Spinal anesthesia for arthroscopic knee surgery

BACKGROUND AND OBJECTIVE: The purpose of the study was to compare the effects of adding 50 microg of morphine, 25 microg of fentanyl or saline to 6 mg of hyperbaric bupivacaine on postoperative analgesia and time to urination in patients undergoing arthroscopic knee surgery under spinal anesthesia. METHODS: The study was designed in a prospective, randomized, double-blinded and placebo-controlled manner. Sixty ASA I-II patients were randomized into the following three groups: Group BM: 6 mg of bupivacaine and 50 microg of morphine, Group BF: 6 mg of bupivacaine and 25 microg of fentanyl, and Group BS: 6 mg of bupivacaine and saline. Selective spinal anesthesia was performed in a lateral decubitus position, with the operative knee dependent for 10 min. RESULTS: In all groups satisfactory anesthesia was provided during the operation. There was a statistically significant difference between all the groups in times to voiding [Group BM 422 +/- 161 min; Group BF 244 +/- 163 min; Group BS 183 +/- 54 min (mean +/- SD)]. The incidence of pruritus was significantly greater in Group BM (80%) and BF (65%) in comparison with Group BS (no pruritus) (P < 0.05). The incidence of nausea was significantly increased in Group BM (35%) in comparison with Group BF (10%) and Group BS (P < 0.05). Analgesic consumption was significantly greater in Group BS in comparison with Groups BM and BF (P < 0.01). CONCLUSIONS: We conclude that during spinal anesthesia even mini-dose intrathecal morphine is not acceptable for outpatient surgery due to side-effects, especially severely prolonged time to urination.     

胸腔镜辅助下胸椎、上腰椎前路手术的体会

目的 探讨胸腔镜技术在胸、腰椎前路手术的适应证、操作要点以及单肺或双肺通气麻醉的选择。方法 对5例结核病人行胸腔镜下结核病灶清除术，其中2例同时行自体髂骨植骨术，1例以自固化磷酸钙人工骨(CPC)植入；对3例爆裂性骨折截瘫及1例L1陈旧性爆裂骨折并马尾综合征病人进行脊髓减压、自体髂骨植骨、钢板螺丝钉内固定术。结果 全部病例都得到随访，术后切口一期愈合，X光、CT检查也都显示病灶清除彻底，脊髓减压充分，复位满意，内固定可靠，位置良好。结论 胸椎、上腰椎结核或骨折，不论是否并发脊髓、马尾神经压迫的病例，均适宜在胸腔镜辅助下进行病灶清除、脊髓减压、脊柱前路内固定术。     

芬太尼对肛门直肠手术患者小剂量罗哌卡因腰麻效果的影响

目的 评价芬太尼对肛门直肠手术患者小剂量罗哌卡因腰麻效果的影响.方法 择期行肛门直肠手术患者40例,性别不限,年龄20 ～ 55岁,BMI 18～ 28 kg/m2,ASA分级Ⅰ或Ⅱ级,采用随机数字表法,将患者分为2组(n=20):0.5％罗哌卡因7.5 mg组(R组)和0.3％罗哌卡因6.0 mg+芬太尼10 μg组(RF组).L3,4间隙行蛛网膜下腔穿刺,穿刺针斜面朝向骶尾部,R组注射重比重0.5％罗哌卡因1.5 ml,RF组注射重比重0.3％罗哌卡因6.0 mg+芬太尼10 μg混合液2.0 ml.记录感觉阻滞起效时间、最高感觉阻滞平面、感觉阻滞持续时间、运动阻滞起效时间和运动阻滞持续时间,记录术毕时改良Bromage评分.结果 与R组比较,RF组感觉阻滞持续时间和运动阻滞持续时间缩短,术毕时改良Bromage评分降低(P＜0.05或0.01);感觉阻滞起效时间、最高感觉阻滞平面、运动阻滞起效时间及不良反应发生率差异无统计学意义(P＞0.05).结论 10 μg芬太尼混合0.3％罗哌卡因6mg腰麻可满足肛门直肠手术要求,运动神经的阻滞轻,恢复快.     

腰-硬联合麻醉用于小儿腹腔镜阑尾切除术的临床研究

目的:探讨腰-硬联合麻醉方法应用于小儿腹腔镜阑尾切除术的可行性。方法:观察54例应用腰-硬联合麻醉实施小儿腹腔镜阑尾切除术(ASAⅠ~Ⅱ)的麻醉效果、平均动脉压(MAP)、心率(HR)及脉搏氧饱和度(SpO2)的变化。结果:全部患儿均顺利完成手术,患儿的MAP、HR和SpO2均在正常范围。结论:腰-硬联合麻醉用于小儿腹腔镜阑尾切除术效果确切、安全、损伤较小且经济实用。     

Complications in lumbar spine surgery: A retrospective analysis

Background:

Surgical treatment of adult lumbar spinal disorders is associated with a substantial risk of intraoperative and perioperative complications. There is no clearly defined medical literature on complication in lumbar spine surgery. Purpose of the study is to retrospectively evaluate intraoperative and perioperative complications who underwent various lumbar surgical procedures and to study the possible predisposing role of advanced age in increasing this rate.

Materials and Methods:

From 2007 to 2011 the number and type of complications were recorded and both univariate, (considering the patients’ age) and a multivariate statistical analysis was conducted in order to establish a possible predisposing role. 133 were lumbar disc hernia treated with microdiscetomy, 88 were lumbar stenosis, treated in 36 cases with only decompression, 52 with decompression and instrumentation with a maximum of 2 levels. 26 patients showed a lumbar fracture treated with percutaneous or open screw fixation. 12 showed a scoliotic or kyphotic deformity treated with decompression, fusion and osteotomies with a maximum of 7.3 levels of fusion (range 5-14). 70 were spondylolisthesis treated with 1 or more level of fusion. In 34 cases a fusion till S1 was performed.

Results:

Of the 338 patients who underwent surgery, 55 showed one or more complications. Type of surgical treatment (P = 0.004), open surgical approach (open P = 0.001) and operative time (P = 0.001) increased the relative risk (RR) of complication occurrence of 2.3, 3.8 and 5.1 respectively. Major complications are more often seen in complex surgical treatment for severe deformities, in revision surgery and in anterior approaches with an occurrence of 58.3%. Age greater than 65 years, despite an increased RR of perioperative complications (1.5), does not represent a predisposing risk factor to complications (P = 0.006).

Conclusion:

Surgical decision-making and exclusion of patients is not justified only by due to age. A systematic preoperative evaluation should always be performed in order to stratify risks and to guide decision-making for obtaining the best possible clinical results at lower risk, even for elderly patients.     

择期手术病人七氟醚全麻诱导的效果

目的 比较七氟醚和异丙酚全麻诱导的效果。方法 择期手术病人60例,ASAⅠ级或Ⅱ级,年龄18～64岁,行全身麻醉。随机分为2组（n=30）：七氟醚组（S组）,吸入1MAC七氟醚麻醉诱导;异丙酚组（P组）,靶控输注血浆靶浓度3 mg/L异丙酚麻醉诱导,2组均靶控输注血浆靶浓度4μg/L瑞芬太尼。病人入室静卧5min后记录血压（BP）、心率（HR）作为基础值。记录插管前即刻、插管后1、2、3min的BP和HR以及病人意识消失的时间。结果 与基础值比较,插管前即刻2组BP下降,S组HR减慢（P＜0．01）;插管后1min P组BP下降（P＜0．01）;插管后3min S组BP下降（P＜0．05）。插管后3 min,P组HR较S组快（P＜0．05）。S组意识消失时间短于P组（P＜0．01）。结论 七氟醚用于全麻诱导,是一种安全有效、方便快捷的技术。     

Anesthesia for video-assisted surgery of the thoracic and lumbar spine: a survey of 44 patients

INTRODUCTION: The development of video-assisted surgery of the dorsolumbar spine has led to the need for adaptations for appropriate anesthetic management. Data concerning anesthesia for such surgery is very sparse in the literature. AIM OF THE STUDY: The aim of this retrospective study of 44 patients was to learn more about anesthesia practices used for patients undergoing this type of surgery. PATIENTS AND METHOD: The files of 44 patients were studied retrospectively. Epidemiologic data and the perioperative phase were analysed. RESULTS: The preoperative phase was not specific with preoperative assessment adapted to each patient. Similarly, monitoring practices during the surgical procedure were not specific. The choice of the anesthetic agents depended on the patient's clinical status. For tracheal intubation, care was taken to enable lung exclusion, even if not often used. Thoracic drainage at the end of the surgery was required in the event of imperfect hemostasis and in selected patients was replaced by pneumothorax exsufflation during closure. The postoperative period was uneventful and did not require admission to intensive care; non-specific analgesia was used. DISCUSSION: Adaptations of anesthetic practices are required each time a new surgical technique is developed. Excepting lung exclusion, anesthesia for video-assisted dorsolumbar spine surgery is not specific.     

老年腰椎患者术后应用利伐沙班的凝血功能变化及对深静脉血栓的预防

目的:观察老年腰椎患者术后使用利伐沙班的凝血功能变化,评估其预防下肢深静脉血栓的有效性及安全性。方法:选取我院2012年3月~2015年12月收治的老年腰椎疾病患者220例,随机分为利伐沙班组(110例,A组)和低分子肝素组(110例,B组),术后2周每日分别使用利伐沙班(10mg,口服)和低分子肝素钙(5000 IU,皮下注射)抗凝。于术前、术后1d、4d行血栓弹力图检查(包括凝血反应时间R值、血细胞凝集块形成时间K值、凝固角α角和最大振幅MA值)动态观察凝血功能变化,并对比分析两组患者下肢深静脉血栓发生率、出血性并发症和术后48h引流量。结果:A、B两组患者术后血栓弹力图中R值(5.87±0.83min,5.72±0.68min)和K值(1.56±0.30min,1.49±0.34min)均较术前(7.27±0.89min,7.45±0.79min;2.06±0.29min,2.11±0.30min)减小(P=0.000),α角(66.21°±3.75°,67.00°±3.43°)和MA值(62.94±3.57mm,63.65±5.06mm)均较术前(62.17±3.59mm,61.39±4.00mm;58.92±3.24mm,58.20±3.26mm)增大(P=0.000),提示血液凝固性增高。短期使用(4d)利伐沙班或低分子肝素后,两组R值(6.97±0.69min,7.07±0.67min)和K值(1.97±0.31min,2.04±0.32min)均增大(P=0.000),α角(61.41°±4.04°,62.16°±4.13°)和MA值(58.15±2.97mm,58.57±4.41mm)均减小(P=0.000),提示高凝状态均得到较好的纠正,两组间比较无统计学差异(P0.05)。在两周随访期内,A组和B组分别有9例(8.18%)、6例(5.45%)出现了无症状性下肢深静脉血栓,两组间比较无统计学差异(χ~2=0.64,P=0.422);两组分别有9例(8.18%)和7例(6.36%)患者出现了出血性并发症,其中严重出血并发症分别为2例和1例(均为硬膜外血肿,行硬膜外血肿清除术后好转),两组间比较无统计学差异(χ~2=0.27,P=0.604);两组间术后48h引流量(412.30±44.65ml,421.71±43.45ml)也无统计学差异(t=-1.58,P=0.115)。结论:老年腰椎患者术后血液凝固性增高,使用利伐沙班或低分子肝素均能较好纠正高凝状态;同时,对于老年腰椎术后下肢深静脉血栓形成的预防,利伐沙班具有与低分子肝素相似的有效性和安全性。     

Epidural anesthesia for lumbar spine surgery

A retrospective review of the hospital records of 80 patients undergoing elective lumbar spine surgery was performed, in order to determine the effect of anesthetic technique on various clinical parameters. Forty patients receiving epidural bupivacaine anesthesia were matched with 40 patients receiving general endotracheal anesthesia; these two groups were homogeneous based on age, sex, type of operative procedure, and number of spinal levels operated upon. Significant results included lower injectable narcotic requirements (p less than 0.001), lower incidence of postoperative urinary retention (p less than 0.01), and lower operative blood loss (p less than 0.1) for patients receiving epidural anesthesia. Epidural bupivacaine provided satisfactory anesthesia, and allowed intraoperative testing of lower extremity motor function. In a follow-up surgery, 38 of 40 patients who received epidural anesthesia were satisfied with the technique. For patients undergoing decompressive lumbar spine surgery, epidural bupivacaine anesthesia is an effective, well tolerated technique with several potential advantages, and an acceptable incidence of complications, as compared with general endotracheal anesthesia.     

Spinal anaesthesia for urological surgery

A survey was conducted on 100 consecutive patients who underwent spinal anaesthesia in our urology operating theatres. Details of the spinal technique were recorded in the operating theatre. In 25% of patients, more than one attempt at subarachnoid puncture was required and 16% of this group went on to require general anaesthesia. The patients were visited between 24 and 48 h postoperatively by one of the authors. On questioning, 24% of patients reported a headache, which had the characteristics associated with dural puncture; 62% of these headaches were described as moderate or severe and lasted between 12 and 24 h. Patients were significantly (p < 0.05) more likely to develop a postdural puncture headache if more than one attempt at subarachnoid puncture was made.     

Spinal anesthesia for noncardiac surgery in infants with congenital heart diseases

Objective/Aim: To compare hemodynamic parameters in infants with congenital heart disease (CHD) undergoing noncardiac surgery (NCS) under awake spinal anesthesia (SA) with controls without CHD also undergoing SA. Background: NCS poses a twofold higher mortality risk in infants with CHD. SA might be a good alternative to general anesthesia (GA) in this setting. Methods: The files of 84 infants were reviewed; 42 had CHD and 42 were controls without CHD. Primary outcome measures were percent decrease in mean arterial pressure (%MAP_decrease) and heart rate (%HR_decrease) from baseline to the lowest intraoperative value. One‐way analysis of variance (anova ), anova with repeated measures, Pearson chi‐square test, Fisher’s exact test, and Pearson correlation were used for statistical analysis. Time to discharge was analyzed with the nonparametric Mann–Whitney U‐test. Results: There were no significant between‐group differences in %MAP_decrease and %HR_decrease; no significant associations and correlations between %MAP_decrease or %HR_decrease and other variables; and no correlation between %MAP_decrease and %HR_decrease. A %MAP_decrease of >20% was documented in 11 patients with CHD (26.2%) and 10 controls (23.8%); a lowest intraoperative HR of <100 b·min^?1 was recorded in two study patients (4.8%) and four controls (9.5%) (P = NS for both). There were no cases of high SA or conversion to GA and no need for mechanical ventilation or inotropic support intra/postoperatively. Conclusions: These preliminary findings show that hemodynamic parameters in infants with CHD undergoing NCS under awake SA are not different from controls without CHD and that SA appears to be safe in infants with CHD.     

气管插管全身麻醉复合腰方肌阻滞用于腰椎手术的效果评价

目的评价气管插管全身麻醉复合腰方肌阻滞(quadratus lumborum block,QLB)用于腰椎手术的临床效果。方法择期行腰椎手术的患者50例,ASA分级Ⅰ~Ⅲ级,采用随机数字表法将患者分为2组(每组25例):对照组(C组)和QLB组(N组)。全身麻醉诱导前N组患者在超声引导下行双侧QLB,在每侧腰方肌和腰大肌之间的筋膜注射0.5%盐酸罗哌卡因15 ml。C组不做QLB,单纯气管插管全身麻醉完成手术。记录患者术前(T0)、麻醉诱导气管插管后即刻(T1)、手术开始前(T2)、手术结束时即刻(T3)、患者清醒拔管后即刻(T4)时点的MAP、心率、SpO2等指标;记录两组患者手术时间、出血量、补液量、术者对肌松满意度评分;记录患者T4、术后4 h(T5)、术后8 h(T6)、术后12 h(T7)、术后24 h(T8)和术后48 h(T9)时静态VAS评分,T7~T9时动态VAS评分;记录术中丙泊酚、瑞芬太尼、顺苯磺酸阿曲库铵用量;记录术后24 h内舒芬太尼用量、患者自控静脉镇痛(patient?controlled intravenous analgesia,PCIA)总按压次数、需额外使用静脉镇痛药补救镇痛的例数;记录术后发生恶心呕吐、呼吸抑制等并发症情况。结果两组患者一般情况差异无统计学意义(P>0.05);N组患者各时点VAS评分均低于C组(P<0.05);N组患者丙泊酚、瑞芬太尼、顺苯磺酸阿曲库铵、舒芬太尼用量比C组降低(P<0.05);N组术后镇痛补救例数、不良反应发生率低于C组(P<0.05);手术医师对N组的肌松满意度高于C组(P<0.05)。结论气管插管全身麻醉复合QLB用于腰椎手术患者的麻醉可以减少全身麻醉药用量,降低不良反应发生率,并降低术后VAS评分,是一种可行的麻醉方法。     

肾移植术患者连续腰麻的效果

目的评价肾移植术患者连续腰麻（CSA）的效果。方法择期肾移植术患者24例，ASAⅢ级，随机分为3组（n=8），DCEA组：L1-2与L3-4间隙硬膜外穿刺，注入2％利多卡因试验剂量5ml，初始剂量10—20ml（0．75％布比卡因＋2％利多卡因，1：1混合液）；CSEA组：L1-2间隙硬膜外穿刺，L3.4间隙经硬膜外针行腰麻穿刺，注入重比重0.5％布比卡因10～13mg，调节体位和硬膜外给药量（0．75％布比卡因＋2％利多卡因，1：1混合液）；CSA组：L3.4间隙经硬膜外针行腰麻穿刺，注入重比重0．5％布比卡因10～13mg，根据阻滞平面给药2—4mg，次。3组目标阻滞平面k，记录入手术室后（基础值）和首剂量局麻药注入后1、5、10、15minSP、DP、MAP、HR。于麻醉前（T1）、移植肾植入髂窝后即刻（T2）、手术结束（T3）测血糖；记录开始注入局麻药至出现满意阻滞平面的时间、肌松程度、肾脏植入髂窝后患者不适感和局麻药总量。结果与CSEA组比较，阻滞平面达T6时间DCEA组延长（P〈0．05），局麻药总量DCEA组增多，CSA组减少（P〈0．05）。3组血糖比较差异无统计学意义（P〉0．05）。镇痛效应及肌松程度CSA组优于DCEA组和CSEA组。结论与硬膜外阻滞和脊椎．硬膜外联合阻滞相比，肾移植术患者连续腰麻产生较好的镇痛、肌松效果，且局麻药用量较少。     

妇科腹腔镜手术腰麻联合硬膜外麻醉的效果

目的:评价妇科腹腔镜手术腰麻联合硬膜外麻醉(combined spinal-epidural anesthesia,CSEA)的效果。方法:择期选择妇科腹腔镜手术患者1000例,ASAⅠ～Ⅱ,随机分为CSEA组和连续硬膜外麻醉组(epidural anesthesia,EA),每组500例,记录入室后(基础值)和注入首剂量局麻药后1min、5min、10min、15min时的SP、DP、MAP、HR、SpO2、PETCO2。观察麻醉前(T1)、气腹即刻(T2)、气腹后20min(T3)、气腹后30min(T4)、气腹后40min(T5)、气腹后50min(T6)两组各指标的变化。记录开始注入局麻药至出现满意阻滞平面的时间、肌松程度、局麻药总量、丙泊酚总量。结果:阻滞平面达T6时间两组有极显著差异(P<0.01)。局麻药总量,丙泊酚总量EA组明显增多(P<0.05),两组SP、DP、MAP、HR、SpO2、PETCO2比较差异无统计学意义(P>0.05)。镇痛效果及肌松程度CSEA组优于EA组。结论:与硬膜外阻滞相比,妇科腹腔镜手术患者腰麻联合硬膜外麻醉有较好的镇痛、肌松效果,且局麻药用量、丙泊酚用量较少。     

Single-dose spinal anaesthesia versus incremental dosing for lower limb vascular surgery

BACKGROUND: In patients scheduled for vascular surgery, atherosclerotic disease is highly prevalent. Haemodynamic reactions are often aggravated when spinal analgesia is used in this population. No randomized studies have been conducted comparing single shot (SS) with continuous spinal analgesia (CSA) for vascular patients. We did a prospective randomized study comparing haemodynamics when SS versus CSA was performed. METHODS: Sixty patients were randomized to have SS or CSA. The power of the study was 0.90. Patients in the SS group received 17.5 mg bupivacaine and in the CSA group 5 mg was given initially and incremental doses of 2.5 mg were given until an analgesic level of T-11 was reached. Mean arterial pressures (MAP) were measured invasively. ST-analysis was done continuously. Postoperatively, the patients were interviewed using a standardized questionnaire. Back pain, neurologic sequelae and post-dural puncture headache (PDPH) were investigated. RESULTS: There was no significant difference between the analgesic levels (T-7/T-8), the decrease in MAP, the number of patients needing ephedrine and the total amount of ephedrine given in the two groups. The motor blockade was more pronounced in the SS group (P < 0.001) and the total amount of bupivacaine used was 17.5 mg compared to 7.5 mg (5-17.5) in the CSA group (P < 0.001). One patient suffered PDPH which was slight and responded to a nonsteroidal anti-inflammatory drug. Two patients in each group had transient paraesthesias in the legs. There were technical problems with the spinal catheter in 4 patients, and these were excluded from the study. CONCLUSION: In this study we found no difference in the haemodynamic response to SS or CSA in patients scheduled for vascular surgery of the legs. SS is easier to apply and is recommended when the duration of surgery allows for it.     

Mivacurium chloride for anesthesia in day surgery

Anesthetic techniques for day surgery must foresee a prompt recovery of alertness, ambulation and alimentation. The aim of our study is to evaluate mivacurium chloride in outpatient general anesthesia. Twenty patients, aged 18–55 years, American Society of Anesthesiologists (ASA) class I–II, undergoing surgical procedures were studied. Mivacurium (0.2 mg/kg) was administered to provide neuromuscular relaxation and endotracheal intubation was performed. Additional doses of 0.1 mg/kg mivacurium were given to maintain neuromuscular block, monitored by Relaxograph (Datex). In all patients, mivacurium provided satisfactory conditions for tracheal intubation after a mean time of 120 ± 15 s. Spontaneous recovery after the last dose of mivacurium was obtained in a mean time of 15 min. No side-effects or significant hemodynamic changes were recorded. The incidence of histamine-related side-effects was low. Mivacurium produces spontaneous recovery of neuromuscular block in a short time and shows some ideal properties for anesthesia in day surgery.     

Influence of lumbar spine pathology on the incidence of paresthesia during spinal anesthesia

Background and Objectives. Paresthesia occasionally occurs during dural puncture or injection of local anesthetic for spinal anesthesia. Although the incidence of neurologic complications after spinal anesthesia is extremely low, the significance of paresthesia is unknown. The influence of known lumbar spine pathology on the incidence of paresthesia during spinal anesthesia is studied. Methods. Incidence of paresthesia with dural puncture (PP) or injection (PI) was studied in two groups of patients. Group 1 included patients for elective total joint replacement without known spine pathology or complaints. Group 2 included patients for elective lumbar spine surgery who received spinal anesthesia. Results. Significantly more PP (20% vs 9%) and PI (16% vs 6%) occurred in the spine surgery group. There were no neurologic sequelae of spinal anesthesia. Conclusions. This information suggests that the incidence of paresthesia during the conduct of spinal anesthesia is higher in patients with lumbar spine pathology. Although there were no neurologic complications, the sample size is too small to exclude an increase in the neurologic risk of spinal anesthesia in patients with known intraspinal pathology.     

不同麻醉方法用于腹腔镜子宫切除术患者的效果

目的 评价不同麻醉方法用于腹腔镜子宫切除术患者的效果.方法 择期拟行腹腔镜子宫切除术患者60例,ASA分级Ⅰ或Ⅱ级,年龄45～60岁,体重55～65 kg,采用随机数字表法,将患者随机分为静吸复合全麻组(Ⅰ组)和脊椎-硬膜外麻醉+全麻组(Ⅱ组),每组30例.Ⅰ组麻醉诱导后,吸入七氟醚,持续输注瑞芬太尼维持麻醉;Ⅱ组先采取脊椎-硬膜外麻醉,麻醉平面稳定后全麻诱导,吸入七氟醚维持麻醉,维持状态熵45～60.于入室后、气腹完成、气腹后10 min、术中持续牵拉子宫、拔除喉罩和拔除喉罩后10 min(T0-5)时采集桡动脉血样,测定血浆肾上腺素(AE)、去甲肾上腺素(NE)和多巴胺(DA)浓度,术毕记录患者自主呼吸恢复时间、拔除气管导管时间和清醒时间,观察术后48 h内不良反应及追加镇痛药物情况,术后48h时行患者满意度评分.结果 与Ⅰ组比较,Ⅱ组患者T3-5时血浆AE和NE浓度、T3,5时血浆DA浓度降低,自主呼吸恢复时间、拔除气管导管时间和清醒时间明显缩短,术后躁动和追加镇痛药物发生率明显降低(P＜0.05),术中知晓、术后恶心呕吐发生率和术后48 h时患者满意度评分差异无统计学意义(P＞0.05).结论脊椎-硬膜外麻醉+全麻用于腹腔镜子宫切除术患者时的效果优于静吸复合全麻.