治疗足癣

目的 观察口服伊曲康唑胶囊联合外用联苯苄唑乳膏治疗足癣的疗效.方法 将180例足癣患者随机分为三组,治疗组60例,口服伊曲康唑胶囊1周,联合外用联苯苄唑乳膏2周;对照Ⅰ组62例,仅口服伊曲康唑胶囊1周;对照Ⅱ组58例,仅予联苯苄唑乳膏外用连用4周.结果 用药后8周治疗组有效率为88.33%,真菌清除率为85%;对照Ⅰ组有效率为75.81%,真菌清除率为77.42%;对照Ⅱ组有效率为68.96%,真菌清除率为53.45%,两对照组有效率与治疗组相比差异有统计学意义.结论 口服伊曲康唑联合外用联苯苄唑乳膏治疗足癣,在缩短疗程、减少费用、提高依从性和疗效、降低复发率等方面有明显优势.     

氟康唑联合伊曲康唑治疗真菌性角膜溃疡的体会

目的观察氟康唑联合伊曲康唑治疗真菌性角膜溃疡的疗效。方法对临床确诊的真菌性角膜溃疡的31例患者，轻型：给予0．2％氟康唑注射液滴眼，1次／h；筋膜囊注射氟康唑注射液0．8ml，1次／d。中型：在轻型治疗方案的基础上加用伊曲康唑口服，200mg／次，1次／d。重型：在中型治疗方案的基础上加用0．2％氟康唑100ml静滴，1次／d。结果23例治愈（74.2％），4例好转，4例无效，总有效率87．1％。结论氟康唑联合伊曲康唑治疗真菌性角膜溃疡疗效好，无明显不良反应。     

伊曲康唑治疗花斑癣42例疗效观察

42例花斑癣患者，每日口服伊曲康唑200mg，连服7天或14天，治愈率52．4％，总有效率100％，真菌阴转率100％，未见明显的副作用。     

伊曲康唑口服与伊曲康唑混合甘油涂抹黏膜治疗口腔念珠菌病的疗效比较

目的 比较伊曲康唑口服与伊曲康唑混合甘油局部涂抹口腔黏膜治疗口腔念珠菌病的疗效。方法 选取口腔念珠菌病患者78例,随机分为伊曲康唑口服治疗（A组）,伊曲康唑混合甘油涂抹口腔黏膜治疗（B组）,每组各39例。比较两组患者治疗后疼痛,黏膜红斑或假膜、病损区念珠菌培养数量。结果 两组疗效比较,治疗黏膜红斑或假膜总有效率分别为69.23%,89.74%,差异有统计学意义（P<0.05）;两组菌检总有效率分别为71.79%,97.44%,差异有统计意义（P<0.05）;两组口腔疼痛总有效率分别为79.48%,100%,差异有统计学意义（P<0.05）。结论 伊曲康唑混合甘油局部涂抹治疗口腔念珠菌病效果优于伊曲康唑口服治疗效果。     

New Beneficial Agents in the Treatment of Acne Vulgaris and Seborrheic Dermatitis

As the number of older women and their average life expectancy increase, physicians will need to focus as much on providing preventive, health-promoting care as on treating disease. Drs South-Paul and Woodson present a guide for multidimensional evaluation of asymptomatic older women that can serve as a framework for designing individualized care.     

维A酸治疗伴色素沉着的脂溢性皮炎的临床疗效和安全性

目的：探讨维胺酯胶囊口服合并0．025％维A酸霜外用治疗伴色素沉着的脂溢性皮炎患者的临床疗效及安全性，并对不同剂量的维胺脂胶囊口服其临床疗效进行了比较。方法：117例伴色素沉着脂溢性皮炎患者随机分为A、B和C3组。A、B两组为治疗组，口服维胺酯胶囊并外用0．025％维A酸霜治疗，同时口服杞菊地黄丸、VitC；但在治疗1个月后，A组口服维胺酯胶囊剂量减少，B组维持原剂量不变。C组为对照组，仅口服杞菊地黄丸、VitC等一般药物治疗，3个月为1个疗程，评价各组临床疗效和安全性，组间比较采用卡方检验。结果：A组与B组临床疗效均优于C组（P〈0．05）；A组与B组间疗效无显著差异（P〉0．05）；两组维A酸治疗组局部出现紧崩感及潮热感，能耐受。117例患者均未出现全身不良反应。结论：维胺酯胶囊口服合并0．025％维A酸霜外用治疗伴异常色素沉着的脂溢性皮炎患者疗效肯定，耐受性好。     

单用功效性护肤品治疗轻中度面部玫瑰痤疮及脂溢性皮炎的多中心临床研究

[目的]探讨单用功效性护肤品治疗轻中度面部玫瑰痤疮及脂溢性皮炎的临床疗效.[方法]在全国范围内17家医院皮肤科门诊招募1个月以上病史的轻中度面部玫瑰痤疮或脂溢性皮炎患者,给予面部单用功效性护肤品2周,每周复诊1次,对其临床症状(干燥、瘙痒、灼热)和体征(脱屑、红斑)进行评分,并检测其皮肤屏障指标.[结果]共324名受试...     

Susceptibilities of Clinical and Laboratory Isolates of Blastomyces dermatitidis to Ketoconazole, Itraconazole, and Fluconazole

Eighteen isolates of Blastomyces dermatitidis were evaluated for their in vitro susceptibilities to ketoconazole, itraconazole, and fluconazole. The MIC ranges were 0.1 to 0.4 μg/ml for ketoconazole, ≤0.018 to 0.07 μg/ml for itraconazole, and 2.5 to 4.0 μg/ml for fluconazole. The ranges for the minimal lethal concentrations were 0.2 to 0.8 μg/ml for ketoconazole, ≤0.018 to 0.07 μg/ml for itraconazole, and 10 to 40 μg/ml for fluconazole. Itraconazole was the most active agent against B. dermatitidis in vitro, while fluconazole was the least active. These results correlate with the clinical efficacies noted to date with doses of these agents used to treat blastomycosis.     

老年脂溢性角化病146例误诊探讨

目的分析老年脂溢性角化病（seborrheic keratosis,SK）的误诊原因,以提高临床对本病的认识。方法对病理证实的老年SK146例的临床特征、病理、误诊情况进行回顾性分析。结果本组病程（8．0±3．6）年,误诊时间（3．0±2．6）年;皮损表现为多发、散在,皮疹色泽、大小变化大,易合并瘙痒等不适。均通过组织病理学得以确诊,病理类型主要是棘细胞型、色素型和角化过度型。误诊为色素痣54例（37．0％）,基底细胞癌或鳞状细胞癌38例（26．0％）,恶性黑色素瘤25例（17．1％）,寻常疣15例（10．3％）,角化棘皮瘤9例（6．2％）,Bowen病5例（3．4％）;予冷冻、激光等物理方法治疗,效果良好。结论误诊原因与漫长病程中皮损出现较大变化、合并不适症状、病理类型及组织学变化有关。     

Palatability and Treatment Efficacy of Various Ibuprofen Formulations in C57BL/6 Mice with Ulcerative Dermatitis

Ibuprofen, a nonsteroidal antiinflammatory drug, is a nonselective inhibitor of cyclooxygenases 1 and 2 that commonly is used for its analgesic, antiinflammatory, and antipyretic properties. We compared the palatability and efficacy of medicated water containing ibuprofen from an oral pediatric suspension or liqui-gel capsules in C57BL/6 and genetically engineered mice of C57BL/6 background with ulcerative dermatitis. Mice (n = 14 or 15 per group) with ulcerated skin lesions of similar average size (capsule group, 6.71 mm²; suspension group, 6.12 mm²) received ibuprofen in their drinking water at a concentration of 1 mg/mL. Water and food consumption, locomotor activity, grooming frequency, and reduction in pruritic behavior and lesion size were measured over a 9-d period. Compared with those treated with water containing the suspension, mice that received medicated water containing the liqui-gel formulation drank more (mean, 6.8 compared with 11.7 mL/d), consumed more food (4.02 compared with 2.73 g/d), and showed less pruritic behavior, greater healing (mean, 29.3% compare with 64.8%), and more locomotor activity over a 9-d period.Veterinarians often use commercial drug formulations when treating laboratory animals. Drug efficacy, palatability, duration of effect, ease of administration, and potential adverse effects are considered when selecting a specific agent.Ulcerative dermatitis is a spontaneous syndrome associated with C57BL/6 mice and those of C57BL/6 background. Ulcerative dermatitis beleaguers staff responsible for mouse colonies worldwide. Although the exact etiology of ulcerative dermatitis has yet to be determined, studies to date indicate a multifactorial syndrome with a genetic link. A recent study indicated that a possible factor in the development of ulcerative dermatitis in C57BL/6J mice and C57BL/6J substrains is related to vitamin A metabolism deficiencies.³⁴ Other indications of genetic links have been described in mice used as a model for systemic lupus erythematosus disease and in Apo E knockout mice in association with vasculitis and alterations in lipid metabolism, respectively.² Severe ulcerative dermatitis has been documented in mice lacking expression of E and P selectins as well as mice lacking inducible nitric oxide synthase,¹² whereas mice lacking expression of both E and P selectins and the Rag1 gene do not develop ulcerative dermatitis.¹² Various other factors that have been associated with the development of ulcerative dermatitis include age, diet,^9,30 immune complex vasculitis,² barbering,²⁶ environmental changes including relative humidity, temperature and season, diets with 11% fat,⁴ elevated vitamin A levels,⁷ and ectoparasites.^20,27-29The clinical presentation of ulcerative dermatitis may include excoriation, epidermal ulceration, granulation tissue, serocellular crusts, and degloved skin segments and in severe cases, the lesions may bleed, expose underlying musculature, or result in scar contracture.^20,21,36 However, all of these lesion attributes are typical of an ulcer regardless of cause, with the exception of vasculitis. In addition, the most effective therapeutic approaches to the treatment of ulcerative dermatitis have involved interrupting the inflammatory process, secondary infection, or the pain associated with inflammation and include cyclosporine,⁸ calamine lotion,²⁰ topical lidocaine, carprofen, diphenhydramine, and administration of topical Ω3 and 6 fatty acids plus vitamin E supplements.⁴ Other treatment combinations attempted include chlorhexidine,²⁴ topical 0.2% cyclosporine in 2% lidocaine supplemented with parenteral gentamicin,⁸ diet supplemented with vitamin E (3000 IU) combined with amoxicillin- or trimethoprim–sulfamethoxazole-supplemented drinking water, and topical bacitracin–neomycin–polymyxin B ointment.^20,21Inflammation is associated with an increase in free radical production, which accumulation results in pruritus.²¹ An increase in dietary vitamin E (3000 IU/kg) was shown to result in the improvement of 45% of ulcerative dermatitis lesions regardless of age, gender, lesion size, or location.²¹ The therapeutic responses observed after vitamin E supplementation suggest that free radical injury and arachidonic acid activation of prostaglandins and leukotrienes contribute to the development or maintenance of ulcerative dermatitis. The effects of dietary vitamin E supplementation (700 and 3000 compared with 50 IU/kg) on reproductive performance in mouse breeding colonies was studied.¹⁵ Mouse breeders that fed a diet supplemented with 700 IU/kg vitamin E produced more litters weaned compared with those that fed diets supplemented with 50 or 3000 IU/kg vitamin E, indicating that breeder mice can safely be fed a diet fortified with 700 IU/kg vitamin E. Recently, mice with ulcerative dermatitis lesions that were treated with maropitant citrate, an antagonist of the inflammatory mediator neurokinin,³⁶ showed a decrease in pruritus and a 25% reduction in the size of ulcerative dermatitis lesions over a 15-d period. One study reports a reduction in damage to the dermis or lesion size when the front and back nails of mice are trimmed weekly,³² suggesting that self-trauma induced during the itch–scratch–itch cycle perpetrates lesions.Ibuprofen, a nonsteroidal antiinflammatory drug, nonselectively inhibits cyclooxygenases 1 and 2 that is commonly used for its analgesic, antiinflammatory, and antipyretic properties. Specifically, ibuprofen reduces inflammation and pain by decreasing leukocyte accumulation and activation^20,36 and proinflammatory cytokines.³¹ These factors have been shown to play a role in the inflammation of ulcerative dermatitis lesions and pruritus.³⁶ Previous authors have described the effectiveness of oral pediatric ibuprofen suspension for postsurgical analgesia in mice.^6,10,17 One study found that ibuprofen-supplemented drinking water (2 mg/mL) was effective at reducing postoperative pain in mice; however, this dose increased water intake and reduced food consumption.⁶ Ibuprofen administered at a dose of 1 mg/mL reduced signs of postsurgical pain yet maintained sufficient water and food consumption.⁶Ibuprofen is available in multiple generic and name-brand formulations, including a pediatric flavored suspension, liqui-gel capsules containing solubilized ibuprofen (free acid + potassium salt), and coated or gel-coated caplets. Pediatric ibuprofen suspensions are sweet and fruit-flavored to increase palatability, and the liqui-gel capsules can be ruptured so that the solubilized ibuprofen particles can be dispersed into water when vortexed. However, coated caplets must be crushed and may sediment when used to create a solution. Gel-coated caplets have not been reported in the literature as a treatment option for mice.The administration of an nonsteroidal antiinflammatory drug, such as ibuprofen, likely would reduce inflammation, pain, and secondarily pruritus and therefore may be effective in treating ulcerative dermatitis. The primary aim of this study was to determine whether orally administered ibuprofen would be an effective therapy for ulcerative dermatitis in mice and, if so, which formulation would be more efficacious. We compared the efficacy of a pediatric suspension of ibuprofen to that of solubilized ibuprofen from liqui-gel capsules when each was added to a concentration of 1 mg/mL to the drinking water of mice with ulcerative dermatitis. We hypothesized that the palatability of the formulation would correlate with its efficacy.     

达克宁散预防尿布接触性皮炎的疗效观察

目的 探讨达克宁散预防尿布接触性皮炎的有效性,为临床预防尿布接触性皮炎提供参考。方法 按随机原则将100例大小便失禁的危重患者分为实验组和对照组各50例,实验组每次更换尿布时分别用温开水、庆大霉素盐水及3％碳酸氢钠清洗,并予清洁干燥的软毛巾吸干水份或风干后涂上适量达克宁散;对照组按常规护理,用温水抹洗,每天2次。结果 实验组尿布接触性皮炎发生率为2％,对照组为14％,两组患者尿布接触性皮炎发生率比较P〈0．01,差异有显著性,实验组疗效优于对照组。结论 达克宁散用于预防尿布接触性皮炎方法简便、经济、有效,值得临床推广使用。     

酮康唑霜治疗扁平疣的临床研究

为了探讨酮康唑霜对扁平疣的治疗作用。我们用酮康唑霜治疗扁平疣患者81例，并设对照组45例。结果。观察治疗40d，治疗组的治愈率和有效率分别为88，9％（72／81）和96．3％（78／81），对照组治愈率和有效率分别为17．8％（8／45）和37馏％（17／45）。两组比较有显著差异（P〈0．01）。因此，酮康唑霜在扁平疣的治疗上具有重要价值．     

多索茶碱联合布地奈德治疗支气管哮喘的疗效分析

目的探讨多索茶碱联合布地奈德治疗支气管哮喘的临床疗效。方法选取收治的支气管哮喘患者80例,随机将其分为2组,观察组采用布地奈德联合多索茶碱进行治疗,对照组仅采用常规治疗。治疗2w后,对比两组的临床疗效与肺通气功能变化,以考察不同治疗方法的临床疗效。结果观察组总有效率为95.0%,对照组为80.0%。两组对比,差异性有统计学意义(P0.05)。观察组肺通气功能明显优于对照组(P0.05)。结论采用多索茶碱联合布地奈德对支气管哮喘进行治疗,能够获得良好的临床疗效,且显著改善患者的肺通气功能,具有安全性与可靠性。值得临床推广应用。