住院精神疾病患者抗精神病药物处方时点调查

目的了解住院精神疾病患者抗精神病药物的处方情况。方法采用一日法对上海市精神卫生中心(总部)住院精神疾病患者的精神药物应用状况进行调查。结果(1)住院精神疾病种类构成发生了一些变化;(2)氯氮平处方量第一,新型精神药物的使用正在逐步扩大;(3)联合用药治疗在住院患者中非常多见;(4)抗精神病药物的使用剂量基本都在推荐的安全剂量之内。结论各种抗精神病药物的处方情况发生了较大改变,对于药物的选择和用量考虑其疗效的同时也要兼顾到不良反应的影响。药物选择多样化、新型化、安全使用精神药物已成为目前临床用药的趋势。     

精神科住院患者的诊断及其用药情况时点调查结果

目的:了解目前我院住院患者的诊断及其精神药物的使用情况,方法:以1999年9月10日为调查日,调查精神科全部住院患者,用自编的调查表登记当日虱的诊断及用药情况,共168例.结果:住院患者中以精神分裂症及情感性精神障碍为主,分别占58.3%,及19.6%,神经症及海洛因领带明显上升,分别8.3%及4.2%,氯氮平及氯丙嗪仍为最常用药物,分别为54.2%及19.0%,以后依次为舒必利,利培酮和氟哌啶醇,抑抑郁剂以赛乐特,万拉法新,美舒郁为主,三环类使用少,结论:随着社会大环境的变化,住院患者的疾病谱发生了改变,氯氮平和氯丙嗪有效,安全和价谦,仍为临床最常选药物,利吉酮也占有一席之地,5-HT再摄取抑制剂亦成为首选的抗抑郁剂.     

镇静催眠药在治疗住院情感性精神障碍患者中的使用现状调查

本研究旨在于调查镇静催眠药在住院情感性精神障碍患者中的使用现状,为合理用药提供依据。１　对象和方法１－１　对象　均为住我院的情感性精神障碍患者。１９９７年１月１日至１２月３１日出院者１７６例（下称Ａ组）,其中男８６例,女９０例,平均年龄为（３８－２３±１５－４５）岁。１９９４年１月１日至１２月３１日住院者１４８例（下称Ｂ组）,其中男７３例,女７５例,平均年龄为（３７－５１±１３－６８）岁;两组间年龄和性别无显著性差异。所有对象均符合１９８９年中国精神疾病分类方案与诊断标准第２版修订本（ＣＣＭＤ—…     

650例精神分裂症时点使用抗精神病药物临床调查

６５０例精神分裂症时点使用抗精神病药物临床调查兰州市第三人民医院（７３００５０）李晓英青岛市精神病院崔维珍上海市精神卫生中心陆明康为了解住院精神分裂症患者精神药物使用情况，本文作者于１９９５年３月３０日对上海市精神卫生中心住院的６５０例精神分裂症患者...     

首发首诊住院分裂症患者精神药物使用情况调查

目的 了解首发首诊住院分裂症患者精神药物的使用情况。方法 自2000年全部首次住院病例中，选择符合CCMD-2-R精神分裂样精神病标准者673例。结果 首选单一用药者587例(92．15％)，常用药物依次为氟哌啶醇占64．52％，氯氮平占14．76％，氯丙嗪占7．69％，舒必利占2．83％，其他药物的使用率均不足1％，首选联合用药者50例(7．85％)，最常见的是氯氮平联合舒必利占4．71％，合用安坦者510例(80．06％)。结论 对初治分裂症的首选用药，仍以经典抗精神病药为主，不应联合用药，必要时可舍用增效剂，氯氮平不宜做为首选用药。     

住院未成年精神疾病患者抗精神病药物使用情况调查

目的 调查2018年广州医科大学附属脑科医院住院未成年精神疾病患者抗精神病药物使用情况.方法 通过电子住院信息系统收集2018年广州医科大学附属脑科医院所有住院年龄≤18岁且确诊为精神疾病的患者的临床、人口学和出院当日使用抗精神病药物情况,进行统计和分析.结果 共入组626例未成年精神疾病患者,出院时93例(14.9％...     

住院抑郁症患者药物治疗的现状调查

目的了解抑郁症患者住院治疗的用药现状。方法选取2011年4月1日～2011年5月31日期间,在本院住院治疗〉2周的患者,并对其出院时的用药状况进行调查分析。结果在药物的使用频率上,奥氮平、艾司西酞普兰及喹硫平居前三位,且95.6%的患者联合非典型抗精神病药物增效。结论本文患者的治疗方案总体符合中国《抑郁障碍防治指南。》     

某专科医院精神科住院病人用药时点调查

目的了解中山市第三人民医院住院精神障碍患者的药物应用情况及其用药规律。方法采用一日法,以2013年5月14日为时间节点,对该院住院病人的用药情况进行分析,总结其用药规律。结果①单用抗精神病药、心境稳定剂、抗焦虑药/镇静催眠药、抗抑郁药和苯海索分别占60.53%、27.70%、30.74%、7.40%和14.23%,未使用抗精神病药、心境稳定剂、抗焦虑药/镇静催眠药、抗抑郁药和苯海索分别占5.50%、69.83%、66.98%、92.60%和85.77%;②使用频率居前5位的抗精神病药分别为利培酮174例(33.02%),氯氮平143例(27.13%),奥氮平107例(20.30%),阿立哌唑75例(14.23%),喹硫平68例(12.90%)。居前3位的心境稳定剂分别为丙戊酸钠110例(20.87%),奥卡西平22例(4.17%),丙戊酸镁19例(3.60%)。结论非典型抗精神病药和新型抗抑郁药已成为临床一线用药,临床用药总体较规范,但仍需要注意苯海索和苯二氮艹卓类(BDZ)药物的合理使用。     

住院精神分裂症患者药物使用情况的时点调查

50年代氯丙嗪应用于临床,开创了精神疾病药物治疗的新时代。随后出现了许多精神药物的新品种,但都因疗效欠佳或副作用较多而难以全面推广使用。到80～90年代,非典型的抗精神病药物氯氮平使用逐渐增多,成为精神科继氯丙嗪以后的又一常用药物。维思通作为丁酰苯类的新成员,在临床上已推广使用。本研究通过对我院住院精神分裂症患者使用抗精神病药物的时点调查,了解目前我院精神分裂症患者临床用药的分布和频度,并作分析和探讨。     

提高对双相抑郁的诊断认识和药物治疗水平

对双相情感障碍的研究，以往更多的兴趣集中在双相躁狂和单相抑郁的急性期和长期治疗上，而对双相抑郁的研究则较少。但在临床实践中，双相抑郁的药物治疗更为复杂，长期治疗的时间也远长于躁狂。近年来通过对双相抑郁的研究发现，临床上常出现由于对双相抑郁的诊断意识低而引起的误诊问题，     

精神科老年住院患者药物治疗时点调查

目的 了解精神科老年住院患者精神药物及内科药物应用情况.方法 采用一日法对上海市精神卫生中心闵行院区老年住院患者的精神药物及内科药物应用状况进行调查.结果 (1)精神科老年住院患者抗精神病药物使用频度依次为奥氮平(37.1%),氯氮平(26.8%),利培酮(24.7%),以单一药物使用为主(80.4%),部分患者二药联合(19.6%),未发现三类抗精神病药物合用;(2)合并躯体疾病的患者较多,均予相应的降压、降糖、降脂治疗.结论 精神科老年住院患者以非典型抗精神病药物治疗为主,并重视了躯体疾病的诊疗.     

2005年住院精神疾病患者药物治疗时点调查

目的:了解住院精神疾病患者精神药物的应用情况及其演变。方法:采用一日法对上海精神卫生中心679例住院精神疾病患者的精神药物应用状况进行调查,将其结果与2004年和2002相比较。结果:精神药物的使用频度发生了显著变化;新型精神药物的使用正在逐渐增多;精神药物的使用剂量基本都在安全范围之内。结论:精神药物应用的多样性已是一种趋势。     

精神障碍患者出院处方中抗抑郁药的分析

目的分析我院抗抑郁药的临床使用和合理用药情况。方法随机抽查我院2007年10～12月出院带药处方,采用限定日剂量(DDD)和药物利用指数(DUI)对抗抑郁药物的使用进行了回顾性分析。结果SSRIs类抗抑郁剂使用频率较高。在联合用药方面,抗抑郁药主要是和抗精神病药物、镇静催眠药、心境稳定剂并用。在使用的13种抗抑郁药中除氟西汀和曲唑酮外,其余药物的DUI均≤1.0。结论我院抗抑郁药物的使用基本合理,且新型抗抑郁药的应用越来越多。     

综合医院住院患者焦虑与抑郁症状调查

目的：调查综合医院中住院患者焦虑抑郁症状的时点发生比率及在不同科室病种的分布情况。方法：采用综合医院焦虑抑郁量表(HADS)，在2003年4月的同一天对综合医院的14个科室中的320例住院患者进行调查。结果：近1／3的患者出现焦虑或抑郁负性情绪；出现焦虑症状阳性者占被调查群体的35．0％，出现抑郁症状阳性者占32．2％，内科患者无论是焦虑和抑郁分，还是出现的焦虑症状和抑郁症状，均显著高于外科患者。焦虑和抑郁症状的发生与患者的年龄密切相关，即随着年龄的增大，其发生率呈增加趋势。结论：综合医院中住院患者的焦虑、抑郁反应是值得重视的现象，应处理这些负性情绪。     

Characteristics of patients with hypnotic-related psychiatric disorders in the nationwide mental hospital survey.

We investigated the characteristics of patients with hypnotic-related psychiatric disorders. Subjects were 90 patients reported in the nationwide Mental Hospital Survey in 1998, who were divided into three groups according to their history of substances use. Group A (patients without history of any illicit substance use) was estimated to be the most common and core group with iatrogenic characteristics. Hypnotic use in Group B (patients with history of any illicit substance use) was recognized as one of behavioral disorders in the psychosocial context. Patients in Group C (patients with multiple-substance use and without history of any illicit substance use) showed the most serious disorders in the context of addiction. More specified treatment programs would be required considering patients' characteristics.     

Evaluation of the hospital anxiety and depression scale as a screening instrument in geriatric medical inpatients

The Hospital Anxiety and Depression Scale (HAD) was developed as a screening instrument for use in medical patients. The depression subscale has been validated as a measure of severity in elderly depressed psychiatric inpatients. This study assessed its usefulness as a screening instrument in inpatients in a geriatric medical unit. One hundred geriatric inpatients were evaluated using the Geriatric Mental State (Community Version) to identify cases. The HAD lacked sensitivity and specificity in this situation.     

The use of antipsychotic medication in child and adolescent psychiatric treatment in Denmark. A cross-sectional survey

The number of children and adolescents with psychiatric disorders being treated with antipsychotic medication is increasing significantly; however, only a limited evidence-base is available on this topic, especially when children are concerned. This study reports and discusses the use of antipsychotic medication in children and adolescents below 19 years of age in Denmark. A national cross-sectional survey registered the use of antipsychotic drugs on a given date. A questionnaire was sent to all child and adolescent psychiatric departments and all consultants in child and adolescent psychiatry throughout the country. All children and adolescents, aged 0–18 years, registered in treatment with antipsychotic medication, were included. Sixty-seven per cent of clinics and 63% of consultants participated. The total number of subjects registered in examination or treatment in the participating units was 3854. Antipsychotic medication was used in n=244 (6.4%) of these cases. Eighty-eight patients received additional medication, of which 24% received antidepressants, 8% sedative medication and 4% psychostimulants. The age of the patients was 4–18 years, and 63% was male. The most frequent diagnoses for patients in antipsychotic treatment were: schizophrenia, schizotypal disorder, autism spectrum disorders and personality disorders. Monotherapy was used in 87% of cases. Sixty-four per cent of patients treated with antipsychotics, received a second-generation antipsychotic as the main treatment. All 244 patients received one or more additional treatment modalities other than medication. Antipsychotic medication has a definite role in the treatment of children and adolescents with psychiatric disorders. Second-generation antipsychotics used as monotherapy prevail.     

Prevalence and characteristics of psychotropic drug use in institutionalized children and adolescents with mild intellectual disability

Psychotropic drugs are a cornerstone in the treatment of psychopathology and/or behavioral problems in children with intellectual disability (ID), despite concerns about efficacy and safety. Studies on the prevalence of psychotropic drug use have mainly been focused on adults with ID or children without ID. Therefore the aim of this cross sectional study was to assess the prevalence and characteristics of psychotropic drug use in children with mild ID who were institutionalized in specialized inpatient treatment facilities in The Netherlands. Demographic data, psychiatric diagnoses, the nature of the behavioral problems, level of intellectual functioning, and medication data were extracted from medical records using a standardized data collection form. Adjusted relative risks (ARR) for the association between patient characteristics and psychotropic drug use were estimated with Cox regression analysis. Of the 472 included children, 29.4% (n = 139) used any psychotropic drug, of which 15.3% (n = 72) used antipsychotics (mainly risperidone), and 14.8% (n = 70) used psychostimulants (mainly methylphenidate). Age, sex, and behavioral problems were associated with psychotropic drug use. Boys had a 1.7 (95%CI 1.1–2.4) higher probability of using psychotropic drugs, compared to girls adjusted for age and behavioral problems. Having any behavioral problem was associated with psychotropic drug use with an ARR of 2.1 (95%CI 1.3–3.3), adjusted for sex and age. The high prevalence of psychotropic drug use in children with ID is worrisome because of the lack of evidence of effectiveness (especially for behavioral problems) at this young age, and the potential of adverse drug reactions.