逆行交锁髓内钉内同定治疗股骨远端骨折

目的 观察股骨逆行交锁钉(GSH钉)治疗股骨远端骨折的疗效.方法 2002年1月～2005年12月,我院采用GSH钉治疗股骨远端骨折28例.按AO/ASIF分类法,A1型12例,A2型7例,A3型3例,C1型4例,C2型1例,C3型1例.结果 随访12-48个月,平均19个月,28例骨折均顺利愈合,平均愈合时闻14周.根据Neer膝关节功能评定标准,优20例,良5例,优良率88.9%.结论 采用GSH钉治疗股骨远端AO/ASIF分类的A型和C型骨折,能提供坚强内固定,手术时间短,创伤小,有利于骨折的愈合和膝关节功能的恢复,是治疗股骨远端骨折的理想方法.     

逆行交锁髓内钉内固定治疗股骨远端骨折

目的 观察股骨逆行交锁钉(GSH钉)治疗股骨远端骨折的疗效.方法 2002年1月-2005年12月,我院采用GSH钉治疗股骨远端骨折28例.按AO/ASIF分类法,A1型12例,A2型7例,A3型3例,C1型4例,C2型1例,C3型1例.结果 随访12-48个月,平均19个月,28例骨折均顺利愈合,平均愈合时间14周.根据Ncer膝关节功能评定标准,优20例,良5例,优良率88.9%.结论 采用GSH钉治疗股骨远端AO/ASIF分类的A型和C型骨折,能提供坚强内固定,手术时问短,创伤小,有利于骨折的愈合和膝关节功能的恢复,是治疗股骨远端骨折的理想方法.     

逆行交锁髓内钉内同定治疗股骨远端骨折

目的 观察股骨逆行交锁钉(GSH钉)治疗股骨远端骨折的疗效.方法 2002年1月～2005年12月,我院采用GSH钉治疗股骨远端骨折28例.按AO/ASIF分类法,A1型12例,A2型7例,A3型3例,C1型4例,C2型1例,C3型1例.结果 随访12-48个月,平均19个月,28例骨折均顺利愈合,平均愈合时闻14周.根据Neer膝关节功能评定标准,优20例,良5例,优良率88.9%.结论 采用GSH钉治疗股骨远端AO/ASIF分类的A型和C型骨折,能提供坚强内固定,手术时间短,创伤小,有利于骨折的愈合和膝关节功能的恢复,是治疗股骨远端骨折的理想方法.     

逆行交锁髓内钉内固定治疗股骨远端骨折

目的 观察股骨逆行交锁钉(GSH钉)治疗股骨远端骨折的疗效.方法 2002年1月-2005年12月,我院采用GSH钉治疗股骨远端骨折28例.按AO/ASIF分类法,A1型12例,A2型7例,A3型3例,C1型4例,C2型1例,C3型1例.结果 随访12-48个月,平均19个月,28例骨折均顺利愈合,平均愈合时间14周.根据Ncer膝关节功能评定标准,优20例,良5例,优良率88.9%.结论 采用GSH钉治疗股骨远端AO/ASIF分类的A型和C型骨折,能提供坚强内固定,手术时问短,创伤小,有利于骨折的愈合和膝关节功能的恢复,是治疗股骨远端骨折的理想方法.     

GSH逆行髁上髓内钉治疗股骨远端骨折疗效分析

应用GSH逆行髁上髓内钉治疗股骨远端骨折35例（其中一例为双侧），采用AO分类法：A1型2例，A2型5例，A3型8例，C1型2例，C2型18例，C3型1例。均采用切开复位GSH逆行髁上髓内钉内固定。探讨应用GSH逆行髁上髓内钉治疗股骨远端骨折的临床疗效。结果：随访时间为6～24个月，所有骨折均获骨性愈合，平均愈合时间6个月。按Kolmert功能评分标准，优20例，良11例，可4例，优良率88．6％。提示GSH逆行髁上髓内钉是治疗股骨远端骨折的有效内固定方式。     

倒打交锁髓内钉治疗股骨远端骨折28例

为探讨倒打髓内钉(GSH)治疗股骨远端骨折的临床疗效,观察28例股骨远端骨折采用GSH固定的临床效果,其中22例采用闭合复位,6例采用切开复位,经皮插钉技术。骨折按AO/ASIF分类,A12例,A23例,A36例,C14例,C23例,股骨中下1/3骨折10例。结果,术后23例随访3~15个月,平均6.4个月,平均愈合时间3.7个月,平均关节活动度108°,无内外翻畸形,2例钉尾稍长,屈膝大于90°后感觉疼痛。应用GSH治疗股骨远端骨折是一种理想的手术方法。     

GSH钉在治疗股骨远端骨折中的应用

总结本组42例股骨髁上髓内钉（GSH）治疗股骨远端骨折（A1、A2、A3、C1及C2型）,平均随访16个月,骨折全部愈合,优良率95．2％。GSH钉是治疗股骨远端骨折（A1、A2、A3、C1及C2型）的较理想的内固定材料．     

GSH钉治疗股骨远端骨折

目的：介绍GSH钉治疗股骨远端骨折的临床应用。方法：股骨远端骨折12例,AO分型,A1型8例,A2型2例,A3型1例,C1型1例。切开复位行GSH倒打钉内固定术。结果：全部病例手术顺利,骨折端复位良好,GSH钉固定牢固,术后2－3周,可扶拐下地活动,术后12－14周骨折已达临床愈合,膝关节活动无受限。结论：GSH钉是治疗股骨远端9cm以内骨折的一种崭新方法,其操作简单,固定可靠,膝关节功能可早期恢复。     

GSH钉和DCS固定治疗股骨髁上骨折的临床分析

目的总结GSH钉和DCS钢板内固定两种方法治疗股骨髁上骨折的效果。方法GSH钉组32例;DCS钢板组40例。平均伤后手术时间GSH钉和DCS钢板组分别为4 d和3.5 d。随访评估患者手术时间,术中出血量,术后膝关节活动度,术后膝关节功能评分,骨折愈合时间,术后并发症之间的差别。结果术后平均随访15个月（8-30个月）。平均手术时间：GSH钉组为100 min,DCS钢板组为90min。术中出血量：GSH钉组平均120 ml,DCS钢板组平均150 ml,愈合时间GSH钉组平均为20周,DCS钢板组平均为22周。结论治疗股骨髁上骨折,GSH钉和DCS钢板内固定两种方法都可以取得理想的效果。     

闭合复位股骨逆行交锁髓内钉治疗股骨远端骨折

目的观察闭合行股骨逆行交锁髓内钉治疗股骨远端骨折的疗效。方法应用闭合复住股骨逆行交锁髓内钉治疗股骨远端骨折26例。A1型4例，A2型6例，A3型4例；C1型5例，C2型4例，C3型3例。结果随访6个月-30个月，平均17个月，所有骨折都得到愈合，平均愈合时间为13周。术后膝关节的平均活动范围为109°。根据Merchan膝关节功能评分标准，优15例，良7例，可3例，差1例。优良率为84．6％。结论闭合复位股骨逆行交锁髓内钉是治疗A型和C1、C2型股骨远端骨折较理想的手术方法。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

The clinicopathological and immuohistochemical analysis of solid-pseudopapillary tumor of the pancreas： report of 9 cases

Objective：To investigate the clinical features, pathological characteristics and immunophenotype of solid-pseudopapillary tumor of the pancreas（SPTP）. Methods：Nine surgically treated cases of SPTP were retrospectively reviewed. Hematoxylin and Eosin（HE） staining and immunohistochemical staining were used to analyze all cases, and the general clinical data was collected. Results：Six patients were asymptomatic except for a palpable mass. Two patients complained of vague-epigastric pain. One patient appeared jaundice. The tumor was encapsulated and solid tissues alternately with cystic tissues. Histologically, the histological structure of solid portion was pseudopapillary with a fibrovascular core. Tumor cells were uniform and medium-sized which were arranged in sheets ets or nests or pseudopapillary patterns. Immunohistochemical studies demonstrated that SPTP proved positive in vimentin（9/9 cases）, AAT（9/9 cases）, NSE（9/9 cases）, ACT（7/9 cases）, CK20（2/9 cases）, CgA（1/9 cases）, S-100（3/gcases）, PR（4/gcases）, Syn（3/9 cases） and CD56（5/9cases）, negative in CEA and ER. Conclusion：SPTP is a tumor predominantly occurring in young women frequently without special symptoms. This tumor has various characteristical histological patterns with different immunophenotype.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.