地榆升白片预防化疗引起骨髓抑制的临床观察

目的:观察地榆升白片对恶性肿瘤患者化疗引起的骨髓抑制的预防效果。方法:全组88例恶性肿瘤患者随机分为治疗组46例和对照组42例。治疗组在化疗同时服用地榆升白片,每次4片,每日3次,20 d为1个疗程。对照组化疗同时服用利血生和鯊肝醇,利血生片每次20 mg,鯊肝醇片每次100 mg,均每天3次,20 d为1个疗程。两组患者均完成2个周期化疗。结果:治疗组化疗后骨髓抑制发生率为37.0%,对照组为78.6%,两组比较有显著性差异(P<0.05),粒细胞集落刺激因子用量治疗组低于对照组,两组间有显著性差异(P<0.05),白细胞减少继发感染情况治疗组低于对照组。结论:地榆升白片能有效预防化疗引起的骨髓抑制。     

地榆升白片治疗恶性肿瘤化疗患者白细胞降低的研究

目的:研究地榆升白片在多种肿瘤化疗致白细胞减少症治疗中的临床疗效。方法:随机选取各种恶性肿瘤化疗患者96例,分为治疗组50例,对照组46例,治疗组采用地榆升白片治疗,对照组采用利血生片治疗。30d为1个疗程,共观察治疗2个疗程。结果:本组病例经地榆升白片治疗有效率达84.0%,明显高于对照组(P<0.05)。结论:地榆升白片系纯中药制剂,安全性好,治疗过程中无明显毒副作用,且价格低廉,为良好的升白细胞药物。     

地榆升白片用于化疗后白细胞减少症疗效观察

目的　观察地榆升白片对恶性肿瘤患者化疗后白细胞升高的效果。方法　选择恶性肿瘤患者 12 0例 ,用药前均有白细胞低下 ,随机分为治疗组 :72例 ,化疗同时服用升白片 ;对照组 :4 8例 ,化疗同时服用安慰剂。结果　用地榆升白片治疗总有效率为 86 .1% ,对照组为 5 2 .1% ,两组相比较差异有显著性统计学意义 (P<0 .0 1)。结论　地榆升白片对恶性肿瘤化疗后白细胞减少症有明显的治疗作用     

地榆升白片防治老年患者化疗后骨髓抑制的疗效观察

目的：观察地榆升白片防治老年患者化疗所致骨髓抑制的疗效。方法：将2006年5月～2011年3月我院收治的83例老年化疗患者随机分为实验组和对照组。实验组43例,患者化疗期间同时应用地榆升白片治疗;对照组40例,给予单纯化疗。观察两组骨髓抑制情况及生活质量变化。结果：实验组骨髓抑制发生率为46.51%,对照组骨髓抑制发生率为87.50%,实验组骨髓抑制发生率低于对照组（χ2=5.07,P〈0.05）;实验组生活质量下降率为9.30%,对照组生活质量下降率为27.50%,两组生活质量下降率比较差异有统计学意义（χ2=4.62,P〈0.05）。结论：地榆升白片能够防治老年患者化疗所致的骨髓抑制,并且减少化疗引起老年患者的生活质量下降。     

九一升白口服液结合化疗治疗恶性肿瘤疗效观察

目的观察九一升白口服液结合化疗治疗恶性肿瘤患者的临床疗效。方法将32例恶性肿瘤患者随机分为两组,九一升白口服液组(治疗组)为化疗加九一升白口服液(口服每次10ml,每日3次);对照组为化疗加鲨肝醇(200mg,每日 3次)、维生素 B4(20 mg,每日 3次)和利血生(每次20 mg,每日 3次),两组均用药4周后,对外周血细胞进行血常规和免疫指标的观察。结果治疗组三系细胞降低幅度较对照组小而回升较对照组为快(P<0.05)。结论 九一升白口服液无毒副作用,是一种较理想的能增强抗肿瘤疗效、缓解骨髓抑制、能升高白细胞的治疗药物。     

地榆升白片预防干扰素所致骨髓抑制的临床观察

目的：观察地榆升白片对干扰素治疗慢性乙型、丙型肝炎所致骨髓抑制的预防效果。方法：88例应用干扰素治疗的慢性乙型、丙型肝炎患者随机分为观察组46例,对照组42例;对照组患者应用α-2b干扰素500万单位,肌肉注射,隔日1次;丙型肝炎患者同时加服利巴韦林300～400mg/次,3次/d。观察组患者在对照组治疗基础上加用地榆升白片300mg/次,3次/d。治疗前及治疗后每周检查血常规1次,观察4周。同时观察地榆升白片的不良反应。结果：观察组骨髓抑制发生率为34.8%（16/46）,对照组为88.1%（37/42）,两组差异有非常显著性（P〈0.01）。其中轻度骨髓抑制发生率观察组为30.4%（14/46）,对照组为47.8%（22/42）,两组相比差异有显著性（P〈0.05）;需要干扰素减量的中度骨髓抑制发生率观察组为4.3%（2/46）,对照组为21.4%（9/42）,两组相比差异有显著性（P〈0.05）;需要停止干扰素治疗的重度骨髓抑制发生率观察组为0,对照组为14.2%（6/42）,两组相比差异有显著性（P〈0.05）。结论：地榆升白片可预防干扰素治疗慢性乙型、丙型肝炎所致骨髓抑制,效果显著,且价廉、方便,安全,值得推广使用。     

强力升白片加VitB4预防化疗后骨髓抑制的作用

目的：探讨一种预防化疗后骨髓抑制，维持白细胞稳定的经济实用的方法。方法：用强力升白片加VitB4对35例化疗病人进行辅助治疗，观察210疗程（观察组）。强力升白片（四川天府药业股份有限公司生产，纯中药制剂）每次4片，每日3次，VitB4每次20mg，每日3次，观察该组病人化疗后1－4周骨髓抑制的发生情况，并与38例未使用该组药物的化疗病人共228疗程（对照组）进行疗效分析。结果：观察组病人第4周骨髓抑制明显控制，观察组在化疗后1周的骨髓抑制发生率明显低于对照组，两间存在显差异（P＜0．01）。结论：强力升白片加VitB4对预防化疗后骨髓抑制，维持白细胞稳定具有较好的疗效，可作为基层医疗机构进行化疗治疗时常规辅助用药。     

恶性肿瘤化疗后骨髓抑制的病机及临床治疗体会

目的：对恶性肿瘤化疗后骨髓抑制的病机以临床治疗效果进行分析和探讨。方法：选取该院2013年4月至2015年4月收治的恶性肿瘤临患者60例并对临床资料进行回顾性分析，以随机方式将两组患者分为治疗组和对照组，每组均有患者30例。对照组患者采取常规化疗治疗方法，治疗组在对照组治疗方法基础上加入药物地榆升白片对患者进行治疗，经过治疗将两组患者治疗效果进行对比分析。全部恶性肿瘤患者所患疾病主要为大肠癌、胃癌、鼻咽癌以及肺癌。结果：经过治疗，对比两组患者的血小板以及血象的干甚情况，治疗组患者明显优于对照组（P＜0．05）。结论：给予化疗后的恶性肿瘤患者药物地榆升白片进行治疗，对患者骨髓抑制有着明显改善作用，同时加快患者康复的速度，在临床中值得推广和应用。     

地榆升白片治疗化疗病人白细胞减少症110例疗效观察

目的进一步验证中药新制剂地榆升白片对白细胞下降患者的治疗作用。方法将110例化疗后白细胞下降的患者随机分为治疗组和对照组,治疗组口服地榆升白片,对照组口服利血生加鲨肝醇,观察两组疗效。结果两组药物对化疗所致白细胞下降的患者,均有升高作用,且其疗效相近(P>0.05);但在临床症状改善方面,差异有统计学意义(P<0.05)。结论地榆升白片对化疗所致白细胞下降患者,确有升高其白细胞的作用,其疗效与利血生和鲨肝醇相近,但在改善患者临床症状方面,其疗效则优于对照组。     

早期应用G-CSF联合地榆升白片干预升白治疗在肿瘤化疗中的效果分析

目的:观察早期应用G-CSF联合地榆升白片干预升白治疗在肿瘤化疗中的疗效及安全性。方法:120例恶性肿瘤患者随机分成两组各60例,治疗组在化疗的同时给予地榆升白片治疗,结合血常规,早期预防性应用粒细胞集落刺激因子(G-CSF)升白治疗;对照组在化疗后出现Ⅱ度以上骨髓抑制才给予升白治疗,疗程6程。比较分析两组白细胞减少及生存质量情况。结果:治疗组化疗后出现白细胞减少12例(20%),Kps评分下降8例(12.5%),提高50例(83.33%),56例(93.33%)按期完成化疗;对照组化疗后出现白细胞减少33例(55%),Kps评分下降23例(38.33%),提高30例(50%),45例(75%)按期完成化疗,有2例因不良反应而中止化疗。两组比较差异有统计学意义(P<0.05)。结论:血常规指导下早期应用G-CSF联合地榆升白片干预升白治疗能显著减少肿瘤化疗后白细胞减少,保障化疗进行,提高生存质量,未发生严重不良反应。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.