慢性完全闭塞冠状动脉病变患者79例的介入治疗

目的:回顾分析慢性完全闭塞(CTO)冠状动脉病变实施经皮冠状动脉介入治疗(PCI)的临床资料,总结CTO病变特征、PCI的技术方法和近、远期疗效。方法:对79例含有CTO病变的患者进行PCI治疗,共对98支CTO病变靶血管进行了PCI,CTO闭塞时间3~120(17.8±26.1)月,置入冠状动脉支架161枚。结果:共开通71例患者的CTO靶病变85处,术终达到TIMI3级血流的病例成功率为89.9%(71/79),病变成功率为86.7%(85/98),完全血运重建率36.7%(29/79)。其中CTO闭塞时间3~6个月及6个月以上者其PCI病变成功率分别为93.9%(62/66)和71.9%(23/32)(P<0.05)。有桥侧支存在者成功率低于无桥侧支者,56.3%(9/16)比93.9%(77/82)(P<0.05)。断端成刀切状成功率低于鼠尾状CTO,77.8%(14/18)比91.3%(21/23)(P<0.05),闭塞段>15mm的长CTO病变成功率低于短病变者,83.3%(55/66)比90.4%(30/32)(P<0.05)。随访患者78例(98.7%),随访时间4~48(16.7±10.9)个月,无事件生存率为79.7%,心脏不良事件(MACE)发生率为12.7%(10/79),血运重建率为8.9%(7/79)。结论:影响成功率的因素有血管闭塞时间、闭塞长度、闭塞末端形态、桥状侧支等,成功PCI治疗可改善CTO患者的临床症状、生活质量及远期预后。     

经皮冠状动脉内介入治疗慢性完全闭塞病变影响因素探讨

目的:探讨慢性完全闭塞性病变(CTO)经皮冠状动脉介入(PCI)治疗的影响因素.方法:回顾2000年4月至2006年6月东南大学附属中大医院行PCI治疗的CTO患者48例,CTO病变共51处,记录患者临床特征、靶病变特点和靶病变PCI操作结果,行logistic逐步回归分析,筛选PCI成功的预测因素.结果:48例患者中33例36处成功,15例15处失败,病例成功率68.8%,靶病变成功率70.6%.2000年4月至2003年5月10例患者10处病变4例4处成功,病例及病变成功率均为40.0%;2003年6月至2006年6月38例患者41处病变中29例32处成功,成功率分别为76.3%,78.0%.2003年6月之后病变成功率较之前明显提高(P＜0.05).经logistic逐步回归分析,介入操作成功的预测因素为桥侧支缺如(P=0.001)、病变闭塞持续时间≤3个月(P=0.005)、功能性闭塞(P=0.005)、病变近端呈鼠尾状(P=0.026).结论:CTO介入治疗操作成功率除与术者经验和新型介入器材应用有关外,与病变特点密切相关,而与临床特点关系较小.在病变特点中,桥侧支缺如、病变闭塞持续时间≤3个月、功能性闭塞、病变近端呈鼠尾状是CTO行PCI操作成功的预测因素.     

冠状动脉闭塞支的双源CT评价

目的 总结冠状动脉完全闭塞病变的影像学特点,以期为介入手术提供指导性信息,提高闭塞支的手术成功率.方法 回顾性分析2008年3月至2010年3月诊断冠心病并经冠脉造影证实有完全闭塞病变患者的双源CT和冠脉造影资料.结果 140例患者共152支冠状动脉发生闭塞:右冠状动脉68支,前降支48支,回旋支20支,左主干1支,分支血管闭塞15支.其中两支冠状动脉闭塞共13例.闭塞段长度5～58 mm,平均(16.8±3.9)mm,其中长度大于1 cm的闭塞病变占91.4%.闭塞残端形态:68支为齐头状闭塞,64支为锥状闭塞,20支为鼠尾状闭塞.多数闭塞病变(73%)为软斑块或以软斑块为主合并少量钙化;其次为混合性斑块及钙化斑块.10支闭塞病变呈膨大改变,为血栓形成.共25支冠状动脉闭塞段成角或弯曲,多见于右冠的长段闭塞.闭塞一端有分支血管发出的62支;两端均有分支血管发出的36支.152例闭塞支中仅3例双源CT可显示明确的侧支血供,无1例可明确显示闭塞两端桥侧支血管.结论 双源CT可很好地显示冠状动脉闭塞支的绝大多数信息,对闭塞病变的手术有指导意义,有助于提高手术成功率.     

经皮冠脉介入治疗慢性完全闭塞病变的临床分析(摘要)

目的：探讨冠脉介入治疗慢性完全闭塞病变（CTO）的可行性和安全性。方法：回顾性分析了我院1995．12－2002.9完成择期冠脉介入治疗569例，其中CTO病变126例。男性78例，女性48例。有心肌梗死病史者91例，合并糖尿病者43例。造影结果显示单支病变51例，双支病变49例，三支病变26例。CTO病变中，前降支病变73例，左回旋支病变17例，右冠状动脉病变36例。结果：冠脉介入治疗的成功率80．9％（102／126），其中闭塞时间小于3个月的成功率90.6%(48/53)，闭塞时间大于3个月的成功率67.1%(49/73)，影响介入治疗成功的因素依次为：闭塞的时间、闭塞段长度、桥侧支存在与否、闭塞末端的形态、闭塞血管近段弯曲度以及闭塞端有无边支血管开口等。失败原因分析：导丝不能通过闭塞病变或进入假腔82.7%(24/29)；球囊不能到位或不能充分扩张病变10.3%(3/29)；因操作时间过长、造影剂用量过大等致病人不能耐受，或出现血流动力学不稳定等原因，被迫终止手术6.9%(2/29)。围手术期无死亡。结论：随着导管等介入器材的不断进步，操作技术及经验的积累，对CTO病变，只要严格选择适应证，操作得当，其介入治疗有较高的成功率，可作为完全血运重建或部分血运重建的重要手段。     

介入治疗冠脉完全闭塞病变影响因素的分析

目的评价冠状动脉（冠脉）慢性完全闭塞病变（CTO）特点对经皮冠状动脉介入治疗（PCI）的影响。方法对300例CTO患者的临床资料、病变特征和PCI结果进行回顾性分析。结果闭塞病变类型为功能性及绝对性、长度≤15mm和〉15mm、有开口和无开口及断端为鼠尾状和刀切状,以上各组内PCI成功率分别为90．1％和76．3％、85．2％和72．1％、88．3％和80％、84．2％和55％（P〈0．05）;闭塞病变的位置、闭塞时间、有无桥血管、有无分支发出、有无钙化、远端有无显影及血管有无迂曲各组内差异无统计学意义（P〉0．05）。结论闭塞病变类型、长度、有无开口及断端的形状是成功PCI的影响因素。     

64排128层CT冠脉成像对心肌桥—壁冠状动脉的诊断价值

目的 探讨64排128层CT冠状动脉血管造影(CTA)对心肌桥-壁冠状动脉的诊断价值.方法 采用64排128层CT对212例有冠心病症状或心脏体检患者行冠状脉成像检查,分析心肌桥-壁冠状动脉的发生率、发生部位、长度、厚度、狭窄程度及心肌桥近端管壁粥样硬化情况.结果 212例中CTA发现心肌桥55例(64处心肌桥),阳性率25.9％; 46例为单一心肌桥,9例为两处受累,同时累及前降支近段、钝缘支5例,同时累及前降支中段、后降支4例;其中前降支48处,第一对角支3处,第二对角支1处,左旋支1处,钝缘支5处,右冠状动脉4处,后降支2处,以前降支最多见,占75％.左前降支心肌桥组近端较无心肌桥组近端冠状动脉粥样硬化发生率高.结论 64排128层CT冠状动脉血管造影可准确诊断心肌桥—壁冠状动脉,为临床诊断和治疗提供有力的依据.     

冠状动脉旁路移植术患者原位冠状动脉的介入治疗

目的探讨冠状动脉旁路移植术（CABG）后移植桥血管严重狭窄和（或）闭塞患者原位冠状动脉行经皮冠状动脉介入治疗（PCI）的疗效及安全性。方法对28例CABG术后患者进行冠状动脉和移植桥血管造影,对其中移植桥血管严重狭窄和（或）闭塞的8例患者原位冠状动脉病变进行了介入治疗。结果28例均完成了冠状动脉和移植桥血管造影,移植血管共83支。其中8例有明显缺血症状,移植桥血管严重狭窄和（或）完全闭塞,共闭塞16支,其中左内乳（LIMA）闭塞1支,大隐静脉桥闭塞15支,对这8例患者的原发冠状动脉血管进行了介入治疗,共对15处靶血管病变（为B2及c型病变）进行PCI,成功率86．7％,均置入雷帕霉素药物洗脱支架（DES）。术中血管出现慢血流3例,无复流1例,2处原位冠状动脉慢性闭塞病变未开通。所有患者住院期间均无主要临床并发症发生,术后随访1—64个月,心绞痛复发l例,再次行PCI成功。术后22个月因心力衰竭死亡1例。结论对CABG术后再发心绞痛患者原位冠状动脉行PCI治疗成功率、有效性、安全性均较高。原位冠状动脉介入治疗可作为CABG术后移植桥血管病变再发缺血的主要治疗手段。     

DSCT数字化血管成像对冠状动脉搭桥术后桥血管的评价

目的：探讨DSCT数字化血管成像对冠状动脉搭桥术后随访应用价值。方法：采用西门子DSCT（Siemens SOMATOM Definition）对16例行冠状动脉搭桥术后患者行DSCT冠状动脉检查,分别评价CT图像桥血管近远端吻合口、桥血管本身有无狭窄、钙化和吻合口远端引流血管的图像质量及冠状动脉图像质量,评价双源CT诊断桥血管通畅性和冠状动脉是否存在狭窄。结果：DSCT显示16例患者共发现桥血管42根,其中6根闭塞,所有桥血管均可评价。42支桥血管中,25支未见狭窄,9支桥血管狭窄程度≤50％,8支桥血管狭窄程度〉50％。搭桥血管通畅率为85．7％（36／42）,乳内动脉桥通畅率较高,为88．9％（8／9）,肱动脉次之,为85．7％（6／7）,大隐静脉桥通畅率最低,为76．9％（20／26）。结论：DSCT数字化血管成像作为一种无创性检查在冠状动脉桥血管随访的诊断和评价中是安全可靠的。     

冠状动脉闭塞病变介入治疗的临床研究

目的：探讨冠状动脉闭塞经皮冠状动脉腔内成形术（PTCA）治疗的效果。方法：对23例行PTCA及支架置入患者进行临床分析。结果：23例患者PTCA及置入支架后24支闭塞血管18支被开通，血管病变开通成功率72．0％，病例成功率78．3％（18／23），闭塞病变时间〈3个月组的患者成功率92．3％，明显高于闭塞病变时间〉3个月组的患者54．5％（P〈0．01）。结论：冠状动脉完全闭塞病变患者行PTCA及置入支架治疗是安全可行的，血管闭塞的时间和病变局部形态特征是手术成功的重要因素。     

侧支循环对急性大脑中动脉闭塞血管内治疗预后的影响

目的 探讨侧支循环对急性大脑中动脉闭塞患者经血管内治疗后预后的影响。方法 收集急性大脑中动脉近端(M1)闭塞并行血管内治疗的患者32例。采用美国介入与治疗神经放射学学会和介入放射学学会(ASITN/SIR)基于数字剪影血管造影(DSA)的侧支代偿分级标准(ACG),将ACG为2～3级者,以侧支代偿供血是否大于闭塞血管供血区50%为界限分为2组,回顾性分析观察2组患者的临床预后。结果 2组患者在卒中高危因素、NIHSS评分、闭塞血管开通、术后即刻CT高密度渗出、早期出血转化方面差异无统计学意义;侧支循环代偿供血≥闭塞血管供血区50%组的患者,90 d临床预后良好率72.73%,显著高于对照组的30.00%(P<0.05)。结论 侧支循环与急性大脑中动脉闭塞行血管内治疗患者的临床预后密切相关,基于DSA的侧支循环评估对血管内治疗预后的判断有重要意义。     

Percutaneous coronary intervention for chronic total occlusion in 1263 patients: a single-center report

Background Coronary chronic total occlusion （CTO） remains one of the most challenging lesion subsets in interventional cardiology, even with the development of medical device and operator expertise. This study was conducted to examine the relationship between lesion characteristics and procedural success and the incidence of in-hospital major adverse cardiac events （MACE） after percutaneous coronary intervention （PCI） for CTO. Methods Clinical and coronary angiographic data of 1263 patients with CTO who underwent PCI between June 1995 and December 2005 in Shenyang General Hospital of PLA were retrospectively analyzed. Results There were 1625 CTO lesions located in 1596 vessels with a mean occlusion time of 48.9 months. A total of 1647 coronary stents were implanted to the target lesions. The overall patient and lesion success rates were 90.8 % （1147/1263） and 88.9 % （1445/1625）, respectively. The success rate of PCI was declined with long duration of occlusion, abrupt missing stump, bridging collaterals ≥15 mm in occluded length, moderate to severe calcification or tortuosity and ostial or distal location of CTO lesions （P〈 0.05）. Procedural failure occurred in 116 patients, caused by impossibility of guide-wire （81.0%） or balloon （19.0%） to pass through the occlusion. There was no death during procedure, but 2 patients suffered from acute stent thrombosis and other 9 patients had acute or late pericardial perforation. Those complications were all successfully treated. After procedure, 3 patients died, 4 experienced urgent target vessel revascularization because of subacute stent thrombosis and 1 underwent coronary bypass graft surgery due to coronary ftstula during in-hospital period. The overall in-hospital MACE rate was 0.6% （8/1263）. Drug-eluting stents were used in 198 patients without in-hospital MACE. Conclusions In an experienced heart center, it is possible to obtain a relatively high success rate of PCI and favorable clinical outcomes for patients with coronary CTO lesions.     

经桡动脉行冠状动脉慢性完全闭塞病变介入治疗28例临床分析

目的评价经桡动脉行冠状动脉慢性完全闭塞病变(CTO)介入治疗的疗效及安全性。方法对2005年3月至2008年5月经桡动脉实施经皮冠状动脉介入(PCI)治疗的28例CTO患者的临床资料、病变特征和PCI结果进行回顾性分析。CTO靶血管共28支,平均闭塞时间为(8.7±4.2)个月,按Seldinger法穿刺右桡动脉后置入6F桡动脉鞘,之后再按标准方法行球囊扩张及支架置入术。结果24例患者成功完成了冠脉内支架植入术,共植入药物洗脱支架25枚。成功率为85.7%(24/28),与我院同期经股动脉途径PCI治疗的31例CTO病例相似,差异无统计学意义(P<0.05)。75%(3/4)的失败病例均是由于导丝无法通过闭塞段所致。所有病例住院期间均未发生主要不良心脏事件。结论经桡动脉途径PCI治疗CTO安全可行,成功率并不低于经股动脉途径,不失为一个较理想的介入治疗途径。     

Multi-wire plaque crushing as a novel technique in treating chronic total occlusions

Background Failure of balloon catheter passing through the occluded segment accounts for 10%-15% of all procedures during percutaneous coronary intervention （PCI） for chronic total occlusion （CTO）. We sought to investigate an original technique for facilitating balloon catheter passing by multi-wire plaque crushing. Methods Between July 2000 and October 2007, 152 patients with 164 CTO lesions who had failed balloon passing were treated by multi-wire plaque crushing technique. The main process of this technique was to insert 1 or 2 wires along with the original wire located in the true lumen of CTO lesions after balloon failure for plaque crushing and then to withdraw the crushing wires to get an enlarged lumen inside of the occlusion segment, thus facilitating the balloon passing. Results Both overall lesion and technique success rates were 91.5% （150/164）. A total of 211 crushing wires were used during. PCI, including 1 crushing wire for 117 （71.3%） lesions and 2 crushing wires for 47 （28.7%） lesions. Approximately 57.3% （121/211） of all crushing wires were those already used in the same procedure. Technique failure occurred in 14 lesions （8.5%）. Technique failure was due to crushing wires entering false lumen （92.9%, 13/14） and coronary perforation （7.1%, 1/14）. Major procedural complications included coronary perforation （1 case） and severe coronary dissection （2 cases）, all of which were successfully treated. Conclusions Multi-wire plaque crushing technique is effective in facilitating balloon catheter passing during CTO PCI. It is feasible, economical and relatively safe with a low rate of procedural complications.     

冠状动脉慢性完全闭塞性病变治疗策略选择的相关影响因素

目的从临床基线资料、病变影像学特征等方面,对影响冠状动脉慢性完全闭塞性(CTO)病变治疗策略选择的相关因素进行探讨。方法 2004年1月—2008年12月在复旦大学附属中山医院经冠状动脉造影检查发现的完全闭塞性病变患者1485例,其中638例确诊为CTO病变,平均年龄为(64.1±11.0)岁。依据首选经皮冠状动脉介入治疗(PCI)、行冠状动脉旁路移植术(CABG)或因无法耐受手术而接受单纯药物治疗将患者分为PCI组(447例)和非PCI组(191例),比较两组间临床基线资料及病变特点等方面的差异。结果 PCI组患者的平均年龄为(63.4±10.4)岁,显著小于非PCI组的(65.7±12.0)岁(P<0.05);中位胸痛时间为160(24,262)周,显著短于非PCI组的242(40,382)周(P<0.05);两组间性别构成及高血压、高血脂、心肌梗死、糖尿病患者的构成比的差异均无统计学意义(P值均>0.05)。PCI组患者的总胆固醇及低密度脂蛋白胆固醇水平分别为(4.18±1.1)和(2.28±1.00)mmol/L,均显著低于非PCI组的(4.39±1.19)及(2.55±1.08)mmol/L(P值分别<0.05、0.01);两组间血清葡萄糖、三酰甘油、高密度脂蛋白胆固醇、肌钙蛋白T、肌酸激酶同工酶和氨基末端脑钠素前体水平的差异均无统计学意义(P值均>0.05)。PCI组冠状动脉造影检查示近段血管严重迂曲、病变钙化、靶血管开口闭塞,以及合并三支病变、左主干病变及靶血管外闭塞的发生率均显著低于非PCI组(P值均<0.01);而闭塞端缺如的发生率显著高于非PCI组(P<0.01)。多元逐步Logistic回归分析结果显示,胸痛时间>3年(OR=0.998,95%CI0.997～1.000,P=0.004)、合并三支病变(OR=0.288,95%CI0.172～0.482,P=0.000)及靶血管开口闭塞(OR=0.288,95%CI0.172～0.482,P=0.000)为CTO病变行PCI的独立负性预测因素。结论胸痛时间>3年、靶血管开口闭塞、合并三支病变为CTO病变行PCI的独立负性预测因素,应权衡患者的临床因素及病变特点选择个体化的治疗策略。     

Retrograde approach for the recanalization of coronary chronic total occlusion: preliminary experience of a single center

Background The success rate of antegrade approach for chronic total occlusions （CTO） recanalization has not dramatically increased, especially in complex CTO subset. The retrograde technique may hold great promise. This report aimed to describe our experience of retrograde recanalization for CTO, focusing on its safety and feasibility. Methods We identified 42 patients who underwent revascularization in CTO with retrograde approach from July 2005 to November 2009 in our center.Results Three kinds of strategy were applied： retrograde as primary strategy （50.0%）, retrograde immediately after antegrade failure （26.2%） and repeat procedure after previous antegrade failure （23.8%）. Septal collaterals were more frequently used as the retrograde access route （92.9%）. Overall success rate was 88.1%. In patients with successful retrograde wire crossing collateral channel to the distal cap of CTO, the success rate of recanalization was 94.1%. In patient with failure to cross the collaterals, the success rate was 62.5%. Eight different kinds of retrograde techniques were used： kissing wire technique （35.3%）, wire trapped and reverse wire trapped technique （17.6%）, back-end balloon and microcatherer reversal technique （14.7%）, controlled antegrade and retrograde subintimal tracking （CART） technique （8.8%）, reverse CART and modified reverse CART technique （8.8%）, retrograde wire crossing technique （2.9%）. There were 4 complications occurred without in-hospital major adverse cardiac events （MACE）. In-hospital MACE was 7.7%. All of them were non-Q wave myocardial infarction. There were no cases of death or target vessel revascularization, either surgery or percutaneous.Conclusions The retrograde approach can be an effective tool for increasing the success rate of recanalization in the very complex CTO. To ensure the success and safety of the approach, careful case selection and device handling by experienced operators is essential.     

Clinical outcomes of percutaneous coronary intervention for chronic total occlusion lesions in remote hospitals without on-site surgical support

Background The safety of percutaneous coronary intervention （PCI） for chronic total occlusion （CTO） lesions in remote hospitals without surgical facilities remains unknown. This study aimed to evaluate three-year outcomes after CTO for PCI in ten centers around China where no on-site coronary artery bypass grafting （CABG） support was available. Methods A total of 152 patients from 10 Chinese hospitals without on-site surgical facilities were prospectively studied. Intra-procedural and in-hospital events were assessed. Angiographic follow-up was indexed eight months after the initial procedure. Clinical follow-up was extended to three years. The primary outcome was the rate of major adverse cardiac events （MACE）, defined as cardiac death, myocardial infarction and target-vessel revascularization （TVR）. Results The incidence of CTO was 7.9% in patients who underwent PCI, Successful recanalization was achieved in 132 patients （86.8%）. Compared with patients in the PCI success group, patients with PCI procedural failure had longer lesion lengths （（42.32±22.08） mm vs （27.61±22.85） mm, P=0.023）, a higher rate of perforation （25.0% vs 0, P=0.014）, and a greater need for pericardial puncture. There were significant differences in MACE in-hospital and at one year and three years between the failure （10.0%, 30.0% and 35.0%） and the success （3.0%, 12.1% and 14.4%） groups （P=0.037, 0.034 and 0.040, respectively）. These led to a significant decrease in the MACE-free survival rate at one and three years in the failure group, compared with the success group （P=0.031 and 0.023, respectively）. Stump was the only predictor of recanalization success （HR 0.158, 95% Cl 0.041-0.612, P=0.008）, whereas procedural failure （OR 13.023, 95% CI 6.67-13.69, P=0.002）, incomplete revascularization （OR 9.71, 95% CI 2.93-5.59, P=0.005）, and total stent length （OR 6.02, 95% Cl 1.55-11.93, P=0.027） were three independent predictors of MACE. Conclusions PCI for CTO was unsafe in remote hospitals without CABG facilities. Paying attention to coronary perforation is important for successful procedures.     

冠状动脉慢性完全闭塞患者的预后及其相关因素的分析

目的 分析冠状动脉慢性完全闭塞(CTO)患者发生心血管事件及其相关因素之间的关系,为加强冠心病的二级预防提供更多的依据.方法 随访CTO患者272例,根据是否发生心血管事件分为A组共167例(非事件组)和B组共105例(事件组).分析其临床资料、冠脉病变程度及治疗情况并随访,用统计学方法 处理数据,以P<0.05为差异有统计学意义.结果 A、B两组间,LDL-C、EF、Gensini评分、病变支数、闭塞支数及成功PCI间差异有统计学意义,P<0.05;经条件Logist回归分析得出Gensini评分与发生心血管事件呈独立相关性(P=0.01).结论 Gensini评分对CTO患者发生心血管事件有较好的预测价值.     

应用冠状动脉旋磨术治疗慢性闭塞性冠状动脉病变

目的：观察冠状动脉旋磨术治疗慢性闭塞性冠状动脉病变的效果。方法：对21支慢性闭塞性冠状动脉（闭塞时间＞1个月）实施冠状动脉旋磨术，包括8例行冠状动脉球囊成行术失败者，TIMI 1级8例，TIMI 0级13例，闭塞病变位于前降支6例，回旋支7例，右冠状动脉8例，结果：13例患者冠状动脉旋磨术成功，TIMI 1级成功率100％，闭塞时间＜3个月者成功率75％，闭塞时间＞3个月者成功率40％，成功者中闭塞时间最长16个月，平均8．12个月，结论：冠状动脉旋磨术治疗慢性闭塞性冠状动脉安全有效。     

合并非梗死相关血管慢性完全闭塞病变对急性ST段抬高型心肌梗死患者预后的影响

目的：研究合并非梗死相关血管慢性完全闭塞(CTO)病变对急性ST段抬高型心肌梗死(STEMI)患者预后的影响。方法选取2014年3月至2015年3月中国人民解放军第92医院心内科收治的170例经皮冠状动脉介入治疗(PCI)的急性STEMI患者为研究对象,其中合并非梗死相关血管慢性完全闭塞者20例(CTO组),非梗死相关血管无慢性完全闭塞者150例(无CTO组)。比较两组患者的临床特征、介入治疗情况及随访结果,并分析影响患者预后的危险因素。结果与无CTO组比较,CTO组糖尿病、既往心肌梗死、多支血管病变及心源性休克患者所占比例较多,分别为40.0%、15.0%、100.0%及35.0%;无CTO组患者院内死亡率为6.3%,明显低于CTO组的21.4%,且两者比较差异有统计学意义(P<0.05);CTO组患者在6个月及一年时的心血管病变死亡发生率为28.5%、35.7%,明显高于无CTO组的5.5%、8.7%,且差异均有统计学意义(P<0.05)。通过COX回归分析发现糖尿病、左室射血分数<40%、心源性休克、梗死相关血管为左前降支以及年龄>75岁是影响患者预后的独立危险因素。结论非梗死相关血管慢性完全闭塞病变可增加急性ST段抬高型心肌梗死患者经皮冠状动脉介入治疗的死亡率,而且患者预后多不良。