Obstetric outcome in women with epilepsy

A comparison of 150 pregnancies in women with epilepsy and 150 pregnancies in matched nonepileptic control women showed similar rates of pregnancy-induced hypertension, albuminuria, premature contractions, premature labor, and bleeding in pregnancy. Duration of labor, blood loss at delivery, cesarean section rates, and vacuum extraction rates were also similar among epileptic and control groups. There were five perinatal deaths in the epileptic group and two in the control group. A fetal heart rate tracing during a maternal grand mal seizure showed bradycardia, reduced short-term and long-term variability, and late decelerations suggesting asphyxia. It is concluded that grand mal seizures during pregnancy should be avoided by the use of antiepileptic drugs. Women with epilepsy require antenatal neurological and obstetric follow-up during pregnancy.     

Obstetric outcome in women with subfertility

BACKGROUND: It has been suggested that a history of subfertility is associated with increased obstetric and perinatal risks. It is unclear if the cause is inherent characteristics in the women or the fertility treatment. OBJECTIVES: To compare the obstetric and perinatal risks of singleton pregnancies in women with a history of subfertility in comparison with the general population. DESIGN: Population cohort. SETTING: Aberdeen, Scotland. POPULATION: Cases were women attending the Fertility Clinic between 1989 and 1999 who subsequently went on to have singleton pregnancies. Controls included the general population of women who delivered singletons over the same period. METHODS: We performed a retrospective cohort study to investigate the obstetric outcome of singleton pregnancies in women with subfertility. The general population of women who delivered singletons over the same period served as controls. MAIN OUTCOME MEASURES: Obstetric and perinatal complications in singleton pregnancies. RESULTS: Maternity records were available for a total of 1437 subfertile women and 21,688 controls. Subfertile women were older [mean (SD) age: 31 (4.7) years vs 27 (5.4) years, P < 0.01] and more likely to be primiparous (70% vs 65%, P < 0.001). After adjusting for age and parity, subfertile women were at increased risk of pre-eclampsia (OR 1.9, 95% CI 1.5-2.5), placenta praevia (OR 3.9, 95% CI 2.2-7.0) and placental abruption (OR 1.8, 95% CI 1.1-3.0), and more likely to undergo induction of labour (OR 1.5, 95% CI 1.3-1.6), caesarean section (OR 2.1, 95% CI 1.8-2.4) and instrumental delivery (OR 2.2, 95% CI 1.8-2.6), and deliver low birthweight (OR 1.4, 95% CI 1.3-1.7) and preterm (OR 1.7, 95% CI 1.2-2.2) infants. There were no differences between treatment-related and treatment-independent pregnancies. CONCLUSION: Subfertile women are at higher risk of obstetric complications, which persist after adjusting for age and parity.     

Obstetric outcome in women with congenital uterine malformations.

Ninety-eight cases of congenital uterine malformations were diagnosed with hysterosalpingography (HSG). Symmetric uterine malformations, composed of bicornuate uterus, uterus didelphys and septate uterus, constituted 80% of the cases. Of them, 75% were of the bicornuate type. Infertility (55%) and a suggestion of cervical incompetence (24%) were the main indication for HSG. Premature deliveries (29%), spontaneous first-trimester abortions (24%), ectopic pregnancies (3%), abnormal fetal presentations (23%) and a high cesarean section rate (27.5%) occurred in those patients. The highest rate of first-trimester abortions (47%) and the lowest rate of term deliveries (21%) occurred in the group with T-shaped uteri as compared to a 7% rate of early abortions (P less than .05) and 61% rate of term deliveries (P less than .03) in the unicornuate uterus group. In 30% of the patients with uterine malformations, cervical incompetence was diagnosed. Improved obstetric outcomes occurred in patients treated with cervical cerclage. There was a statistically significant difference between the number of premature deliveries and spontaneous late abortions in the group without cerclage (50%) and that with cerclage (21%) (P less than .001).     

Obstetric outcome in women with threatened miscarriage in the first trimester

OBJECTIVE: To assess pregnancy outcomes in women with threatened miscarriage in the first trimester. METHODS: This was a retrospective cohort study based on data extracted from the Aberdeen Maternity and Neonatal Databank. Cases included all primigravid women with first-trimester vaginal bleeding who delivered after 24 weeks of gestation between 1976 and 2004. The control group comprised all other women who had first pregnancies during the same period. Data were analyzed by univariate and multivariate statistical methods. RESULTS: Compared with the control group (n = 31,633), women with threatened miscarriage (n = 7,627) were more likely to have antepartum hemorrhage of unknown origin (odds ratio [OR] 1.83, 95% confidence interval [CI] 1.73-2.01). Elective cesarean (OR 1.30, 95% CI 1.14-1.48) and manual removal of placenta (OR 1.40, 95% CI 1.21-1.62) were performed more frequently in these women, who also had a higher risk of preterm delivery (OR 1.56, 95% CI 1.43-1.71) and malpresentation (OR 1.26, 95% CI 1.13-1.40). Threatened miscarriage in the first trimester is required in 112, 112, 17, 85, 32 patients, respectively, for each additional case of manual removal of placenta, elective cesarean, antepartum hemorrhage of unknown origin, malpresentation, and preterm delivery. CONCLUSION: Pregnancies complicated by threatened miscarriage are at a slightly higher risk of obstetric complications and interventions. LEVEL OF EVIDENCE: II-2.     

Obstetric outcome in women after multiple spontaneous abortions

Obstetric outcome in 88 women with a past history of three or more consecutive pregnancy losses was studied. The results were compared to those in our total obstetric population for the same period (control group). The incidence of small-for-gestational-age infants, prematurity, low-birth-weight infants and toxemia in the study group was not significantly different from that in the control group. Gestational diabetes and chronic hypertension, however, occurred more frequently in the study group than in the control group (P less than .001). These data could be helpful in counseling women with repeated pregnancy loss.     

Obstetric and prenatal outcome in menopausal women: a 12-year clinical study

The obstetric and prenatal outcome in post-menopausal women of advanced age in an oocyte donation programme is described in this paper, the oldest being aged 63 years. A total of 2729 candidates were visited up to November 2000. Only 1150 (42%) were accepted, with 1579 being rejected during a rigorous selection procedure. Several excluding clinical conditions were noted, including hypertension of varying severity, cardiovascular disease, smoking, dysfunctions of the hepatic, thyroid and renal systems and diabetes. Overall, 489 (38%) clinical pregnancies were established in 1288 recipient cycles, with 390 healthy babies delivered out of 363 pregnancies (28%), while 126 (25.7%) were lost. In all, 327 (90%) of the pregnancies reached full term, with 36 involving premature deliveries, 24 involving multiple gestation, 21 sets of twins, three sets of triplets (0.9%) and no quadruplets. Antenatal complications arising in 86 patients (23.6% of deliveries) included 33 preterm deliveries, 43 cases of gestational hypertension, four cases of pre-eclampsia, three cases of gestational diabetes and three of abruptio placentae. A total of 272 (75%) of all deliveries were by Caesarean section. Neonatal complications included two cases of growth retardation. There were no neonatal or maternal deaths. The 63-year-old woman reached full term pregnancy in July 1994, with delivery by Caesarean section of a boy in good health. Proper screening for risks has enabled this treatment to be given to a preselected group of patients.     

Obstetric and perinatal outcome in women with twin pregnancy and gestational diabetes

Objective: The aim of this study was to evaluate pregnancy complications and obstetric and perinatal outcomes in women with twin pregnancy and GDM. Study Design: An observational multicentre retrospective study was performed and 534 pregnant woman and 1068 twins infants allocated into two groups, 257 with GDM and 277 controls, were studied. Main Outcome Measures: Pregnant women characteristics, hypertensive complications, preterm delivery rate, mode of delivery and birthweight were analysed. Results: Pregnant women with GDM were older (p?<?0.001) and had higher body mass index (p?<?0.001) than controls. GDM was associated with higher risk of prematurity in twin pregnancy (odds ratio 1.64, 95% confidence interval [1.14–2.32], p?=?0.005). This association was based on the association with other pregnancy complications. Birthweight Z-scores were significantly higher in the GDM group (p?=?0.02). The rate of macrosomia was higher in the GDM group (p?=?0.002) and small for gestational age (SGA) babies were significantly less frequent (p?=?0.03). GDM was an independent predictor of macrosomia (p?=?0.006). Conclusion: The presence of GDM in twin pregnancy was associated with a higher risk of hypertensive complications, prematurity and macrosomia, but significantly reduces the risk of SGA infants. Prematurity was related to the presence of other associated pregnancy complications.     

Obstetric characteristics and neonatal outcome of unplanned out-of-hospital term deliveries: a prospective, case-control study

OBJECTIVE: To describe the obstetric characteristics and neonatal outcomes in unplanned out-of-hospital deliveries. STUDY DESIGN: Obstetric characteristics and neonatal outcomes were compared between 151 consecutive parturients with unplanned, out-of-hospital term deliveries and 151 hospital term deliveries. RESULTS: Women who delivered out of hospital tended to be older (32 +/- 5.5 vs. 28 +/- 5.0 years, p = 0.046) and less educated (4.4 +/- 5.1 vs. 6.5 +/- 5.0 years, p = 0.005) as compared to women who delivered in the hospital. Unplanned out-of-hospital deliveries resulted in statistically significant higher rate of low-birth-weight newborns (< 2,500 g) (OR= 3.9, 95% CI 2.0-7.7, p<0.001), postpartum hemorrhage (OR = 8.4, 95% CI 1.1-181.1, p = 0.018) and trended for higher rate of manual lysis of retained placenta and membranes (4.0% vs. 0%, p = 0.013). Higher rates of admission to the neonatal intensive care unit due to neonatal complications, such as polycythemia (12.6% vs. 0%, p < 0.001), hypoglycemia (9.3% vs. 0.6%, p = 0.001) and convulsions (3.3% vs. 0%, p = 0.024), were noted in the out-of-hospital delivery group as compared to the controls. Using a multivariable analysis, lower educational level (OR = 0.4, 95% CI 0.3-0.4, p < 0.001), maternal age > 35 (OR = 6.2, 95% CI 2.3-16.7, p < 0.001) and high parity (OR = 7.9, 95% CI 4.9-12.9, p<0.001) were found to be independent risk factors for an unplanned outof hospital delivery. CONCLUSION: Unplanned out-of-hospital birth is an important risk factor for such complications as postpartum hemorrhage, low birth weight and adverse neonatal outcome.     

Obstetric outcome in women complaining of reduced fetal movements.

Reduction of fetal movements causes concern and anxiety and is a common indication for the assessment of fetal well-being. The aim of this study was to review the outcome of women who presented primarily with reduced fetal movements and to compare with women of similar age and gestation who did not present with reduced fetal movements (controls). Some 19% of intrauterine growth restricted babies were found in the study group, compared with none in the control group. In the study group, 32% of women needed intervention solely due to fetal compromise compared with 21% in the control group. There was no perinatal or neonatal death in either group. We suggest that these women should be carefully investigated and monitored to improve the obstetric outcome.     

Socioeconomic and lifestyle factors associated with HPV infection in pregnant women: a matched case-control study in Beijing,China

Background

Human papillomavirus (HPV) infection plays key role in the development of cervical cancer. The purpose of this study was to investigate socioeconomic and lifestyle factors associated with HPV infection in pregnant women in Beijing, China.

Methods

An age matched case-control study designed with 66 women as the case group (HPV positive) and 132 women as the control group (HPV negative) was carried out in two hospitals in Beijing. Socioeconomic and lifestyle factors were obtained using a standard questionnaire. Cervical cells from study subjects were collected for HPV detection. An unconditional logistic regression model with backward stepwise selection was performed to predict the odds ratio (OR) and 95% confidence interval (CI) for the significant factors associated with HPV infection.

Results

The analyses of present data show that alcohol consumption during pregnancy was the strongest significant factor (OR?=?3.35, 95% CI?=?1.40–8.03, p =?0.007) when comparing the case (HPV positive) group with the control (HPV negative) group. There were no statistical differences observed in any of the socioeconomic factors when comparing the case and control groups.

Conclusion

The results of this study may help to prevent HPV infection in China by providing evidence to support improving the national policy on alcohol restriction and introducing public health interventions, especially for pregnant women in Beijing.

     

Obstetric outcome

Pregnancy outcome after in vitro fertilization (IVF) is influenced by many factors, some specific to IVF pregnancies and others shared with the general obstetric population. These factors include the characteristics of infertile couples and their underlying causes of infertility, the criteria used by IVF programmes for selecting couples for treatment, the techniques of fertilization and embryo transfer, the management of the early stages of pregnancy and the high incidence of multiple pregnancy. In comparing outcomes in different IVF programmes or with naturally conceived pregnancies, careful attention must be given to definitions and to the methods used to diagnose pregnancies. Very few studies of pregnancy outcome after IVF have been published so far. The incidence of ectopic pregnancy and spontaneous abortion seems higher than in natural pregnancies. Multiple pregnancy is common in those programmes electing to transfer more than one embryo into the uterus. In one study, preterm birth and low birthweight were about three times more common than in population-based figures. As a result, higher perinatal mortality would also be expected, but no studies are yet available. The sex ratio and the incidence of major congenital malformations appear similar to natural pregnancies, but there are insufficient data to determine whether the risks of chromosomal abnormalities are altered in IVF pregnancies. Further studies are needed to confirm these preliminary results, to obtain better information about the occurrence of chromosomal abnormalities in spontaneous abortions, and to assess fetal growth. Comparisons of results would be enhanced by international agreement on terminology and definitions for pregnancy losses, particularly those occurring in the early stages of pregnancy. Couples considering in vitro fertilization as an option for treatment of their infertility should be counselled about their overall chances of achieving a pregnancy and live births, as well as about the outcome of these pregnancies.     

Obstetric outcome in women over the age of 40 years.

This is a retrospective review of 109 deliveries during a 5-year period in women aged 40 years or over and the results were compared with other studies in literature. The incidence was 1%. There was no increase in complications of pregnancy though there was an increased caesarean section rate and perinatal mortality rate. It is imperative that all mature pregnant women are managed as a high risk group but we should be mindful of the need to justify intervention in the same way as in the younger age group.     

Obstetric outcome after oocyte vitrification and warming for fertility preservation in women with cancer

Obstetric outcome of first pregnancies achieved after vitrification and warming oocytes from women being treated for cancer was evaluated. Of a total of 493 women who consulted for fertility preservation, 357 had their oocytes cryopreserved after being diagnosed with cancer, and 11 returned after being cured for assisted reproduction treatments (eight had breast cancer, one Hodgkin lymphoma, one endometrial adenocarcinoma, and one thyroid cancer). The oocyte survival rate was 92.3%, the fertilization rate was 76.6%, and the mean number of embryos transferred was 1.8 ± 0.7. Beta-human chorionic gonadotropin was detected in seven out of the 11 embryo transfers carried out. Four ongoing pregnancies were achieved and delivered at term with normal fetal weight and no major or minor malformations. Women diagnosed with cancer who have their eggs cryopreserved before anti-cancer treatment have good assisted reproductive technology performance and good perinatal outcomes. Cryopreservation of oocytes seems to be a good alternative for fertility preservation in these women.     

Obstetric outcome of excessively overgrown fetuses (> or = 5000 g): a case-control study

AIMS: To compare the obstetric outcome of excessively- and appropriately-grown fetuses. METHODS: Medical records of mothers who delivered excessively overgrown fetuses, defined as birthweight > or = 5000 g, in our hospital between 1996 and 2000 (n = 47, study group), and a control group who delivered fetuses with normal birthweight (n = 47) were reviewed. RESULTS: Incidence of excessively overgrown fetuses was 0.24% and 68% were boys. Mothers in this group were significantly older, overweight and multiparous (p < 0.0001) and had gestational diabetes mellitus (p < 0.0001) and prolonged pregnancies (p = 0.04). A previous big baby was also significant (p < 0.0001) and the commonest risk factor. There were no obvious risk factors in nine (19.1%) cases. More than half (n = 28, 59.5%) of these babies were delivered vaginally without clinical suspicion of excessive fetal size. Duration of second stage of labor and incidence of maternal trauma were similar in both groups. Cesarean delivery (p = 0.0003), postpartum hemorrhage (p = 0.004), birth asphyxia (p = 0.007), shoulder dystocia (p < 0.0001) and fetal trauma (p = 0.03) were significantly more frequent in the study group. CONCLUSIONS: Excessively overgrown fetuses are associated with the same risk factors as fetal macrosomia and should be delivered by cesarean if diagnosed antenatally because of increased maternal and perinatal morbidity during vaginal delivery.     

Obstetric outcome and behavior of women after transabdominal isthmocervical cerclage

OBJECTIVES: The aim of this study was to evaluate the course of the life in women with preconception transabdominal cervicoisthmic cerclage. MATERIALS AND METHODS: The studied material consisted of 9 women with cervical incompetence treated with transabdominal cervicoisthmic cerclage in period 2001-2005 in II Department of Gynaecology and Obstetrics of Medical University in Lód?. We paid special attention to mental condition. RESULTS: In analysed group 7 women got pregnant. Actually 6 of them have children and 1 is in 32 weeks pregnant. CONCLUSIONS: 1. Women after repetitive abortion or premature delivery because of serious defect of cervical isthmus are likely to suffer from depression. 2. Management with transabdominal cervicoisthmic cerclage makes carrying pregnancy up to term possible. 3. Prophylactic transabdominal cervicoisthmic cerclage left after childbirth seriously improves feeling of this women. 4. Women with transabdominal cervicoisthmic cerclage left after birth don't complain about dysurical symptoms.