Bladder cancer, GSTs, NAT1, NAT2, SULT1A1, XRCC1, XRCC3, XPD genetic polymorphisms and coffee consumption: a case–control study

The aim of the study was to investigate NAT1, NAT2, GSTM1, GSTT1, GSTP1, SULT1A1, XRCC1, XRCC3 and XPD genetic polymorphisms, coffee consumption and risk of bladder cancer (BC) through a hospital-based case–control study. The study population included 197 incident BC cases and 211 controls. The association between genetic polymorphisms, coffee drinking and BC risk was assessed by logistic regression taking into account age, education, tobacco smoking and occupational exposures to polycyclic aromatic hydrocarbons and aromatic amines. No association was found between the genetic polymorphisms investigated and BC risk according to coffee consumption apart of a significant increased BC risk among GSTP1 105-114 Val carriers heavy coffee drinkers (>3 cups/day) (OR 3.18, 95%CI 1.06–9.55). In conclusion our findings suggest a very limited role, if any, of genetic polymorphisms investigated in modulating the BC risk in coffee drinkers.     

资源整合,1+1>2

正江苏省太仓市民小王和未婚妻来到婚姻登记处,一进门,坐在"计生宣教处"牌子后的一位工作人员迎上来,热心地向他们介绍婚检的好处。让一对新人没有想到的是,B超、甲状腺等都包含在免费项目内,而且婚检就在登记处隔壁,"真是太方便了"。近年来,不少地方不约而同地实行了卫生、计生资源整合,合署办公的体制改革,收到了明显的效果。原来分别隶属卫生、计生系统的妇保所和计生站,服务对象都是妇女、儿童和老人,很多工作多有重叠,过去各自工作的同时,也带来了不同程度的"内     

1天1片,全面调理肠道问题

正肠胃问题不消化、胀气、腹泻…要用美国原装进口"超级"益生菌美国原装进口美国FDA认证肠道问题闹翻天,老人肠道缺什么?人上了年龄,有时肠道收缩运动不协调会引起排便困难或腹泻,凉的、油的、硬的啥都不敢吃,稍微不甚肠道就闹,腹泻、便秘、胀气……折磨人,苦不堪言。肠道中主导消化的物质就是益生菌。随着年龄的增长肠道菌数量会从90%降低到10%,60岁以后体内的有益菌数量     

Household Transmission of Pandemic (H1N1) 2009, San Antonio, Texas, USA, April�CMay 2009

To assess household transmission of pandemic (H1N1) 2009 in San Antonio, Texas, USA, during April 15–May 8, 2009, we investigated 77 households. The index case-patient was defined as the household member with the earliest onset date of symptoms of acute respiratory infection (ARI), influenza-like illness (ILI), or laboratory-confirmed pandemic (H1N1) 2009. Median interval between illness onset in index and secondary case-patients was 4 days (range 1–9 days); the index case-patient was likely to be <18 years of age (p = 0.034). The secondary attack rate was 4% for pandemic (H1N1) 2009, 9% for ILI, and 13% for ARI. The secondary attack rate was highest for children <5 years of age (8%–19%) and lowest for adults >50 years of age (4%–12%). Early in the outbreak, household transmission primarily occurred from children to other household members and was lower than the transmission rate for seasonal influenza.     

发作性晕厥,呼吸困难,咯血胸痛1例

1 病历摘要患者,男,45岁。因活动后反复发作晕厥,短阵意识丧失,伴有心悸、气短、胸痛于1992年3月9日入院。检查:BP10.7/9.3kPa轻度呼吸困难,紫绀(+),面色苍白,巩膜黄染(-)。双肺底少量湿罗音,心率120次/min,律整,肺Aa无亢进,肝脾未触     

糖尿病合并冠心病,1+1>2

临床上,冠心病合并糖尿病十分常见,但这决不是两种疾病简单意义上相加,它们在增加心血管不良事件和死亡率方面可产生乘积效应,或称之为"1+1>2"效应。糖尿病是冠心病的等危症等危症这个概念,是说病症的危险性相同。糖尿病是冠心病的等危症,是说无冠心病的糖尿病患者和既往有冠心病病史的非糖尿病患者有同样的冠心病危险性。     

二甲基甲酰胺中毒致胃粘膜,肝,肾,皮肤损伤1例

报道一例急性二甲基甲酰胺中毒后致胃粘膜、肝、肾及皮肤务。该患经皮肤、消化道、呼吸道吸入大量二甲基甲酰胺，第一天感到上腹部剧烈烧灼痛、恶心、呕吐、四肢麻木住院。经化验：尿糖、尿蛋白、尿胆元；、ＲＢＣ、颗粒管型０－２个／低倍视野。纤维胃镜检查示：胃粘膜广泛充血，水肿、糜烂。Ｂ超示：肝肿大，双手为接触性皮炎。入经五天巩膜深度黄染、全身皮肤中度黄染，经治疗２多月痊愈出院。     

Chronic,Inhalation Exposure of Rats,Rabbits , and Monkeys to 1 , 2 , 4–Trichlorobenzene

Three groups composed of rats, rabbits, and monkeys were exposed for 26 weeks to 1,2,4-trichlorobenzene (-TCB), and one group of each species was used as a control group. TTie nominal exposure concentrations of 1,2,4-TCB were 25.0, 50.0, and 100.0 ppm. Pulmonary function and operant behavior tests in monkeys, ophthalmoscopic examinations in rabbits and monkeys, and measurement of body weights and hematologic and serum biochemical determinations in all species were conducted before and during the exposure period. At termination of 1, 3, and 6 months of exposure, microscopic examination of selected rat tissues was performed. Microscopic changes were seen in the parenchymal cells of livers and kidneys from all groups of rats exposed to 1,2,4-TCB when sacrificed after 4 and 13 weeks of exposure, but no exposure-related abnormalities or other effects were seen after 26 weeks of exposure in any species.     

燃煤型砷中毒皮肤病变中P16,P21^WAF1／CIP1,CyclinD1蛋白 …

目的 探讨砷中毒与皮肤病变的关系。方法 用免疫组织化学法检测燃煤型砷中毒患者皮肤病变中Ｐ１６、Ｐ２１＾ＷＡＦ１／ＣＩＰ１、ＣｙｃｌｉｎＤ１蛋白的表达情况。结果 Ｐ１６的表达强度和密度随患者皮肤病变程度的加重而逐渐减弱,Ｐ１６蛋白在癌变组（Ａ组）、癌前病变组（Ｂ组）和过度角化组（Ｃ组）中普遍缺失表达,明显低于一般增生病变组（Ｄ组）和正常组;Ｐ２１＾ＷＡＦ／ＣＩＰ１、ＣｙｃｌｉｎＤ１的表达强度和密度随     

《每天1碗沙拉,等于瘦身1小时》

出版社:中国轻工业出版社出版时间:2013-08定价:29.8元本书是一本时尚女性的健康瘦身书,以10周70道健康营养美味的各色沙拉为主题,严格计算每道沙拉的热量。不用克制,不花大钱,不费时间,让所有怕胖爱美、渴望瘦身的女性通过科学正确的制作并食     

减肥——体重减少1公斤,血压下降约1毫米汞柱

减肥的最佳方式是控制饮食和适量运动。预防肥胖、防止高血压,要从儿童做起。过去,人们对胖人不管男女老幼,认为“胖嘟嘟”都是福相。其实,胖,到一定程度不单是“美”的问题了,而是一种病态。俗话说“有钱难买老来瘦”,这从另一个侧面说明,老年肥胖对健康更不利,一胖生百病,肥胖会导致一些可危及生命的疾病。高血压和肥胖是一对“好兄弟”,它们形影不     

小组合作学习策略,英语课堂效率1+1>2

当前社会上都在热议钱学森提出的问题,为什么我们的学校总是培养不出杰出人才?作为一名教育工作者当然是很着急的问题.据专家深入分析,其中与教育观的陈旧、教学模式的僵化、教学方法的落后有着重要关系.因此,转变教育观念,改革培养模式和改善教学方法是当前教育的当务之急.     

食疗,给您1个暖冬

冬季气候寒冷干燥,人们很容易患上感冒、咳嗽、鼻炎等病症。下面介绍几款行之有效的药膳方供大家参考。茶豆饮原料:绿豆30克,茶叶9克,白糖适量做法:将茶叶用纱布包好,与绿豆一起加水煎煮,待绿豆熟时,去茶叶,加入白糖后饮用。功效:绿豆甘寒,清热解毒,能治痧痘热毒。     

糖尿病患者血HbA1c,HbA1测定的临床意义

血红蛋白 Al(HbAl)是血红蛋白 A(HbA)的非酶糖基化的产物,又称糖基化血红蛋白,已被广泛用作糖尿病患者血糖控制的监测指标。其中,HbAlc 更准确。我们用 Bio—Rad DiamatAnalyzer system 测定了53名糖尿病人和50名正常人 HbAlc、HbAl 值现总结如下。病人和方法糖尿病患者53名(男33,女20),年龄18—72岁,病程1月一20年,均根据 WHD 标准,其中,IDDM11人,NIDPM42人。正常对照     

Pandemic (H1N1) 2009 Surveillance for Severe Illness and Response, New York, New York, USA, April�CJuly 2009

On April 23, 2009, the New York City Department of Health and Mental Hygiene (DOHMH) was notified of a school outbreak of respiratory illness; 2 days later the infection was identified as pandemic (H1N1) 2009. This was the first major outbreak of the illness in the United States. To guide decisions on the public health response, the DOHMH used active hospital-based surveillance and then enhanced passive reporting to collect data on demographics, risk conditions, and clinical severity. This surveillance identified 996 hospitalized patients with confirmed or probable pandemic (H1N1) 2009 virus infection from April 24 to July 7; fifty percent lived in high-poverty neighborhoods. Nearly half were <18 years of age. Surveillance data were critical in guiding the DOHMH response. The DOHMH experience during this outbreak illustrates the need for the capacity to rapidly expand and modify surveillance to adapt to changing conditions.     

1+1＞2,口服降糖药联合用药效果好

日常生活中,经常会有糖尿病患者质疑医生所开的药物太多,其实这是对医生的误解.为了减少糖尿病及其并发症对患者的影响,保证患者的血糖等各项指标达到正常水平,多种药物联合应用对于某些患者来说是"必选项",并非医生要"多卖药".     

一个月后,甲型H1N1流感进入中国

4月底,当墨西哥政府确认埃尔南德斯是墨西哥发现的最早的甲型H1N1患者时,全世界已经有数十个国家相继发现甲型H1N1流感病例,一场惊动世界的防控流感措施在各国展开.     

Adverse events following influenza A (H1N1) 2009 monovalent vaccines reported to the Vaccine Adverse Event Reporting System,United States,October 1, 2009–January 31, 2010

The United States (US) influenza A (H1N1) 2009 monovalent (2009-H1N1) vaccination program began in October 2009. Reports to the vaccine adverse event reporting system (VAERS), a US spontaneous reporting system, were reviewed to identify potential rare events or unusual adverse event (AE) patterns after 2009-H1N1 vaccination. The adverse event profile after 2009-H1N1 vaccine in VAERS (∼10,000 reports) was consistent with that of seasonal influenza vaccines, although the reporting rate was higher after 2009-H1N1 than seasonal influenza vaccines, this may be, at least in part, a reflection of stimulated reporting. Death, Guillain–Barré syndrome and anaphylaxis reports after 2009-H1N1 vaccination were rare (each <2 per million doses administered).