年轻冠心病患者子女血脂,脂蛋白,载脂蛋白的研究

本文对５２名父母于４５岁之前患冠心病的儿童和６３名父母无ＣＨＤ的儿童，进行ＴＣ，ＴＧ，ＨＤＬ－Ｃ，ａｐｏＡ－Ｉ，ａｐｏＢ－１００水平的对比研究。结果显示：父母较早发生ＣＨＤ的儿童，血清ＴＧ，ＴＣ，ａｐｏＢ－１００水平及ＴＣ／ＨＤＬ－Ｃ显著高于对照组；ＨＤＬ－Ｃ，ａｐｏＡ－Ｉ，ａｐｏＡ－Ｉ／ａｐｏＢ－１００水平显著低于对照组。     

老年脑血管病患者脂蛋白（α）检测及其临床意义

用放免的方法测定了５０例脑血管病（ＣＶＤ）患者血清脂蛋白（α）［Ｌｐ（α）］浓度，对比分析了患者Ｌｐ（α）、甘油三脂（ＴＧ）、总胆固醇（ＴＣ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）、低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）、脱脂蛋白Ａ－Ｉ（ａｐｏＡ－Ｉ）、ａｐｏＢ１００的浓度及变化，分析了Ｌｐ（α）浓度及ＴＧ、ＴＣ和胶脂蛋白的相关性。结果：ＣＶＤ患者血清Ｌｐ（α）浓度（０．２２４±０．０４ｇ／Ｌ），显著高于对     

长寿老人血脂,脂蛋白和载脂蛋白价值的研究

对９０岁以上３６例长寿老人的血脂、脂蛋白和载脂蛋白进行了测定，并与陈旧性心肌梗塞（ＯＭＩ）和成人组对比。结果显示：与ＯＭＩ组比较，长寿老人血清ＨＤＬ－ｃ／ＴＣ、ＨＤＬ－ｃ／ＬＤＬ－Ｃ和ＡｐｏＡ１／ＡｐｏＢ１００比率明显高于ＯＭＩ，而ＴＣ、ＴＧ、ＬＤｃ、ＶＬＤＬ－ｃ、ＡｐｏＢ１００和ＡｐｏＡ１明显低于ＯＭＩ，ＨＤＬ－ｃ在两组间无显著性差异，与成人组比较，长寿老人血清ＴＧ、ＶＬＤＬ－ｃ、ＡｐｏＡ、／Ａ     

冠心病患者血脂与载脂蛋白A_1和B测定的临床意义

对６０例冠心病患者与６０例健康人血脂及载脂蛋白Ａ１和Ｂ进行测定显示，冠心病患者血清Ｔｃｈ、ＨＤＬ与健康人无显著差异；ＴＧ、ＬＤＬ、ＡｐｏＢ、ＡｐｏＢ／ＡｐｏＡ－Ｉ比值均显著高于健康人（Ｐ＜０．０１）；ＡｐｏＡ－Ⅰ显著低于健康人（Ｐ＜０．０５）。血脂正常的冠心病患者ＡｐｏＢ、ＡＰＯＢ／ＡｐｏＡ－Ⅰ比值也显著高于健康人（Ｐ＜０．０１）；ＡｐｏＡ－Ⅰ也显著低于健康人（Ｐ＜０．０１）．表明检测载脂蛋白比血脂能更好地预测冠心病，ＡｐｏＢ／ＡｐｏＡ－Ⅰ比值是鉴别有无冠心病的最佳指标。     

冠心病患者血清过氧化脂质的变化及其与动脉硬化关系的研究

对３０例不稳定型心绞痛（ＵＡ）、１９例急性心肌梗塞（ＡＭＩ）患者血清过氧化脂质（ＬＰＯ）、血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－ｃ）进行了测定，并计算动脉硬化指数（ＡＩ）。发现ＵＡ及ＡＭＩ患者ＬＰＯ、ＴＣ、ＴＧ、ＡＩ值均显著高于正常人，ＨＤＬ－ｃ均低于正常人。ＵＡ与ＡＭＩ患者血清ＬＰＯ及血脂诸值比较差异均无显著性。ＵＡ与ＡＭＩ两组患者的ＬＰＯ水平均与ＡＩ呈显著正相关。     

载脂蛋白E不同基因型胆囊结石患者的血脂水平分析

为了解载脂蛋白Ｅ不同基因型胆囊结石患者的血脂水平，应用ＰＣＲ技术研究了８７例胆囊结石患者和５０例正常人的ＡｐｏＥ基因型，另测定参加者空腹血脂。结果发现：Ｅ２／３基因型的胆囊结石患者血清ＴＧ、ＶＬＤＬ－Ｃ水平显著升高，ＬＤＬ－Ｃ水平显著降低。Ｅ３／３基因型胆囊结石患者ＨＤＬ－Ｃ、ＨＤＬ２－Ｃ、ＨＤＬ３－Ｃ水平显著下降。Ｅ３／４基因型胆囊结石患者ＶＬＤＬ－Ｃ轻度降低，ＬＤＬ－Ｃ轻度升高。结果提示：同一ＡｐｏＥ基因型胆囊结石患者血脂异常较正常人突出，不同基因型的胆囊结石患者血脂异常的特征各不相同。为研究胆囊结石病发病机理提供了资料。     

汉族人载脂蛋白E基因多态性对血脂、载脂蛋白和脂蛋白(a)水平的影响

应用ＰＣＲ－ＲＦＬＰ技术研究我国汉族人群ａｐｏＥ基因型与等位基因频率分布特征，并分析ａｐｏＥ基因多态性对脂质代谢的影响。发现我国汉族人群ａｐｏＥε３等位基因频率（８３．２％）明显高于欧美人群，而ε４频率（７．５％）显著低于欧美人群。ε４与血清ＴＣ、ＬＤＬ－Ｃ和ａｐｏＢ水平增加呈显著正相关。ａｐｏＥ等位基因变异对血清ＴＧ、ＨＤＬ－Ｃ、ａｐｏＡＩ及Ｌｐ（ａ）水平无明显影响。研究提示，ａｐｏＥ基因多态性影响血清脂质和脂蛋白水平，我国汉族人群ａｐｏＥ基因多态性特征可能与中国人群冠心病患病率明显低于欧美人群相关。     

振动对动物体内血脂水平的影响

为了研究振动对生物体内物质的耗散作用，本文在振动频率为２０Ｈｚ，振幅为０．１ｃｍ条件下对土母鸡的腹部脂肪作局部振动。并于振动一个疗程（２小时／天，５－７ｘ）的前后分别测试了血清中总胆固醇（ＴＣ）、甘油三脂（ＴＧ）和高密度脂蛋白胆固醇（ＨＤＬ－Ｃ）等各项指标。结果表明：上述特定频率、振幅与时间的振动使实验动物体内血清中总胆固醇、高密度脂蛋白胆固时与低密度脂蛋白胆固醇（ＬＤＬ－Ｃ）显著增加；甘油三酯显著减少（Ｐ＜０．０５）。ＴＣ的变化与ＨＤＬ－Ｃ、ＬＤＬ－Ｃ的变化呈正相关；ＴＧ的变化与ＨＤＬ－Ｃ的变化呈负相关。从而证实了特定参数的振动对动物体内的脂肪代谢有明显的作用，为人体施局部伍振动减肥的可行性提供了有益的参考。     

低密度脂蛋白亚组分的组成和抗氧化性

超速离心提取了正常人低密度脂蛋白（ＬＤＬ,密度１．０２５－１．０５０ｇ／ｍＬ）,再运用密度梯度离心将ＬＤＬ分成不同亚组分,观察它们的组成和抗氧化性。结果表明密度越高的亚组分,电泳迁移率越快。甘油三酯（ＴＧ）／胆固醇（ＣＨ）比值越低。通过观察体外Ｃｕ２氧化ＬＤＬ不同亚组分裂化产物２３４ｎｍ处吸光度的变化（氧化曲线）,示ＴＧ／ＣＨ比值越高的亚组分抗氧化修饰的能力越低,氧化曲线中表现为延迟时间缩短。实验中在氧化体系中加入刺梨汁。能明显延长延迟时间,起到抗氧化作用,提示刺梨汁中有关成份对动脉粥样硬化（Ａｓ）的防治有一定价值。     

膳食与妊高征血脂代谢的关系

通过对３０名妊高征孕妇、２８名正常孕妇、１０名非孕妇女的膳食调查，了解营养与妊高征的关系。结果：妊高征孕妇摄取总热量和动物性食物较多，随膳食动物百分比升高，血脂升高。正常孕妇各项血脂指标均升高。妊高征孕妇在孕早期ＬＤＬ－Ｃ／ＨＤＬ－Ｃ、ＡＩ显著升高，ＨＤＬ－Ｃ、ＨＤＬ－Ｃ／ＴＣ下降。孕末期ＴＧ、ＴＣ、ＬＤＬ－Ｃ、ＬＤＬ－Ｃ／ＨＤＬ－Ｃ、ＡＩ较正常孕妇升高更显著。ＯＧ与ＬＤＬ－Ｃ／ＨＤＬ－Ｃ、ＡＩ有回归关系，孕末期ＬＤＬ－Ｃ／ＨＤＬ－Ｃ、ＡＩ越高，妊高征越严重。提示：膳食摄入不平衡，可使正常孕妇高脂状态发生紊乱，影响妊高征的发生和发展。建议孕妇膳食中减少动物脂肪用量，进食足量蛋白，注意热能消耗和摄入平衡。     

Paraoxonase-1 (PON1) activity in patients with coronary artery diseases and in diabetic patients

Cardiovascular diseases are the main cause of mortality in the world, diabetics and patients with coronary artery diseases in particular. In fact, the increase of cardiovascular risk was established in many epidemiological and clinical studies. The aim of this work is to study both the lipid profile and the enzymatic activity of PON1 in diabetics and coronary patients from Morocco (Casablanca region) along with the cardiovascular risk factors in this population. Three groups of Moroccan subjects were investigated: 36 patients with coronary artery diseases, 110 diabetic patients and 100 healthy subjects (control group). Total cholesterol (TC), triglycerides (TG) and high-density lipoprotein cholesterol (c-HDL) levels were evaluated using colorimetric methods. Low-density lipoprotein cholesterol (c-LDL) was calculated according to the Friedewald's formula. Serum activity of PON1 was measured by spectrophotometry. Compared to healthy subjects, we noted a significant decrease of PON1 activity in coronary artery disease (285?U/mL?±?180?U/mL; P?相似文献   

血脂异常与老年冠心病患者冠脉病变程度的相关性研究

目的 探讨血脂异常与老年冠心病患者冠脉病变程度的相关性。方法 选取2015年5月~2017年1月本院心内科住院的明确诊断为冠状动脉粥样硬化性心脏病（CHD）的150例老年患者设为CHD组。选取同期收治的150例非CHD患者为对照组。比较两组血清中总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）水平,并计算N-HDL-C、LDL-C/N-HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值。比较不同冠脉病变支数、不同病情严重程度的CHD患者的血脂及其比值。对血脂与冠脉病变支数、病情严重程度积分进行相关性分析。结果 CHD组患者LDL-C、TG、TC、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值均高于对照组,HDL-C水平低于对照组,差异均有统计学意义（P＜0.05）;不同冠脉病变支数各亚组间的TC、TG、N-HDL-C水平、TC/HDL-C比值差异存在统计学意义（P＜0.05）;TC、TG、N-HDL-C水平、TC/HDL-C比值均与冠脉病变支数均呈正相关（P＜0.05）;不同病情严重程度亚组间的LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值差异存在统计学意义（P＜0.05）;CHD患者LDL-C、TC、TG、N-HDL-C水平、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C比值与冠状动脉病变积分均呈正相关（P＜0.05）。结论 可以通过对血脂指标的监测,并计算N-HDL-C、TC/HDL-C、LDL-C/HDL-C、TC/HDL-C、TG/HDL-C值,来评估CHD病情的临床进展。     

小而密低密度脂蛋白及常见血脂指标与冠心病的相关性研究

目的 探讨血清小而密低密度脂蛋白(small dense low-density lipoprotein, sd-LDL)水平与血清胆固醇(cholesterol,CHO)、甘油三酯(triglyceride, TG)、低密度脂蛋白(low density lipoprotein,LDL)指标与冠心病(coronary heart disease, CHD)的发生发展及各指标之间的相互关系.方法 选取CHD患者87例作为病例组,其中男48例,女39例.纳入109例健康体检者作为对照组,男52例,女57例.采用全自动日立7600仪器,日本积水相关检测试剂测定各组血清CHO、TG、LDL水平,血清sd-LDL水平采用九强小而密低密度脂蛋白测定试剂于雅培C16000仪器上进行测定.采用SPSS 22.0软件进行相关数据分析.结果 病例组血清CHO水平、LDL水平及sd-LDL水平高于正常对照组,差异具有统计学意义(P<0.01).女性病例组TG水平高于对照组,男性及总体病例组与对照组TG水平差异无统计学意义.年龄和sd-LDL水平为冠心病相关的独立危险因素.冠心病患者血清sd-LDL与CHO、TG及LDL水平均呈显著正相关,血清LDL与CHO呈显著正相关(P<0.01).结论 血清sd-LDL是独立的冠心病危险因素,血脂常规项目联合sd-LDL对于冠心病的早期预测可能具有更好的提示和诊断作用.     

Apolipoprotein A-I,apolipoprotein B,high-sensitivity C-reactive protein and severity of coronary artery disease in tunisian population

BackgroundThe relationship between Apolipoprotein A-I, Apolipoprotein B, C-reactive protein and the severity coronary artery disease in Tunisian CAD patients has not been examined. We investigated the association between serum ApoA-I, ApoB, hs-CRP and the severity of coronary artery disease.MethodsThis study was carried out on 180 patients who underwent angiography and 129 healthy controls. ApoA-I and ApoB as well as the serum total cholesterol, HDL, triglyceride, LDL and hs-CRP levels were measured. The ApoB/ApoA-I ratio was calculated.ResultsWe showed a decreased level of ApoA-I and an increased level of ApoB, ApoB/ApoA-I ratio and hs-CRP in CAD patients compared to the control group (P<.001). In addition, we showed a significant increase of ApoB, ApoB/ApoA-I ratio and hs-CRP in CAD patients presenting 0 to 3 vessels stenosis (P<.001). Multivariate analysis showed that ApoB (P<.001), and hs-CRP (P<.001) were independent predictors of the severity of CAD.ConclusionIn this study, ApoB and hs-CRP levels were markedly associated with the severity of CAD in Tunisian patients. We suggested that synergistic effects between dyslipidemia and inflammation led to increase the risk of the severity of CAD.     

The oxidation ratio of LDL: a predictor for coronary artery disease

Objective: Oxidized LDL cholesterol (ox-LDL-C) is considered to be a key factor of initiating and accelerating atherosclerosis (AS). The purpose of this study is to elucidate the sensitivity and specificity of ox-LDL and oxidation ratio of LDL in the diagnosis of coronary artery disease (CAD). For the first time, we investigated the ratio of ox-LDL to ALB(ox-LDL/ALB). Methods and results: Blood ox-LDL, total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG) and albumin (ALB) were measured in patients with acute myocardial infarction (AMI, n = 80), unstable angina pectoris (UAP, n = 80), stable angina pectoris (SAP, n = 80), normal control (n = 60), and dyslipidemia control (n = 60). Ox-LDL was measured by competitive ELISA. The level of ox-LDL and oxidation ratio of LDL(ox-LDL/TC, ox-LDL/HDL-C, ox-LDL/ LDL-C and ox-LDL/ALB) were significantly higher in each diseased group than controls (P < 0.001). In CAD group, ox-LDL and oxidation ratio of LDL in subjects complicated with hypertension (HT) and/or diabetes mellitus (DM) increased further (P < 0.001). Ox-LDL/ALB in the AMI group was 7 times higher than normal control group (0.068 ± 0.017 vs 0.009 ± 0.007, P < 0.001). The area under the curve (AUC) of receiver operating characteristic curve (ROC curve) is a criterium to evaluate the accuracy of diagnosing a disease. The AUC of ROC curve of ox-LDL/TC, ox-LDL/HDL-C, ox-LDL, ox-LDL/ALB and ox-LDL/ LDL-C for diagnosing CAD were 0.975, 0.975, 0.966, 0.966, 0.957 respectively (P < 0.001). When ox-LDL/TC = 0.175, the sensitivity and specificity of diagnosing CAD were 0.917 and 0.925, which were almost equal to each other, indicating that the rates of missed diagnosis and misdiagnosis for CAD were the lowest. Conclusions: The level of ox-LDL and the ratio of ox-LDL/TC, ox-LDL/LDL-C, ox-LDL/HDL-C and ox-LDL/ALB are better biomarkers than TC, TG, HDL-C and LDL-C for discriminating between patients with coronary artery disease and healthy subjects. And patients who have a high ratio of ox-LDL /TC may have a higher risk for CAD.     

The haplotype analyses using multiple markers of the apolipoprotein B gene in patients with coronary artery disease.

The high level of low density lipoprotein (LDL) is a risk factor for cardiovascular disease. Apolipoprotein (apo) B is a major protein component of LDL and plays an important role in the maintenance of cholesterol homeostasis. In this study, six polymorphic sites of the apoB gene were anlaysed in 235 patients with coronary artery disease (CAD) and 216 normal control subjects. There were no significant differences in the allele frequencies of apoB polymorphisms between the control and patient groups. However, haplotype frequencies were significantly different between the CAD patients and control (p<0.05). In addition, the allelic distributions of both EcoRI and MspI polymorphisms in Koreans were similar to those in Chinese but significantly different from those in Caucasians. ApoB polymorphisms showed no association with plasma lipid levels. In conclusion, haplotype analysis of the apoB gene using multiple diallelic markers might be a useful marker for Korean CAD patients.     

广东汉族人PCSK9基因E670G位点多态性与冠心病相关性研究

目的通过对中国广东地区冠心病（CAD）患者和健康个体前蛋白转化酶枯草杆菌蛋白酶/西布曲明9a型（PCSK9）基因E670G位点单核苷酸多态性（SNP）的研究,分析其在CAD患者和健康人中的分布,以及与冠心病和血脂代谢的相关性。结论采集经冠脉造影确诊的CAD患者血液标本165例,健康人血液标本180例,分别提取基因组DNA模板,采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）方法分析PCSK9基因E670G位点SNP,并用基因测序法验证结果。血清总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）浓度水平采用酶法测定。结果中国广东地区CAD患者和健康人群在该位点的等位基因频率、基因型频率分布差异无统计学意义（P〉0.05）。CAD患者组和对照组之间TC、LDL-C、HDL-C水平差异具有统计学意义（P〈0.05）,TG水平差异无统计学意义（P〉0.05）。CAD患者组中AA和AG基因型之间LDL-C、HDL-C的差异具有统计学意义（P〈0.05）,TC、TG的差异没有统计学意义（P〉0.05）;与非670G携带者比较,670G携带者血LDL-C水平增高,血HDL-C水平降低。AG基因型的冠脉病变支数明显高于AA基因型,其差异具有统计学意义（P〈0.05）。结论 PCSK9基因E670G多态性与血LDL-C、HDL-C水平,以及冠心病病变严重程度相关联。     

Autoantibody against, malondialdehyde-modified low density lipoprotein in patients with non-diabetic unstable angina: a potential role in immunologic reaction of plaque instability

The role of autoantibody against oxidized low-density lipoprotein (LDL) in the pathogenesis of atherosclerosis is still unknown. The purpose of this study was to determine whether autoantibodies against malondialdehyde (MDA)-modified LDL are associated with coronary artery disease (CAD) and clinical presentations of CAD in non-diabetic patients without acute myocardial infarction (AMI). We determined the serum levels of autoantibody against MDA-modified LDL by ELISA in 71 patients with angiographically significant CAD (> or = 50% diameter stenosis in at least 1 vessel) and 80 controls without angiographically significant CAD. Among the total 151 subjects, 30 subjects did not have any clinical ischemic event, 90 subjects had stable angina symptoms, and 31 subjects had unstable angina symptoms. The autoantibody titer, expressed mean optical density units, was significantly higher in patients with CAD than in controls (0.177 +/- 0.014 versus 0.127 +/- 0.011, respectively; p=0.006) and higher in unstable angina group than in stable angina group (0.240 +/- 0.025 versus 0.145 +/- 0.007, respectively; p < 0.001). By logistic regression analysis, the high autoantibody titer was associated significantly with CAD (P=0.008), independent of age, gender, body mass index, triglyceride concentration, and the ratio of total cholesterol-high density lipoprotein (HDL) cholesterol. In multiple regression analysis, presence of CAD, smoking history and low HDL-cholesterol level were independent factors associated with a increased anti-oxLDL Ab titer. The autoantibody titer was significantly lower in nonsmoker than smoker (p=0.019) and higher in low HDL- cholesterol (< or = 35 mg/dl) group than in high HDL-cholesterol group (p=0.012). Elevated autoantibody titer was associated with CAD and the unstable clinical presentation of CAD. Our results suggest that immune response to oxidized LDL may play a role in the pathogenesis of atherosclerosis and plaque instability.     

Effect of Interleukin-2 Level and Genetic Variants on Coronary Artery Disease

Inflammation plays important roles in the development of atherosclerosis and coronary artery disease (CAD). Interleukin-2 (IL-2) is a proinflammatory cytokine and induces proliferation of T cells. The aim of the study was to understand the effect of IL-2 on the development of CAD from genetic polymorphism perspective and serum level perspective. IL-2 ?330T/G and +114T/G polymorphisms were tested in 692 CAD cases and 723 healthy controls. IL-2 expression of these two polymorphisms was compared. Serum level of IL-2 in CAD patients and controls was analyzed. Data showed that prevalence of IL-2 ?330GG genotype was significantly increased in CAD than in controls (p?=?5.1?×?10^?6). Function analysis revealed that subjects carrying IL-2 ?330GG genotype had higher serum level of IL-2 than those with TG or TT genotypes (p?<?0.01). Serum level of IL-2 in the study subjects was further analyzed, and results showed that CAD patients had significantly increased IL-2 level than healthy controls (p?<?0.01). Also, cases with three vessels affected were observed to have higher IL-2 level than cases with one vessel affected (p?<?0.05). These data suggested IL-2 polymorphism could affect the susceptibility to CAD by elevating protein expression, and serum level of IL-2 may be closed correlated with the development and progression of this disease.     

High ratio of triglycerides to HDL-cholesterol predicts extensive coronary disease

An abnormal ratio of triglycerides to HDL-cholesterol (TG/HDL-c) indicates an atherogenic lipid profile and a risk for the development of coronary disease. OBJECTIVE: To investigate the association between lipid levels, specifically TG/HDL-c, and the extent of coronary disease. METHODS: High-risk patients (n=374) submitted for coronary angiography had their lipid variables measured and coronary disease extent scored by the Friesinger index. RESULTS: The subjects consisted of 220 males and 154 females, age 57.2+/-11.1 years, with total cholesterol of 210+/-50.3 mg/dL, triglycerides of 173.8+/-169.8 mg/dL, HDL-cholesterol (HDL-c) of 40.1+/-12.8 mg/dL, LDL-cholesterol (LDL-c) of 137.3+/-46.2 mg/dL, TG/HDL-c of 5.1+/-5.3, and a Friesinger index of 6.6+/-4.7. The relationship between the extent of coronary disease (dichotomized by a Friesenger index of 5 and lipid levels (normal vs. abnormal) was statistically significant for the following: triglycerides, odds ratio of 2.02 (1.31-3.1; p=0.0018); HDL-c, odds ratio of 2.21 (1.42-3.43; p=0.0005); and TG/HDL-c, odds ratio of 2.01(1.30-3.09; p=0.0018). However, the relationship was not significant between extent of coronary disease and total cholesterol [1.25 (0.82-1.91; p=0.33)] or LDL-c [1.47 (0.96-2.25; p=0.0842)]. The chi-square for linear trends for Friesinger >4 and lipid quartiles was statistically significant for triglycerides (p=0.0017), HDL-c (p=0.0001), and TG/HDL-c (p=0.0018), but not for total cholesterol (p=0.393) or LDL-c (p=0.0568). The multivariate analysis by logistic regression OR gave 1.3+/-0.79 (p= .0001) for TG/HDL-c, 0.779+/-0.074 (p= .0001) for HDL-c, and 1.234+/-0.097 (p=0.03) for LDL. Analysis of receiver operating characteristic curves showed that only TG/HDL-c and HDL-c were useful for detecting extensive coronary disease, with the former more strongly associated with disease. CONCLUSIONS: Although some lipid variables were associated with the extent of coronary disease, the ratio of triglycerides to HDL-cholesterol showed the strongest association with extent.