先天性皮肤平滑肌错构瘤1例

先天性平滑肌错构瘤((congenitalsmoothmusclehamartoma,CSMH)是一种来源于平滑肌的皮肤良性肿瘤,皮损最常见于腰部,位于鼻部者罕见。现将笔者所在医院门诊所见1例报告如下。患者女,31岁。因鼻部左侧不规则隆起性环状斑块31年于2002年3月来笔者所在医院就诊。患者出生后不久,其父母即发现患者鼻部左侧有数个粟粒大的肤色结节,未引起重视。此后结节缓慢增大,融合形成环状斑块,边缘轻度不规则隆起,无明显自觉症状。体检:一般情况好,各系统检查无异常,全身浅表淋巴结未触及。皮肤科检查:鼻部左侧可见一2.3cm×2.8cm轻度隆起的环状皮色斑块,边…     

先天性皮肤平滑肌错构瘤1例

患者男,2岁.左上臂淡褐色条索状硬结性斑块2年.组织病理示基底色素增加,真皮全层可见大量纵横交错的平滑肌纤维束,部分与粗大的毛囊相连.免疫组化示平滑肌表达平滑肌肌动蛋白阳性.诊断为先天性皮肤平滑肌错构瘤.     

面部先天性皮肤平滑肌错构瘤1例

患者女,15岁。颏部淡粉色包块15年,缓慢增大。皮损组织病理：表皮大致正常,真皮全层可见增生的平滑肌纤维束,增粗的平滑肌束边界清楚,纵行分布。免疫组化：平滑肌肌动蛋白SMA（＋）,高倍镜下可见清晰的阳性表达横纹肌结构。诊断：先天性皮肤平滑肌错构瘤。     

幼儿先天性皮肤平滑肌错构瘤1例

先天性皮肤平滑肌错构瘤的肿瘤细胞可来源于毛囊立毛肌、血管平滑肌及生殖器皮肤平滑肌等不同组织的平滑肌细胞,临床常表现为肤色或色素沉着性斑片,部分伴有毳毛增生.本病为一种临床罕见的良性皮肤肿瘤,现将笔者诊治的1例报告如下. 1病历摘要 患儿男,2岁.因左背部褐色斑块2年就诊.患儿2年前出生后不久背部即出现指甲大淡褐色斑片,...     

皮肤平滑肌错构瘤1例

患者女，21岁，因左臀部片状斑块伴触痛1个月，于2006年4月11日来我院就诊，患者出生时左臀部一处皮肤肤色略深，无自觉症状，未予以治疗。最近几年发现左臀部有一斑片，并逐渐增大，摩擦后颜色加深，略有触痛。     

先天性平滑肌错构瘤1例

患儿男,2岁.因左背部淡褐色斑、丘疹2年,增大伴瘙痒半年,于2008年12月8日就诊.患儿出生时发现左背部小片淡褐色斑,其上有数个米粒大的丘疹,无自觉症状,未予治疗.近半年来,背部丘疹逐渐增大、增多伴轻微瘙痒.体格检查:一般情况好,系统检查无异常.     

先天性皮肤平滑肌错构瘤1例并文献复习

报告先天性皮肤平滑肌错构瘤1例并文献复习。患者男,64岁,右前胸壁浅褐色斑片、丘疹伴粗长毛发60余年。皮肤科检查:右前胸壁边界不清的浅褐色斑片,伴有毛囊性丘疹,其上可见增多的粗长毛发,不硬,无触痛、压痛;假Darier's征阴性。皮损组织病理检查:表皮轻度角化过度,真皮内见大量的纵横交错的平滑肌束,可见毛囊;Masson染色平滑肌纤维束呈红色;免疫组化平滑肌肌动蛋白阳性。诊断:先天性皮肤平滑肌错构瘤。     

先天性平滑肌错构瘤16例临床及组织病理分析

目的：探讨先天性平滑肌错构瘤（CSMH）的临床及组织病理特点。方法：回顾性分析2014年1月—2020年10月于该皮肤医院确诊的16例CSMH患者的临床及组织病理资料。结果：16例患者中女性9例（56.3%）,男性7例（43.7%）,就诊年龄2～28岁,平均（11±12）岁。其中15例患者（93.7%）出生即有皮损,1例（6.3%）于2岁发病。15例患者（93.7%）表现为单发皮损,1例（6.3%）为多发皮损;皮损发生于面部者11例（68.7%）,四肢者3例（18.8%）,躯干者2例（12.5%）;皮损表现为斑片或斑块者14例（87.5%）,表现为群集性丘疹者2例（12.5%）;皮损颜色为褐色者11例（68.7%）,红色者3例（18.8%）,肤色者2例（12.5%）;8例患者（50.0%）表现为多毛。皮肤镜下可见病变区域毛发数量增加。皮损组织病理均表现为真皮内无一定走向的成熟平滑肌束,肿瘤细胞胞质呈明显的嗜酸性,细胞核呈雪茄样,两端钝圆。免疫组化示肿瘤细胞表达平滑肌肌动蛋白（SMA）及结蛋白（desmin）。结论：CSMH多出生即有,单发多见,可发生于面部、四肢和躯干,主要表现为褐色斑...     

先天性平滑肌错构瘤一例北大核心CSCD

患儿男,14个月。左股部条状斑块8个月。患儿8个月前无明显诱因,左股外侧出现条索状斑块,略隆起,质地较硬,无明显自觉症状。在当地医院诊断为硬斑病,给予积雪苷霜、维生素E二甲亚砜溶液及艾洛松外用,用药后局部变红,出现瘙痒及脱屑。皮损逐渐增大、变硬,为进一步诊治来我院就诊。既往健康,喂养良好,家族中无类似疾病患者。体检：各系统检查无明显异常。     

皮肤平滑肌瘤1例

报告1例多发性毛发平滑肌瘤。患者女，64岁。躯干出现皮疹3年，临床表现为躯干、四肢散在红褐色丘疹、结节。皮肤组织病理显示，真皮可见较多群集束关和团块状杂乱排列平滑肌束。免疫组化证实过度增生的纤维为平滑肌。     

Congenital Smooth Muscle Hamartoma of the Skin

Abstract: Three cases of circumscribed congenital smooth muscle hamartoma (CSMH) in the neonate are described, including typical characteristics and differential diagnosis. This condition is a clearly defined, distinct entity, separate from simitar lesions that are considered in the differential diagnosis. It is possibly more common than is evident from the literature.     

Congenital Smooth Muscle Hamartoma of the Skin

Abstract: : A 2-month-old white girl had a congenital, tan-colored, slightly elevated, 3 × 2-cm plaque on the left midback. Clinically, the lesion was suspected to be a solitary masiocytoma. Rubbing the lesion produced a transient erythema and edema that was similar to Darier sign seen in mastocytoma. Analysis of a skin biopsy specimen revealed a smooth muscle hamartoma; special stains did not show evidence of increased numbers of mast cells. This relatively uncommon condition can be confused with a variety of other cutaneous diseases. Light microscopic examination of a skin biopsy specimen establishes the diagnosis. A review of the approximately 50 cases reported in the literature showed that there is no known associated systemic involvement or malignant transformation. The clinical lesions usually become less prominent with time.     

A Case of Acquired Smooth Muscle Hamartoma on the Sole

A smooth muscle hamartoma is a benign proliferation of smooth muscle bundles within the dermis. It arises from smooth muscle cells that are located in arrector pili muscles, dartos muscles, vascular smooth muscles, muscularis mammillae and the areolae. Acquired smooth muscle hamartoma (ASMH) is rare, with only 10 such cases having been reported in the English medical literature to date. Most of these cases of ASMH were shown to have originated from arrector pili and dartos muscles. Only one case was reported to have originated from vascular smooth muscle cells. A 21 year-old woman presented with a tender pigmented nodule, with numbness, on the sole of her foot, and this lesion had developed over the previous 18 months. The lesion showed no hyperpigmentation or hypertrichosis, and the biopsies demonstrated increased smooth muscle bundles in the dermis, and especially around the blood vessels. Moreover, the specimens stained positive with Masson trichrome stain and α-smooth-muscle actin antibodies, thus supporting our diagnosis of ASMH of the foot sole. Herein, we report on a rare case of ASMH on the foot sole, and this lesion originated from vascular smooth muscle cells. This type of case has not been previously described in the English medical literature.     

Congenital Smooth Muscle Hamartoma on the Face Treated Using Vascular Laser

Abstract: A congenital smooth muscle hamartoma is a rare, benign proliferation of smooth muscle bundles in the dermis that is usually diagnosed in the neonatal period or infancy. Surgical excision is the first‐line therapeutic option, but in certain areas such as the face, surgery may be too aggressive, and different treatments should be considered. We present the case of a congenital smooth muscle hamartoma on the face treated using pulsed dye laser with good response.     

Congenital Smooth Muscle Hamartoma Presenting as a Linear Atrophic Plaque: Case Report and Review of the Literature

Abstract: Congenital smooth muscle hamartoma usually manifests as a well-circumscribed, hyperpigmented plaque, frequently hypertrichotic, on the trunk or extremities. We report such a lesion in a 7-month-old girl that presented as a linear, mottled, purplish red plaque appearing In areas to be atrophic, involving her right buttock, posterior thigh and leg, and fifth toe. Although the clinical appearance suggested linear morphea, a biopsy specimen had numerous haphazardly oriented bundles of smooth muscle in the reticular dermis. Masson trichrome staining, smooth muscle specific actin, and electron microscopic studies confirmed the smooth muscle nature of the cells. A diagnosis of smooth muscle hamartoma was made. To our knowledge, this linear clinical presentation has not been described previously.     

Michelin-Tire Baby Syndrome Resulting from Diffuse Smooth Muscle Hamartoma

We cared for an infant who was born with the Michelin-tire baby syndrome characterized by dermatomegaly and hypertrichosis. Histology revealed a diffuse smooth muscle hamartoma.     

Generalized Smooth Muscle Hamartoma with Multiple Congenital Anomalies without the “Michelin Tire Baby” Phenotype

We report a patient with generalized smooth muscle hamartoma who presented with many of the variety of congenital anomalies that have been reported in babies with multiple symmetric circumferential rings of folded skin known as Michelin tire baby (MTB) syndrome, but our patient did not show the MTB phenotype. This constellation of findings in the absence of the MTB phenotype has not been previously reported.