老年患者腹腔镜胆囊切除术并发症发生的相关危险因素分析

目的:探讨老年患者腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)并发症发生情况及其相关危险因素,为LC并发症的防治提供可借鉴依据。方法:收集2013年4月至2016年4月783例行LC的老年患者的临床资料,分析并发症情况,并采用单因素及多因素分析的方法筛选并发症发生的相关危险因素。结果:并发症总发生率为4.47%(35/783),单因素回归分析结果显示,病程、专科手术经验、手术时间、胆囊壁厚度、胆囊与周围粘连、Calot三角粘连、胆囊颈结石、解剖变异、放置引流、合并基础疾病等10个因素与并发症密切相关。多因素分析表明,影响并发症发生的因素包括专科手术经验(OR=2.954)、胆囊壁厚度(OR=2.496)、胆囊与周围粘连(OR=3.286)、Calot三角粘连(OR=4.212)、放置引流(OR=0.321)、合并基础疾病(OR=4.532)。结论:老年患者行LC的并发症发生率仍较高,手术并发症发生的影响因素较多,临床应提高防范意识,采取针对性的预防措施,以降低并发症发生率,改善患者预后。     

腹腔镜胆囊切除术并发症及影响因素分析

目的探讨腹腔镜胆囊切除术(LC)的并发症及影响因素。方法对550例接受LC治疗患者的临床资料进行回顾性分析。结果患者的年龄、性别、体质量、病程、结石数量、腹腔手术史、胆囊解剖结构等因素与LC并发症的发生无相关性,差异无统计学意义(P0.05);胆囊颈部结石、胆囊壁厚度、胆囊与周围脏器是否粘连、Calot三角是否粘连与LC的并发症有相关性,差异有统计学意义(P0.05)。结论胆囊颈部结石、胆囊壁的厚度、胆囊与周围器官是否粘连、Calot三角是否粘连是LC并发症的影响因素。     

腹腔镜胆囊切除术严重并发症的危险因素及预防措施分析

目的:观察腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)的严重并发症,分析其相关危险因素及预防措施。方法:回顾分析近年行LC患者的临床资料,共纳入2 584例研究对象,统计严重并发症发生率,对可能引起并发症的临床因素进行单因素及logistic多因素回归分析。结果:单因素分析结果提示急性期、胆囊壁厚度、胆囊三角电灼、Calot三角粘连、解剖变异与并发症发生率有关(P<0.05)。将有意义的因素纳入多因素logistic回归分析,按照OR值由高至低依次排列,Calot三角粘连、解剖变异、急性期、胆囊三角电灼是LC严重并发症的独立危险因素(P<0.05),而胆囊壁厚度超过5 mm不是独立危险因素。结论:正确认识危险因素,严格掌握手术适应证,规范术中操作,可降低严重并发症的发生。     

腹腔镜胆囊切除术并发症相关因素分析

目的 探讨导致腹腔镜胆囊切除术(laparoscopic cholecystectomy,LC)并发症发生的危险因素。方法 回顾分析我院自1991年3月-2003年6月间11974例腹腔镜胆囊切除术患者中发生并发症的临床资料,采用X~2检验和Logistic回归方法对可能导致腹腔镜胆囊切除术并发症发生的15个临床病理相关因素,进行多因素回归分析。结果 本组资料LC术后并发症的发生率为1.896％(227/11 974),中转手术率为2.386％(286/11 974),其中因发生并发症而中转开腹65例,占22.727％(65/286)。Logistic回归分析显示,按作用强度,Calot三角粘连、病期、手术经验、胆囊壁厚度(B超)、胆囊与周围粘连依次为导致腹腔镜胆囊切除术并发症发生的主要危险因素。结论 加强医师的腹腔镜技术培训,正确掌握LC相关危险因素是提高LC手术成功率的关键,正确掌握中转开腹的时机及开腹后处理方法,是降低LC手术严重并发症发生和死亡的有效措施。     

腹腔镜胆囊切除术并发症的危险因素分析

目的　探讨腹腔镜胆囊切除术 (LC)后并发症的危险因素。方法　回顾性分析 1991年3月至 2 0 0 3年 6月 11974例腹腔镜胆囊切除术并发症的临床资料 ,采用 χ2 检验和Logistic回归方法对可能导致LC并发症的 15个临床相关因素进行多因素回归分析。结果　LC术后并发症的发生率为1 896 % (2 2 7/11974 ) ,中转手术率为 2 389% (2 86 /11974 ) ,其中因发生并发症而中转开腹 6 5例 ,占2 2 7% (6 5 /2 86 )。Logistic回归分析显示 ,按其对并发症发生影响强弱程度 ,Calot三角粘连、病期、术者的手术经验、胆囊壁厚度 (B超 )、胆囊与周围粘连依次为导致LC并发症发生的主要危险因素。结论　加强医师的腹腔镜技术培训 ,正确掌握中转开腹的时机是降低LC手术严重并发症发生的有效措施。     

单孔腹腔镜胆囊切除术的并发症及影响因素分析

目的:探讨单孔腹腔镜胆囊切除术(SILC)并发症及其影响因素。方法:收集2011年1月至2019年6月收治的977例行SILC患者的临床资料,分析并发症发生情况及相关影响因素。先后采用χ~2检验与多因素logistic回归分析SILC并发症的19个相关因素。结果:本组共21例患者出现并发症,发生率为2.15%。χ~2检验结果显示,并发症与Calot三角粘连、胆囊区解剖变异、急性期、腹部手术史及胆囊壁厚度超过5 mm有关(P<0.05)。多因素Logistic回归分析结果显示,Calot三角粘连(P<0.05,OR=6.537)、胆囊区解剖变异(P<0.05,OR=5.253)、腹部手术史(P<0.05,OR=4.762)、胆囊壁厚度(P<0.05,OR=4.318)是SILC并发症发生的危险因素。结论:术前充分评估围术期可能存在的危险因素,以降低并发症发生率,提高SILC的安全性。     

腹腔镜胆囊切除术致严重并发症的分布及危险因素分析—单中心71238例临床资料总结

目的探讨腹腔镜胆囊切除术(LC)导致严重并发症的分布及相关危险因素。方法回顾性分析1992年10月～2011年07月71238例腹腔镜胆囊切除术并发症的临床资料,采用χ2检验和Logistic回归方法对可能导致LC并发症的16个临床相关因素进行统计学分析。结果 LC术后严重并发症的发生率为0.37%(262/71238),其中因发生并发症而中转开腹173例,占66.1%(173/262)。Logistic回归分析显示:Calot三角粘连、解剖变异、病期、胆囊壁厚度、胆囊萎缩为导致LC并发症发生的主要危险因素。结论加强医师的腹腔镜技术培训,严格掌握LC适应证,正确掌握中转开腹的时机是降低LC手术严重并发症发生的有效措施。     

The risk factors of distribution and serious complications induced by laparoscopic cholecystectomy in a single center: an analysis of 71238 cases

目的 探讨腹腔镜胆囊切除术(LC)导致严重并发症的分布及相关危险因素.方法 回顾性分析1992年10月-2011年07月71238例腹腔镜胆囊切除术并发症的临床资料,采用x2检验和Logistic回归方法对可能导致LC并发症的16个临床相关因素进行统计学分析.结果 LC术后严重并发症的发生率为0.37％( 262/71238),其中因发生并发症而中转开腹173例,占66.1％(173/262).Logistic回归分析显示:Calot三角粘连、解剖变异、病期、胆囊壁厚度、胆囊萎缩为导致LC并发症发生的主要危险因素.结论 加强医师的腹腔镜技术培训,严格掌握LC适应证,正确掌握中转开腹的时机是降低LC手术严重并发症发生的有效措施.     

腹腔镜胆囊切除术并发症相关因素分析

目的 探讨导致腹腔镜胆囊切除术(lapawscopic cholecystectomy，LC)并发症发生的危险因素。方法 回顾分析我院自。1991年3月—2003年6月间11974例腹腔镜胆囊切除术患中发生并发症的临床资料，采用x^2检验和Logistic回归方法对可能导致腹腔镜胆囊切除术并发症发生的15个临床病理相关因素，进行多因素回归分析。结果 本组资料LC术后并发症的发生率为1．896％(227／11974)，中转手术率为2．386％(286/11974)，其中因发生并发症而中转开腹65例，占22．727％(65／286)。Logistic回归分析显示，按作用强度，Calot三角粘连、病期、手术经验、胆囊壁厚度(B超)、胆囊与周围粘连依次为导致腹腔镜胆囊切除术并发症发生的主要危险因素。结论 加强医师的腹腔镜技术培训，正确掌握LC相关危险因素是提高LC手术成功率的关键，正确掌握中转开腹的时机及开腹后处理方法，是降低LC手术严重并发症发生和死亡的有效措施。     

萎缩性胆囊炎腹腔镜胆囊切除术中胆囊Calot三角的处理

目的探讨萎缩性胆囊炎腹腔镜下胆囊切除术(LC)术中Calot三角的处理。方法对125例慢性结石性萎缩性胆囊炎进行LC的资料进行回顾性分析。结果 125例中行LC成功117例,成功率93.6%,中转开腹8例,4例因Calot三角严重粘连、解剖不清、胆囊管无法分离,1例胆囊与周围组织致密粘连无法分离,2例因为胆囊动脉出血,1例胆囊十二指肠瘘而中转开腹。全组术后无并发症,均治愈出院。结论萎缩性胆囊炎LC手术成功的关键是Calot三角的解剖,可以通过术前B超,CT,MRI来判断三角区的情况,术中对三角区的胆囊动脉,胆囊管的正确处理可以提高手术成功率,减少手术并发症。     

维生素D受体在糖尿病肾病足细胞损伤及蛋白尿缓解中的作用

目的探讨维生素D受体(VDR)在糖尿病肾病(DKD)足细胞中的表达水平及在足细胞损伤及蛋白尿缓解中的作用。方法(1)本研究纳入了65例诊断患有2型糖尿病(伴或不伴蛋白尿)的患者,并纳入了25例年龄和性别相匹配的健康体检者为对照组。根据白蛋白/肌酐(ACR)的尿排泄比例对2型糖尿病患者进行分组,分别为无蛋白尿(ACR<30 mg/g,n=24)、微量白蛋白尿(ACR 30~300 mg/g,n=18)和临床蛋白尿(ACR>300 mg/g,n=23)。另选择25例经肾活检确诊的DKD患者作为DKD组。正常肾脏组织标本均取自泌尿外科同一时期肾脏肿瘤切除患者10例。将各组检测指标进行对比,同时采用实时定量PCR、ELISA法和免疫组化法检测VDR在各组患者的血液、尿液样本和肾脏组织中的表达情况,以及使用Pearson相关分析分析VDR与尿蛋白的相关性。(2)在2型糖尿病肾病小鼠模型中对上述结果进行验证,将遗传背景均为C57BLKs/J的雄性db/db小鼠及同窝出生的db/m小鼠,随机分为正常对照组(A组)、DKD对照组(B组)、DKD二甲基亚砜处理组(C组)、DKD帕立骨化醇(VDR激动剂)处理组(D组),C、D组连续腹腔注射处理8周,对照组不做任何处理。小鼠10周龄时开始连续干预8周,在小鼠22周龄(开始干预后12周)检测各组小鼠体重、血、尿生化指标对比;Western印迹法检测β⁃catenin、VDR的变化;免疫荧光观察足细胞标志蛋白podocin及足细胞损伤蛋白α⁃SMA的表达变化。结果(1)与正常健康对照组相比,无蛋白尿组、微量白蛋白尿组和临床蛋白尿组的糖尿病患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05);与无蛋白尿组的糖尿病患者相比,微量白蛋白尿组和临床蛋白尿组的糖尿病患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05)。(2)与正常健康对照组相比,无蛋白尿糖尿病组和DKD组患者血浆中VDR的mRNA和蛋白水平均较低(均P<0.05);与无蛋白尿糖尿病组患者相比,DKD组患者血浆中VDR的mRNA和蛋白水平亦较低(均P<0.05)。(3)免疫组化结果显示,DKD组肾组织中VDR的表达明显少于正常对照组。(4)DKD患者血浆中VDR mRNA相对水平与ACR呈负相关(r=-0.342,P<0.05)。(5)各组尿液上清液中VDR的水平与血浆中的水平呈相反趋势。(6)Western印迹结果显示,B组、C组肾小球足细胞β⁃catenin蛋白表达高于D组(均P<0.05),VDR蛋白的表达低于D组(均P<0.05);免疫荧光结果显示,B组、C组肾小球足细胞podocin的表达低于D组(均P<0.05),α⁃SMA的表达高于D组(均P<0.05)。结论VDR高表达缓解DKD足细胞损伤及蛋白尿。     

Anterior Interosseous Nerve Palsy After Shoulder Arthroscopy Treated With Surgical Decompression: A Case Series and Systematic Review of the Literature

Background: Anterior interosseous nerve (AIN) palsy is a very uncommon cause of upper extremity pain and weakness that comprises less than 1% of all upper extremity nerve palsies. Rarely reported but also mentioned in the literature is AIN palsy after shoulder arthroscopy. Methods: A systematic review of the literature to date using PubMed was conducted to identify patients who suffered AIN palsy after shoulder arthroscopy procedures. Articles included met the following criteria: (1) published in English; (2) primary presentation of the data; (3) patients had undergone shoulder arthroscopy before developing symptoms of AIN palsy; and (4) diagnosis was confirmed with clinical symptoms of AIN palsy. Measured outcomes included patient demographics, specific shoulder procedure, anesthesia procedure, intra-operative patient positioning, intra-operative compressive dressing, intra-operative traction, surgical versus conservative treatment, abnormal findings during decompression procedure, proposed mechanism of injury, and follow-up. Results: The search yielded 6 articles, of which 4 (13 cases) met inclusion criteria. An additional 2 cases were included in this report totaling 15 cases. The average patient age was 49 years (range: 31-64) with 73% males. At average follow-up of 24 months, 67% of patients experienced complete resolution of symptoms—more than half of which underwent surgical decompression. Patients who failed to progress experienced weakness of the flexor digitorum profundus and flexor pollicis longus muscles. Conclusions: Proposed injury mechanisms for AIN palsy after shoulder arthroscopy range from mechanical trauma, compressive hematoma, and direct anesthetic neurotoxicity. Management should be directed by clinical symptoms, imaging, and patient factors with majority of patients expected to have excellent clinical outcomes.     

不同尿钙水平的Gitelman综合征患者临床特点比较

目的观察不同尿钙水平Gitelman综合征(GS)患者的临床特点,探讨尿钙在GS疾病临床分型中的价值。方法收集2016—2018年来自中国国家罕见病注册系统(NRSC)、在北京协和医院行SLC12A3基因检测诊断为GS患者的临床资料,分析其尿钙特点,比较不同尿钙水平患者的临床和实验室检查指标。氢氯噻嗪试验按照标准操作流程进行,测定患者基线和用药后3 h内氯离子排泄分数改变量的最大值(ΔFECl)。结果共有83例GS患者被纳入研究,其中低尿钙患者53例(63.86%)。低尿钙组尿钙/肌酐比明显低于非低尿钙组[(0.085±0.058)mmol/mmol比(0.471±0.284)mmol/mmol,t=7.349,P<0.001]。两组患者在年龄、性别、估算肾小球滤过率、血压、血尿电解质水平、代谢性碱中毒方面差异均无统计学意义。低尿钙组患者乏力(χ2=4.595,P=0.032)及多尿(χ2=5.778,P=0.016)发生比例低于非低尿钙组,两组患者在其他临床症状方面差异无统计学意义。低尿钙和非低尿钙组各有16例患者行氢氯噻嗪试验,中位ΔFECl结果分别为0.539%(0.430%,1.283%)和0.829%(0.119%,1.298%),均提示对氢氯噻嗪无反应,组间差异无统计学意义(U=130.000,P=0.956)。结论GS患者中低尿钙比例为63.86%,尿钙水平与疾病临床表型、NCC功能损伤严重程度之间均无明确相关性。     

Role of Conventional and Diffusion-Weighted Magnetic Resonance Imaging of Spinal Treatment Protocol for Hydatid Disease

Objective:

To demonstrate the role of magnetic resonance imaging (MRI) in determining the treatment protocol for hydatid disease of the spine.

Design:

Case report; literature review.

Findings:

Diffusion-weighted MRI can help differentiate complicated infected hydatidosis from abscesses, epidermoid cysts from arachnoid cysts, and benign from malignant vertebral compression fractures. It is also helpful in differentiating between abscesses and necrotic tumors.

Conclusion:

Diffusion-weighted MRI can help differentiate between infections requiring immediate surgery and those that can be treated medically with antihelmintic treatment.     

Fibrinogen-thrombin collagen patch reinforcement of highrisk colonic anastomoses in rats

AIM To evaluate the effectiveness of human fibrinogenthrombin collagen patch(TachoSil~?) in the reinforcement of high-risk colon anastomoses.METHODS A quasi-experimental study was conducted in Wistar rats(n = 56) that all underwent high-risk anastomoses(anastomosis with only two sutures) after colectomies. The rats were divided into two randomized groups: Control group(24 rats) and treatment group(24 rats). In the treatment group, high-risk anastomosis was reinforced with TachoSil~? (a piece of Tacho Sil? was applied over this high-risk anastomosis, covering the gap). Leak incidence, overall survival, intra-abdominal adhesions, and histologic healing of anastomoses were analyzed. Survivors were divided into two subgroups and euthanized at 15 and 30 d after intervention in order to analyze the adhesions and histologic changes. RESULTS Overall survival was 71.4% and 57.14% in the TachoSil~? group and control group, respectively(P = 0.29); four rats died from other causes and six rats in the treatment group and 10 in the control group experienced colonic leakage(P 0.05). The intra-abdominal adhesion score was similar in both groups, with no differences between subgroups. We found non-significant differences in the healing process according to the histologic score used in both groups(P = 0.066).CONCLUSION In our study, the use of TachoSil~? was associated with a non-statistically significant reduction in the rate of leakage in high-risk anastomoses. TachoSil~? has been shown to be a safe product because it does not affect the histologic healing process or increase intra-abdominal adhesions.     

Fluorescence in the Sclera,Nails, and Teeth Secondary to Favipiravir Use for COVID-19 Infections

Favipiravir, an antiviral agent originally used for influenza infections, has become popular due to its beneficial signals in coronavirus disease. It is currently used in some countries within COVID-19 treatment protocols. This is an initial report of favipiravir-related fluorescence observed in three healthcare providers working in the same ward in our hospital. All three individuals had been diagnosed with COVID-19 two months earlier and were treated with favipiravir. None of the three individuals received hydroxychloroquine or tetracyclines. Wood’s light examination led to an incidental discovery of favipiravir-induced fluorescence involving the sclera, nails, and teeth. In all patients, white linear, square, and band-like specks of fluorescence were noticed on the sclera of both eyes, some teeth, and the proximal part of all fingernails and toenails. Exposure of the eyes to the Wood’s light was for a brief duration of 3 to 5 seconds during examination and photodocumentation. Favipiravir might cause bright white fluorescence of nails, sclera, and teeth, detectable by Wood’s light even two months after its cessation.     

Safety and tolerability of single intravenous doses of sugammadex administered simultaneously with rocuronium or vecuronium in healthy volunteers

BACKGROUND: Sugammadex rapidly reverses rocuronium- and vecuronium-induced neuromuscular block. To investigate the effect of combination of sugammadex and rocuronium or vecuronium on QT interval, it would be preferable to avoid the interference of anaesthesia. Therefore, this pilot study was performed to investigate the safety, tolerability, and plasma pharmacokinetics of single i.v. doses of sugammadex administered simultaneously with rocuronium or vecuronium to anaesthetized and non-anaesthetized healthy volunteers. METHODS: In this phase I study, 12 subjects were anaesthetized with propofol/remifentanil and received sugammadex 16, 20, or 32 mg kg(-1) combined with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1); four subjects were not anaesthetized and received sugammadex 32 mg kg(-1) with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1) (n=2 per treatment). Neuromuscular function was assessed by TOF-Watch SX monitoring in anaesthetized subjects and by clinical tests in non-anaesthetized volunteers. Sugammadex, rocuronium, and vecuronium plasma concentrations were measured at several time points. RESULTS: No serious adverse events (AEs) were reported. Fourteen subjects reported 23 AEs after study drug administration. Episodes of mild headache, tiredness, cold feeling (application site), dry mouth, oral discomfort, nausea, increased aspartate aminotransferase and gamma-glutamyltransferase levels, and moderate injection site irritation were considered as possibly related to the study drug. The ECG and vital signs showed no clinically relevant changes. Rocuronium/vecuronium plasma concentrations declined faster than those of sugammadex. CONCLUSIONS: Single-dose administration of sugammadex 16, 20, or 32 mg kg(-1) in combination with rocuronium 1.2 mg kg(-1) or vecuronium 0.1 mg kg(-1) was well tolerated with no clinical evidence of residual neuromuscular block, confirming that these combinations can safely be administered simultaneously to non-anaesthetized subjects. Rocuronium and vecuronium plasma concentrations decreased faster than those of sugammadex, reducing the theoretical risk of neuromuscular block developing over time.     

罗伊适应模式对腹股沟疝无张力疝修补术后恢复情况的影响

目的探讨罗伊适应模式对患者腹股沟疝无张力疝修补术后恢复情况的影响。 方法将2016年1月至2019年5月在秦皇岛市第二医院择期进行无张力修补术治疗的120例腹股沟疝患者，按照随机数字法分为对照组和观察组，每组各60例。对照组采用常规护理治疗，观察组在对照组的基础上采用罗伊适应模式。比较2组患者的术后临床指标、心理状态、围手术期并发症发生情况及满意度。 结果术后观察组患者的首次排气时间、恢复正常饮食时间、离床活动时间和术后住院时间均低于对照组（P<0.05）；术后观察组患者的抑郁自评量表（SDS）和焦虑自评量表（SAS）评分显著低于对照组（P<0.05）；术后2组患者均无切口感染发生，2组患者尿潴留、急性疼痛、认知功能障碍、发热、血肿等发生率相比无统计学差异（P>0.05）；术后观察组患者护理满意度为96.67%，显著高于对照组的83.33%（P<0.05）。 结论在常规护理的基础上，罗伊适应模式用于患者腹股沟疝无张力修补围手术期，能有效改善术后患者的焦虑/抑郁情绪，不增加围手术期并发症，促进术后患者的恢复及提高治疗满意度。     

Factors Associated With Reoperation After Silicone Proximal Interphalangeal Joint Arthroplasty

Background: Silicone proximal interphalangeal (PIP) joint arthroplasty has a high revision rate. It has been suggested that persistent ulnar deviation and joint instability influence the durability of PIP silicone arthroplasties. The goal of this study was to evaluate what factors are associated with reoperation after silicone PIP arthroplasty. Methods: We retrospectively evaluated all adult patients who underwent PIP silicone arthroplasty between 2002 and 2016 at one institutional system for inflammatory-, posttraumatic-, and primary degenerative arthritis. After manual chart review, we included 91 patients who underwent 114 arthroplasties. Fingers operated included 14 index, 41 middle, 38 ring, and 21 small fingers. Results: The overall reoperation rate was 14% (n = 16). Non-Caucasian race (P = .040), smoking (P = .022) and PIP silicone arthroplasty for post-traumatic osteoarthritis (P = .021) were associated with reoperation. The 1-, 5- and 10-year implant survival rates were 87%, 85%, and 85%, respectively. Conclusion: Caution should be exercised when considering PIP silicone arthroplasty of the index finger or in patients with post-traumatic osteoarthritis. It may be worthwhile addressing smoking behavior before pursuing silicone PIP arthroplasty.     

血浆凝血因子VIII水平与IgA肾病患者临床病理改变及预后的关系

目的探讨血浆凝血因子VIII(factor VIII,FVIII)水平与IgA肾病(IgAN)患者临床参数及预后的关系。方法收集2016年1月至2016年12月中南大学湘雅二医院确诊的IgAN患者的临床资料。按照时间依赖的受试者工作特征曲线(ROC)得出的血浆FVIII预测IgAN预后的临界值,将患者分为高FVIII组(FVIII>140.50%)和低FVIII组(FVIII≤140.50%),比较两组患者肾活检时基线临床参数的差异。以估算肾小球滤过率(eGFR)下降≥30%或进入终末期肾脏病(ESRD)为终点事件,采用Kaplan-Meier生存曲线及Cox回归方程法分析血浆FVIII水平对IgAN患者预后的影响。结果共93例IgAN患者纳入本研究,中位随访时间为35.15(33.77,36.76)个月,12例(12.90%)患者发生终点事件。高FVIII组患者年龄、血肌酐、尿素氮、血三酰甘油、血总胆固醇、血浆纤维蛋白原、D-二聚体、24 h尿蛋白量、蛋白C、蛋白S和eGFR下降速率高于低FVIII组(均P<0.05);eGFR、血白蛋白、中位随访时间低于低FVIII组(均P<0.05)。Kaplan-Meier生存分析结果显示,与低FVIII组比较,高FVIII组患者肾脏累积生存率降低(χ2=5.635,P=0.018)。在校正收缩压、eGFR、尿蛋白、肾小管萎缩/间质纤维化程度等因素后,多因素Cox回归分析结果显示,高血浆FVIII水平是IgAN患者肾脏预后不良的独立危险因素(HR=4.147,95%CI 1.055~16.308,P=0.042)。结论血浆FVIII水平与IgAN患者临床指标及预后相关,高血浆FVIII水平是IgAN患者肾脏预后不良的独立危险因素。