Endoglin与肿瘤血管生成及在肿瘤研究中的意义

Endoglin是内皮细胞表面与增殖相关的膜抗原，主要表达于肿瘤新生血管内皮细胞，可作为肿瘤诊断、转移、复发和判断预后的早期指标，是治疗人体恶性肿瘤的理想的分子靶位。     

肿瘤血管生成与抗血管生成治疗

恶性肿瘤的死亡率已逐渐占据各种疾病的首位,肿瘤的侵袭性生长和转移又是恶性肿瘤的最重要生物学特性,一般实体瘤在诊断时就有2/3左右已经存在转移,而转移也恰恰是肿瘤治疗失败的主要原因,绝大多数肿瘤患者最终死于转移瘤的生长和毒副作用,因此对肿瘤侵袭和转移的早期诊断和合理治疗是恶性肿瘤治疗取得成功的关键。肿瘤的生长和转移是一个依赖于血管的过程,当肿瘤体积大于2mm3     

血管生成与肿瘤治疗

为寻找逆转录病毒体内直接转导的有效方法,Fassati等用逆转录病毒包装细胞PA317经低剂量丝裂霉素 C(0.5～2μg/ml)处理后(处理后的细胞在体内仍能存活10天左右)移植到nude、nude/md、C57BL/6小鼠的胫骨肌群,移植前24小时肌组织预先注射BaCl_2以诱导肌细胞再生并刺激干细胞.用LacZ报告基因检测发现移植后1月,外源基因就有高效表达,并至     

血管抑素与肿瘤的抗血管生成治疗

血管抑制是一种新发现的特异的血管内皮细胞增殖抑制剂，对肿瘤血管形成具有强烈的抑制作用，是非常有效的抗肿瘤血管形成抑制因子，可能在血管生成调控中起重要的作用。     

肿瘤血管生成与乳腺癌研究进展

肿瘤新生血管生成在肿瘤的生长和转移过程中起着重要作用，抗血管生成治疗可能成为肿瘤治疗的新方法。本文综述了乳腺癌的血管生成机制及乳腺癌抗血管生成治疗的研究进展。     

肿瘤血管生成及抗血管生成基因治疗

肿瘤的侵袭和转移明显影响患者的预后,而肿瘤的血管生成是肿瘤生长、侵袭、转移的基本条件。因而抑制肿瘤血管生成是治疗肿瘤的关键。本文就肿瘤血管生成的调控及抗肿瘤血管生成基因治疗的研究进展作一综述。     

血管生成在肿瘤发展和转移中的作用及治疗策略

肿瘤转移是肿瘤病人死亡的主要原因。肿瘤转移是多阶段的、复杂的，只有高度选择性的过程，它涉及肿瘤细胞自身与宿主之间错综复杂的关系，并受多种相关基因的调控。其中，血管生成是实体瘤转移发展的关键。如能抑制或破坏这些新生血管就可防止恶性肿瘤的生长与转移。这是近年来肿瘤研究的一个新课题。寻找毒性低、效果好的血管生长抑制剂在肿瘤治疗和预防肿瘤转移方面具有良好的应用前景。一、肿瘤血管生成的临床意义血管增殖是正常组织生长与发育所必须的一个过程，并受机体严格调控。在成年人，除女性的生殖系统及机体的修复过程发生血管…     

肿瘤血管生成抑制剂研究进展

肿瘤生长、侵袭、转移和复发是血管生成依赖性的,以肿瘤血管生成的各个环节为靶点,研制血管生成抑制剂,可有效地抑制肿瘤的转移和复发,成为肿瘤防治的新途径.本文就目前已进入临床试验的30多种血管生成抑制剂研究进展作一综述.     

Endoglin与肿瘤血管生成、浸润及转移之间的关系

恶性肿瘤的浸润和转移是导致患者死亡的主要原因,而肿瘤新生血管对肿瘤的生长和转移具有重要的营养支持作用。Endoglin是参与调节TGF-β信号传导的跨膜蛋白,作为TGF-β家族的辅助受体发挥生物学效应。Endoglin作为新生血管内皮细胞的标志物之一,在肿瘤血管内皮细胞中呈异常高表达,并且促进肿瘤血管的形成。目前以endoglin为靶点抑制肿瘤血管生成的抗肿瘤策略已被证实具有一定成效,但肿瘤细胞依然存在对药物的抵抗、复发及转移等现象。为寻求这一现象的原因,近年来研究发现在某些原发肿瘤细胞中表达的endoglin可以抑制肿瘤细胞的浸润及转移。本文结合国内外最新报道,就endoglin与肿瘤血管生成、肿瘤浸润及转移之间的关系作以一简要综述,为今后如何抑制其促血管生成作用及发挥其抑制肿瘤细胞的浸润及转移作用提供思路。     

视黄酸对肿瘤血管形成影响的研究进展

血管形成是肿瘤增殖及转移所依赖的基础.多种因素影响肿瘤血管形成,视黄酸在此方面有其独特的作用及机制,在多种实验模型中,视黄酸均表现有明显的抑制肿瘤血管形成的作用,其作用机制可能与影响细胞因子活性、抑制内皮细胞增殖及迁移、调节细胞外基质成分及诱导相应抑制因子有关.     

The clinical significance of tumor angiogenesis and invasiveness-related gene expressions in gastric cancer

Gastric cancer is a malignant tumor with the highest morbidity and mortality in China. Despite improvement of surgical treatment, postoperative metastasis remains the leading cause of death. Therefore, searching for biological indicators, which can predict the metastatic potential of gastric cancer, and treating the high risk cases individually have become one of the important subjects in the current research. With the deepening of the research on molecular biology, some biological indicators …     

Prognostic significance of tumor angiogenesis in epithelial ovarian cancer.

Since angiogenesis is considered essential for tumor growth and the development of metastasis, we assessed the correlation of microvessel density (MVD) with overall survival in patients with epithelial ovarian cancer. Histologic slides were immunostained for CD34-antigen. MVD was determined within each tumor by enumeration under a light microscope at 200x magnification and an examination area of 0.25 mm2. The Cox proportional-hazards model was used for multivariate analysis. In 63 patients with epithelial ovarian cancer the 5-year survival rate (OS-%) was as follows: 55.0% (+/-12.5) in 18 patients whose tumors had an MVD < 10/field, and 23.6% (+/-6.7) in 45 patients whose tumors had an MVD(10/field (log-rank P = 0.038). MVD showed a significant influence on survival in univariate analysis, but failed to attain a significant value after adjustment for established prognostic parameters such as patients' age at diagnosis, stage of disease, and histologic grading. High MVD was significantly associated with advanced patients' age at diagnosis. This and a considerable heterogenity in the vascular architecture of ovarian carcinoma tissue might be the reasons why MVD did not reveal prognostic significance in multivariate analysis. In contrast to a variety of solid neoplasms, MVD does not seem to be a useful predictor of survival in patients with epithelial ovarian cancer.     

Prognostic significance of tumor angiogenesis in primary fallopian tube cancer.

Tumor angiogenesis has been found to be prognostically significant in many types of malignant tumors. We assessed tumor vascularity in 43 cases of histologically proven primary fallopian tube cancer, FIGO stage I-IV, using the highly specific endothelial cell marker CD34. Microvessel count was determined by counting CD34-positive cells at 200 x magnification. The 5-year disease-free survival probability was 43.8% (+/- 11.5%) in 24 patients whose tumors had a microvessel count < or = 19 microvessels/field and 19.7% (+/- 9.5%) in the > 19 microvessels/field group (P = 0.046). Stage and microvessel count were statistically significant for disease-free survival in univariate analysis. Therefore, a larger sample size would be required to detect an independent and statistically significant prognostic effect of microvessel density in primary fallopian tube cancer in multivariate analysis.     

肿瘤血管生成在胃癌侵袭,转移和预后判断中的意义

采用CD34单克隆抗体QB－END／10免疫组织化学SP法检测了68例胃癌组织中的微血管密度（MicrovesseldensityMVD），旨在探讨肿瘤血管生成在胃癌侵袭、转移和预后判断中的意义。结果发现，所有胃癌组织中平均MVD为18．2土10．9，MVD随肿瘤侵袭深度、TNM分期的增加而增大，有淋巴结转移患者的MVD（20．85士10．19）明显高于无淋巴结转移患者（14．32土10．67）（P＜0．01）。有血管、神经侵犯的胃癌患者MVD明显高于无血管、神经侵犯者（P＜0．01）。单因素、多因素分析表明，高MVD（≥18）胃癌患者比低MVD（＜18）患者预后明显为差（P＜O．05），MVD是影响胃癌预后的独立因素。研究表明，肿瘤血管生成是胃癌侵袭、转移发生必不可少的环节，MVD是衡量胃癌细胞侵袭转移能力和判断患者预后的一个有用指标。     

The role of matrix metalloproteinases in tumor angiogenesis and tumor metastasis

Although a considerable amount of effort has been placed on discovering the etiologies of cancer, the majority of the basic cancer research existing today has focused on understanding the molecular mechanism of tumor formation and metastasis. Metastatic spread of tumors continues to be a major obstacle to successful treatment of malignant tumors. Approximately 30% of those patients diagnosed with a solid tumor have a clinically detectable metastasis and for the remaining 70%, metastases are continually being formed throughout the life of the tumor. Even after the tumor is excised, the threat of death is attributable to the metastasis that may occur through the remaining tumor cells. In addition, treating the metastasis often proves futile since metastasis often vary in size, composition, and anatomical location. New treatments blocking the formation of metastasis will provide greater chances of survival for cancer patients. One family of enzymes that has been shown over the years to play a role in tumor progression is the matrix metalloproteinase (MMP) family. The main function of MMPs, also known as matrixins, is degradation of the extracellular matrix physiologic function involving MMPs include wound healing, bone resorption and mammary involution. MMPs, however, also contribute to pathological conditions including rheumatoid arthritis, coronary artery disease, and cancer. Tumor cells are believed to utilize the matrix degrading capability of these enzymes to spread to distant sites. In addition, MMPs also are thought to promote the growth of these tumor cells once they have metastasized. This review will discuss the role of MMPs and their inhibitors in tumor invasion, angiogenesis and metastasis with special emphasis on the gelatinases, MMP-2 and MMP-9.     

The role of integrins in tumor angiogenesis

Integrins are cell adhesion molecules that play an important role in the regulation of angiogenesis. In this overview, the vascular integrins and their mechanisms of action are outlined. Integrins have been evaluated in preclinical and clinical studies for the treatment of cancer and as diagnostic markers of angiogenesis. Furthermore, integrins are the basis for targeted therapy for solid tumors and novel imaging techniques to assess the angiogenic response of tumors.     

Tumor angiogenesis and tumor angiogenesis inhibitors

It is important to survey the molecular targets which are involved in tumor angiogenesis for the development of antiangiogenic agents as one of the cancer therapy. This article is meant to review the recent molecular targets of tumor angiogenesis and the molecular mechanism of antiangiogenic agents in human clinical trials.