原发性视网膜色素变性的血液流变学改变及临床意义

本文对44例视网膜色素变性患者进行了血液流变学检查,与40例健康人进行对照。发现全血粘度与红细胞聚集指数明显高于正常人。作者认为,这种变化可导致全身、局部血液循环障碍,导致组织器官的缺血、乏氧,乃致引起一系列的病理改变,更加重了视网膜功能损害,从而作者提出了用降低血液粘度,降低胆固醇、血脂和增强血液流变性的一些药物来对视网膜色素变性患者进行治疗。     

CYTOGENESIS IN THE DEVELOPING RETINA OF THE CAT

Cytogenesis in the cat retina was studied using tritiated pH) thymidine autoradiography and nuclear stains. Three zones of cell division were recognized. In the first zone cell cleavage occurs at the outer limiting membrane. The distribution of these mitotic figures is uniform as early as an embryonic age of 29 days (E29) until E50. At about E50 a "cold spot", made apparent by the absence of mitotic figures, is evident at the site of the developing area centralis. This spreads to encompass the whole retina by postnatal day 10 (P10). A second zone of cell division was recognized by the presence in the developing inner nuclear layer of ³H-thymidine labelled nuclei which do not migrate to the outer limiting membrane (ventricular surface) to divide. Some of these labelled nuclei are located in regions of the retina where cytogenesis at the ventricular surface has ceased. A third zone was observed in the optic nerve fibre/ganglion cell layers from about E54 until beyond the first postnatal month. This activity gives rise to vascular endothelial cells in the nerve fibre/ganglion cell layers. Once established, the developing vascular cells invade the inner plexiform and inner nuclear layers to form the deeper capillary net.