NSAIDs相关性肠病14例的临床分析

目的：分析因服用非甾体类抗炎药物（ NSAIDs）而并发相关性肠病的临床特征。方法：对我院2008年2月～2014年8月间收治的14例NSAIDs相关性肠病患者的临床资料进行回顾性分析。结果：本组14例NSAIDs 相关性肠病患者均存在不同程度的消化道出血,伴或不伴腹痛、腹部不适等症状,便血者多见;经过服药史的调查,14例均存在 NSAIDs 长期服用史,胃镜下均未发现明显出血灶,结肠镜结果示肠道黏膜糜烂,偶可见出血;停用NSAIDs药后,应用抑酸剂及黏膜保护剂可达到治疗效果。结论：服用NSAIDs能显著增加消化道溃疡患者并发出血的风险,NSAIDs相关肠病症状较为隐匿,具有非特异性,临床诊断在考虑用药史、临床症状和主诉的基础上,应结合胃肠镜、胶囊内镜或小肠镜检以帮助提高诊断率。     

非甾体类抗炎药相关性上消化道出血的临床分析

目的 探讨非甾体类抗炎药相关性上消化道出血的临床特征.方法 选择因呕血或黑便就诊并行急诊胃镜检查确诊的178例患者,分为NSAIDs组和非NSAIDs组,比较两组患者临床特征、内镜下表现及幽门螺杆菌(Hp)感染情况.结果 两组患者的年龄、伴随的消化道症状、心脑血管病史、内镜下表现比较差异有统计学意义(P<0.05);而性别、出血方式、Hp感染比较差异无统计学意义(P>0.05).结论 非甾体类抗炎药相关性上消化道出血多见于伴有心脑血管疾病或病史的老年患者,多不伴有消化道症状,以胃黏膜糜烂及溃疡居多,两组患者Hp感染率无显著性差异.     

非甾体抗炎药相关性上消化道出血临床分析

目的探讨非甾体抗炎药(non-steroidal anti-inflammatory drugs,NSAIDs)相关性上消化道出血的临床特点,为预防非甾体抗炎药相关性上消化道出血的发生提供依据和措施。方法收集新疆医科大学附属中医医院急诊科2007年1月—2009年12月因上消化道出血住院的167例患者的临床资料。以出血前1周是否服用过NSAIDs将患者分为NSAIDs组和非NSAIDs组。分析NSAIDs组的服药的种类、服药原因、用药时间等,比较两组患者临床特征[年龄、性别、既往有无心血管疾病病史、溃疡病史、幽门螺杆菌(Helicobacter pylori,HP)感染情况],临床症状(腹痛、消化不良)以及胃镜表现。结果 167例中有39例(23.35%)出血前1周服用过NSAIDs。NSAIDs组服药种类以阿司匹林占多数(19例,占48.71%);用药时间以1周以内最多见(15例,占38.46%);服药原因以预防心脑血管疾病为主(17例,占43.59%)。组间比较:NSAIDs组年龄≥60岁患者所占比例高于非NSAIDs组(P<0.05);NSAIDs组既往心脑血管病史较非NSAIDs组多见(P<0.05);NSAIDs组出血前消化道症状不明显(P<0.05);胃镜下NSAIDs组以胃溃疡、糜烂性出血多见,非NSAIDs组以十二指肠溃疡多见,差异有统计学意义(P<0.05)。NSAIDs组出血量>1 000mL者所占比例高于非NSAIDs组,差异有统计学意义(P<0.05)。结论高龄、既往心脑血管病史、既往消化性溃疡病史为NSAIDs相关性上消化道出血的危险因素。NSAIDs相关性上消化道出血临床表现的特点为起病隐匿、无明显腹痛,且出血量大。     

非甾体抗炎药相关性上消化道出血临床分析

目的:研究非甾体抗炎药(NSAIDs)诱发上消化道出血的临床特点。方法:回顾性分析58例NSAIDs相关性上消化道出血与同期172例溃疡及胃黏膜病变致上消化道出血的临床资料,比较两组患者年龄、既往史、出血前服药史、临床症状、幽门螺杆菌(Hp)感染、治疗及预后的情况。结果:NSAIDs相关性上消化道出血占上消化道出血的25.2%(58/230),多发生在服药后2周内,NSAIDs组年龄偏大、多有心脑血管病史、出血前临床症状不明显、Hp感染可能加剧NSAIDs诱发胃肠黏膜损害,两组性别、消化道溃疡史、治疗及预后差异无显著性(P>0.05)。结论:老年患有心脑血管疾病者易发NSAIDs相关性上消化道出血,无腹痛性消化道出血是其临床表现的特点,应加强预防措施。     

老年人药物相关性消化道出血临床特点及诊治分析

目的探讨老年人药物相关性消化道出血的临床特点及诊疗措施。方法收集郑州大学第一附属医院2013年6月至2015年6月108例发生消化道出血的60岁及以上住院患者的临床资料,并根据住院前2周服药史、临床症状、出血量、出血时间及胃镜检查结果 Forrest分级做出诊断并进行治疗。依据临床用药指南治疗8周后,对其预后进行统计分析。结果 108位药物相关老年消化道出血患者中NSAIDs 70例(64.8%)、糖皮质激素19例(17.6%)、抗菌药12例(11.1%)、抗肿瘤药7例(6.5%),A组治愈率为60.4%、B组治愈率为75%、C组治愈率为79.2%。结论 NSAIDs是引起老年消化道出血最常见的药物,阿司匹林在引起老年消化道出血中占重要因素,老年人联合应用NSAIDs(A组)更易出现消化道出血且治疗效果欠佳。     

非甾体类抗炎药相关性上消化道出血的临床特征分析

目的：探讨非甾体类抗炎药（Non-Steroidal Anti-Inflammatory Drugs,NSAIDs）相关性上消化道出血的临床特征。方法选择因呕血或黑便就诊并行急诊胃镜检查确诊的144例患者,分为NSAIDs组和非NSAIDs组,将两组患者进行分析比较。结果NSAIDs组患者年龄≥60岁占67.7%、有消化道症状占32.3%、有心脑血管病史占61.3%、胃镜下糜烂性胃炎和胃溃疡占92.0%、HP 阳性占25.8%,与非 NSAIDs 组比较,差异有统计学意义（P〈0.05）;而 NSAIDs 组患者男性占54.8%、呕血占22.6%,与非NSAIDs组比较,差异无统计学意义（P〉0.05）。结论非甾体类抗炎药是上消化道出血的重要病因,伴有心脑血管疾病或病史的老年患者多见,多不伴有消化道症状和HP感染,且以胃溃疡居多。     

非甾体抗炎药相关性溃疡出血临床特点

目的 探讨非甾体抗炎药(NSAIDs)所致相关性溃疡并出血的临床特点.方法 选择因上消化道出血行胃镜检查的126例患者,分为服用NASIDs组(观察组)和未服用NSAIDs组(对照组),比较两组患者临床、内镜下病变特点及幽门螺杆菌(Hp)感染情况.结果 结果显示两组患者的性别、消化性溃疡出血病史比较差异无显著性(P＞0.05);而年龄、出血前消化道症状、心脑血管病史、Hp感染及内镜下溃疡特点两组比较差异有显著性(P＜0.05).结论 非甾体抗炎药相关性溃疡的主要临床特点为:常见于老年人,较多患者有心脑血管病史,内镜下胃溃疡和复合溃疡多见,Hp感染增加发生胃黏膜糜烂、水肿的机会.     

腹腔镜联合结肠镜诊疗急性下消化道出血(附6例报告)

目的 对结肠镜辅助下腹腔镜手术诊疗急性下消化道出血的可行性及其方法进行初步探讨.方法 对6例行急性下消化道出血患者进行结肠镜辅助下腹腔镜手术患者的临床资料进行回顾性分析.结果 6例手术均顺利完成,无中转开腹.手术时间短,术中出血量少,肠功能恢复快.术后随访2～15个月疗效满意.结论 结肠镜辅助下腹腔镜手术对于内科保守治疗失败的急性下消化道出血是一种安全有效的治疗手段.     

非甾体类抗炎药致上消化道出血的临床特征分析

目的研究非甾体类抗炎药（NSAIDs）诱发上消化出血的临床特征。方法调查亳州市人民医院2008年1月～2011年5月因诊断上消化道出血收住院治疗142例患者,根据入院前10 d内有无服用过NSAIDs的病史,将患者分为NSAIDs组（49例）及非NSAIDs组（93例）两组进行分析比较。结果两组比较,患者的性别、消化道溃疡病史差异无统计学意义,但NSAIDs组患者在年龄、心血管病史、出血前消化道症状、血红蛋白含量、内镜下消化道溃疡、住院时间、72 h止血率等方面与非NSAIDs组比较,差异有统计学意义（P〈0.05）。结论 NSAIDs是上消化道出血的重要病因,年老、患有心脑血管疾病者更易出现并发症,且止血效果欠佳。应掌握NSAIDs类药物的适应证和禁忌证,可同时使用胃肠道保护药。     

急诊结肠镜诊治下消化道出血56例临床体会

目的探讨紧急结肠镜检查对急性下消化道出血的临床应用价值。方法对65例急性下消化道出血患者进行急诊结肠镜检查和相应止血治疗,并对资料进行分析。结果急诊结肠镜检查阳性率为93.85%,成功率为100%,止血成功率为94.29%,无并发症发生。结论急诊结肠镜检查是急性下消化道出血的首选方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.