富含巨细胞的骨肉瘤放射鄄病理讨论

病例男,13岁,江苏人。左侧膝部疼痛5个月。左膝关节正侧位片显示左胫骨近侧干骺端破坏性病变(图1)。在当地医院行病灶刮除和异体骨植入术,病理诊断为巨细胞瘤。术后疼痛加剧,并出现软组组织肿胀。3个月后再摄左膝关节正侧位片示左胫骨上端病变的范围更大、骨质破坏和骨皮质中断更明显,并出现软组织肿块(图2),转我院诊治。病理学观察病变由大量巨细胞和单个核细胞构成(图3)。巨细胞的形态似破骨细胞;单个核细胞较肥硕,似上皮样,核大小不一,染色深,高度异型,分裂相多(图4～6)。局部肿瘤细胞间有嗜伊红的不规则骨样基质形成,部分区域为典型毛细…     

巨细胞型骨肉瘤1例

巨细胞型骨肉瘤是骨肉瘤的一种罕见类型，病理学上易误诊为骨巨细胞瘤。文献报道甚少，本院最近遇1例．经手术病理证实，报告如下。     

富于巨细胞的骨肉瘤1例报道并文献复习

目的探讨富于巨细胞的骨肉瘤的临床、影像学、病理学特点,以提高诊治水平。方法通过影像学、组织学及免疫组织化学对富于巨细胞的骨肉瘤进行观察,总结其特点,并结合文献加以分析。结果富于巨细胞的骨肉瘤呈溶骨性破坏,有大量破骨细胞样巨细胞且分布均匀,与出血无空间关系。背景为成骨性骨肉瘤。免疫组化示破骨细胞样巨细胞、少量组织细胞样单核细胞CD68( ),异型性单核细胞及瘤巨细胞CD68(-);所有细胞vimentin( ),CK、S-100、CD34(-)结论富于巨细胞的骨肉瘤属罕见病例,在影像学、组织学上极易误诊,诊断依赖临床、影像学、病理学三方面的结合。     

富巨细胞骨肉瘤一例报告

富于巨细胞的骨肉瘤,是指破骨细胞样巨细胞数量异常增多以至于几乎掩盖了作为肿瘤本质的肉瘤成分,形成类似骨巨细胞瘤的组织学图像。骨肉瘤中约有25％的病例伴有破骨细胞样细胞出现,但真正以大量破骨细胞样巨细胞出现骨巨细胞瘤样组织像的并不多见。此类骨肉瘤有大量破骨细胞样巨细胞的出现,无论在X线片上还是在组织学上极易误诊为骨巨细胞瘤。作者诊治一例,现总结报道如下。     

富含巨细胞的骨肉瘤放射-病理讨论

男，13岁，江苏人，左侧膝部疼痛5个月。左膝关节正侧位片显示左胫骨近侧干端破坏性病变（图1），在当地医院行病时刮除和异体针植入术，病理诊断为巨细胞瘤，术后疼痛加剧。并出现软组织肿胀，3个月后摄左膝关节正侧位片示左胫骨上端病变的范围更大，骨质破坏和骨皮质中断更明显，并出现软组织肿块（图2），转我院诊治。     

婴儿纤维母细胞型骨肉瘤1例

病例患儿 ,男 ,１ ３１２ 岁。出生后即发现右上臂下段包块 ,形如鸡蛋大小 ,就诊我院诊断为骨肿瘤。由于婴儿太小 ,不宜手术。尔后包块进行性长大。４个月后患儿就诊重庆医大儿童医院 ,因Ｈｂ６８ ５ｇ／ｌ不能耐受手术出院。三月前患儿再次就诊重庆医大儿童医院 ,先后两次摄右肱骨片 ,可见溶骨性破坏 ,病变进展明显。经会诊诊为恶性肿瘤 ,建议做活检明确诊断后行截肢手术。后入我院治疗。体检 :右上臂畸形肿大呈纺锤状（图１） ,扪及１３ｃｍ×１６ｃｍ巨大包块 ,质硬 ,无压痛。皮下浅静脉怒张。右肘关节屈伸活动受限。Ｘ线表现 :右肱骨中…     

斜坡巨细胞修复性肉芽肿1例

患儿男,16岁,无明显诱因左耳听力下降2年、间歇性头痛1年余,未经处理.查体:右眼鼻侧偏盲;外耳道无异常,听力未测.实验室检查:血清生长激素9.49 ng/ml.头颅平扫CT:斜坡及鞍区见团块状稍高欠均匀密度肿块,内见线状及小片状骨化影;斜坡、前床突及后床突骨质不完整(图1A).头颅MRI:斜坡内见团块状等T1、等及稍...     

巨细胞动脉炎的护理

巨细胞动脉炎（giant cell arteritis,GCA）是一种原因不明,主要累及大中动脉的系统性血管炎,多发生于50岁以上人群,是欧美国家最常见的血管炎。本病主要临床表现为发热、头痛、间歇性咀嚼困难、视力下降,伴有失眠、乏力、关节酸痛、血沉明显增高等。近年来在我国有关本病亦有报道。     

甲氨蝶呤对骨肉瘤细胞株的作用观察

目的研究甲氨蝶呤(MTX)对体外培养骨肉瘤细胞株(HOS)生长的影响及端粒酶活性方面的作用。方法采用MTT法检测不同浓度的甲氨蝶呤对骨肉瘤细胞株(HOS)生长作用;TRAP-PCR-ELISA法检测端粒酶活性的变化。结果甲氨蝶呤对骨肉瘤细胞株(HOS)有生长抑制作用,且呈时间,浓度依赖性。甲氨蝶呤可以降低骨肉瘤细胞株(HOS)端粒酶活性。结论甲氨蝶呤对体外培养骨肉瘤细胞株(HOS)的生长及端粒酶活性有抑制作用。     

Giant cell tumor of a tendon sheath mimicking an axillary lymph node

A giant cell tumor of the tendon sheath (GCTTS) is 1 of the most common soft‐tissue tumors of the hand and wrist, while the 2nd most frequent site is the ankle‐foot complex. Although various solid tumors can develop in the axilla, GCTTS has not yet been reported. We describe the sonographic appearance of GCTTS in the axilla. © 2010 Wiley Periodicals, Inc. J Clin Ultrasound 2010     

喉巨细胞瘤的临床病理分析

目的：探讨喉巨细胞瘤的临床病理学特征及诊断、鉴别诊断要点。方法：报道1例喉巨细胞瘤,结合文献对其临床表现、影像学情况、病理形态学特点及鉴别诊断进行分析和探讨。结果：巨细胞瘤好发于长骨末端,约5％累及扁骨,不足5％的病例累及手足部的短管状骨,2％发生于头颈部。喉巨细胞瘤极罕见,发病平均年龄为42．4岁,男性多见。本例34岁,男性,左侧声门下3cm×2cm×2cm肿块。镜下表现为圆形、卵圆形单核细胞及均匀分布其间的破骨细胞样巨细胞混合组成。结论：喉巨细胞瘤罕见,临床易误诊为恶性肿瘤,其病理学检查有特征性形态改变,结合影像学改变,可以确诊。     

MCAM is associated with metastasis and poor prognosis in osteosarcoma by modulating tumor cell migration

BackgroundAlthough there are standard treatment options for osteosarcoma (OS), the prognoses of patients with OS remain varied. Therefore, it is important to profile OS patients at a high risk of mortality to develop focused interventions. Although tumor biomarkers are closely associated with clinical outcomes, data on prognostic biomarkers for OS remain scarce.MethodsWe collected RNA expression profiles and clinical data of 90 OS patients from the GEO database (dataset {"type":"entrez-geo","attrs":{"text":"GSE21257","term_id":"21257"}}GSE21257 and {"type":"entrez-geo","attrs":{"text":"GSE39055","term_id":"39055"}}GSE39055) and 96 patients in the TARGET program. The data were analyzed using univariate Kaplan‐Meier survival analysis to screen candidate gene sets that might be associated with OS survival.ResultsOur analysis demonstrated that melanoma cell adhesion molecule (MCAM) was associated with overall survival of patients with OS in the three cohorts. The data showed that MCAM was upregulated in OS patients who had metastases within 5 years compared to those without metastases. GO analysis revealed that genes correlated with MCAM were mainly involved in cell migration and wound healing processes. In addition, wound healing assays and gene set enrichment analysis results from RNA sequencing data of small interfering (si)‐MCAM‐transfected OS cells demonstrated that MCAM modulated tumor cell migration.ConclusionsOur data demonstrate that MCAM may be a novel prognostic biomarker for OS. MCAM is associated with increased cell migration ability and risk of metastasis, thus leading to poor prognoses in OS patients.     

Giant cell arteritis on 18F‐FDG PET/CT

Purpose: We present a case of incidentally noted giant cell arteritis in a patient undergoing 18F‐fluorodeoxyglucose (FDG) positron emission tomography (PET)/CT imaging. The patient was originally referred to PET/CT for staging of his renal transitional cell carcinoma. Methods: The patient was injected intravenously with 370 MBq of 18F‐FDG. After a 60 min uptake period, PET/CT imaging was performed from the skull base to the mid thighs. Results: A small para‐aortic node in the region of the surgical bed showed increased tracer uptake of concern for malignancy. In addition, there were several non‐calcified pulmonary nodules present, also concerning for malignancy. Incidentally noted was diffusely increased tracer uptake throughout the aorta and a thickened aortic wall on CT images. Diffuse tracer uptake was also present in the proximal branches of the aorta, including the carotid, iliac, femoral, and subclavian arteries. The patient had biopsy proven giant cell arteritis. Conclusion: Increased 18F‐FDG uptake by the aorta on PET/CT imaging is an abnormal finding that prompts a more thorough assessment for malignancy, and also can indentify important co‐morbidities in cancer patients. Evaluation of aortic uptake should be a routine practice in the interpretation of 18F‐FDG PET/CT scans.