Exposure and effects of persistent organic pollutants in European shag (Phalacrocorax aristotelis) hatchlings from the coast of Norway

Although the coast of Norway is relatively clean regarding contaminants compared to areas of Europe with higher density of both people and industry, levels of persistent organic pollutants (POPs) exist in the marine ecosystem that may cause chronic exposure effects in wildlife. In this study, polychlorinated biphenyls (PCBs), some organochlorinated pesticides (OCPs), polybrominated diphenyl ethers (PBDEs), and hexabromocyclododecane (HBCD) were analyzed in yolk sac of European shag (Phalacrocorax aristotelis) hatchlings from an island situated on the coast of Mid-Norway. In addition, levels of retinol (vitamin A), retinyl palmitate, and alpha-tocopherol (vitamin E) were measured in plasma and liver. The shag hatchlings seemed to be relatively highly contaminated by PBDEs and HBCD on a European scale. A negative relationship between PBDE-28 and liver tocopherol levels was revealed, and plasma retinol levels correlated negatively to levels of several PCB congeners, the summed PCB concentrations (sigmaPCBs), and some OCPs. More studies should be done to reveal the effects of POPs, and especially PBDEs, on vitamin status in wild birds.     

Feathers as a nondestructive biomonitor for persistent organic pollutants

Keratinous tissues of mammals and humans, such as hair, have been used to determine the exposure to polychlorinated biphenyls (PCBs) and organochlorine pesticides. In the present study, we investigated the accumulation of persistent organic pollutants (POPs; PCBs, p,p'-DDT, p,p'-dichlorodiphenyldichloroethane [DDD], p,p'-dichlorodiphenyldichloroethylene [DDE], hexachlorobenzene [HCB], oxychlordane, trans-nonachlor, polybrominated diphenyl ethers, and polybrominated biphenyls [PBBs]) in feathers of the great tit (Parus major). The accumulation of POPs in feathers and fat samples of 27 adult great tits collected in April 2000 and December 2002 was compared with regard to possible temporal and spatial differences. Polybrominated diphenyl ethers, PBBs, trans-nonachlor, and HCB could not be quantified in feathers. Most PCB congeners and DDTs (p,p'-DDE, p,p'-DDD, and p,p'-DDT) could be determined in feathers, although concentrations in feathers were markedly lower (sigmaPCB concentration range, 28.2-87.1 ng/g) than concentrations in fat (sigmaPCB concentration range, 1244-10074 ng/g). Feathers had relatively higher levels of low-chlorinated PCBs (tetra- and pentachlorinated biphenyls) and p,p'-DDD compared to levels in fat, presumably reflecting levels in blood. Persistent organic pollutant concentrations did not increase with the age of the feather, suggesting that exogenous or aerial depositions of POPs onto the feather surface had no, or only minimal, influence on levels in feathers. For almost all compounds studied, POPs in feathers and fat were significantly positively correlated in samples collected during the breeding season but not in samples collected during the winter. This temporal difference may have been caused by seasonal changes in lipid reserves. Although further research is required, feathers appear to be a promising new, nondestructive biomonitor for PCBs and DDTs in avian wildlife.     

Circulating levels of persistent organic pollutants (POPs) and carotid atherosclerosis in the elderly

Background and objective: Increased circulating levels of persistent organic pollutants (POPs) have been associated with myocardial infarction. Because myocardial infarction is an atherosclerotic disease, we investigated, in a cross-sectional study, whether POP levels are related to atherosclerosis.Methods: In the population-based Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study (n = 1,016 participants 70 years of age), the prevalence of carotid artery plaques was determined by ultrasound. The number of carotid arteries with plaques (0, 1, or 2) was recorded. Also, the intima-media thickness (IMT) and gray scale median of the intima-media complex (IM-GSM) were measured. Twenty-three POPs, comprising 16 polychlorinated biphenyls (PCBs), 5 pesticides, 1 dioxin, and 1 brominated compound (brominated diphenyl ether congener BDE-47), were analyzed by high-resolution chromatography coupled to high-resolution mass spectrometry.Results: Seven of the POPs (PCB congeners 153, 156, 157, 170, 180, 206, and 209) were significantly associated with the number of carotid arteries with plaques even after adjusting for multiple risk factors (sex, waist circumference, body mass index, fasting blood glucose, systolic and diastolic blood pressure, high-density lipoprotein and low-density lipoprotein cholesterol, serum triglycerides, smoking, antihypertensive treatment, and statin use; p = 0.002–0.0001). Highly chlorinated PCBs (congeners 194, 206, and 209) were associated with an echolucent IM-GSM (p < 0.0001 after adjustment), whereas associations between POPs and IMT were modest.Conclusions: Circulating levels of PCBs were associated with atherosclerotic plaques and echogenicity of the intima-media complex independent of cardiovascular risk factors, including lipids. This suggests that POPs may be a risk factor for myocardial infarction, but associations need to be confirmed in prospective studies.     

Gender differences in the effects of organochlorines, mercury, and lead on thyroid hormone levels in lakeside communities of Quebec (Canada)

Environmental chemicals can disrupt endocrine balance and in particular thyroid hormone (TH) homeostasis. However, studies differ with respect to thyroid profile changes and gender differences are rarely examined. This study investigated the THs, triodothyronine (T3), thyroxine (T4), and thyroid stimulating hormone (TSH), in relation to serum organochlorines (OCs), bioindicators of mercury (Hg) and blood lead (Pb) in 211 freshwater fish consumers (124 men and 87 women) from two communities in Canada. Thyroid hormones were within the normal range and the bioindicators of exposure were low compared to other reports on fish consumers. Stratified analysis showed that for women, serum T3 concentrations were negatively related to serum concentrations of PCB 138, PCB 153, the non-coplanar congeners, Arochlor 1260, and ΣPCB, as well as p,p′-DDE. No relations were observed between T4 and any of the chemicals measured, but TSH was negatively related to blood Pb. For men, serum T4 was inversely related to PCB 138, non-ortho-substituted (dioxin-like) PCBs and ΣPCB. A significant positive relationship was observed between serum TSH and different PCB congeners (PCB 138, PCB 180, non-coplanar congeners, mono-ortho coplanar congeners, dioxin-like PCBs), as well as ΣPCB. Serum TSH increased with hair and blood Hg concentrations and was highest among those in the highest 50th percentile for both Hg and dioxin-like PCB congeners compared to the others. No associations were observed for T3 in men. These findings suggest that even at low concentrations, these environmental contaminants can interfere with thyroid status and effects may differ by gender.     

Persistent Organochlorine Contaminant Residues in Tissues of Hedgehogs from Turkey

The residues of persistent organochlorinated pollutants (POPs), namely polychlorinated biphenyls (PCBs) and organochlorine pesticides (OCPs) (HCHs, CHLs, HCCPs, DDTs, and dicofol congeners) were investigated in the hair and muscle of road-killed Erinaceus roumanicus and E. concolor in Turkey. Mean residue levels were as follows: in hair, PCBs?=?7.43?±?4.88 ng/g and OCPs?=?9.21?±?1.27 ng/g; in muscle, PCBs?=?30.73?±?2.51 ng/g and OCPs?=?145.04?±?16.59 ng/g. There was no significant difference between species and sex, while there was significant difference between habitats and regions in terms of either total PCB and OCP levels, or POP levels (p?<?0.05). Age was a determinative factor for the bio-accumulation of POPs. The contaminant levels were high in the species, sample areas, and habitats. The data also showed that tissues of hedgehogs are suitable for monitoring and evaluating the bioaccumulation of POP levels in Turkey.     

Concentrations and Accumulation Features of Organochlorine Pesticides in the Baiyangdian Lake Freshwater Food Web of North China

Organochlorine pesticides (OCPs), such as hexachlorocyclohexane (HCH) and dichlorodiphenyltrichloroethane (DDT), are ubiquitous anthropogenic environmental contaminants. They are persistent, broad-spectrum toxicants that accumulate in the food web with potential risks to the ecosystem and human health. HCHs were the predominant contaminants in Baiyangdian Lake, North China. Concentrations of HCHs and DDTs ranged from 58 to 563 ng/g lipid weight (lw) and 21 to 401 ng/g lw, respectively, for aquatic biota samples. The highest levels of HCHs and DDTs were observed in muscles of yellow catfish. The mean concentrations of OCPs were 4.6 ng/L for water, 95 ng/g dry weight (dw) for aquatic plants, and 14 ng/g dw for sediments. Among the isomers and metabolites, α-HCH and p,p′-1,1-di(p-chlorophenyl)-2,2-dichloroethylene (p,p′-DDE) were the predominant congeners in biota samples. Correlations between log lipid-normalized concentrations of HCHs and DDTs and trophic levels (TLs) based on analysis of stable isotopes of nitrogen confirmed that persistent organic pollutants were magnified in the Baiyangdian Lake food web. Significant positive relationships were found for α-HCH and p,p′-DDT and their trophic magnification factors, which were 1.6 and 1.7, respectively. These results provide evidence of biomagnification of persistent organic pollutants (POPs) in freshwater food webs.     

Thyroid hormones in pregnancy in relation to environmental exposure to organochlorine compounds and mercury

Polychlorinated biphenyls (PCBs), chlorinated pesticides, and mercury are global environmental contaminants that can disrupt the endocrine system in animals and humans. However, there is little evidence that they can interfere with endocrine status in pregnant women and neonates at low levels of exposure. The aim of this study was to examine thyroid hormone levels during pregnancy and in cord blood in relation to blood concentrations of organochlorine compounds (OCs) and Hg in healthy women recruited during pregnancy. We found a significant negative correlation between maternal total triiodothyronine levels and three non-coplanar congeners (PCB-138, PCB-153, and PCB-180), three pesticides (p,p -DDE, cis-nanochlor, and hexachlorobenzene), and inorganic Hg independently, without any other changes in thyroid status. No significant relationships were observed between OCs and cord serum thyroid hormones. Cord serum free thyroxin was negatively correlated with inorganic Hg. These results suggest that at even low levels of exposure, persistent environmental contaminants can interfere with thyroid status during pregnancy.     

Impact of polychlorinated biphenyls contamination on estrogenic activity in human male serum

Polychlorinated biphenyls (PCBs) are thought to cause numerous adverse health effects, but their impact on estrogen signaling is still not fully understood. In the present study, we used the ER-CALUX bioassay to determine estrogenic/antiestrogenic activities of the prevalent PCB congeners and PCB mixtures isolated from human male serum. The samples were collected from residents of an area with an extensive environmental contamination from a former PCB production site as well as from a neighboring background region in eastern Slovakia. We found that the lower-chlorinated PCBs were estrogenic, whereas the prevalent higher-chlorinated PCB congeners 138, 153, 170, 180, 187, 194, 199, and 203, as well as major PCB metabolites, behaved as antiestrogens. Coplanar PCBs had no direct effect on estrogen receptor (ER) activation in this in vitro model. In human male serum samples, high levels of PCBs were associated with a decreased ER-mediated activity and an increased dioxin-like activity, as determined by the DR-CALUX assay. 17beta-Estradiol (E2) was responsible for a major part of estrogenic activity identified in total serum extracts. Significant negative correlations were found between dioxin-like activity, as well as mRNA levels of cytochromes P450 1A1 and 1B1 in lymphocytes, and total estrogenic activity. For sample fractions containing only persistent organic pollutants (POPs), the increased frequency of antiestrogenic samples was associated with a higher sum of PCBs. This suggests that the prevalent non-dioxin-like PCBs were responsible for the weak antiestrogenic activity of some POPs fractions. Our data also suggest that it might be important to pay attention to direct effects of PCBs on steroid hormone levels in heavily exposed subjects.     

Is the fact of parenting couples cohabitation affecting the serum levels of persistent organohalogen pollutants?

Organohalogen compounds constitute one of the important groups of persistent organic pollutants (POPs). Among them, due to their long-term health effects, one should pay attention on organochlorine pesticides, polychlorinated biphenyls (PCBs) and perfluoroalkylated substances (PFASs). This paper is an attempt to answer the question about relation between the fact of cohabitation by couples expecting a child and the level of the organohalogen compounds in the blood serum of both parents. The study was done on a population of parent couples from Greenland, Poland and Ukraine, from whom blood samples were collected in order to establish the levels of marker organohalogen compounds. We selected, as the representative of these compounds, the most persistent metabolite of DDT, i.e. p,p′-DDE, the most frequently detected PCB congener – CB-153, and PFOS and PFOA as the representatives of PFASs. The results show that in case of all compounds under study the highest concentrations were present always in men in relation to the levels detected in the blood serum of their female partners, regardless of the country of origin of the couple. A positive correlation was noted between the concentrations of the studied compounds in the blood serum of men and women in parenting couples. In some cases these correlations were statistically significant, e.g. for concentrations of p,p′-DDE in pairs from Greenland and Ukraine, of CB-153 in pairs from Poland and Ukraine, and of PFOS for parents from Greenland and Poland, while for PFOA – only for couples from Greenland. The concentrations of the compounds included in the study were similar to the levels found in general population in other countries. Our results show that the exposure to POPs resulting from cohabitation plays a role in the general exposure to these compounds.     

Organochlorines in Swedish women: determinants of serum concentrations

We studied associations between lifestyle/medical factors and lipid-adjusted serum concentrations of seven polychlorinated biphenyl (PCB) congeners and five chlorinated pesticides/metabolites among 205 Swedish women (54-75 years old). Serum concentrations were significantly associated with age, body mass index, body weight change, diabetes mellitus, consumption of fatty fish, and place of residence. The findings suggest that lifestyle/medical factors may confound results in epidemiologic studies when they are related to both serum concentrations and disease. Moreover, disease itself may influence serum concentrations of some organochlorines, as indicated by the negative associations between recent weight change and serum concentrations of some PCB congeners, p,p -dichlorodiphenyldichloroethylene (DDE), and hexachlorobenzene (HCB) and the positive association between diabetes mellitus and HCB concentrations. Age was the only determinant that showed a consistent association with all compounds studied (positive); otherwise associations with single determinants varied among compounds even within the PCB group. This shows that the studied organochlorines should not be treated as a homogeneous group of compounds in epidemiologic studies.     

Associations between organochlorine contaminant concentrations and clinical health parameters in loggerhead sea turtles from North Carolina, USA

Widespread and persistent organochlorine (OC) contaminants, such as polychlorinated biphenyls (PCBs) and pesticides, are known to have broad-ranging toxicities in wildlife. In this study we investigated, for the first time, their possible health effects on loggerhead sea turtles (Caretta caretta). Nonlethal fat biopsies and blood samples were collected from live turtles for OC contaminant analysis, and concentrations were compared with clinical health assessment data, including hematology, plasma chemistry, and body condition. Concentrations of total PCBs (Sigma PCBs), Sigma DDTs, Sigma chlordanes, dieldrin, and mirex were determined in 44 fat biopsies and 48 blood samples. Blood concentrations of Sigma chlordanes were negatively correlated with red blood cell counts, hemoglobin, and hematocrit, indicative of anemia. Positive correlations were observed between most classes of OC contaminants and white blood cell counts and between mirex and Sigma TCDD-like PCB concentrations and the heterophil:lymphocyte ratio, suggesting modulation of the immune system. All classes of OCs in the blood except dieldrin were correlated positively with aspartate aminotransferase (AST) activity, indicating possible hepatocellular damage. Mirex and Sigma TCDD-like PCB blood concentrations were negatively correlated with alkaline phosphatase (ALP) activity. Significant correlations to levels of certain OC contaminant classes also suggested possible alteration of protein (increasing blood urea nitrogen, decreasing albumin:globulin ratio), carbohydrate (decreasing glucose), and ion (increasing sodium, decreasing magnesium) regulation. These correlations suggest that OC contaminants may be affecting the health of loggerhead sea turtles even though sea turtles accumulate lower concentrations of OCs compared with other wildlife.     

Serum persistent organic pollutants (POPs) and prostate cancer risk: A case-cohort study

It is still unclear whether persistent organic pollutants (POPs) exposure increases the prostate cancer incidence risk. This prospective cohort study evaluated the associations between serum POPs concentrations and prostate cancer risk.Within a case-cohort study, we identified 110 people diagnosed with prostate cancer and randomly selected 256 sub-cohort participants without prostate cancer. Serum concentrations of 32 polychlorinated biphenyl (PCB) congeners and 19 organochlorine pesticides (OCPs) were measured. The hazard ratios (HRs) and 95% confidence interval (95% CI) for determining the associations between POPs and risk of prostate cancer were estimated using the weighted Cox regression model.Compared to the lowest tertile, increased risks of prostate cancer incidence were observed in the upper tertile of following PCBs: the moderately chlorinated (HR: 4.19; 95% CI: 1.30–13.54), the highly chlorinated (HR: 4.14; 95% CI: 1.75–9.79), biologically persistent as CYP1A and CYP2B inducers (HR: 4.44; 95% CI: 1.33–14.83), the sum of non- dioxin-like (HR: 3.47; 95% CI: 1.21–9.98), and ∑PCBs (HR: 4.29; 95% CI: 1.52–12.08). In dose-response curves, ∑PCBs was associated with the increased risk of prostate cancer.Our findings suggested a possible role of POPs in the etiology of prostate cancer.     

Maternal blood levels of persistent organic pollutants can be used to estimate in utero exposure

The presence of persistent organic pollutants (POPs) in the fetal environment raises concerns for their possible interferences with the developmental process, resulting into morphological and/or functional impairments of the organism. Human biomonitoring has been widely recognized as the action to be undertaken to characterize children's exposure to environmental pollutants in the different life stages, starting from conception. The main objective of the present study was to analyze the relationship between concentrations assessed in maternal blood versus those present in umbilical cord blood to evaluate if POP levels determined in maternal blood can be considered representative of fetal exposure. Data on POP concentrations determined in maternal blood and umbilical cord blood were retrieved from literature. Studies selected used highly specific analytical techniques, and were published within the last 15 years. Our analysis involved POPs of high toxicological significance, as organochlorinated pesticides, polychlorodibenzodioxins and poliychlorodibenzofurans, polychlorobiphenyls and their hydroxylated metabolites, and polybromodiphenylethers. Linear correlations between maternal and cord blood concentrations, expressed on a lipid base, were observed for most of these pollutants. This result indicates a possible use of data on maternal blood POP levels to quantitatively predict in utero exposure.     

Concentration of organochlorines in human brain, liver, and adipose tissue autopsy samples from Greenland.

Organochlorines are persistent lipophilic compounds that accumulate in Inuit people living in circumpolar countries. Organochlorines accumulate as a result of the Inuits' large consumption of sea mammal fat; however, available data are limited to blood lipids, milk fat, and adipose tissue. We report results of organochlorine determination in liver, brain, omental fat, and subcutaneous abdominal fat samples collected from deceased Greenlanders between 1992 and 1994. Eleven chlorinated pesticides and 14 polychlorinated biphenyl congeners were measured in tissue lipid extracts by high-resolution gas chromatography with electron capture detection. Mean concentrations of polychlorinated biphenyls, 2, 2'-bis(4-chlorophenyl)-1,1-dichloroethylene, ss-hexachlorocyclohexane, hexachlorobenzene, mirex, trans-nonachlor, and oxychlordane in adipose tissue samples from Greenlanders were 3-34-fold higher than those measured using the same analytical method in samples from Canadians in Quebec City, Quebec. Brain lipids contained lower concentrations of all organochlorines than lipids extracted from other tissues. Organochlorine residue levels in lipid extracts from liver, omental fat, and subcutaneous abdominal fat samples were similar, with the exception of ss-hexachlorocyclohexane, which reached a greater concentration in liver lipids than in lipids from both adipose tissues (4-fold; p < 0. 05). Comparisons with available international data on adipose tissue levels reveal that the organochlorine body burden in the Inuit population of Greenland is presently among the highest resulting from environmental exposure.     

Pilot study on the exposure of the German general population to non-dioxin-like and dioxin-like PCBs

In the past, polychlorinated biphenyls (PCBs) have been widely used and were distributed in the environment. Due to their high persistence and bioaccumulative potential, they can still be detected in the blood of the general population, despite their ban more than 20 years ago. Among the various congeners, the presence of dioxin-like PCBs in blood raises the highest environmental concerns due to their critical toxicological properties. We determined the plasma concentrations of 6 non-dioxin-like and 12 dioxin-like PCBs as well as the organochlorine pesticides HCB and p,p'-DDE (p,p'-dichlorodiphenyldichloroethylene) in a group of 105 non-smokers out of the German general population by GC/MS as an estimate of the background burden to these compounds. The organochlorine compounds were extracted from plasma with n-hexane, cleaned up on a silica gel column and finally quantified using GC/MS and (13)C(12)-labelled internal standards. The limit of detection for all congeners was determined to be 0.01 μg/Lplasma. Age had a strong influence on the plasma levels of HCB (hexachlorobenzene), p,p'-DDE and all higher chlorinated PCB congeners, while no gender difference was observed. Among the dioxin-like PCBs, PCB 118, PCB 156 and PCB 167 were detectable in 74-98% of all samples. Highly significant correlations between several PCB-congeners were observed. Our results provide for the first time volume-based data on the extent of the age-related background burden to dioxin-like PCBs in Germany.     

Relationships of Polychlorinated Biphenyls and Dichlorodiphenyldichloroethylene (p,p’-DDE) with Testosterone Levels in Adolescent Males

Background: Concern persists over endocrine-disrupting effects of persistent organic pollutants (POPs) on human growth and sexual maturation. Potential effects of toxicant exposures on testosterone levels during puberty are not well characterized.Objectives: In this study we evaluated the relationship between toxicants [polychlorinated biphenyls (PCBs), dichlorodiphenyldichloroethylene (p,p´-DDE), hexachlorobenzene (HCB), and lead] and testosterone levels among 127 Akwesasne Mohawk males 10 to < 17 years of age with documented toxicant exposures.Methods: Data were collected between February 1996 and January 2000. Fasting blood specimens were collected before breakfast by trained Akwesasne Mohawk staff. Multivariable regression models were used to estimates associations between toxicants and serum testosterone, adjusted for other toxicants, Tanner stage, and potential confounders.Results: The sum of 16 PCB congeners (Σ16PCBs) that were detected in ≥ 50% of the population was significantly and negatively associated with serum testosterone levels, such that a 10% change in exposure was associated with a 5.6% decrease in testosterone (95% CI: –10.8, –0.5%). Of the 16 congeners, the more persistent ones (Σ8PerPCBs) were related to testosterone, whereas the less persistent ones, possibly reflecting more recent exposure, were not. When PCB congeners were subgrouped, the association was significant for the sum of eight more persistent PCBs (5.7% decrease; 95% CI: –11, –0.4%), and stronger than the sum of six less persistent congeners (3.1% decrease; 95% CI: –7.2, 0.9%). p,p´-DDE was positively but not significantly associated with serum testosterone (5.2% increase with a 10% increase in exposure; 95% CI: –0.5, 10.9%). Neither lead nor HCB was significantly associated with testosterone levels.Conclusions: Exposure to PCBs, particularly the more highly persistent congeners, may negatively influence testosterone levels among adolescent males. The positive relationship between p,p´-DDE and testosterone indicates that not all POPs act similarly.Citation: Schell LM, Gallo MV, Deane GD, Nelder KR, DeCaprio AP, Jacobs A; Akwesasne Task Force on the Environment. 2014. Relationships of polychlorinated biphenyls and dichlorodiphenyldichloroethylene (p,p´-DDE) with testosterone levels in adolescent males. Environ Health Perspect 122:304–309; http://dx.doi.org/10.1289/ehp.1205984     

Blood pressure in relation to concentrations of PCB congeners and chlorinated pesticides

Background

Residents of Anniston, Alabama, live near a Monsanto plant that manufactured polychlorinated biphenyls (PCBs) from 1929 to 1971 and are relatively heavily exposed.

Objectives

The goal of this study was to determine the relationship, if any, between blood pressure and levels of total serum PCBs, several PCB groups with common actions or structure, 35 individual PCB congeners, and nine chlorinated pesticides.

Methods

Linear regression analysis was used to determine the relationships between blood pressure and serum levels of the various contaminants after adjustment for age, body mass index, sex, race, smoking, and exercise in 394 Anniston residents who were not taking antihypertensive medication.

Results

Other than age, total serum PCB concentration was the strongest determinant of blood pressure of the covariates studied. We found the strongest associations for those PCB congeners that had multiple ortho chlorines. We found the associations over the full range of blood pressure as well as in those subjects whose blood pressure was in the normal range. The chlorinated pesticides showed no consistent relationship to blood pressure.

Conclusions

In this cross-sectional study, serum concentrations of PCBs, especially those congeners with multiple ortho chlorines, were strongly associated with both systolic and diastolic blood pressure.     

Smoking as a determinant of high organochlorine levels in Greenland

The authors investigated the accumulation of organochlorines among smoking and nonsmoking Inuit hunters (n = 48) in Uummanaq, Greenland, a population with high dietary exposure to persistent organic pollutants (POPs). Human plasma organochlorine levels were positively correlated with age, marine diet, and smoking or plasma cotinine in multiple linear-regression models (p < 0.001). Body mass index was inversely correlated with organochlorine accumulation, independent of smoking status. These findings confirm that the source of POPs among the Inuit in Greenland is diet, but smoking is an important determinant of POP bioaccumulation. Smoking cessation may provide a means to lower the body burden of POPs.     

Polybrominated Diphenyl Ethers,Polychlorinated Biphenyls,and Organochlorine Pesticides in Adipose Tissues of Korean Women

Studies on residue levels and accumulation profiles of persistent organic pollutants (POPs) in human adipose tissues of Korean populations are scarce. In this study, concentrations and accumulation features of polychlorinated biphenyls (PCBs), organochlorine pesticides (OCPs), and polybrominated diphenyl ethers (PBDEs) were measured in adipose tissues of Korean women age 40–68 years. The highest concentrations were found for PCBs and DDTs, which were 1–2 orders of magnitude greater than the concentrations of hexachlorocyclohexanes, chlordanes, and PBDEs. The concentrations of PCBs and OCPs were lower than those reported for other countries. However, PBDE concentrations were greater than those reported for other countries, suggesting that ongoing exposure to PBDEs is a concern in Korea. The profiles of PBDEs were characterized by the predominance of BDE 209, followed by nona- and octa-BDEs, which are consistent with the consumption patterns of products containing PBDEs in Korea. The concentrations of PCBs and some OCPs were significantly correlated with each other, whereas PBDEs showed low or moderate correlations with other POPs, suggesting differences in exposure routes and biotransformation potentials of the compounds studied. The concentrations of organochlorines and PBDEs were not correlated with subjects’ age and body mass index. The results of this study provide baseline information on POPs in adipose tissues of the general population in Korea.