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High neutrophil‐to‐lymphocyte ratio predicts worse overall survival in patients with advanced/metastatic urothelial bladder cancer 下载免费PDF全文
Yu Guang Tan Ernest Wen Cong Eu Hong Hong Huang Weber Kam On Lau 《International journal of urology》2018,25(3):232-238
Objectives
To study the role of the neutrophil‐to‐lymphocyte ratio in predicting survival outcomes for patients with advanced bladder cancer.Methods
We retrospectively reviewed 150 patients diagnosed with advanced or metastatic bladder cancer between January 2004 and June 2014. The neutrophil‐to‐lymphocyte ratio was computed on diagnosis and after the first cycle of chemotherapy. A neutrophil‐to‐lymphocyte ratio cut‐off of 3.0 was determined, with a concordance index of 0.89. Kaplan–Meier curves, log–rank tests, Cox proportional hazards and logistic regression models were used to predict the association of the neutrophil‐to‐lymphocyte ratio with survival outcomes.Results
Just five patients were alive at the end of the study; the rest died from metastatic bladder cancer. On multivariate analysis, higher Eastern Cooperative Oncology Group status, lymphadenopathy, visceral metastases and neutrophil‐to‐lymphocyte ratio ≥3.0 were associated with poorer overall survival (hazard ratio 1.67, P = 0.03; hazard ratio 1.97, P = <0.01; hazard ratio 2.02, P = <0.01; hazard ratio 5.06, P = <0.01), whereas chemotherapy conferred better overall survival (hazard ratio 0.546, P = 0.01). Furthermore, the role of chemotherapy prolonged survival longer in patients with a neutrophil‐to‐lymphocyte ratio <3.0 (median overall survival 13.0 vs 22.0 months, hazard ratio 0.273, P = 0.008) compared with a neutrophil‐to‐lymphocyte ratio ≥3.0 (median overall survival 4.0 vs 7.0 months, hazard ratio 0.452, P = 0.020). More importantly, when dichotomized to the four different pre‐ and post‐chemotherapy groups, patients with a pre‐ and post‐chemotherapy neutrophil‐to‐lymphocyte ratio <3.0 had the best additional median overall survival of 19.0 months compared with patients with a pre‐ and post‐chemotherapy neutrophil‐to‐lymphocyte ratio ≥3.0 (3.0 months).Conclusions
Elevated neutrophil‐to‐lymphocyte ratio is independently associated with poorer chemotherapeutic response and overall survival in patients with advanced or metastatic bladder cancer. The neutrophil‐to‐lymphocyte ratio can be an inexpensive novel factor in prognosticating disease progression and providing better patient counseling. 相似文献2.
High neutrophil‐to‐lymphocyte ratio predicts poor clinical outcome in patients with castration‐resistant prostate cancer treated with docetaxel chemotherapy 下载免费PDF全文
Akihisa Yao Takehiro Sejima Hideto Iwamoto Toshihiko Masago Shuichi Morizane Masashi Honda Atsushi Takenaka 《International journal of urology》2015,22(9):827-833
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Various studies have been reported to predict the success of varicocelectomy. Neutrophil‐lymphocyte ratio (NLR) is a frequently used indicator of systemic inflammation. We aimed to evaluate the effect of inflammation on the success of varicocelectomy using the NLR. The data of 86 patients who underwent varicocelectomy for infertility were evaluated retrospectively. Pre‐operative demographic characteristics of patients, laboratory results such as haemogram, and semen analysis and clinical data were recorded. The semen analysis with the highest total motile sperm count was accepted as pre‐operative value. Control was performed with semen analysis at post‐operative 6th month. As described in previous studies, in our study, more than 50% increase in total motile sperm count in post‐operative semen analysis was defined as a significant improvement. However, at least a 100% increase was required for patients with a total motile sperm count <5 million in the definition of recovery. Patients were divided into two groups as those with improvement in the semen parameters (Group 1) and those without (Group 2). NLR was statistically significantly higher in Group 2 compared with Group 1. The area under the curve (AUC) in the ROC curve for NLR was 0.89. According to the Youden index, the best cut‐off value of NLR for varicocelectomy success was 1.98 (sensitivity: 94.7%, specificity: 75.9%, p < 0.001). Logistic regression analysis showed that NLR (odds ratio: 3.6, 95% confidence interval: 1.69–8.38, p < 0.001) is independent predictor factors in predicting the success of varicocelectomy. The results of this study show that systemic inflammation adversely affects the likelihood of improvement in sperm parameters by varicocelectomy. Additionally, NLR has been shown to be an independent factor in the prediction of varicocelectomy success. 相似文献
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Prognostic value of pretreatment peripheral blood markers in paranasal sinus cancer: Neutrophil‐to‐lymphocyte and platelet‐to‐lymphocyte ratio 下载免费PDF全文
Mario Turri–Zanoni MD Giovanni Salzano MD Alessia Lambertoni MD Marta Giovannardi MS Apostolos Karligkiotis MD Paolo Battaglia MD Paolo Castelnuovo MD 《Head & neck》2017,39(4):730-736
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Pretreatment neutrophil‐to‐lymphocyte ratio as an independent predictor of survival in patients with metastatic urothelial carcinoma: A multi‐institutional study 下载免费PDF全文
Satoru Taguchi Tohru Nakagawa Akihiko Matsumoto Yasushi Nagase Taketo Kawai Yoshinori Tanaka Kanae Yoshida Sachi Yamamoto Yutaka Enomoto Yorito Nose Toshikazu Sato Akira Ishikawa Yukari Uemura Tetsuya Fujimura Hiroshi Fukuhara Haruki Kume Yukio Homma 《International journal of urology》2015,22(7):638-643
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To examine the relation between NLR (neutrophil–lymphocyte ratio) and PLR (platelet–lymphocyte ratio) rates and the severity of ED (erectile dysfunction) and the effect of tadalafil 5 mg/day on these, a total of 143 patients were retrospectively evaluated. Sixty‐three patients with ED who came for follow‐up examinations in the 1st month of the treatment were included as the study group, and 80 men who were not diagnosed with ED were as the control group. The age and Charlson Comorbidity Indexes (CCI) of the study and control groups were compared with the IIEF 5, NLR and PLR values before and after the treatment. The mean age and median CCI were higher in the severe ED group (p < 0.05). The mean NLR and PLR values were lower in the control group (p < 0.001). In the study group, the NLR and PLR values decreased with the increase in the IIEF 5 scores (p < 0.001). The ROC curve was significant for the NLR and PLR scores (AUC = 0.779, [95% CI: 0.698–0.860]; AUC = 0.754, [95% CI: 0.670–0.838] p < 0.001). Although more prospective and randomized studies are needed, the systemic inflammation decreases and the clinical symptoms improve in patients who use tadalafil 5 mg/day. 相似文献
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The pretreatment neutrophil‐lymphocyte ratio may predict prognosis of patients with liver cancer: A systematic review and meta‐analysis 下载免费PDF全文
Guang‐Tao Min Yu‐Min Li Nan Yao Jun Wang Hong‐Peng Wang Wei Chen 《Clinical transplantation》2018,32(1)
Background
At present, several studies have reported that the pretreatment neutrophil‐lymphocyte ratio (NLR) may be associated with the prognosis of liver cancer. Nevertheless, their conclusions remain controversial. Thus, we performed a meta‐analysis of 54 studies to evaluate the prognostic value of NLR.Method
Databases including PubMed, Embase, Cochrane Library, and Web of Science were searched to July 2017.Result
A total of 54 studies including 12 979 patients were included in this meta‐analysis. Elevated NLR had a close relationship with the overall survival (OS) (HR 1.52; 95% CI 1.39‐1.67), recurrence‐free survival (RFS) (HR 1.84; 95% CI 1.48‐2.30), and disease‐free survival (DFS) (HR 1.71; 95% CI 1.39‐2.11) of liver cancer, respectively. In addition, elevated NLR was associated with the presence of tumor vascular invasion (OR 2.35; 95% CI 1.93‐2.86), multiple tumors (OR 1.38; 95% CI 1.15‐1.66), alpha‐fetoprotein ≥ 400 ng/mL (OR 1.51; 95% CI 1.15‐1.98), presence of HbsAg (+) (OR 0.68; 95% CI 0.51‐0.90), and cirrhosis (OR: 0.59; 95% CI 0.44‐0.80).Conclusion
This meta‐analysis indicated that elevated NLR may be an effective and noninvasive indicator for prognosis of patients with liver cancer. 相似文献11.
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Pretreatment hematologic markers as prognostic factors in patients with nasopharyngeal carcinoma: Neutrophil‐lymphocyte ratio and platelet‐lymphocyte ratio 下载免费PDF全文
Wei Sun MD Linli Zhang MD Min Luo MD Guangyuan Hu MD Qi Mei MD Dongbo Liu MD Guoxian Long MD Guoqing Hu MD 《Head & neck》2016,38(Z1):E1332-E1340
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Aim Previous studies have demonstrated that raised preoperative neutrophil to lymphocyte ratio (NLR) is associated with poor prognosis in colorectal cancer (CRC). The aim of this study was to assess whether preoperative NLR could predict patients at risk of recurrence of CRC. Method All consecutive patients who underwent surgical resection for CRC over a 2‐year period at our institution were analysed. Demographic data including CRC recurrence were prospectively collected from our institutional cancer database. CRC recurrence was diagnosed on radiological and endoscopic histopathological data. Preoperative NLR was calculated on baseline blood results, with a value >5 being a poor prognostic factor. Parametric survival analysis was used to identify risk factors for CRC recurrence. Hazard ratios (HRs) were calculated for gender, CRC stage using Jass score, preoperative NLR and CRC site. P < 0.05 was considered statistically significant. Results In all, 297 patients (157 men) underwent CRC resection at a median age of 70 years (range 23–93); 164 patients had colon cancer, 111 rectal cancer and 22 recto‐sigmoid cancer. The distribution by stage of CRC was 30.2% for stage 1, 23.8% for stage 2, 19.5% for stage 3 and 26.5% for stage 4. Over a median follow‐up period of 3.35 (0.1–8) years, 59 (19.8%) patients had recurrent CRC. Multivariate analysis revealed CRC stage (HR 8.69, 95% CI 3.85–19.6, P < 0.0001) and NLR >5 (HR 1.81, 95% CI 1.07–3.07, P = 0.028) to be significant and independent risk factors predictive of recurrent CRC. Conclusion These data suggest that preoperative NLR >5 is predictive of CRC recurrence. 相似文献
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Pretreatment lymphocyte‐to‐monocyte ratio as an independent prognostic factor for head and neck cancer 下载免费PDF全文
Satoshi Kano MD PhD Akihiro Homma MD PhD Hiromitsu Hatakeyama MD PhD Takatsugu Mizumachi MD PhD Tomohiro Sakashita MD PhD Tomohiko Kakizaki MD Satoshi Fukuda MD PhD 《Head & neck》2017,39(2):247-253
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