辅酶Q10片对小鼠缓解体力疲劳功能的实验研究

目的 研究辅酶Q10片对小鼠缓解体力疲劳功能的影响,并初步探讨其作用机制. 方法从小鼠游泳时间、血清尿素氮水平、肝糖原含量和血乳酸变化四方面观察辅酶Q10片对小鼠缓解体力疲劳功能影响. 结果辅酶Q10片能明显延长小鼠游泳时间、提高小鼠肝糖原含量;同时显著降低小鼠血清尿素氮水平及血乳酸曲线下面积. 结论 辅酶Q10片具有缓解体力疲劳功能,其作用机制可能与辅酶Q10参与氧化磷酸化作用有关.     

辅酶Q_(10)胶囊缓解疲劳作用的研究

目的研究一种辅酶Q10胶囊对小鼠有否缓解疲劳功能。方法40只成年雄性小鼠随机分4组,3个辅酶Q10胶囊组,剂量分别为4.2、42.0、125.0mg/(kg.d),连续给予30d,灌胃量为0.02ml/(g.d);对照组给予同体积溶剂(大豆油)。末次给予30min后,进行负重游泳时间、血清尿素、肝糖原、血乳酸测定,比较各试验组之间的差异。结果125.0mg(kg.d)剂量组能延长小鼠负重游泳时间,减少小鼠游泳时血清尿素的产生,增加肝糖原储备(P0.05),与对照组比较,差异均有统计学意义;对游泳后血乳酸的产生及小鼠体重未见影响(P0.05)。结论该辅酶Q10胶囊对小鼠具有缓解疲劳功能。     

辅酶Q_(10)缓解小鼠运动性疲劳的实验研究

[目的]研究辅酶Q10对小鼠运动性疲劳的缓解作用。[方法]将小鼠随机分为1个对照组和3个剂量组,分别以辅酶Q10含量为0.084,0.167,0.250g/kg.d的剂量连续灌胃30d,测定负重游泳时间、血乳酸含量、血清尿素氮含量以及肝糖原含量。[结果]高剂量组小鼠的游泳时间长于对照组(P﹤0.05);游泳后20min高剂量组小鼠的血乳酸值与对照组相比明显降低(P﹤0.05);低剂量组小鼠肝糖原含量明显高于对照组,差异具有统计学意义(P﹤0.05)。[结论]辅酶Q10具有缓解运动性疲劳的作用。     

牡蛎提取物软胶囊缓解体力疲劳功能研究

目的 研究牡蛎提取物软胶囊对缓解体力疲劳功能的效果。方法 ICR种雄性小鼠随机分为低、中、高剂量组和阴性对照组,剂量组分别灌胃给予0.30g/kg.bw、0.60g/kg.bw、1.80g/kg.bw的牡蛎提取物软胶囊内容物,阴性对照组给予食用植物油,连续灌胃30d后,对小鼠进行负重游泳试验、血清尿素、肝糖原和血乳酸测定。结果 高剂量组延长小鼠的负重游泳时间、提高肝糖原含量、降低小鼠血清尿素含量,与对照组比较有显著性差异 (P<0.05 )。结论 牡蛎提取物软胶囊具有缓解体力疲劳功能的作用。     

红景天洋参片缓解体力疲劳的实验研究

目的研究红景天洋参片缓解体力疲劳作用。方法经口给予健康ICR小鼠0、200、400、1 200mg/kg剂量的红景天洋参片30d后,分别进行负重游泳实验、肝糖原测定、血乳酸测定和血清尿素氮测定。结果低剂量组小鼠负重游泳时间比对照组延长,差异有统计学意义(P0.01);中、低剂量组小鼠运动前后3个时间点血乳酸曲线下面积均低于对照组,差异具有统计学意义(P0.05);低剂量组小鼠运动后血清尿素氮值低于对照组值,差异有统计学意义(P0.01)。结论红景天洋参片在本实验条件下具有缓解体力疲劳作用。     

类维生素物质—辅酶Q10的研究进展

本简要回顾了辅酶Q10（CoQ10)的研究发展历程，阐述了其定义，特点和生理活性，同时对CoQ10缺乏的原因，CoQ10的临床研究进展和应用前景以及人们关心的若干问题作了综述论述。     

类维生素物质——辅酶Q10的研究进展

本文简要回顾了辅酶Q10 (CoQ10 )的研究发展历程 ,阐述了其定义、特点和生理活性 ,同时对CoQ10缺乏的原因、CoQ10的临床研究进展和应用前景以及人们关心的若干问题作了综合论述     

复方牛磺酸肌醇口服液缓解小鼠体力疲劳的研究

目的了解复方牛磺酸肌醇口服液缓解小鼠体力疲劳的作用。方法设41.7、83.3、250.0ml/kg·bw 3个剂量组及蒸馏水对照组和白砂糖对照组,连续给予小鼠30d后检测小鼠负重游泳时间和血清尿素、肝糖原及血乳酸的含量[1]。结果受试物能延长小鼠负重游泳时间（P〈0.05）,增加肝糖原含量（P〈0.05）,降低血乳酸曲线下面积（P〈0.05）。结论复方牛磺酸肌醇口服液对小鼠具有缓解体力疲劳的功能。     

枸杞多糖缓解小鼠体力疲劳作用研究及机制探讨

<正>现代竞技体育运动对运动员体能和生理等方面要求增加,竞争也愈加激烈~([1])。为创造新的成绩,运动员需从事长时间、高强度、超负荷的训练,并在训练之外寻找各种方法提高运动水平。《本草纲目》记载枸杞有强精健体之功效,其减缓体力疲劳的机制及其活性成分已有少量报道,但各项研究涉及的缓解体力疲劳活性组分不尽统一,功能评价方法和指标也存在差异。本实验以运动疲劳的特殊生理变化和枸杞多糖(Lycium     

148 类维生素物质--辅酶Q10的研究进展

本文简要回顾了辅酶Q10(CoQ10)的研究发展历程,阐述了其定义、特点和生理活性,同时对CoQ10缺乏的原因、CoQ10的临床研究进展和应用前景以及人们关心的若干问题作了综合论述.     

辅酶Q10提高小鼠抗疲劳和耐缺氧能力的实验研究

目的:研究辅酶Q10对小鼠抗疲劳和耐缺氧能力的影响。方法:分别以133.3、66.7、33.3 mg/kgBW剂量辅酶Q10给小鼠连续灌胃35 d,通过负重游泳试验、尿素、肝糖原和血乳酸测定评价其抗疲劳功能,通过常压耐缺氧试验、亚硝酸钠中毒试验和急性脑缺血(断头)试验评价其耐缺氧功能。结果:在本实验条件下,辅酶Q10能够延长小鼠的负重游泳时间,增加肝糖原储备,减少小鼠运动后血中乳酸和尿素氮含量;辅酶Q10能够延长小鼠缺氧存活时间和急性脑缺血后张口呼吸时间,对硝酸钠中毒后存活时间无明显影响。结论:辅酶Q10可以提高小鼠的抗疲劳能力和耐缺氧能力。     

辅酶Q_（10）的人体抗氧化作用研究

目的探讨辅酶Q10对人体的抗氧化作用。方法将120例符合要求的健康志愿者按血清丙二醛含量随机分为样品组和对照组,样品组连续服用受试物120 d,测定两组人群血清中丙二醛（MDA）含量及超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）活性和安全性指标。结果样品组丙二醛含量下降率、超氧化物歧化酶和谷胱甘肽过氧化物酶活性升高率均显著大于对照组,差异有统计学意义（P〈0.01）。两组人群的各项安全性指标试验前后均无明显改变。结论辅酶Q10对人体具有抗氧化作用。     

辅酶Q10在免疫调节中的作用

目的:研究辅酶Q10对小鼠免疫调节功能的影响,并初步探讨其作用机制。方法:从细胞免疫、体液免疫、单核-巨噬细胞吞噬作用及自然杀伤细胞的攻击作用四方面观察辅酶Q10对小鼠免疫功能的影响。结果:与阴性对照组(蒸馏水)和溶剂对照组(植物油)比较,辅酶Q10 8.0、12.0和24.0 mg/kg.BW剂量组均能提高ConA诱导的小鼠脾淋巴细胞的增殖能力;4.0、8.0和12.0 mg/kg.BW剂量组均能增加小鼠左后足跖部厚度差24 h测量值;12.0和24.0 mg/kg.BW剂量组均能提高小鼠溶血空斑数;4.0、8.0、12.0和24.0 mg/kg.BW剂量组均能提高小鼠NK细胞活性及小鼠腹腔巨噬细胞吞噬鸡红细胞的吞噬率;12.0 mg/kg.BW剂量组能提高小鼠腹腔巨噬细胞吞噬鸡红细胞的吞噬指数。结论:辅酶Q10具有增强小鼠免疫力作用,其作用机制可能与辅酶Q10能激活NK细胞、T细胞、巨噬细胞功能及清除氧自由基、稳定膜电位等有关。     

Coenzyme Q10 as a treatment for fatigue and depression in multiple sclerosis patients: A double blind randomized clinical trial

Objectives: Multiple sclerosis (MS) is the chronic inflammatory and demyelinating disorder of central nervous system which is accompanied with disability and negative life style changes such as fatigue and depression. The aim of this study is to investigate the effect of coenzyme Q10 (CoQ10) supplementation on fatigue and depression in patients with MS.

Methods: We performed a randomized, double-blinded, placebo-controlled trial to determine the effect of CoQ10 supplement (500?mg/day) vs. placebo for 12?weeks. Fatigue symptoms were quantified by means of fatigue severity scale (FSS) and the Beck depression inventory (BDI) was used to assess depressive symptoms.

Results: A significant decrease of FSS was observed in CoQ10 group during the intervention (P?=?0.001) and significant increase of FSS change was observed within placebo group (P?=?0.001). Repeated measure analysis of variance showed a significant time-by-treatment interaction for FSS (baseline 41.5?±?15.6 vs. endpoint 45?±?13.6; F_1,45?=?55.23, P?<?0.001, η²?=?0.56) and BDI (baseline 17.8?±?12.2 vs. endpoint 20.4?±?11.4; F_1,45?=?40.3, P?<?0.001, η²?=?0.48), indicating significant decrease of FSS and BDI in CoQ10 group compared to placebo group.

Conclusion: Our study suggests that CoQ10 supplementation (500?mg/day) can improve fatigue and depression in patients with multiple sclerosis.     

辅酶Q_（10）联合果糖二磷酸治疗小儿病毒性心肌炎的疗效分析

目的探讨辅酶Q10联合果糖二磷酸治疗小儿病毒性心肌炎的疗效。方法选取2011年2-8月湖南省儿童医院收治的病毒性心肌炎患儿54例作为研究对象,将上述患儿随机分成2组,观察组、对照组均为27例,观察组在常规治疗的基础上再联合使用辅酶Q10、果糖二磷酸,对照组仅给予常规治疗,比较两组患者的疗效。结果观察组的治疗效果显著优于对照组,两组比较差异有统计学意义（P〈0.05）。治疗2周后,观察组肌酸激酶（CK）、天冬氨酸氨基转移酶（AST）、乳酸脱氢酶（LDH）的降低幅度显著高于对照组,两组比较差异有统计学意义（P〈0.01）。结论在常规治疗基础上联合使用辅酶Q10、果糖二磷酸可显著提高小儿病毒性心肌炎的疗效。     

Augmenting effect of vitrification on lipid peroxidation in mouse preantral follicle during cultivation: Modulation by coenzyme Q10

Cryopreservation-induced oxidative stress (OS) may lead to lipid peroxidation, which may be responsible for decreased cell survival rate. Coenzyme Q10 (CoQ10) as a potent antioxidant may improve cell viability by neutralizing OS. In this study, oxidative lipid injury following the vitrification of preantral follicles was investigated. The effects of CoQ10 treatment on the malondialdehyde (MDA) levels, lipid peroxidation products, and activities of enzymatic and nonenzymatic antioxidants of vitrified preantral follicles were also studied. Preantral follicles were isolated from immature mouse ovaries and were vitrified. After warming, these follicles were cultured with or without CoQ10 for four days. The levels of total antioxidant capacity (TAC) and MDA, as well as the activities of superoxide dismutase (SOD), glutathione peroxidase (GPX), and catalase (CAT), were assessed at 0, 24, 48, 72, and 96 hours of culture period. The MDA level in the vitrified preantral follicles was higher than that in the fresh groups. By contrast, the MDA level was significantly lower in the groups with CoQ10 treatment than in those without this treatment during cultivation. The TAC level was higher in the fresh preantral follicles than in the vitrified groups. The rates were also higher in the CoQ10-treated groups than in those without this treatment. The activities of SOD, GPX, and CAT were also significantly higher in the fresh groups than in the vitrified groups, especially in the groups with CoQ10 treatment than in those without this treatment. Lowering the vitrification-induced lipid peroxidation of preantral follicles by CoQ10-supplemented maturation medium may be mediated by increasing SOD, GPX, and CAT activities and TAC level during cultivation.     

Oral coenzyme Q10 supplementation in patients with migraine: Effects on clinical features and inflammatory markers

Backgrounds and aims: Migraine and inflammation are correlated. Coenzyme Q10 (CoQ10) as an anti-inflammatory agent has shown useful effects in other diseases. The present study aimed to assess the effect of CoQ10 supplementation on inflammation and clinical features of migraine.

Methods: This randomized double-blind placebo-controlled clinical trial was conducted among 45 non-menopausal women aged 18–50 years, diagnosed for episodic migraine according to the International Headache Society. After one month run-in period, subjects received CoQ10 (400 mg/day CoQ10, n = 23) or placebo (wheat starch, n = 22) for three months. All the patients got prophylactic medication too. Serum CoQ10 concentration, Calcitonin gene-related peptide (CGRP), interleukin (IL)-6, IL-10 and tumor necrosis factor-α (TNF-α) were measured at the beginning and end of the study.

Results: CoQ10 supplementation reduced CGRP and TNF-α significantly (p = 0.011 and p = 0.044, respectively), but there were no significant differences in serum IL-6 and IL-10 between the two groups. Significant increase in serum CoQ10 levels was evident with CoQ10 therapy (P < 0.001). A significant improvement was found in frequency (p = 0.018), severity (p = 0.001) and duration (p = 0.012) of migraine attacks in CoQ10 group compared to placebo.

Conclusion: CoQ10 supplementation may decrease CGRP and TNF-α with no favorable effects on IL-6 and IL-10 in patients with migraine.     

辅酶Q10改善冠心病无症状心肌缺血的效果与评价

目的评价辅酶Q10治疗冠心病无症状性心肌缺血的疗效与安全性。方法随机将84例冠心病无症状心肌缺血患者分为两组,其中治疗组42例,采用辅酶Q10治疗;对照组42例,服用安慰剂。同时两组均服用硝酸异山梨酯、阿司匹林、阿托伐他汀钙片,治疗10周。治疗前后进行24 h动态心电图监测,对比观察缺血及其相关指标。结果治疗10周后,两组治疗后动态心电图ST段压低的次数、持续时间均明显改善,与治疗前比较,差异均有统计学意义(P<0.05)。两组组间比较,治疗组的疗效显著,差异有统计学意义(P<0.05)。治疗期间未见辅酶Q10明显不良反应。结论辅酶Q10治疗冠心病无症状性心肌缺血有效、安全,值得在临床上推广应用。     

林蛙油对小鼠缓解体力疲劳作用的研究

目的研究林蛙油缓解小鼠体力疲劳作用的影响,探讨林蛙油缓解体力疲劳作用的机制。方法将64只昆明种雄性小鼠随机分为4组:对照组和林蛙油低、中、高剂量组,分别为成人剂量(6g/60kg体重)的1倍、5倍和10倍,每组16只小鼠。对照组灌胃生理盐水;林蛙油各剂量组灌不同剂量的林蛙油匀浆液,连续28d,于末次灌胃1h后,每组8只小鼠进行负重游泳实验;另8只小鼠游泳30min,休息30min后,测定血糖、血尿素氮、血乳酸、肝糖原和肌糖原。结果林蛙油低、中、高剂量组小鼠负重游泳时间均高于对照组(P<0.05,P<0.01);林蛙油低、中、高剂量组小鼠血尿素氮、血乳酸含量降低并低于对照组(P<0.05,P<0.01);血糖、肝糖原和腓肠肌糖原含量增加并高于对照组(P<0.05,P<0.01)。结论林蛙油对小鼠具有一定的缓解疲劳作用。