TGF—β1对细胞周期的调控作用

β１－型转化生长因子（ＴＧＦ－β１）对细胞的抑制作用通过细胞周期中多种非独立的、具有协同作用的通道来完成。Ｃｄｋ家族可能是ＴＧＦ－β１抑制信号的最终靶蛋白。ＴＧＦ－β１对Ｃｄｋ的负调节作用，可能是通过激活或增加Ｃｄｋ抑制物如ｐ１６＾ＩＮＫ４Ａ、ｐ１５＾ＩＮＫ４Ｂ、ｐ２１＾Ｗａｆｌ／Ｃｉｐｌ或ｐ２７＾Ｋｉｐｌ的表达。另外，ＴＧＦ－β１还可抑制Ｇ１期ｃ－ｍｙｃ基因的表达。     

A Comparison in Healing of Skull Defect Repaired with Four Different Kinds of Graft Materials in Rabbits

ＡＣＯＭＰＡＲＩＳＯＮＩＮＨＥＡＬＩＮＧＯＦＳＫＵＬＬＤＥＦＥＣＴＲＥＰＡＩＲＥＤＷＩＴＨＦＯＵＲＤＩＦＦＥＲＥＮＴＫＩＮＤＳＯＦＧＲＡＦＴＭＡＴＥＲＩＡＬＳＩＮＲＡＢ┐ＢＩＴＳＤＩＮＧＺｈｅｎ－ｑｉ（丁真奇）１，ＴＡＮＦｕ－ｓｈｅｎｇ（谭富生）２，...     

ANTI-INFLAMMATORY DRUGS,KIDNEY FUNCTION,AND EXERCISE

ＡＮＴＩ－ＩＮＦＬＡＭＭＡＴＯＲＹＤＲＵＧＳ，ＫＩＤＮＥＹＦＵＮＣＴＩＯＮ，ＡＮＤＥＸＥＲＣＩＳＥＢｉｌｌＦａｒｑｕｈａｒ，Ｍ．Ｓ．ＮｏｌｌＰｈｙｓｉｏｌｏｇｉｃａｌＲｅｓｅａｒｃｈＣｅｎｔｅｒ，ＴｈｅＰｅｎｎｓｙｌｖａｎｉａＳｔａｔｅＵｎｉｖｅｒｓ...     

GROSS TRANSPLANTATION OF A LEG IN CASES OF MULTISEVERED LIMBS AND LITERATURE REVIEW

ＧＲＯＳＳＴＲＡＮＳＰＬＡＮＴＡＴＩＯＮＯＦＡＬＥＧＩＮＣＡＳＥＳＯＦＭＵＬＴＩ┐ＳＥＶＥＲＥＤＬＩＭＢＳＡＮＤＬＩＴＥＲＡＴＵＲＥＲＥＶＩＥＷＹＩＮＹｕｎ－ｓｈｅｎｇ（尹芸生），ＷＡＮＧＤｏｎｇ（王东），ＧＡＯＦｕ－ｇｕｉ（高富贵），ＬＵＺｈｉ（吕...     

烟雾病的磁共振成像诊断

目的：回顾分析８例烟雾病的磁共振成像表现，探讨磁共振成像对烟雾病的诊断价值。方法：８例烟雾病中男女各４例。年龄４～４９岁，平均２０．４岁。磁共振成像应用Ｓｉｅｍｅｎｓ１．０ＴＭＲ系统和头表面线圈。均有ＳＥ序列Ｔ１ＷＩ和Ｔ２ＷＩ，７例有三维时间飞跃法磁共振血管造影（３Ｄ－ＴＯＦＭＲＡ），１例有ＤＳＡ。结果：ＳＥ序列ＭＲＩ均见丘脑－基底节区（单侧２例，双侧６例）有扩张的烟雾血管，其中以Ｔ１ＷＩ显示更为清楚直观。７例３Ｄ－ＴＯＦＭＲＡ和１例ＤＳＡ均见ＩＣＡ上端、ＭＣＡ和ＡＣＡ近端闭塞以及丘脑－基底节区的烟雾血管。这些病理血管分布侧别与ＳＥ序列磁共振成像所见一致。结论：ＳＥ序列磁共振成像和３Ｄ－ＴＯＦＭＲＡ是诊断烟雾病的有效方法。Ｔ１ＷＩ显示丘脑－基底节区烟雾血管优于Ｔ２ＷＩ。３Ｄ－ＴＯＦＭＲＡ尚适用于烟雾病血管旁路术后随诊及其高危人群普查。     

METHODS AND STRATEGIES FOR WEIGHT LOSS IN ATHLETES

ＭＥＴＨＯＤＳＡＮＤＳＴＲＡＴＥＧＩＥＳＦＯＲＷＥＩＧＨＴＬＯＳＳＩＮＡＴＨＬＥＴＥＳＰａｒｔｉｃｉｐａｎｔｓ：ＰｒｉｓｃｉｌｌａＣｌａｒｋｓｏｎ，Ｐｈ．ＤＤｅｐｔ．ｏｆＥｘｅｒｃｉｓｅＳｃｉｅｎｃｅＵｎｉｖｅｒｓｉｔｙｏｆＭａｓｓａｃｈｕｓｅｔｔｓ...     

Three-Dimensional Motion Measurement of the Atlantoaxial Joint

ＴＨＲＥＥ┐ＤＩＭＥＮＳＩＯＮＡＬＭＯＴＩＯＮＭＥＡＳＵＲＥＭＥＮＴＯＦＴＨＥＡＴ┐ＬＡＮＴＯＡＸＩＡＬＪＯＩＮＴＬＵＹｉ－ｓｈｅｎｇ（卢一生），ＪＩＡＬｉａｎ－ｓｈｕｎ（贾连顺），ＤＩＮＧＺｈｕ－ｑｕａｎ（丁祖泉），ＤＡＩＬｉ－ｙａｎｇ（戴力扬）Ｏ...     

Moyamoya病的MRI和MRA诊断(附15例报告)

探讨ＭＲＩ和ＭＲＡ对Ｍｏｙａｍｏｙａ病的诊断价值。材料与方法；１５例Ｍｏｙａｍｏｙａ病患者中男６例，女９例。年龄４－４９岁２０岁以下者１１例。应用 Ｓｉｅｍｅｒｎｓ １．０Ｔ超导型ＭＲ系统行ＳＥ序列ＭＲＩ和三维时间飞跃法ＭＲＡ。均有ＳＥ序列Ｔ１Ｗ１和Ｔ２ＷＩ，１４例有３Ｄ－ＴＯＦ ＭＲＡ，１例有ＤＳＡ，６例有平扫ＣＴ。     

Preparing Athletes for Competition in the Heat: Developing an Effective Acclimatization Strategy

ＰＲＥＰＡＲＩＮＧＡＴＨＬＥＴＥＳＦＯＲＣＯＭＰＥＴＩＴＩＯＮＩＮＴＨＥＨＥＡＴ：ＤＥＶＥＬＯＰＩＮＧＡＮＥＦＦＥＣＴＩＶＥＡＣＣＬＩＭＡＴＩＺＡＴＩＯＮＳＴＲＡＴＥＧＹＲｏｎａｌｄＪ．Ｍａｕｇｈａｎ，Ｐｈ．ｄ．Ｍｅｍｂｅｒ，ＧＳＳＩＳｐｏｒｔｓＭｅ...     

THE INJURIOUS EFFECTS OF HEMODYNAMIC CHANGES RESULTING FROM GUNSHOT WOUNDS ON REMOTE ORGANS

ＴＨＥＩＮＪＵＲＩＯＵＳＥＦＦＥＣＴＳＯＦＨＥＭＯＤＹＮＡＭＩＣＣＨＡＮＧＥＳＲＥＳＵＬＴ┐ＩＮＧＦＲＯＭＧＵＮＳＨＯＴＷＯＵＮＤＳＯＮＲＥＭＯＴＥＯＲＧＡＮＳＬＩＳｈｕ－ｇｕａｎｇ（李曙光），ＬＩＵＹｉｎ－ｑｉｕ（刘荫秋），ＷＡＮＧＪｉａｎ－ｍｉｎ...     

血小板第4因子造血保护作用的实验研究

目的 :研究血小板第 4因子 (PF4)对环磷酰胺 (CTX)处理小鼠体内造血系统的保护作用。方法 :实验鼠用PF4注射 2次 ,间隔 6h ,第二次注射后 2 0h给予CTX 2 0 0mg·kg- 1 。动态观察小鼠外周血白细胞数以及不同时期外周血T细胞亚群 ,骨髓粒-巨噬系集落形成单位 (CFU -GM)、细胞周期和小鼠脾脏、胸腺的变化。结果 :PF4能增加CTX处理小鼠骨髓CFU -GM的产率 ,加速体内CFU -GM的恢复 ;短时增加CTX处理小鼠骨髓G0 /G1 期细胞 ,减少骨髓细胞的坏死和凋亡 ;增加胸体比和脾体比。但是PF4对小鼠外周血白细胞数和T细胞亚群未见明显影响。结论 :PF4能保护小鼠骨髓及胸腺、脾脏等器官组织免受CTX损伤 ,增加骨髓CFU -GM的形成能力     

Identification and structural characterization of four novel synthetic cathinones: α-methylaminohexanophenone (hexedrone,HEX), 4-bromoethcathinone (4-BEC), 4-chloro-α-pyrrolidinopropiophenone (4-Cl-PPP), and 4-bromo-α-pyrrolidinopentiophenone (4-Br-PVP) after their seizures

Over 560 new psychoactive substances have been detected via the European Union Early Warning System (EU-EWS) of the European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) between 2005 and 2015. Among them, 103 synthetic cathinones have been identified, which are the second largest group monitored by EMCDDA. National Medicines Institute in Poland analyzed over six thousands samples of designer drugs containing psychoactive substances from 2008 to 2015 by applying complementary techniques, i.e., liquid chromatography with high resolution mass spectrometry, gas chromatography with mass spectrometry, and nuclear magnetic resonance spectroscopy. Among over 150 identified psychoactive substances from different groups, the largest was an ensemble of substituted cathinones containing 48 items. Most of them were cathinones not covered by the Act on Counteracting Drug Addiction in Poland at the time of identification; however, they have been added successively to the list of banned compounds in the consecutive amendments of the Act. The present study describes the structure identification and spectral characterization of four novel substituted cathinones: hexedrone [2-methylamino-1-(phenyl)hexan-1-one], 4-BEC [1-(4-bromophenyl)-2-(ethylamino)propan-1-one], 4-Cl-PPP [1-(4-chlorophenyl)-2-(pyrrolidin-1-yl)propan-1-one], and 4-Br-PVP [1-(4-bromophenyl)-2-(pyrrolidin-1-yl)pentan-1-one], seized prior to being sold on the drug market. They were identified for the first time by us and reported to EU-EWS EMCDDA.