高锌蛋治疗小儿锌铁缺乏症疗效观察

高锌蛋治疗小儿锌铁缺乏症疗效观察刘美煌（广西柳州市妇幼保健院儿科柳州５４５００１）高锌蛋是一种生物转化的天然保健食品，我院儿科微量元素专科门诊应用高锌蛋治疗３６例锌、铁缺乏小儿，现将结果分析如下。１临床资料１．１对象：３６例经微量血检测诊断为缺锌、缺...     

硫酸锌治疗小儿厌食症——170例疗效分析

<正> 近年来有关小儿锌营养状况与疾病的关系报告较多。缺锌后可能引起一系列的生理功能异常,生长发育停滞,创伤愈合困难,厌食、异食,免疫功能低下等,并与能量代谢,性机能和小儿智力有关。[1][2][4]鉴于小儿厌食,反复感染,生长发育迟缓等确也是儿科临床常见的、迫切需要解决的问题,因此我院儿科也开展了用锌制剂治     

发锌与小儿喂养方式临床症状的关系

近年来的临床和实验证明 ,微量元素锌与小儿生长发育、免疫防御、创伤愈合等有密切关系 ,缺锌使小儿生长发育迟缓、反复感染、厌食等 ,影响小儿身心健康。为了解小儿锌营养状况与喂养方式的关系及缺锌的发病情况 ,在基层不具备检测血锌的条件下 ,我们选择了简单易行、能够被小儿及家长接受的发锌检测。现将 5 10名小儿发锌检测结果、喂养方式和临床症状分析报告如下。1　对象和方法1.1　对象　儿科门诊就诊小儿 ,其中 2个月～ 1岁 2 10名 ,1岁1个月～ 6岁儿童 30 0名 ,排除二度以上营养不良、免疫缺陷及内分泌系统疾病。1.2　方法　受检者均…     

低锌小儿的血红蛋白及微量元素锌、铁相互作用的研究

本文通过对缺锌小儿服用锌剂和铁剂后发锌和外周血血红蛋白的变化来研究锌剂与铁剂在体内的相互作用。研究对象及方法研究对象为1987年3月至1988年6月在我院锌门诊诊治的儿童,凡有厌食,反复呼吸道感染、生长发育迟缓等缺锌表现以及发锌检查证实为低锌的患儿(我院小儿发锌正常值为117±34.86ppm/g,中子活化分析法)144例,男76例,女68     

儿童缺锌对健康的影响

锌是儿童生长发育最重要的微量元素之一,据报道,我国约有60％的学龄前儿童缺锌。缺锌的临床表现为:食欲不振、生长停滞或缓慢、味觉减退、创伤愈合不良及肢端性皮炎等;严重缺锌者有异食癖,喜吃墙土、灰渣等。 缺锌可使小儿机体免疫功能降低,免疫球蛋白减少,抵抗力低下,细胞免疫系统发生不良影响,所以容易引起感染;小儿容易患感冒和慢性腹泻,可能与平日摄取的锌量不足有关。研究证明,锌能防止感冒病毒的繁殖,减少引起炎症物质的组织胺产生;还有助于组织的生长与修复。     

葡萄糖酸锌治疗缺锌儿童疗效观察

锌是一种人体必需元素。锌与小儿的生长发育、防卸机能、创伤愈合以及某些疾病的发生发展都有密切关系。由于小儿发育快 ,对锌的需要量相对较多 ,而小儿的食物往往较单调 ,部分孩子还有偏食、挑食习惯 ,从而减少锌摄入量 ,因而儿童缺锌很常见。对儿童锌缺乏的防治研究 ,国内外已有许多报道 ,本文对本地区八个县市 3～ 7岁缺锌儿童进行了治疗 ,现报告如下。1　对象和方法1.1　对象　随机抽取玉林地区八所幼儿园 3～ 7岁儿童32 80名进行发锌测定及体检 ,其中对检出发锌 <110× 10 - 6及根据体检出生长发育迟缓、厌食、头发稀黄、营养不良等共 …     

婴幼儿锌缺乏与反复呼吸道感染

人体缺锌时极易发生各种感染.婴幼儿缺锌.更易发生反复呼吸道感染,后者又常常影响小儿生长发育,故防治婴儿反复呼吸道感染已成为儿科医生十分关切的课题.为探讨反复呼吸道感染患儿体内锌的状态及观察锌剂的防治效果,我们在小儿锌缺乏症专科门诊中系统观察了67例婴幼儿,现将观察结果予以报告. 一、观察对象:均为我院小儿锌缺乏症专科门诊诊治67例,其中10个月至1_(2/1)岁33例,11/2岁至3岁34例,男34例,女22例.     

铁缺乏症小儿血清锌与血清锌原卟啉关系探讨

目的 :探讨铁缺乏症小儿血清锌与血清锌原卟啉的关系。方法 :对 6 2例铁缺乏症小儿及 6 0例对照组小儿采取清晨空腹血 2 .0～ 2 .5 ml,右手无名指末梢血 4 0μl进行血清锌、血红蛋白、血清锌原卟啉检测。结果 :观察组血清锌较对照组明显减低 ,血清锌原卟啉值明显增高 ,差异有显著性 (P<0 .0 5 ) ;缺铁同时伴有缺锌小儿和单纯缺铁小儿比较 ,血清锌原卟啉值偏低 ,但差异无显著性。结论 :检测血清锌诊断小儿铁缺乏症较检测红细胞内游离原卟啉方法简单、经济、敏感、准确 ,值得推广。     

小儿缺锌研究的若干问题——“微量元素与健康”研究的资料分析

<正> 一、在微量元素与健康研究中怎样看待小儿缺锌?全国近千家“微量元素与健康”研究机构和专科门诊的研究人员与世界上一流水平的专家工作证实:小儿普遍存在锌营养不足。在群体儿童调查中小儿低锌率为55％～75％。象北京、珠海儿保门诊儿童低锌率分别为62.52％、72.04％。其中一些儿     

锌与老年人健康

锌是人体生理活动必需的微量元素之一,它对人体的发育,包括对中枢神经系统的发育和脑、生殖的功能等,都有重要的影响。近年来研究发现,锌与小儿发育和一些疾病有很大关系,因而对儿童缺锌和补锌已引起了广泛重视,而对老年人体内锌的改变以及锌与老年疾病关系方面的研究甚少,故人们对老年人缺锌不以为然。据流行病学调查表明,健康老年人血浆锌值显著低于健康青年人。锌对老年人的生理活动和身体健康同样有重要作用,老年人也应防止缺锌。     

广州市4200例婴幼儿全血锌检测结果分析

目的探讨缺锌对婴幼儿健康的影响。方法使用原子吸收光谱法对广东省妇幼保健院医院门诊4200例0-3岁婴幼儿进行全血锌的测定。结果婴幼儿缺锌率为30．26％,〈1岁组高于1～3岁组,女高于男,体弱儿高于正常儿,体弱儿夏季缺锌率最高（P〈0．001）。结论婴幼儿生长发育期易缺乏锌元素。缺锌会影响儿童健康,故应重视儿童期低血锌的综合防治．加强监测,注重营养平衡。     

婴幼儿腹泻时血清锌含量测定的意义

目的:探讨婴幼儿腹泻时血清锌含量变化,改善腹泻患儿锌营养状况,提高婴幼儿腹泻病防治水平。方法:2010年1月~2012年10月诊治的1个月至3岁腹泻患儿95例和同期门诊健康体检的271名婴幼儿为研究对象,化学发光检测法测定血锌含量,SPSS16.0统计学软件进行统计学分析。结果:健康对照组、急性腹泻组和迁延性腹泻组患儿血清锌含量(x珋±s)分别为:19.64±2.82μmol/L,13.15±3.18μmol/L,14.11±3.06μmol/L,锌缺乏发生率分别0,12.98%,5.56%,急性腹泻组及迁延性腹泻组患儿血清锌含量显著降低,锌缺乏发生率明显升高。结论:腹泻婴幼儿血清锌含量显著降低,锌缺乏发生率明显升高。婴幼儿腹泻可常规检测体内锌值,指导临床合理补锌。     

2015年中国18〜60岁成人锌营养状况

目的了解中国18~60岁成人血清锌水平、锌缺乏状况的分布及影响因素。方法基于"2015年中国成人慢性病与营养监测"数据资料,采用分层随机抽样方法选取3903人份血样品,利用电感耦合等离子质谱分析血清锌在不同性别、年龄、地区类型、地域成人中的分布情况,以及体质指数、运动、吸烟、饮酒、维生素A水平等因素对血清锌浓度及锌缺乏率的影响。采用多因素Logistic回归模型分析锌的缺乏与各影响因素间的关联性。结果 2015年中国18~60岁成人血清锌中位数为103.44(95%CI 64.84~186.12)μg/dL,总体锌的缺乏率为6.04%。血清锌水平在不同性别、地区类型、地域分布、维生素A状况、吸烟状态、饮酒状态上差异有统计学意义(P<0.05)。在锌缺乏率的比较中,少数民族(10.67%)高于汉族(5.44%),农村(7.35%)高于城市(4.90%),维生素A缺乏者(9.12%)高于正常者(5.90%),非运动人群(6.29%)高于运动人群(5.09%),西部地区最高(7.33%),不同体质指数者中超重者最低(4.81%),差异有统计学意义(P<0.05)。在相关因素分析时,维生素A缺乏者发生锌缺乏的风险是正常者的1.89倍(95%CI 1.13~3.18),超重人群发生锌缺乏的风险是正常人群的0.71倍(95%CI 0.52~0.96)。结论 2015年中国18~60岁成人血清锌缺乏处于较低风险。维生素A缺乏是锌缺乏的危险因素,但超重是锌缺乏的保护因素。     

Zinc Deficiency in Nursing Infants

Zinc deficiency during nursing can occur even in breast-fed infants. Zinc reserves accumulated during fetal development modulate the infant’s susceptibility to zinc deficiency. Improvement of maternal zinc nutrition during pregnancy is the key for infant’s zinc nutritional support and prevention of low-for-lactation-age zinc concentrations of breast-milk.     

锌缺乏与艾滋病

综述了锌缺乏与艾滋病发病机理之间的关系,认为锌缺乏导致的机体免疫功能下降或改变对HIV感染具有重要影响,并认为适当补锌对恢复HIV感染者免疫能力有一定作用。     

Protein microparticulation: the principle and the process.

Objective: To evaluate the usefulness of the body zinc clearance test in the diagnosis of marginal zinc deficiency and to estimate the efficacy of oral zinc supplementation on growth in short children.

Methods: Zinc status was evaluated in 30 (19 boys and 11 girls) Japanese children with short stature using the body zinc clearance test. Changes in growth after oral zinc supplementation (ZnSO₄ · 7H₂O; 5 mg/kg/day in two divided doses) were studied.

Results: Basal serum zinc concentrations were 75.0±12.7 μg/dl and zinc clearance values were 19.1±5.8 ml/kg/hour in the 30 subjects. The correlation coefficient between serum zinc concentrations and zinc clearance values was as small as ?0.36. There were nine cases whose body zinc clearance values were high and serum zinc concentrations were low, indicating definite zinc deficiency. There were nine cases whose body zinc clearance values were high, despite normal serum zinc concentrations, indicating marginal zinc deficiency. The mean height velocity for males was 5.3 cm/year before zinc supplementation and 7.8 cm/year after the therapy; and the mean SD score for height for age improved from ?1.85 to ?1.53. The mean height velocity for females was 5.1 cm/year before zinc supplementation and 5.9 cm/year after the therapy, and the mean SD score for height for age changed from ?2.02 to ?2.03.

Conclusion: The body zinc clearance test was much more useful than serum zinc concentrations in diagnosing marginal zinc deficiency. Oral zinc supplementation improved the height velocity in short males, but not in short females.     

Transient symptomatic zinc deficiency in a breast-fed infant: relevance of a genetic study

Objective

We present a case of acrodermatitis enteropathica in a full-term, breast-fed, 7-mo-old infant born from consanguineous parents with a family history of acrodermatitis enteropathica.

Methods

The patient presented with periorificial and symmetric acral lesions, which prompted us to review the clinical features of acrodermatitis enteropathica and its pathogenesis. Laboratory investigations showed low zinc levels in the infant’s and mother’s sera and in the mothers’ milk.

Results

A diagnosis of acrodermatitis enteropathica was made. A mutation screening of the SLC39A4 gene in the patient and his mother showed heterozygosity for the deletion c.1223_1227delCCGGG. The diagnosis of transient symptomatic zinc deficiency was then established.

Conclusion

Transient symptomatic zinc deficiency is generally reported in premature infants but should also be considered in full-term, breast-fed infants, as in the present case.     

缺锌和补锌对运动大鼠锌营养状况的影响

通过建立大鼠缺锌模型，观察缺锌及补锌对游泳大鼠血清、肝脏锌含量和五种含锌金属酶活性的影响。结果表明：（１）血浆锌浓度和碱性磷酸酶（ＡＫＰ）活性是评价机体锌缺乏的灵敏指标；（２）血浆ＡＫＰ活性同时也是评价运动大鼠锌缺乏的较好指标，而血管紧张素Ｉ转换酶、酸性α－Ｄ－甘露糖苷酶５－核苷酸酶等不太理想；（３）运动时，缺锌大鼠血浆锌金属酶活性多数变化剧烈，表明机体内环境遭受较大破坏。而补锌后上述指标均接近正常水平，说明适量补锌有助于改善机体缺锌状况，维持机体内环境的稳定     

缺锌对大鼠脑组织和血液中乙酰胆碱和5—羟色胺含量的影响

目的：研究缺锌对大鼠脑组织和血液中乙酰胆碱（ACh)和5－羟色胺（5－HT）含量的影响。方法：采用85克左右的Wistar大鼠,随机均分为3组;缺锌组（ZD）,饲喂缺锌饲料,对喂组（PF）,饲喂加锌饲料,但饲喂量与ZD组一致;缺锌补锌组（ZS）,先饲喂缺锌饲料,21天以后改为加锌饲料,给料量与ZD组一致。结果：缺锌组血液中ACh明显升高;皮质中ACh与其他组差异无显性。血液中5－HT显升高,大脑皮质中5－HT显升高,结论：提示缺锌可影响脑组织和血液中乙酰胆碱和5－羟色胺的代谢。     

Zinc Nutritional Status and Risk Factors of Elderly in the China Adult Chronic Disease and Nutrition Surveillance 2015

Objectives: To analyze the serum zinc nutrition status of the Chinese elderly, and to assess the risk factor for zinc deficiency. Methods: 3727 elderly people over 60 years old were randomly selected from 302 monitoring points in 31 provinces of China Adult Chronic Disease and Nutrition Surveillance (CACDNS) 2015. Blood samples were selected from the biological sample bank of CACDNS 2015 and the basic information were collected by questionnaires. The criteria of serum zinc deficiency recommended by the International Zinc Nutrition Consulting Group (IZiNCG) were adopted, and the related factors were also analyzed. Results: The median serum zinc concentration of Chinese elderly was 99.2 (84.3~118.7) μg/dL. The overall adjusted prevalence of zinc deficiency was 8.68%, with a 95% confidence interval (CI) of 7.74% and 9.61%. Significant differences were found in different sex, age groups, Body Mass Index (BMI), residence region, race and education level in terms of serum zinc status in the elderly (p < 0.05). Participants who are males, aged above 70y, with BMIs of less than 18.5 kg/m², living in rural areas, minority, and with the lowest income had a higher prevalence of zinc deficiency in the subgroups under different classifications. The risk of zinc deficiency in the elderly over 70y was 1.44 higher than those aged 60–69y (OR = 1.44, 95%CI 1.14–1.82), and the minority elderly has a 1.39 higher risk than Han nationality (OR = 1.39, 95%CI 1.01–1.91), while overweight/obesity and female elderly were at lower risk (OR < 1, p < 0.05). Conclusions: The overall prevalence of zinc deficiency in the elderly was highest in all adults in the CACDNS. It is recommended that the male elderly, over 70 years, and the minority elderly should pay more attention to the zinc nutrition status of their own.