探讨乙胺碘呋酮治疗心肌病合并心功能不全的临床效果

目的:探讨乙胺碘呋酮治疗心肌病合并心功能不全的临床效果。方法:针对90例心肌病合并新功能不全患者,在基础治疗手段相同、进行严密指数监控的前提下平均分为照常组和治疗组,对治疗组患者加之乙胺碘呋酮进行联合治疗,在对数据进行严格统计和分析以后,得出结果。结果:经过严密的数据统计和分析,得出结果,90例心肌病合并心功能不全患者在接受乙胺碘呋酮治疗以后,共有80例患者有所疗效,占总人数的88.88%。结论:乙胺碘呋酮治疗能够有效治疗心功能不全疾病,能够有效缓解患者痛苦。     

乙胺碘呋酮在心律失常中的治疗应用分析

目的探讨乙胺碘呋酮治疗心律失常的临床疗效。方法对160例随机筛选的以期前收缩为主的心律失常患者采用乙胺碘呋酮治疗,观察和记录患者治疗前后的血压、心率、疗效以及不良反应等情况。结果经治疗后,160例以期前收缩为主的心律失常患者的治疗总有效率为91.9%,治疗后血压、心率等情况明显改善,与治疗前比较,差异具有统计学意义(均P<0.05)。有1例患者在用药后出现血压降低,1例患者出现了心律恶化,2例患者出现窦性心动过缓的不良情况,但是经调整用药后很快恢复。结论乙胺碘呋酮治疗心律失常有着较好的临床效果,且无效率和恶化率较低,值得在临床上推广应用。     

乙胺碘呋酮治疗多源性房性心动过速的疗效观察

目的探讨乙胺碘呋酮治疗多源性房性心动过速的临床效果。方法将2010年1月-2012年3月收治的62例多源性房性心动过速患者随机分为两组,对照组患者给予常规治疗,试验组患者给予乙胺碘呋酮治疗,对比观察两组患者的疗效。结果试验组患者转为窦性心律快,患者复发率低,与对照组患者比较,差异明显,P<0.05;试验组与对照组不良反应对比差异不显著,P>0.05。结论乙胺碘呋酮治疗多源性房性心动过速的临床效果较好,值得应用。     

32例阵发性心房颤动患者的临床分析与治疗

目的:分析阵发性心房颤动患者的临床特点和治疗方法,提高患者的生活质量。方法:回顾分析收治的32例阵发性心房颤动患者临床资料,给予乙胺碘呋酮加卡托普利治疗,与单用乙胺碘呋酮组进行比较。结果:乙胺碘呋酮加卡托普利组疗效(90.6%)优于对照组(78.1%)(P<0.05)。结论:乙胺碘呋酮与卡托普利联合治疗阵发性房颤,安全有效,不良反应小,阵发性房颤控制率较高,适宜在临床推广应用。     

口服乙胺碘呋酮、心律平治疗老年人室性过早搏动的对比分析

本文报道221例老年人频发室性过早搏动患者,随机分为乙碘呋酮组和心律平组。进行临床疗效的对比观察。结果两组总有效率无显著差异(P>0.05),显效率心律平组显著优于乙胺碘呋酮组(P<0.01)。心律平用药前后心率减慢无明显差异(P>0.05),乙胺碘呋酮组用药后显著减慢(P>0.05)。乙胺碘呋酮组发生致命性心律失常3例,死亡2例。心律平组未发生严重副作用。两药比较心律平更适于老年人室性过早搏动的治疗。     

胺碘酮治疗顽固性室性心动过速的临床观察

胺碘酮(乙胺碘呋酮)属广谱抗心律失常药物,为各种心律失常合并有心功能不全治疗的首选药物.我院心内科于2000年1月～2005年1月应用大剂量胺碘酮静脉注射加口服治疗9例顽固性室性心动过速(室速)病人,现将临床用药及观察效果报告如下.     

乙胺碘呋酮治疗心律失常50例临床分析

目的探讨乙胺碘呋酮在心律失常的临床治疗效果,并总结乙胺碘呋酮的应用价值。方法对2011年3月—2012年3月收治的50例确诊为心律失常的患者进行随机分组,分别是观察组25例(采用乙胺碘呋酮进行治疗)与对照组25例(采用心律平进行治疗),并对两组治疗方法的临床疗效进行对比。结果经对比,观察组的临床疗效明显优于对照组,差异有统计学意义(P<0.05)。而两组药物副作用发生率相比,对照组明显高于观察组。结论在心律失常患者的临床治疗中应用乙胺碘呋酮进行治疗,不仅可提高对病情的临床疗效,还有效降低了副作用的发生率,有效改善患者的心律功能,相比心律平而言,更为安全可靠,值得在心律失常的临床治疗中推广应用。     

胺碘酮与美托洛尔治疗慢性心功能不全合并室性心律失常的疗效观察

目的:主要讨论了胺碘酮与美托洛尔治疗慢性心功能不全合并室性心律失常的临床效果。方法:选取我院收治的130例慢性心功能不全合并室性心律失常患者,随机将其分为观察组、对照组,其中观察组患者65例,接受胺碘酮联合美托洛尔治疗;对照组患者65例,单方面接受美托洛尔治疗,比较两组患者治疗效果。结果:在本次研究中,观察组治疗总有效率为93.85%(61/65),对照组治疗总有效率为80.0%(52/65),两组结果相比,差异具有统计学意义(P0.05)。结论:胺碘酮与美托洛尔在治疗慢性心功能不全合并室性心律失常中发挥着重要作用,应该在临床上做进一步推广。     

胺碘酮、美托洛尔及两者合用治疗慢性心功能不全合并室性心律失常的临床疗效

目的:探讨胺碘酮、美托洛尔及两者合用治疗慢性心功能不全合并室性心律失常的临床疗效。方法:选取150例慢性心功能不全合并室性心律失常患者,按照随机方法将其分为治疗一组、治疗二组和治疗三组,治疗一组患者采用胺碘酮联合美托洛尔进行治疗,治疗二组仅采用胺碘酮治疗,治疗三组仅采用美托洛尔进行治疗,比较三组患者1年后的治疗效果。结果:治疗一组的心功能改善情况明显优于治疗二组和治疗三组,对比结果差异有统计学意义(P<0.05)。同时治疗二组和治疗三组的心功能改善情况结果对比,差异无统计学意义(P>0.05)。结论:采用胺碘酮联合美托洛尔治疗慢性心功能不全合并室性心律失常患者,疗效好,能够明显改善患者的心功能情况,不良反应情况发生少,值得在临床上推广应用。     

心可舒联合乙胺碘呋酮治疗冠心病快速心房纤颤45例

目的:探讨冠心病快速心房纤颤心可舒联合乙胺碘呋酮治疗的临床疗效。方法:我院治疗的冠心病快速心房纤颤患者90例,随机分为观察组和对照组各45例。观察组患者采用心可舒和乙胺碘呋酮治疗,对照组患者采用心律平治疗。比较两组患者的临床疗效和不良反应。结果:观察组45例患者,总有效率为93.33%;对照组总有效率为91.11%。观察组患者的总有效率与对照组患者的总有效率相比,差异无统计学意义(P>0.05)。观察组患者的不良反应发生率明显低于对照组患者(P<0.05)。结论:心可舒与乙胺碘呋酮联合应用治疗冠心病快速心房纤颤,具有疗效确切、不良反应发生率低的特点。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.