Distance from the growth plate and Its relation to the outcome of unicameral bone cyst treatment

Background  

Interventions to treat unicameral bone cysts vary. Nonetheless, regardless of the intervention modality, the outcome is not certain. The purpose of this study was to determine if the distance between the growth plate and the cyst can be used to predict the outcome of the treatment.     

异体骨移植结合中药治疗儿童孤立性骨囊肿

在儿童孤立性骨囊肿的治疗中,骨移植是常用方法.但骨移植的来源较困难,异体骨又存在愈合慢,有排异反应等缺点.自1994年5月至1999年4月,我们采用异体骨植骨结合中药治疗该病7例,疗效满意,现报告如下.     

肝胰十二指肠切除术治疗胆囊癌疗效的系统评价

目的 系统评价肝胰十二指肠切除术治疗胆囊癌的疗效.方法 检索中国知网、万方数据、PubMed、Embase等数据库关于肝胰十二指肠切除治疗胆囊癌的随机对照试验(RCT)、非随机对照研究、非随机实验性研究、病例对照研究、队列研究、案例系列研究等,各数据库检索时间均由建库至2019年12月.由两位学者按照纳入与排除标准筛选...     

Economic evaluation of bone stimulation modalities: A systematic review of the literature

Various bone stimulation modalities are commonly used in treatment of fresh fractures and nonunions; however, the effectiveness and efficiency of these modalities remain uncertain. A systematic review of trials evaluating the clinical and economical outcomes of ultrasounds, electrical stimulation, and extracorporeal sound waves on fracture healing was conducted. We searched four electronic databases for economic evaluations that assessed bone stimulation modalities using ultrasound therapy, electrical stimulation, or extracorporeal shock waves. In addition, we searched the references and related articles of eligible studies, and a content expert was contacted. Information on the clinical and economical outcomes of patients was independently extracted by reviewers. Fourteen studies met the inclusion criteria; therefore, very limited research was found on the cost associated with treatments and the corresponding outcomes. The data available focus primarily on the efficacy of newly introduced treatment methods for bone growth, but failed to incorporate the costs of implementing such treatments. One economic analysis was identified that assessed different treatment paths using ultrasound. A total cost savings of 24–40% per patient occurred when ultrasound was used for fresh fractures and nonunions (grade C recommendation). The results suggest that the ultrasound is a viable alternative for bone stimulation; however, the impacts of the other modalities are left unknown due to the lack of research available. Methodological limitations leave the overall economic and clinical impact of these modalities uncertain. Large, prospective, randomized controlled trials that include cost-effectiveness analyses are needed to further define the clinical effectiveness and financial burden associated with bone stimulation modalities.     

Steroid injection of a unicameral bone cyst of the calcaneus: literature review and two case reports

Two interesting cases are presented, describing the diagnosis and treatment of unicameral bone cysts of the calcaneus. The first case report presents a patient who had a 5-month history of a painful right heel. The pain had been getting progressively worse and was aggravated by prolonged walking and physical activity. The second case report presents a patient whose unicameral bone cyst was discovered as a relatively incidental finding on radiographs; however, the patient later admitted that he had mild tenderness upon the plantar-lateral aspect of his right calcaneus with weightbearing. The authors reviewed the literature concerning the etiology and treatment of unicameral bone cysts. Attention is directed to the use of injectable steroid as an alternative means to open surgical intervention. Certain potential problems exist, in spite of the various surgical approaches utilized, including infection, postoperative fracture, recurrence, immobilization, and prolonged hospitalization.     

髋臼邻关节骨囊肿的诊断与治疗

目的 探讨髋臼邻关节骨囊肿的诊断、鉴别诊断与治疗方法.方法 回顾性分析1990年8月至2009年4月收治的19例髋臼邻关节骨囊肿患者的I临床资料,男11例,女8例;年龄18～59岁,平均42.3岁.17例有髋关节酸痛不适症状,病程2个月至20年,中位时间为15个月.X线片均显示髋臼负重区近侧椭圆形或圆形溶骨性病变,紧贴软骨下骨,边界清晰,伴有硬化边缘.5例合并髋关节发育不良.刮除病变后予以髂骨植骨14例、异体松质骨颗粒植骨3例、人工骨植骨2例.结果 术前18例确诊,14例依据X线片确诊,4例依据CT和MRI确诊.另1例诊断为单纯性骨囊肿.病灶长径2～4cm者16例,4～8 cm者3例,病灶大小与是否有症状及病程长短无关.17例病灶位于髋臼负重面前上方,2例位于髋臼后上方.全部病例随访11个月至13年,平均6.2年,无囊肿复发.14例无症状,3例偶有髋部不适,2例髋关节发育不良者症状先改善后加重,出现关节间隙狭窄.结论 刮除植骨治疗髋臼邻关节骨囊肿有效,其影像学上病灶分布特点表明病灶发生与应力集中有关.     

Prognostic Factors and Optimal Treatment Strategy for Intrahepatic Nodular Recurrence After Curative Resection of Hepatocellular Carcinoma

Background Intrahepatic recurrence is a major problem after curative resection of hepatocellular carcinoma. However, the most effective treatments for patients with intrahepatic recurrence still remain unclear. In addition, the selection of various treatment modalities such as repeat resection, local ablation therapy, and transarterial chemoembolization is only applicable to patients with intrahepatic nodular recurrence. Methods Of 353 patients who underwent curative resection, 97 patients with intrahepatic nodular recurrence were retrospectively studied. The prognostic factors for survival after recurrence and treatment modalities were analyzed. The patients were divided into two groups, a control group and a progression group, according to their response to initial treatment for recurrent tumors. Results The 1-, 3-, and 5-year overall survival rates after recurrence in patients with intrahepatic nodular recurrence were 91.0%, 71.0%, and 37.5%, respectively. Multivariate analysis revealed that early recurrence (≤12 months), Child-Pugh class B or C at diagnosis of recurrence, and serum albumin level of ≤3.5 g/dL at diagnosis of recurrence were poor prognostic factors for survival after recurrence. With regard to the response to the initial treatment, time to recurrence of ≤12 months was found to be the only statistically significant risk factor for progression of disease in multivariate analysis. Conclusions Time to recurrence, which usually corresponds with the cellular origin of recurrence, seems to be more important when determining the prognosis of patients with recurrent disease and treatment response than treatment modality. Therefore, different treatment methods should be selected according to the time to recurrence of intrahepatic nodular recurrence.     

Treatment of unicameral calcaneal bone cysts in children: review of literature and results using a cannulated screw for continuous decompression of the cyst

Nine unicameral bone cysts of the calcaneus in children were managed surgically using the technique of continuous decompression with titanium cannulated cancellous screws. The average age of the patients at surgery was 12.8 years. At follow-up a minimum of 2 years after surgery, eight cysts showed complete healing; one patient showed healing with residuals. Irritation at the screw insertion site necessitated early removal of the screw in one patient; implant-related problems were not observed in the other patients. Patients were allowed to bear weight after surgery. Implant extraction was performed after full consolidation of the cyst and was uneventful in all patients. A review of the literature and the different treatment modalities used for managing calcaneal cysts is also presented.     

Treatment of displaced intraarticular calcaneal fractures with or without bone grafts: A systematic review of the literature

Background:

The necessity of bone grafts in the treatment of intraarticular calcaneal fractures continues to be one of the most debated topics in foot and ankle surgery. The purpose of this study was to determine whether there are sufficient objective cumulative data in the literature to compare the two methods and if the bone graft was needed in surgical treatment of intraarticular calcaneal fractures.

Materials and Methods:

A comprehensive search of all relevant articles from 1990 to 2010 was conducted. Two reviewers evaluated each study to determine its suitability for inclusion and collected the data of interest. Meta-analytic pooling of group results across studies was performed for the two treatment methods.

Results:

The systematic review identified 32 primary studies with 1281 fractures, which contained 4 comparative studies, 13 with bone grafts, and 15 without bone grafts in treatment methods. The infection rate in bone graft group was higher through statistically insignificant than in non-graft group (8.3% vs. 6.3%) No significant difference was found between good reduction rate, postoperative osteoarthritis rate, and subtalar fusion rate. The average full weight-bearing time in bone graft group was significantly lower (5.4 months) than in non-graft group (10.5 months). The mean postoperative Böhler''s angle was significantly higher in bone graft group (lose due to collapse was significancy less). For the efficacy outcomes, the bone graft group had a lower American Orthopaedic Foot and Ankle Society Score (AOFAS) (71.4 points vs. 80.5 points) but a higher Creighton score (89.9 points vs. 81.0 points) compared with non-graft group. Pooled mean results showed 35% of the patients in bone graft group had an excellent result, 40% had a good result, 21% had a fair result, and 4% had a poor result. In the non-graft group, the corresponding values were 34, 42, 14, and 10%, respectively.

Conclusions:

The operative treatment of intraarticular calcaneal fractures with bone grafts could restore the Böhler''s angle better and the patients could return to full weight bearing earlier. However, the functional and efficacy outcomes appear to be similar between the two treatment groups. There were more joint depression and comminuted fractures in the bone graft group, and the mean followup time was shorter. Large sample comparative studies are still needed.     

骨板旋转植骨加人工骨移植联合治疗长管骨骨折延迟愈合

目的 :探讨骨板旋转植骨加人工骨移植联合治疗长管骨骨折延迟愈合的疗效。方法 :12例四肢长管骨内固定术后骨折延迟愈合患者 ,均采用骨板旋转植骨加骨骼生髓内移植联合治疗并随访 6～ 9个月 ,观察骨愈合时间。结果 :12例患者全部骨性愈合 ,平均愈合时间 2 .5个月 ,肢体功能恢复满意。结论 :骨板旋转植骨加骨骼生移植术不干扰骨折部血运 ,是治疗四肢长管骨骨折延迟愈合的良好方法。     

自体骨髓血注射结合弹性髓内针治疗儿童长骨骨囊肿

目的:观察自体骨髓血注射结合弹性髓内针植入方法治疗儿童长骨骨囊肿的临床疗效。方法:自2010年1月至2015年12月采用自体骨髓血注射结合弹性髓内针植入的方法治疗儿童长骨骨囊肿29例,男22例,女7例;年龄2～12岁,平均7.7岁;病程12～84个月。其中肱骨近端17例,股骨近端9例,股骨远端2例,尺骨近端1例。全部骨囊肿患儿行术前X线片检查,必要时加做CT或MRI检查,明确诊断后,治疗方法采用骨髓血注射结合弹性髓内针支撑引流,术后行多次X线检查随访,采用Capanna骨囊肿治疗评价标准进行疗效评价。结果:29例患儿中27例获得随访,随访时间12～60个月,平均31.8个月。按照Capanna骨囊肿评价标准,其中26例治愈,1例部分愈合残留部分病灶。结论:采用自体骨髓血注射结合弹性髓内针治疗单纯性儿童长骨骨囊肿具有疗效确定、高治愈率、并发症少、治疗过程客观可控的特点。     

Treatment of acute scaphoid fractures: a systematic review and meta-analysis

Background/Methods  

The purpose of this review was to assess the current evidence supporting operative fixation versus casting for acute scaphoid fractures through a systematic review and meta-analysis of the literature.     

Changes in bone mineral density and bone metabolism after sleeve gastrectomy: a systematic review and meta-analysis

BackgroundRoux-en-Y gastric bypass surgery adversely affects bone health. The evidence is less well-described for sleeve gastrectomy (SG).ObjectivesTo better characterize bone metabolism changes after SG.SettingSystematic review and meta-analysis.MethodsMEDLINE and EMBASE were searched through March 2019 for eligible studies assessing adults with obesity aged 18 years or older that underwent SG. Bone mineral density (BMD), serum calcium, serum phosphate, serum 25-hydroxyvitamin D, serum parathyroid hormone, or serum alkaline phosphatase were reported at baseline and after SG; and a follow-up duration was at least 6 months. Preoperative and postoperative mean of each outcome of interest and corresponding standard deviations were extracted from each study and the mean difference (MD) was calculated. Pooled MD was then calculated by combining MDs of each study using random-effects model.ResultsA total of 22 studies with 1905 patients with obesity that underwent SG were included. There were significant decreases in total hip BMD (pooled MD of −.06 g/cm²; 95% confidence interval −.09 to −.03; I² = 0%) and femoral neck BMD (pooled MD of −.05 g/cm²; 95% confidence interval −.09 to −.02; I² = 0%) after SG. No significant change in lumbar spine BMD was observed. There were significant increases in serum calcium, serum 25-hydroxyvitamin D, and serum phosphate. Serum parathyroid hormone was significantly decreased. Serum alkaline phosphatase was not significantly altered after SG.ConclusionsThe present study found a decreased BMD among patients with obesity after SG.     

前哨淋巴结微转移与乳腺癌复发风险的系统评价及Meta分析

目的系统评价在未行腋窝淋巴结清扫时,前哨淋巴结（SLN）微转移对乳腺癌患者复发相关事件发生率（RRER）的影响。 方法检索PubMed、EMBASE、WanFang数据、CNKI、CBM建库至2018年5月1日的文献资料,严格按照纳入和排除标准筛选相关研究,对纳入的研究进行资料提取,采用NOS量表进行质量评价,使用RevMan 5.2软件进行Meta分析。 结果最终筛选出6篇相关文献共1 730例患者,其中3项前瞻性观察研究,3项回顾性研究。中位随访33~77个月,SLN微转移组（370例）与SLN阴性组（1 360例）的RRER差异无统计学意义（OR=1.37,95%CI：0.72~2.59,I²=47%,P=0.34）;同时,在局部复发率方面,SLN微转移组354例,复发12例,SLN阴性组1 337例,复发35例,两者比较差异亦无统计学意义（OR=1.49,95%CI：0.75~2.97,I²=40%,P=0.26）。 结论SLN微转移并不增加乳腺癌患者的复发风险。     

Endoscopic curettage and allografting of simple bone cysts of the calcaneus in young soccer players: Report of three cases

Open curettage with bone graft has been the traditionally suggested surgical treatment for the symptomatic simple (or unicameral as they used to be called) calcaneal bone cyst. Less invasive endoscopically assisted treatment with curettage and bone grafting with allograft have recently provided less postoperative morbidity. The aim of the present study is to present our experience with this method in young soccer athletes. Between April 2014 and May 2016 three consecutive young soccer players with symptomatic calcaneal bone cysts underwent endoscopic curettage, and percutaneous injection of demineralized bone matrix allograft. The mean age was 17.3 (16, 17 and 19 years old), and the mean follow-up was 32.1 (range 24–47) months. Both radiographic and functional follow-up, using the AOFAS score, showed good to excellent results. All lesions were radiographically healed. Preoperative AOFAS score (max. 100 pts) was 78.6 ± 4.7, improving to 98.0 ± 4.1. The patients returned to their initial level of sports activities within 18.3 (range 17–19) weeks after surgery. Evidence suggests an earlier return to sports using bone substitutes. However, the present study showed that endoscopic curettage and percutaneous injection of bone allograft is also an excellent treatment option for young athletes with a symptomatic calcaneal bone cyst.Level of clinical evidence4.