Two new 18-carbon norditerpenoid alkaloids from Aconitum sinomontanum

Two new 18-carbon norditerpenoid alkaloids, sinaconitines A (1) and B (2), together with two known alkaloids, ranaconitine (3) and lappaconitine (4), were isolated from the roots of Aconitum sinomontanum. Their structures were elucidated on the basis of spectral evidences and X-ray crystallographic analysis for 1. Furthermore, the reversed ¹³C NMR assignments for C-10 and C-13 of 3, 4, puberanine, puberanidine and demethyllappaconitine were revised. Compounds 1–4 were evaluated for cyclooxygenase-2 (COX-2) enzyme inhibitory activity. However, they did not show any inhibition at 10 μM.     

Five new norditerpenoid alkaloids from Aconitum sinomontanum

From the roots of Aconitum sinomontanum, five new norditerpenoid alkaloids, sinomontanitines A (1) and B (2), sinomontanines A (3), B (4) and C (5), were isolated together with the known alkaloids lappaconitine (6) and ranaconitine (7), The structures of the new alkaloids were determined by spectral analysis.     

New norditerpenoid alkaloids from Aconitum hemsley anum var. pengzhouense

Two new norditerpenoid alkaloids, 13-deoxyludaconitine (1) and 8-deacetylsungpaconitine (3), were isolated from the roots of Aconitum hemsleyanum Pritz var. pengzhouense and their structures were elucidated by spectral data.     

Two new C19-diterpenoid alkaloids from Aconitum straminiflorum

Two new C₁₉-diterpenoid alkaloids, straconitines A (1) and B (2), were isolated from the roots of Aconitum straminiflorum. Their structures were elucidated as 14-benzoylducloudine D (1) and 6-hydroxy-14-benzoylducloudine D (2) based on spectroscopic analysis, including IR, ESI-MS, HR-ESI-MS, 1D, and 2D NMR.     

Two new diterpenoid alkaloids, beiwusines A and B, from Aconitum kusnezoffii

Two new atisine-type diterpenoid alkaloids, beiwusine A (1) and B (2), have been isolated from the roots of Aconitum kusnezoffii Reichb. Their structures were established on the basis of spectroscopic data. Beiwusines A and B are the first examples of atisine-type diterpenoid alkaloids having a hydroxyl group at C-1. In addition, one known diterpenoid alkaloid spiramine H (3) has been isolated.     

Two norditerpenoid ester alkaloids from Aconitum bulleyanum

Two new norditerpenoid alkaloids, 8-acetyl-14-p-methoxybenzoate of talatisamine (1) and 14-p-methoxybenzoate of talatisamine (2), were isolated from Aconitum bulleyanum Diels. The structures were elucidated on the basis of spectroscopic and chemical studies.     

Norditerpenoid alkaloids from Aconitum manshuricum

A new norditerpenoid alkaloid, manshuritine (1) has been isolated from Aconitum manshuricum, together with seven known alkaloids; beiwudine (2), beiwutine (3), 16-epi-pyromesaconitine (4), mesaconitine (5), aconitine (6), hypaconitine (7) and 14-benzoylmesaconine (8). The structure of the new compound was elucidated on the basis of spectral data and chemical correlations.     

Four new C19-diterpenoid alkaloids from the roots of Aconitum ouvrardianum

Four new C₁₉-diterpenoid alkaloids, 3-dehydroxyl-lipoindaconitine (1), 8-dehydroxyl-bikhaconine (2), 19R-acetonyl-talatisamine (3), and 16-hydroxyl-vilmorisine (4), were isolated from the roots of Aconitum ouvrardianum. Their structures were elucidated by spectral analyses, including ESI-MS, HR-ESI-MS, IR, UV, 1D and 2D NMR.     

New Norditerpenoid Alkaloids from the Roots of Aconitum Geniculatum

Abstract

Four new norditerpenoid alkaloids, geniculatines A (1), B (4), C (7) and D (8), were isolated from the roots of Aconitum geniculatum Fletcher, and their structures were elucidated by spectral methods.     

New Norditerpenoid Alkaloids from the Roots of Aconitum Geniculatum

Four new norditerpenoid alkaloids, geniculatines A (1), B (4), C (7) and D (8), were isolated from the roots of Aconitum geniculatum Fletcher, and their structures were elucidated by spectral methods.     

Two new C19-diterpenoid alkaloids from Aconitum tsaii

Two new C₁₉-diterpenoid alkaloids, 14-benzoylliljestrandisine (1) and 14-anisoylliljestrandisine (2), were isolated from the roots of Aconitum tsaii. Their structures were elucidated by different spectroscopic (IR, UV, 1D and 2D NMR) and mass-spectrometric techniques.     

Two new C19-diterpenoid alkaloids from Aconitum kongboense

Two new C₁₉-diterpenoid alkaloids, kongboentine A (1) and kongboentine B (3), were isolated from the roots of Aconitum kongboense Lauener and their structures were elucidated by spectral data.     

Diterpenoid alkaloids from Aconitum kirinense

A new C₁₈-diterpenoid alkaloid, kirinenine A (1), was isolated from the root of Aconitum kirinense, along with eight known diterpenoid alkaloids. The structures of all compounds were characterized on the basis of extensive NMR and MS analyses and by comparison with literature values, and the new one was further confirmed by X-ray crystallographic diffraction. All the compounds were isolated from the title plant for the first time.     

太白乌头中一新的去甲二萜生物碱

为了研究太白乌头(Aconitum taipaicum)根的化学成分，采用硅胶柱色谱进行分离纯化，根据其理化性质和波谱数据确定化合物结构。从该植物的根中分离得到1个新的去甲二萜生物碱isodelelatine (1)和5个已知生物碱，分别为atisine (2)、 delfissinol (3)、 liangshanine (4)、 hypaconitine (5)和delelatine (6)。化合物2～6均为首次从该植物中分离得到。     

Two new bis-C20-diterpenoid alkaloids with anti-inflammation activity from Aconitum bulleyanum

Two new bis-C₂₀-diterpenoid alkaloids, bulleyanines A and B (1 and 2), were isolated from Aconitum bulleyanum. Their structures were elucidated by comprehensive spectroscopic analyses including UV, IR, MS, 1D and 2D NMR. Biological activity tests indicated that compound 1 exhibited significant inhibitory activity against nitric oxide (NO) production in lipopolysaccharide (LPS)-activated RAW264.7 macrophages with the inhibition rate of 74.60% (40 μmol/L), while positive control dexamethasone gave 78.70% inhibition at 100 μg/ml.     

Diterpenoid alkaloids from Aconitum racemulosum Franch var. pengzhouense

A new diterpenoid alkaloid, racemulotine (1), was isolated from the whole plants of Aconitum racemulosum Franch var. pengzhouense, and its structure was elucidated by 1D-and 2D-NMR spectra.     

Two new norditerpenoid alkaloids from Delphinium potaninii

Further studies on the chemical constituents of Delphinium potaninii roots led to the isolation of two new lycoctonine-type norditerpenoid alkaloids, potanisines A (1) and B (3). The structures of these compounds were determined by interpretation of the spectroscopic data. They are the first examples of naturally occurring lycoctonine-type norditerpenoid alkaloids possessing an N-formyl moiety.     

A new diterpenoid alkaloid from Aconitum jaluense

A new diterpenoid alkaloid, jaluenine (1), has been isolated from the roots of Aconitum jaluense. The structure of jaluenine was determined by spectroscopic methods including two dimensional NMR (¹H-¹H COSY, HMQC, HMBC, NOESY).     

A new diterpenoid alkaloid from Aconitum jaluense

A new diterpenoid alkaloid, jaluenine (1), has been isolated from the roots of Aconitum jaluense. The structure of jaluenine was determined by spectroscopic methods including two dimensional NMR (¹H-¹H COSY, HMQC, HMBC, NOESY).     

Two new compounds from Aconitum tanguticum

A phytochemical investigation on the whole plant of Aconitum tanguticum (Ranunculaceae) resulted in the isolation and characterization of two new phenylpropanoid glycosides (1 and 2). Their structures were elucidated as 4-hydroxyphenethoxy-8-O-β-d-[6-O-(4-O-β-d-glucopyranosyl)-sinapoyl]-glucopyranoside (1) and 3,4-dimethoxy-trans-cinnamic acid-9-O-β-d-allopyranoside (2) on the basis of spectroscopic data (1D NMR, 2D NMR, and MS) and comparison with the literature data.