Opioid use prior to total hip arthroplasty leads to worse clinical outcomes

Purpose

The purpose of this study was to compare the clinical outcomes of patients undergoing total hip arthroplasty (THA) who had been using narcotic medications prior to surgery to those who had not used them.

Methods

Fifty-four patients (62 hips) who had required opioid analgesia for hip pain in the three months prior to THA were compared to a matched group of opioid-naïve patients. Narcotic consumption was converted to a standardized morphine equivalent dose and compared between both groups of patients during their hospital stay, after six weeks, and at final follow-up. Other outcome measures included clinical outcome scores and the proportion of patients remaining on narcotic pain medication at final follow-up.

Results

The narcotic group required significantly higher total daily opioid doses as inpatients had a longer hospital stay and a higher proportion of patients who remained on opioids at six weeks and at final follow-up. Of the patients who were taking opioids pre-operatively, 81 % were able to wean off opioids at final follow-up. At a mean post-operative follow-up of 58 months (range, 24–258 months), Harris hip scores were lower in the narcotic group, with a mean of 84 compared to 91 points in the matching group. However, in both cohorts, there were significant improvements in Harris hip scores compared to pre-operative outcomes.

Conclusions

Patients who use narcotics prior to total hip arthroplasty may be more likely to suffer from opioid-induced hyperalgesia after surgery and have worse clinical outcomes. When possible, efforts should be made to use other modes of analgesia or wean patients from their use prior to total hip arthroplasty.     

A retrospective study of total hip arthroplasty

Aim:

To evaluate the functional and radiological outcome of primary total hip replacement (THR) using modular total hip system at 2-10 years follow-up.

Materials and Methods:

The cohort comprised 100 operated cases for total hip replacement using modular hip system, with an average follow-up of 6.02 years ranging from 2-10 years. In 61 cases cemented THR, in 36 cases hybrid and in three cases uncemented THR was done. Harris hip score was used for clinical evaluation. Osteolysis was recorded in three acetabular zones described by DeLee and Charnley and the seven femoral zones described by Gruen et al.

Results:

The average age at operation was 52.46±9.58 years. Mean follow-up duration was 6.02 years ranging from 2-10 years. Four patients died due to causes unrelated to surgery. At the last follow-up mean Harris Hip score was 83.5. Radiolucent lines were present in 39(39%) acetabular and 32 (32%) femoral components. Osteolysis was most common in Zone 7 of the femoral and Zone II and III of the acetabular component. Eight hips have been revised, five for aseptic loosening as proved by negative culture at revision and three hips for posttraumatic periprosthetic femoral fracture. One girdle stone resection was done for deep infection. Out of 96 hips available at latest follow-up, 87 primary arthroplasties were intact and functioning well.

Conclusion:

The results of our study support the continued use of the modular hip system. The acetabular loosening was more common than femoral in our study.     

全髋关节置换术假体周围骨溶解的临床分析

目的分析股骨假体周围骨溶解的发生情况、程度和方式,了解骨溶解与假体松动的关系。方法根据Ｇｒｕｅｎ’ｓ分区法,在标准正位Ｘ光片上对１９８０年１９９６年间进行连续Ｘ线随防的全髋关节置换术病人共１１２例进行分析,其中骨水泥固定８４例,非骨水泥固定２８例,平均随访时间为８３月。结果骨水泥固定和非骨水泥固定的假体周围骨溶解的总发生率分别为５８．３％和２５．０％,假体周围骨溶解进行性发展的发生率分别为８６％和     

Primary cemented total hip arthroplasty: 10 years follow-up

Background:

Primary cemented total hip arthroplasty is a procedure for non-traumatic and traumatic affections of the hip. Long term follow-up is required to assess the longevity of the implant and establish the procedure. Indo-Asian literature on long term result of total hip arthroplasty is sparse. We present a 10-year follow-up of our patients of primary cemented total hip arthroplasty.

Materials and Methods:

We operated 31 hips in 30 patients with primary cemented total hip arthroplasty. We followed the cases for a minimum period of 10 years with a mean follow-up period of 12.7 years. The mean age of the patients was 60.7 years (range 37–82 yrs) male to female ratio was 2:1. The clinical diagnoses included - avascular necrosis of femoral head (n=15), sero positive rheumatoid arthritis (n=5), seronegative spondylo-arthropathy (n=4), neglected femoral neck fractures (n=3), healed tubercular arthritis (n=2) and post traumatic osteoarthritis of hip (n=2). The prostheses used were cemented Charnley’s total hip (n=12) and cemented modular prosthesis (n=19). The results were assessed according to Harris hip score and radiographs taken at yearly intervals.

Results:

The mean follow-up is 12.7 yrs (range 11-16 yrs) Results in all operated patients showed marked improvement in Harris hip score from preoperative mean 29.2 to 79.9 at 10 years or more followup. However, the non-inflammatory group showed more sustained long term improvement as compared to the inflammatory group, as revealed by the Harris hip score. Mean blood loss was 450ml (±3.7 ml), mean transfusion rate was 1.2 units (±.3). The complications were hypotension (n=7), shortening >1.5 cm (n=9), superficial infection (n=2) and malposition of prosthesis (n=1).

Conclusion:

The needs of Indian Asian patients, vary from what is discussed in literature. The pain tolerance is greater than western population and financial constraints are high. Thus revision surgery among Indian-Asian patients is less compared to western yard sticks.     

Dual mobility cups in total hip arthroplasty

Total hip arthroplasty (THA) is considered one of the most successful surgical procedures in orthopaedics. With the increase in the number of THAs performed in the world in the next decades, reducing or preventing medical and mechanical complications such as post-operative THA instability will be of paramount importance, particularly in an emerging health care environment based on quality control and patient outcome. Dual mobility acetabular component (also known as unconstrained tripolar implant) was introduced in France at the end of the 1970s as an alternative to standard sockets, to reduce the risk of THA dislocation in patients undergoing primary THA in France. Dual mobility cups have recently gained wider attention in the United States as an alternative option in the prevention and treatment of instability in both primary and revision THA and offer the benefit of increased stability without compromising clinical outcomes and implant longevity. In this article, we review the use of dual mobility cup in total hip arthroplasty in terms of its history, biomechanics, outcomes and complications based on more than 20 years of medical literature.     

Metal-cancellous Lübeck total hip arthroplasty in hemodialysis patients

We report the results of total hip arthroplasty (THA) in patients on hemodialysis (HD). The metal-cancellous cementless Lübeck (MCCL) prosthesis was used in a series of consecutive 17 patients between April 1996 and March 2000. The patients were evaluated clinically and radiographically, and data were recorded during prospective follow-up. We reviewed the 17 patients after follow-up for more than two years (mean, 3.7 years). At the latest review the mean Merle d`Aubigne and Postel total hip score had improved to 15.9 from a preoperative value of 7.8. Radiologically, there was no evidence of loosening. The revision rate was 6% (one hip) for the acetabular component and 6% (one hip) for the femoral component, which both occurred in the same patient due to deep infection. The complication rate was low, with no cases of intraoperative fracture or symptomatic deep venous thrombosis, but there was a 6% (one hip) rate of deep infection and a 6% (one hip) rate of dislocation. These findings demonstrate that good short-term results can be obtained using the MCCL prosthesis for HD patients. However, further follow-up is needed to determine the long-term outcome of this prosthesis. Received: 30 August 2002, Accepted: 2 September 2002 Correspondence to: T. Nakai     

Comparison of implant related complications amongst patients with opioid use disorder and non-users following total knee arthroplasty

BACKGROUND The influence of opioid use disorder on implant related complications, infection and readmission rates, and total global episode-of-care costs following primary total knee arthroplasty(TKA) is limited.AIM To examine whether opioid abuse in patients undergoing primary TKA.METHODS A retrospective analysis of the Medicare dataset, using the PearlDiver database,from 2005-2014 comparing outcomes in patients with opioid abusers(OUD) to non-opioid abusers(NOU) undergoing primary TKA was performed. Patient outcomes were analyzed including implant complications, readmission rates, and day-of-surgery and 90-d cost. Statistical analysis was performed with R(University of Auckland, New Zealand) calculating odds-ratio(OR) along with their respective 95% confidence interval(95%CI) and P-values.RESULTS The OUD group was at greater odds of having implant related complications overall(20.84% vs 11.25%; OR: 2.07; 95%CI: 1.93-2.23; P 0.001). Revision(OR:2.07; 95%CI: 1.11-3.84; P 0.001), infection(OR: 1.92; 95%CI: 1.72–2.18; P 0.001),periprosthetic fractures(OR: 1.83; 95%CI: 1.16-4.79; P 0.001), and 90-dreadmission rates(OR: 1.47, 95%CI: 1.35-1.61, P 0.001) were also significantly increased. OUD patients also incurred in higher day-of-surgery and total global 90-d episode-of-care costs compared to NOU.CONCLUSION Patients with OUD show an increased risk of complications compared to the nonopioid users group. Appropriate recognition, pre-surgical optimization, and patient education are essential to mitigate these complications and improve patient outcome.     

Ceramic/ceramic total hip arthroplasty

Alumina-on-alumina total hip arthroplasty has been used for 30 years, mainly in Europe. The theoretical advantages of this combination are represented by its remarkable sliding characteristics, its very low wear debris generation, and its sufficient fracture toughness. These advantages are achieved if the material is properly controlled with high density, high purity, and small grains. The authors summarize the results obtained with ceramic/ceramic total hip arthroplasty. Information is provided about in vivo behavior regarding wear debris characterization and quantification, and histological tissue examinations for inflammatory reactions, which were not encountered except when alumina debris was mixed with metal or cement. Modification of socket fixation resulted in improved clinical outcomes. With a press-fit metal shell and an alumina liner utilized for 10 years, the results are excellent especially in a young and active population. Alumina-on-alumina seems at the moment to be one of the best choices when a total hip arthroplasty has to be performed in young and active patients. Received: March 22, 2000     

Intrapelvic complications after total hip arthroplasty failure

BACKGROUND: Severe total hip arthroplasty failure with central migration of prosthetic components is uncommon. If perforation of the medial acetabular wall occurs, injuries of intrapelvic structures may result. DATA SOURCES: A meta-analysis of the English literature was performed. A human pelvic cadaver was used to demonstrate the proximity of intrapelvic structures to a centrally dislocated cup. RESULTS: Fifty cases of intrapelvic injury were identified. Structures involved most frequently were the external iliac artery and the bladder. The most common types of complication included fistula formation, development of a false aneurysm, and hemorrhage. The human cadaver pelvis demonstrated the proximity of intrapelvic vessels, the bladder, the ureter, the vagina, the deferent duct, the sigmoid colon, the rectum, and the sciatic nerve to an intrapelvically intruded prosthesis. CONCLUSIONS: Failed total hip replacements should be considered to cause damage to pelvic viscera.     

Navigation for total hip arthroplasty

Despite increasing advantages in biomaterials, prosthetic designs, and implant fixation, clinical outcome of total hip arthroplasty (THA) has 10% failure rate after 10 years. Component malposition is well known to be responsible for instability, impingement, excessive wear and early loosening. Computer-assisted procedures are expected to improve the accuracy of the components positioning and also the outcome of total hip replacements. We present the Amplivision. system (Amplitude, Porte-du-Grand-Lyon, Neyron, France) that has been used since October 2005 for total hip replacements at our institution. The surgical technique as well as the advantages of this system is described. The Amplivision© system allows accurate positioning of the acetabular and femoral components during THA and also the control of leg lengthening, offset and stability.     

The accuracy of preoperative templating in cementless total hip arthroplasty

We evaluated the accuracy and clinical usefulness of preoperative templating in 109 cementless total hip arthroplasties. The size of the prosthesis was exactly predicted in 46 (42.2%) acetabular and 75 (68.8%) femoral components. The accuracy increased to greater than 90% if the prosthesis size was within 1 or 2 sizes (above or below) for femoral component and acetabular components, respectively. Having a contralateral total hip arthroplasty as a guide for preoperative templating was associated with greater accuracy in predicting the femoral component size only. Eighty-eight percent of the acetabular components were oriented inside the presumed safe range for inclination; 42% of the acetabular components were in the presumed safe range of anteversion. The mean postoperative leg length discrepancy was 0.9 +/- 6.8 mm; 93.5% had a discrepancy within 10 mm.     

Birmingham hip resurfacing versus cementless total hip arthroplasty in patients 55 years or younger: A minimum five-year follow-up

Objective

The optimal reconstructive method for advanced degenerative hip disease in young adults is a topic of ongoing discussion. The purpose of this study is to report the largest single institution experience from the United States on the outcomes of Birmingham hip resurfacing (BHR) vs. cementless total hip arthroplasty (THA) in patients 55 years or younger at a minimum follow-up of five years. Currently, BHR is the only FDA-approved hip resurfacing implant available in the US.

Diagnosis of infection after total hip arthroplasty

Forty-eight total hip arthroplasties for which revision surgery was performed were reviewed to determine the accuracy of laboratory tests, plain radiographs, hip aspiration, and technetium-99m MDP and gallium-67 scans in demonstrating the presence or absence of infection of the prosthesis. Six of the 48 hips were diagnosed as having an infection at the revision surgery. The erythrocyte sedimentation rate and the C-reactive protein levels were significantly higher in the patients with infected prostheses. The difference in the white blood cell count was not significant. There was no signifi-cant relationship between the presence of infection and the severity of loosening and instability of the implants diagnosed by plain radiographs. The accuracy of hip aspiration in diagnosing the infection was 83%, with a sensitivity of 40% and a specificity of 92%. The accuracy of technetium-99m MDP bone scan was 79%, with a sensitivity of 83%, and a specificity of 79%. Gallium-67 scan had an accuracy of 96%, a sensitivity of 67%, and a specificity of 100%. The findings in the present study indicated that diagnostic tests consisting of laboratory tests and plain radiography, followed by hip aspiration and sequential use of technetium-99m MDP and gallium-67 scintigraphies, are suitable for differentiation between mechanical loosening and infection of total hip arthroplasty. Received: November 17, 2000 / Accepted: February 14, 2001     

人工全髋关节置换治疗髋臼内陷症的早期疗效

目的探讨人工全髋关节置换治疗髋臼内陷症的方法及早期疗效。方法 2006年1月-2010年2月,收治髋臼内陷症16例16髋。男6例,女10例;年龄39～72岁,平均56.5岁。病程1年6个月～35年,中位病程6.4年。左髋7例,右髋9例。原发性3例,继发性13例。髋关节Harris评分为(49.5±5.5)分。髋臼内陷按Dunlop等的诊断标准分度:轻度3例,中度9例,重度4例。患者均行人工全髋关节置换,髋臼重建时采用植骨及非骨水泥型髋臼假体恢复患髋股骨偏心距及髋臼旋转中心。结果术后16例切口均Ⅰ期愈合,无感染及下肢深静脉血栓形成等并发症发生。患者均获随访,随访时间12～62个月,平均37个月。末次随访时,髋关节Harris评分为(90.5±4.5)分,与术前比较差异有统计学意义(t=49.578,P=0.000)。X线片显示假体位置良好,无松动、下沉,植骨与髋臼融合,无髋臼再次内陷。结论人工全髋关节置换治疗髋臼内陷时,采用植骨及非骨水泥型髋臼假体恢复患髋股骨偏心距及髋臼旋转中心,可获满意早期疗效。     

全髋关节置换术的软组织平衡

目的探讨THA术后股骨偏心距恢复的重要性及重建方法,恢复髋关节的软组织平衡。方法对73例单侧THA术患者进行随访,手术均采用髋关节后外侧入路。X线片上测量股骨偏心距及髋外展肌的力臂,使用Cybex测量髋外展肌力量,对X线片测量数据进行统计学处理。结果股骨偏心距是否能够重建与髋最大外展肌肌力存在显著性差别(t=3.859;P=0.002);髋关节外展活动范围与股骨偏心距存在明显回归相关关系(r=0.593,P<0.001)。结论THA术中重建股骨偏心距可以增加髋外展肌的力臂,改善髋外展肌的力量,增强髋关节的稳定性。术中应选用近似解剖颈干角的股骨柄假体,适当地增加假体颈的长度。     

Metal hypersensitivity in total hip and knee arthroplasty: Current concepts

Metal hypersensitivity (MHS) is a rare complication of total joint arthroplasty that has been linked to prosthetic device failure when other potential causes have been ruled out. The purpose of this review was to conduct an analysis of existing literature in order to get a better understanding of the pathophysiology, presentation, diagnosis, and management of MHS. It has been described as a type IV hypersensitivity reaction to the metals comprising prosthetic implants, often nickel and cobalt-chromium. Patients suffering from this condition have reported periprosthetic joint pain and swelling as well as cutaneous, eczematous dermatitis. There is no standard for diagnosis MHS, but tests such as patch testing and lymphocyte transformation testing have demonstrated utility, among others. Treatment options that have demonstrated success include administration of steroids and revision surgery, in which the existing metal implant is replaced with one of less allergenic materials. Moreover, the definitive resolution of symptoms has most commonly required revision surgery with the use of different implants. However, more studies are needed in order to understand the complexity of this subject.     

非骨水泥型全髋关节置换术中心腔内栓子来源与效应的研究

目的 查找全髋关节置换术(total hip arthroplasty,THA)心腔内栓子的组织学来源及其生理效应. 方法 选择30例美国麻醉医师协会(ASA)分级Ⅰ～Ⅲ级行非骨水泥型全髋置换术的全麻患者,术中采用经食道超声(transesophageal echocardiography,TEE)观察手术开始、磨锉髋臼、植入髋臼假体、股骨锉髓、股骨假体植入和关节复位各时段心腔内栓子的发生率;同时在超声引导下经颈内静脉置管至右心房,当TEE观察到栓子影像时同步采血行病理学检查;行有创血压监测和动脉血气分析,观察各时段循环呼吸系统的变化. 结果 30例患者心腔内均观察到了微栓影像,栓子从磨锉髋臼开始间断出现直至手术结束.手术开始、磨锉髋臼、植入髋臼假体、股骨锉髓、植入股骨假体和关节复位出现栓子影像分别为0、5、19、30、23、24例,差异有统计学意义(P＜0.05).有形栓子的检出率分别为0、0、0、47、61、38％,栓子的组织学成分包含脂肪滴和骨碎粒,组织学构成差异有统计学意义(P＜0.05).心率(HR)、脉氧饱和度(SpO2)、呼末二氧化碳(PETCO2)、氧分压(PO2)全程无明显变化,收缩压(SBP)、舒张压(DBP)在股骨假体植入后开始下降(P＜0.05),以关节复位5 min后下降幅度最大.结论 非骨水泥式THA中心腔内微栓普遍存在.植入髋臼假体、股骨锉髓、股骨假体植入和关节复位是微栓的频发阶段;微栓子的成份中包含了脂肪滴和骨碎粒;术中的微栓常伴有血流动力学改变.