血清尿酸与四年后血压变化及高血压发病的关系

目的　探讨中年人群血清尿酸(SUA)与四年后血压变化及高血压(HYP)发病的关系。方法　在1984年基线调查的35～59岁血压正常(低于135/85mmHg)、有SUA值的1656名男女中,1988年有1480人（男性609,女性871）参加了复查,以此为队列人群,观察高血压的发病率及血压变化。结果　随防四年高血压发病率为13.1%。无论男女,按尿酸四分位分析显示高血压发病率随分位数增加而升高。多元Logistic回归分析,当控制年龄后在男性SUA增加1个标准差（1.14mg/dl）是显著地增加HYP发病危险（HYP发病相对危险RR=1.40,95%可信限1.12～1.74）。当BMI、吸烟、饮酒和基线SBP加入模型,SUA与HYP发病的关系减弱但仍有统计学显著性（RR=1.28,95%可信限1.01～1.61）。多元线性回归分析,在男性基线年龄、SUA、BMI、和体重变化与4年的SBP变化呈正的显著关联。在女性SUA与高血压发病及血压变化均无显著关联。结论结果表明在男性SUA对血压升高及高血压发病是个独立于体重指数（BMI）、吸烟和饮酒的危险因素。     

血清尿酸与四年后高血压发病的关系-青岛港健康研究

目的 探讨青岛港职工的血清尿酸（SUA）与四年后高血压发病的关系.方法 在2000年基线调查的血压正常（低于135/85 mmHg）、有SUA值的5843名18～54职工中,2004年参加复查的有4688人（男 3115,女 1573）,以此为队列人群,观察高血压的发病率.结果 随访四年高血压发病率为13.0%.无论男女,按尿酸四分位分析显示高血压发病率随SUA水平增加而升高.采用多元Logistic回归分析,在调整年龄后,男性SUA水平最高的四分位组相对于最低四分位组的高血压相对危险度为2.14（95%可信限：1.63～2.81）;在女性组高血压的相对危险度为2.11（95%可信限：1.27～3.50）.当基线SBP、DBP、空腹血糖水平、TC、HDL-C、TG、降脂治疗、体重指数（BMI）、吸烟、饮酒加入模型,男性SUA与高血压发病的关系减弱但仍有统计学意义（RR=1.60,95%可信限：1.19～2.16）.在调整年龄后,男性四年前后SUA升高明显（升高值≥P75）者相对于升高不明显（升高值＜P25）者,高血压的发病危险增加（RR=2.42,95%可信限：1.53～3.81）.结论 SUA对高血压发病是个独立于空腹血糖水平、TC、HDL-C、TG、降脂治疗、BMI、吸烟、饮酒的危险因素.男性四年前后的SUA升高将增加高血压的发病危险.     

原发性高血压患者血清尿酸水平的变化

目的:分析原发性高血压患者血清尿酸(UA)水平的变化。方法:116例原发性高血压患者分为高血压老年组(71例)和高血压非老年组(45例),102例正常的健康体检者分为正常血压老年组(31例)和正常血压非老年组 (71例),测定血清UA水平。结果:高血压老年组UA水平明显高于正常血压老年组(P<0．05),高血压非老年组 UA水平明显高于正常血压非老年组(P<0．01)。结论:原发性高血压患者血清尿酸水平明显高于血压正常者,血清尿酸水平是反映高血压的一个指标。     

女性人群血清尿酸水平与高血压及高血压前期的关系

目的 探讨女性人群中血清尿酸水平与高血压及高血压前期的关系.方法 以苏州市金间区1884位女性常住居民为研究对象,调查吸烟、饮酒、家族史等情况,测量血压、身高、体质量及腰围,检测血糖、血脂和尿酸等指标.采用单因素和多因素分析方法,进行血尿酸与血压水平、高血压及高血压前期的关联性分析.结果 高血压组、高血压前期组、血压正...     

高血压并发脑卒中病人血清尿酸水平的分析

目的观察高血压并发脑卒中病人血清尿酸水平的变化.方法分析我院住院的298例高血压病病人,其中单纯高血压病病人150例,高血压并发脑卒中者148例,观察两组病人的血清尿酸水平,并进行比较.结果高血压并发脑卒中病人的血清尿酸水平明显高于单纯高血压病人（P＜0.01）,校正年龄、性别、高血压病程和其他危险因素（吸烟、糖尿病、高脂血症）,血尿酸仍与脑卒中的发生有明显相关性.结论血清尿酸升高,在高血压引发脑卒中的发生、发展中起到了一定的作用,尿酸升高是高血压并发脑卒中的独立危险因子.     

血清尿酸水平与高血压及高血压前期的关系

目的 探讨血清尿酸水平与高血压及高血压前期的关系.方法 以天津大港油田常住居民为研究对象,调查吸烟、饮酒、家族史等情况,测量血压、体质量及腰围,检测血糖、血脂和尿酸等指标.采用单因素和多因素分析方法,进行血尿酸与血压水平、高血压及高血压前期的相关性分析.结果 高血压组、高血压前期组、血压正常组的尿酸水平依次为331(273 ～ 389)、288(237 ～ 351)、240(202 ～ 293)μmol/L,3组间差异有统计学意义(P=0.000).尿酸水平处于第1、2、3、4分位者其收缩压分别为(120.8±15.7)、(123.6±14.6)、(125.1 ±14.6)、(129.4±15.8) mmHg,舒张压分别为(78.0±11.0)、(79.8±10.3)、(80.5±10.3)、(83.6±11.1)mmHg.随尿酸水平升高,患高血压前期和高血压的危险也升高,存在剂量—反应关系.与尿酸水平处于最低四分位者相比,调整了多因素后最高四分位者患高血压和高血压前期的危险比分别为3.393(95％CI2.192 ～5.252)、1.974(95％CI1.419 ～2.748).结论 高尿酸水平是高血压和高血压前期的独立危险因素.     

充血性心力衰竭患者血清尿酸浓度的变化及与高血压的关系

目的　观察充血性心力衰竭 (CHF)患者血清尿酸浓度的变化规律及与高血压的关系。方法　比较 CHF患者(77例 )与心功能代偿的心血管病患者 (5 4例 )的血清尿酸浓度 ;比较 CHF患者不同心功能状态下尿酸浓度 ;比较入院时用利尿剂及未用利尿剂患者的尿酸浓度 ;比较 18例 CHF患者心力衰竭控制前后的尿酸浓度 ;比较 CHF组中有高血压者 (30例 )与血压正常者 (4 7例 )的尿酸浓度。结果　 CHF组与心功能代偿组的血清尿酸浓度分别为(32 7.72± 98.5 7)和 (2 30 .6 4± 5 3.14) mmol/ L;CHF组心功能按 NYHA分级 、 、 级的尿酸浓度分别为(2 5 0 .2 6± 6 7.2 9)、(314.99± 77.6 0 )和 (4 0 9.0 6± 78.15 ) mm ol/ L;入院时用利尿剂及未用利尿剂患者的尿酸浓度无明显差异 (P>0 .0 5 ) ;18例 CHF患者心力衰竭控制前后的尿酸浓度分别为 [(34 3.71± 10 3.32 )和 (2 6 9.42± 87.6 5 )mm ol/ L (P<0 .0 5 ) ];CHF组中有高血压者与血压正常者的尿酸浓度分别为 (36 5 .74± 110 .6 6 )和 (30 3.45± 88.10 )mm ol/ L。结论　 CHF患者血清尿酸浓度增高 ,且随着心力衰竭加重而逐渐升高 ;CHF组中有高血压病者尿酸浓度高于血压正常者     

中国成年人血清尿酸与高血压前期的关系

目的 探讨中国成年人中血清尿酸水平与高血压前期的关系,评估年龄、肥胖、空腹血糖(FPG)和脂类对其影响.方法 对14 451例非高血压者的血压、BMI、FPG、血脂、血尿酸水平进行分析.结果 将血清尿酸水平按五分位法进行分层,校正相关因素后高血压前期风险的OR值随尿酸水平升高而升高.血清尿酸水平200～380 μmol/L,与高血压前期风险呈线性相关,200 μmol/L为这种线性相关的转折点,FPG可影响两者的相关性(P＜0.0001).结论 血清尿酸水平与高血压前期相关联,并独立于其他代谢危险因素.这种关联性在年长个体中差异无统计学意义.FPG可影响这种相关性.     

Association between serum uric acid level and hypertension in a Chinese elderly rural population

Previous studies have examined the association between elevated serum uric acid (SUA) level and hypertension; however, the association in the Chinese elderly is still uncertain. A cross-sectional study was performed in a rural district of Beijing. A total of 2,397 participants (967 men and 1,430 women) completed the survey. The SUA levels of participants were categorized into four levels using the quartiles (P25, P50, and P75) as cutoff values. Participant was diagnosed as hyperuricemia if the SUA level was ≥417 μmol/L (male) or ≥357 μmol/L (female). Hypertension was defined as systolic blood pressure (BP) ≥140 mmHg and/or diastolic BP ≥90 mmHg and/or receiving antihypertensive drug treatment. Multiple logistic regression was used to estimate the association between SUA and hypertension. We found that higher SUA level was associated with the increased risk of hypertension in both sexes, even after adjusting for potential confounding variables. In total, the risk for having hypertension increased by 0.3% per 1 μmol/L increment in SUA level, increased by 95% for the highest vs. lowest quartile of SUA level, and increased by 111% in the hyperuricemia patients. Moreover, we found that the association was more pronounced in the male participants. There were approximately J-shaped relationships between SUA level (quartiles) and hypertension in all age groups. Higher SUA levels are positively associated with hypertension among the Chinese rural elderly. Further studies are still required to determine the relationship between SUA level and hypertension and to explore its potential biological mechanisms underlying the gender-related association in the elderly population.

Abbreviations: CVD; cardiovascular disease; BMI: body mass index; BP: blood pressure; SUA: serum uric acid; TC: total cholesterol; TG: triglycerides; HDL-C: high-density lipoprotein; LDL-C: low-density lipoprotein; FPG: fasting blood glucose; OR: odds ratio; CI: confidence interval; SD: standard deviation     

老年高血压合并糖尿病患者血尿酸水平的临床观察

目的探讨老年高血压、糖尿病及高血压合并糖尿病患者的血尿酸(UA)水平。方法随机选择老年男性高血压36例、糖尿病33例、高血压合并糖尿病患者41例,对照组27例,比较4组血UA水平。结果3个试验组与对照组比较,血UA水平均明显升高,高血压合并糖尿病组差异显著(P<0.01);高血压合并糖尿病组与高血压组、糖尿病组比较均有显著性差异(P<0.01);高血压组与糖尿病组间无显著性差异。结论血UA水平与高血压、糖尿病密切相关。监测血UA水平有利于及时对原发病进行有效干预并改善其预后。     

Serum uric acid and its change with the risk of type 2 diabetes: A prospective study in China

ObjectiveTo assess the association of baseline uric acid levels and their changes from baseline to Year 1 with the risk of type 2 diabetes.Research design and methodsThis study cohort included 9471 subjects without a history of diabetes at baseline. The incident diabetes was diagnosed according to the American Diabetes Association standard.ResultsDuring a mean follow-up of 2.9 years, we identified 762 type 2 diabetes cases. Multivariate-adjusted hazard ratios (HRs) of diabetes across baseline tertiles of serum uric acid were 1.00, 1.15, and 1.32 (P for trend = 0.018), respectively. Participants with hyperuricemia compared with those without had a 1.20-fold (95% confidence interval [CI] 1.01−1.44) risk of diabetes. When uric acid was examined as a continuous variable, multivariable-adjusted HR of diabetes for each 1 mg/dL (60 μmol/L) increase in serum uric acid was 1.09 (95% CI 1.03−1.15). Compared with subjects with stable serum uric acid from baseline to Year 1 (±10%), those with uric acid gain ≥30% had a 30% (95% CI 1.01–1.79) increased risk of diabetes and those with uric acid loss ≥10% had a 21% (95% 0.62−0.99) decreased risk of diabetes. This positive association between baseline serum uric acid and diabetes risk was consistent among subjects younger and older than 45 years, non-obese and obese participants, and men.ConclusionsHigh level of baseline serum uric acid and serum uric acid gain from baseline to Year 1 are associated with an increased risk of type 2 diabetes among Chinese adults.     

Serum uric acid is independently associated with hypertension in patients with polymyositis and dermatomyositis

Serum uric acid (UA), as an antioxidant, has been associated with hypertension in the general population. Hypertension is highly prevalent in patients with polymyositis and dermatomyositis (PM/DM). Owning elevated levels of reactive oxygen species, patients with PM/DM have lower concentrations of UA in comparison with healthy people. We explored a potential association between UA levels and hypertension in PM/DM and evaluated whether this association is independent of hypertension risk factors, PM/DM characteristics and relevant drugs. A total of 472 PM/DM patients were assessed. UA and related laboratory data were measured. Demographic, hypertension-related factors, PM/DM characteristics and drug use were assessed as potential covariates. Results were analyzed using logistic models to test the independence of the association between UA and hypertension. UA levels were higher in hypertension subjects compared to non-hypertensive PM/DM patients [284.70 (239.93-357.38) vs 264.00(222.50-322.75), p = .017]. When adjusted for hypertension risk factors, PM/DM characteristics and drugs, the odds of being a hypertensive PM/DM patient per 1 μmol/L UA increase were significantly increased: odds ratio = 1.473 (95% confidence interval:1.063-2.042, p = .020). This cross-sectional study suggests that UA levels are independently associated with hypertension in PM/DM patients.     

血脂正常原发性高血压患者血尿酸水平与颈动脉粥样硬化的关系

目的探讨血脂正常原发性高血压患者血尿酸水平与颈动脉粥样硬化(carotid atherosclerosis,CAS)斑块及硬化程度的关系。方法选择血脂正常的原发性高血压患者288例,行颈动脉彩色多普勒超声检查,测量左右颈动脉内膜中层厚度,根据测量结果分为斑块组(104例)和无斑块组(184例),将患者CAS程度分为0～4级,所有患者测血脂、血尿酸水平。结果斑块组血尿酸浓度明显高于无斑块组(481 μmol/L vs 289μmol/L,P0.05)。斑块组高尿酸血症发生率较无斑块组明显增高(66.2% vs 13.8%,P0.05)。与CAS 3级患者比较,CAS 0级、1级患者血尿酸水平明显下降;与CAS 4级患者比较,CAS 0级、1级、2级患者血尿酸水平明显下降,差异有统计学意义(P0.05)。结论血脂正常的原发性高血压患者中,CAS斑块形成可能与血尿酸水平升高有关,CAS程度愈高,其相关性愈大。     

血尿酸与心房颤动研究进展

心房颤动(房颤)是临床上最常见的心律失常之一,同时也增加了心血管疾病和脑卒中的患病风险。既往研究表明氧化应激与房颤的发生发展、预后及复发均存在相关性,尿酸作为一种氧化应激标志物,由于具有安全、廉价及方便的检测特性,它可以更好地帮助临床医师对发生房颤的高危人群进行早期诊断、疗效判断和预后评估,在临床上具有较好的应用前景。     

Related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia

Objective: To investigate the related factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. Methods: One hundred and ten patients with primary hypertension and hyperhomocysteinemia (homocysteine levels >10 μmol/L) were enrolled into this study, ages from 18 years to 75 years. They were divided into the normal serum uric acid group which contained 74 cases patients (41 cases of male and 33 cases of female) and the hyperuricemia group which contained 36 cases patients (20 cases of male and 16 cases of female). Plasma concentrations of homocysteine, serum uric acid, serum folic acid, blood sugar, triglyceride, total cholesterol, serum low density lipoprotein cholesterol, serum high density lipoprotein cholesterol, blood urea nitrogen, and creatinine were detected in these patients, and the deference of them between the two groups was compared. And then the risk factors of serum uric acid with univariate analysis and multivariate analysis by logistic regression analysis were analyzed. Results: The result of multivariate analysis showed that the incidence of serum uric acid in patients with primary hypertension and hyperhomocysteinemia had significant relationships with systolic blood pressure (OR [odds ratio]: 1.132, 95%CI [confidence interval]: 1.003~1.290, p = 0.043), diastolic blood pressure (OR: 1.353 95%CI: 1.023~1.789, p = 0.034, homocysteine (OR: 1.264, 95%CI: 1.016~1.573, p = 0.035), triglyceride (OR: 9.726, 95%CI: 1.288~73.466, p = 0.027), and creatinine (OR: 1.031, 95%CI: 1.005~1.508, p = 0.018). Conclusion: The indices of systolic blood pressure, diastolic blood pressure, homocysteine, triglyceride, and creatinine were important risk factors of serum uric acid in patients with primary hypertension and hyperhomocysteinemia. It is of great significance to measure multiple risk factors in patients with primary hypertension and hyperhomocysteinemia.     

Relationship between serum uric acid and hypertension in patients with primary Sjögren's syndrome: A retrospective cohort study

Primary Sjögren''s syndrome (pSS) patients with hypertension (pSS‐HT) have a significantly increased risk of cardio‐cerebrovascular events. Serum uric acid (SUA), a potential inflammatory substance, is considered to be closely related to hypertension in the general population. Our aim is to assess the association between SUA and pSS‐HT. This is a retrospective cohort study. The diagnosis of pSS is based on the American European Consensus Classification criteria. Primary outcome was incident hypertension in pSS patients. Cox regression model was used to estimate the hazard ratios (HR) and 95% CI of SUA in pSS‐HT. The authors also plotted Kaplan–Meier plots to assess the cumulative risk of first hypertension in patients with hyperuricemia and normal uric acid. In addition, the dose‐response curve was also used to discuss the relationship between SUA and pSS‐HT. Finally, three hundred and fifty‐one pSS patients were enrolled from May 2011 to May 2020, of which 166 cases developed hypertension within a mean follow‐up of 3.91 years. Univariate Cox regression demonstrated that SUA was associated with the onset of hypertension in pSS (HR: 1.005 95%Cl: 1.002–1.009). After adjusting for the potential risk factors, the relationship remained unchanged (HR: 1.003, 95%Cl: 1.001–1.005). Kaplan‐Meier survival analysis showed a statistically significant difference of hypertension risk between hyperuricemia patients and normal uric acid patients (P = .026). There was also a significant dose‐effect relationship between SUA and hypertension in pSS in dose‐response model. In this study, the authors find that SUA may be closely associated with the development of hypertension in pSS, which is also confirmed by our dose‐response model. Therefore, SUA could be considered in the management of pSS‐HT.