SPECT心肌灌注显像评价介入栓塞法猪急性心肌梗死模型

目的 应用SPECT心肌灌注显像（MPI）对介入栓塞法猪急性心肌梗死（AMI）模型进行评价,总结获得最佳图像质量的显像条件,为相关实验研究提供借鉴.方法 采用经冠状动脉丝线堵塞法制作小型猪AMI模型18头,于模型制作后1周行MPI.观察显像剂不同剂量、注射后不同显像间隔时间、采集方式及每帧采集时间对图像质量的影响;同时应用ECToolBox软件进行图像半定量分析.结果 （1）注射低剂量显像剂,采用注射至采集间隔30 min＋门控采集30 s/帧与间隔时间≥60 min＋门控采集25 s或30 s/帧图像无统计学差别;（2）注射高剂量显像剂,注射至采集间隔时间5～10 min＋门控采集25 s/帧,与低剂量组间隔≥30 min＋门控采集30s/帧图像无统计学差别.（3）应用半定量分析软件ECToolBox能够同时获得心肌梗死面积、舒张末期容积（EDV）、收缩末期容积（ESV）、左心室射血分数（LVEF）等定量参数,且可重复性好.结论 SPECT MPI能够无创性、直观评价猪AMI模型成功与否,并同时能半定量分析多项参数,结果重复性好;应用适宜的显像条件和操作方法能够有效地提高图像质量.     

显像时间与活性对PET/CT图像质量的影响

目的探讨显像时的活性水平与显像时间对PET/CT图像质量的影响.方法分别在Jaszczak模型内高活性短采集时间、推荐活性和采集时间以及低活性长采集时间下,以全身显像方式采集发射数据;采用X线CT作衰减校正(CTAC)和全身显像方式进行图像重建.相同患者按5.18 MBq/kg给药,分别于给药50 min和90 min后采集数据,采用CTAC和全身显像方式进行图像重建.以152.026 MBq、每床位采集3 min 30 s对1例74 kg女性志愿者进行显像.结果三种显像条件所得图像都可清晰分辨模型中直径为6.4 mm的冷、热区,且均匀区域未见伪影.给药50 min后开始采集所得患者图像清晰,但有时病灶难以与正常组织区分;给药90 min后开始采集所得患者图像清晰,对比度良好,能进一步明确病灶轮廓与数量.低活性较长采集时间也能获得较好的图像质量.结论通过对活性和显像时间的平衡,明显降低了二者对PET/CT图像质量的影响.给药与开始采集数据的时间间隔最好在90 min以上.     

脑血流灌注显像操作技术对图像质量的影响

目的探讨脑血流灌注显像操作技术对图像质量影响的因素。方法对我科2002年6月至2009年11月210例脑血流灌注显像的图像进行回顾性分析。结果脑血流灌注显像操作技术对图像质量影响的因素有：①仪器环境;②放射性药物的标记和注射技术;③视听封闭条件;④摆位和头位固定的准确性;⑤图像采集的方法。结论机房湿度大,仪器保养不及时、不到位,图像质量差;放射性药物标记不好、注射外漏者图像欠清晰;患者视听封闭不够,影响图像采集质量;检查中摆位不当,固定不好,患者头部移位图像较差;断层融合显像病灶定位效果较好。     

病灶靶/本底比值随时间的变化规律观察

目的 回顾性分析符合线路 (SPECT/CT)显像,观察良性病灶和恶性病灶18F-FDG摄取随时间的变化规律,指导合理选择FDG显像时段.方法 对160人次的(男112人次,女48人次)的262个病灶(恶性176个,良性86个)FDG肿瘤显像的图像进行回顾性分析.病人无糖尿病病史,空腹血糖正常,禁食6小时以上,静脉注射18F-FDG 5.0～10.32 mCi (185～381.84 MBq),平均为(7.5±1.40) mCi (227.5 MBq)后使用多功能ECT MillenniunTMVG8 Hawkeye (SPECT/CT)进行2D图像采集.最早显像时间为66 min,最晚为399 min(其中有一部分选择的是延时显像数据).每人采集1～3个床位,每床位40cm.用CT数据进行衰减校正,使用OSEM法进行图像重建.结果 分析病灶靶/本底比值时间曲线①注药后的120～180 min,良恶性病灶的靶/本底比值差别最显著.此时为鉴别良恶性病灶的最佳显像时间.②双时相采集可以根据实际情况选择①注药后30 min时进行第一时相图像采集,90 min进行第二时相的图像采集.此时,良性病灶的靶/本底比值降低,恶性病灶为初始上升期.有利于良性病灶的排除.②第一时相注药后的60～120 min内进行,第2时相在注药后的120～180 min内进行,有利于鉴别恶性病灶(此时良性病灶为平台期、缓慢上升或下降期),恶性病灶为上升期.3 必要时可进行3时相显像,通过三个时间点病灶摄取值的特点,鉴别病灶的性质.理论上会提高FDG的鉴别诊断价值.结论 准确掌握不同性质病灶的FDG代谢时间曲线,利用多时相显像技术可以更好利用和提高FDG肿瘤显像的价值.     

骨显像检查饮水及排尿困难患者的护理

目的探讨护理对饮水及排尿困难患者的骨显像图像质量的影响。方法将72例有饮水及排尿困难患者随机分为两组：给予护理指导的36例（实验组）,护理内容包括检查前对患者的心理护理,解答他们提出的各种问题,利用常规治疗的静脉输液量缓解部分有饮水困难患者的压力,采用多种饮品便于患者饮用,开展腹部按摩帮助患者排尿。无护理指导的36例（对照组）。对两组饮水、排尿情况及图像质量进行对比分析。结果实验组患者足量饮水和及时排尿完成情况优于对照组（P〈0．05）。实验组图像质量优于对照组（P〈0．05）,两组差异均有统计学意义。结论采用护理指导可缓解患者行骨显像检查的紧张情绪从而提高主动饮水能力。有效指导患者排尿,减少膀胱过度充盈显影对骨盆的遮挡,使骨显像图像质量得到保障。     

探讨一种改良的201Tl心肌显像方法

目的 探讨适当延长再分布显像数据采集时间对²⁰¹Tl心肌显像图像质量和诊断结论的影响。方法 对 31例患者于腺苷负荷试验和静脉注射²⁰¹Tl后6 min内开始采集腺苷负荷显像(ASI)数据,(200.61±13.64)min后采集常规再分布显像(TRI)数据,然后每帧增加12 s,采集加时再分布显像(PTRI)数据。用完全一致的参数重建图像后,比较分析ASI、TRI和PTRI的总计数(TC)差异。3位医师通过双盲法分别对图像质量进行目测评价,再比较分析ASI-TRI和ASI-PTRI方法所得心肌图像的诊断结论。结果 31例患者中,2例因PTRI的TC大于ASI的TC而未纳入本研究数据分析。29例有效患者ASI与TRI的TC的平均差异为(21.58±0.02)%,差异有统计学意义(t=48.799,P＜0.05);而ASI与PTRI的TC的平均差异为(2.95±0.03)%,差异无统计学意义(t=2.100,P=0.151);PTRI的图像质量有明显改善;共有11例患者(11/29,37.93%)可能根据PTRI改变诊断结论,其中2位医师一致认可者为6例(6/29,20.69%),3位医师一致认可者为3例(3/29,10.34%),另外2例(2/29,6.90%)分别有1位医师认可。可疑诊断结论从ASI-TRI的24人次下降到ASI-PTRI的13人次(χ²＝4.978,P=0.004)。结论 ASI-PTRI ²⁰¹Tl心肌显像法可明显提高图像质量,有可能进一步提高诊断的客观性。     

核素肾动态显像当日再进行骨显像的可行性

目的 观察肾动态显像当日进行全身骨显像对骨显像图像质量及患者的安全性的影响。方法 选取检查申请中既有肾动态显像又有全身骨显像检查的成年患者53例为观察组,常规接受⁹⁹Tc^m-DTPA肾动态显像检查2 h后,再注射⁹⁹Tc^m-MDP,按骨显像流程接受全身检查;另选取53例仅接受骨显像检查患者为对照组。两组于注射⁹⁹Tc^m-MDP后即刻、30 min、1 h、2 h、4 h、6 h、24 h观察患者不良反应。观察两组患者骨显像图像质量,统计图像质量优良率。测量骨后位像T12、L4、髂嵴、肱骨中段、股骨中段和髂骨上2 cm处软组织的放射计数,计算各部位靶/非靶比值（T/NT）值;对两组数据进行统计学分析。结果 两组患者均无不良反应。观察组和对照组肉眼观察图像质量优良率为90.57%（48/53）、92.45%（49/53）,差异无统计学意义（χ²=0.12,P > 0.05）。两组间T12、L4、肱骨中段、股骨中段T/NT值差异均无统计学意义（P均> 0.05）,髂嵴T/NT值差异有统计学意义（t=3.45,P<0.05）。结论 核素肾动态显像检查同日行全身骨显像检查对图像质量无明显影响。     

单光子发射计算机断层成像术全身骨显像检查患者的护理

目的:探讨单光子发射计算机断层成像术全身骨显像检查患者的护理配合方法。方法:选择2012年6月~2013年6月在我科行单光子发射计算机断层成像术全身骨显像检查患者共4254例,通过加强患者的心理护理,检查前、检查中及检查后护理配合,观察患者骨显像图像质量,评价显像效果。结果:4254例患者的检查顺利完成,且获得了优质的图像,为临床提供了可靠的影像学诊断依据,体现了护理配合在全身骨显像检查中的重要性。结论:护理配合是全身骨显像顺利完成并获得优质图像的重要保障。     

螺旋采集对99Tcm-ECD SPECT/CT脑血流灌注显像图像质量的影响

目的 观察螺旋采集模式对⁹⁹Tc^m-ECD SPECT/CT脑血流灌注显像图像质量的影响。方法 回顾性分析55例接受螺旋采集模式⁹⁹Tc^m-ECD SPECT/CT的脑血流灌注减低患者资料，经后处理获得步进式(SS,SS组)、步进连续式(SSC,SSC组)、SSC_75%-time(模拟SSC减少25%采集时间)及SSC_50%-time(模拟SSC减少50%采集时间)SPECT/CT图像；采用视觉模拟评分法(VAS)及半定量法对比4组图像质量。结果 SS组、SSC组、SSC_75%-time组及SSC_50%-time组图像VAS评分分别为4.0(4.0,4.5)分、5.0(4.5,5.0)分、3.5(3.0,3.5)分及2.5(2.0,3.0)分，差异有统计学意义(χ²=89.02,P<0.001)。4组图像中，脑血流低灌注灶放射性计数最大值、最小值及平均值差异均有统计学意义(P均<...     

骨显像患者饮水时间对其周围剂量当量率影响的研究

目的 探讨骨显像受检者饮水开始时间对周围剂量当量率的影响,以采取相应措施减少对公众的影响。方法 将60例住院骨显像患者随机分为试验组和对照组,前者于注射骨显像剂前1 h开始饮水1 000 ml,后者予注射骨显像剂后2 h饮水1 000 ml,均1 h内饮完。采用辐射剂量仪分别测量注射显像剂后0.5 h、1 h、2 h、3 h、6 h、12 h、24 h的7个时间点,距受检者正面0.5 m、1 m、2 m、3 m处4个距离点的周围剂量当量率;比较2组周围剂量当量率降为2.5 μSv/h时所需时间及距离。 结果 两组在注射显像剂后0.5 h、1 h、2 h、3 h、6 h的5个时间点、距受检者0.5 m、1 m、2 m、3 m处,试验组的周围剂量当量率低于对照组,差异有统计学意义（P<0.05）。试验组与对照组相比,减少了周围剂量当量率降低为2.5 μSv/h所需的时间和距离。两组图像质量均比较满意,达到诊断标准。 结论 骨显像受检者在注射前1 h饮水1 000 ml可以在保证显像质量的前提下,加快显像剂的排泄,降低注射后6 h内的周围剂量当量率。护理人员可利用测量结果来指导患者、家属及公众的放射防护。     

骨外组织摄取骨显像剂的所见及临床意义探讨(附497例报告)

目的:探讨骨外组织摄取99Tcm-MDP的临床意义。材料和方法:回顾性分析6602例99Tcm-MDP骨显像并识别骨外组织显影。结果:骨外组织显影497例。弥漫性摄取见于四肢、胸、腹部(淋巴和/或静脉回流障碍120例,恶性胸、腹腔积液各146及44例,甲状旁腺功能亢进3例,肝脏转移瘤20例);局灶性摄取见于不同部位多种类型的肿瘤(107例,除1例良性外其余均为恶性),心肌炎及脑梗死灶各1例、横纹肌炎症1例、近期骨折或手术后局部软组织各16及18例,术后瘢痕7例、术后造瘘13例。上述显影的骨外组织良性病变占33%,恶性病变占67%。结论:正确识别核素骨显像的骨外组织显影有助于对骨显像的正确分析并可提供有价值的信息。     

99）Tcm-MDP骨显像监测可注射组织工程骨的成骨活性

背景：有关牵张成骨传统的新骨生长形态观察方法如超声、X射线、CT文献报道较多,但有关核素监测的报道较少。目的：探讨经皮注射可注射组织工程骨促进牵张间隙成骨的可行性及放射性核素骨显像对其的早期监测作用。方法：将20只日本大耳白兔以随机数字表法分为实验组和对照组,两组均于右胫骨中下段造成20mm的骨缺损,干骺端截骨。7d后延长,1mm/次、1次/d。造模前实验组分离培养自体骨髓间充质干细胞,传至第2代后诱导成骨。延长达靶位点后,实验组牵张间隙内注射自体干细胞悬液,并同时注射自体富血小板血浆;而对照组只注射等量生理盐水。采用核素骨显像监测移植后2,4,8周时成骨情况。结果与结论：放射性骨显像99Tcm-MDP注入3h后,实验组与对照组可见显像剂明显沉积于牵张间隙区,均较对侧健性部位显影强。骨骼、肾及膀胱显像清楚,骨/软组织的对比度清晰,各组均可见大关节及肌腱附着处有对称性放射性增高区。两组在2,4周时牵张间隙放射性聚集呈现出上升的趋势,实验组上升趋势更为显著;8周时实验组和对照组核素浓聚变弱,但两者差异仍有显著性意义（P〈0.01）。结果说明经皮注射移植复合富血小板血浆的可注射组织工程骨能够促进牵张间隙成骨能力,缩短成骨时间。放射性核素骨显像在早期修复过程有比较灵敏的监测效果。     

类风湿性关节炎患者血清可溶性细胞间粘附分子-1测定与核素骨显像相关性研究

目的 研究类风湿性关节炎(RA)患者血清可溶性细胞间粘附分子-1(sICAM-1)水平变化及其与99Tcm-MDP骨关节显像的相关性,探讨在本病早期诊断中的意义.方法 用ELISA法检测达标组(23例)、非达标组(28例)及对照组(20例)血清sICAM-1水平.以99Tcm MDP为示踪剂,对上述3组受检者行核素骨关节显像,进行肉眼定性及半定量分析.结果 达标组、非达标组血清sICAM-1水平明显高于对照组(P<0.01和P<0.05),达标组与非达标组比较,血清sICAM-1水平差异无统计学意义(P>0.05).非达标组、达标组血清sICAM-1水平与手足关节指数有相关性(P<0.01或P<0.05).达标组、非达标组手、足、腕、踝病变关节放射性浓聚明显高于对照组.结论 检测血清sICAM-1水平及99Tcm-MDP骨关节显像定性、半定量分析,有助于类风湿性关节炎患者,尤其是早期进行诊断及判断病情活动程度,改善预后.     

不同骨病患者99Tcm-MDP骨显像与其病理结果对照研究

目的通过对81例骨病患者的核素骨显像与其病理结果进行回顾性分析,以期找出骨良、恶性病变,特别是结核与恶性病变影像学的规律及鉴别要点。方法对81例仅有骨痛或肢体功能障碍症状的骨病患者行99TcmMDP全身骨显像,并与手术及穿刺病理结果进行对照。结果对各病种自身来说,结核多发病灶比单发病灶多82%,其他良性骨病单发病灶比多发病灶多20%,骨转移瘤与原发恶性肿瘤多发病灶比单发病灶分别多36%和18%。恶性病变的病灶在中轴骨及外周骨同时出现(占18%),而良性病变则未见到。良性骨病病灶比邻分布明显多于无规律分布,占90%,而骨转移瘤无规律分布占84%。骨转移瘤及原发恶性肿瘤绝大多数病灶形态不规则(分别占82%及94%)、摄取放射性不均匀(分别占71%及76%)。骨结核病灶累及关节最多,占73%。结论99TcmMDP全身骨显像中除结核外的其他良性骨病以单发分布多见。恶性病变以多发分布多见,并可同时无规律地出现于中轴和外周骨上,绝大多数病灶形态不规则、摄取放射性不均匀。骨结核以多发及易累及中轴骨多见,病灶多形态规则、摄取放射性较均匀,极易累及关节是其显著特征。     

18F-FDG PET/CT与99Tcm-MDP骨显像诊断肿瘤骨转移价值的Meta分析

目的评价18F-FDG PET/CT与99Tcm-MDP骨显像对肿瘤骨转移早期诊断的价值。方法计算机检索MEDLINE、PubMend、EMbase、Ovid、Cochrane Library数据库,检索时间截至2010年,搜集18F-FDG PET/CT与99Tcm-MDP骨显像诊断恶性肿瘤骨转移的文献。由3位研究者根据纳入与排除标准独立筛选文献、提取资料和评价质量后,采用MetaDisc软件进行Meta分析,计算合并敏感性、特异性、诊断优势比(DOR),并绘制SROC曲线,计算曲线下面积(AUC)与Q*。结果最终纳入5个研究。Meta分析结果显示:18F-FDG PET/CT与99Tcm-MDP骨显像在诊断肿瘤骨转移的敏感性合并分别为0.95[95%CI(0.90,0.97)]和0.77[95%CI(0.71,0.83)],特异性合并分别为0.98[95%CI(0.97,0.99)]和0.90[95%CI(0.88,0.92)],DOR合并分别为602.81[95%CI(214.07,1 697.51)]和41.37[95%CI(8.15,210.05)];SROC AUC与Q*分别为0.984 2、0.901 7和0.945 4、0.833 1。结论应用18F-FDG PET/CT早期诊断肿瘤骨转移明显优于99Tcm-MDP骨显像。     

Subarachnoid Hemorrhage Diagnosis: Lumbar Puncture Is Still Needed When the Computed Tomography Scan Is Normal

Objectives: To determine the sensitivity of third-generation CT scanners for diagnosed nontraumatic subarachnoid hemorrhage (SAH) and to assess the impact of symptom duration on sensitivity.
Methods: A retrospective chart review was performed in a university-affiliated tertiary care hospital with an annual ED volume of >100,000 patients. The target population was all patients who presented to the ED from January 1991 to September 1994 with symptoms suggestive of SAH and who had a final diagnosis of nontraumatic SAH based on either a positive CT scan or positive spinal fluid analysis. Patients referred from outside facilities were included if they had a CT done at the study site. All CT scans were done using third-generation scanners. Official CT scan reports were used to categorize scans as positive or negative.
Results: There were 140 patients identified with SAH, with a mean age of 56 years (range 10–88). The sensitivity of CT in the diagnosis of nontraumatic SAH when performed at or before 12 hours of symptom duration was 100% (80/80), and 81.7% (49/60) after 12 hours of symptom duration (95% CI 95–100% and 69.5–90.4%, respectively; p < 0.0001). Eleven of the 140 patients had a negative CT and positive spinal fluid analysis, yielding an overall sensitivity of 92.1% (129/140).
Conclusion: The sensitivity of third-generation CT scans for SAH decreases with time from the onset of symptoms. In this sample population, CT was able to detect all patients scanned ^12 hours after symptom onset. Although the study demonstrated good sensitivity of CT scan reports for SAH when the scan was performed after S12 hours of symptom onset, additional real-time experience is needed to better define the potential risk of a missed SAH should this population not receive the customary lumbar puncture examination in the setting of a negative CT scan.     

Tc-99m MIBI uptake in traumatic vertebral fractures and metastatic vertebral lesions: Comparison with Tc-99m MDP

This study compared technetium-99m-hexakis-2-methoxyisobutyl-isonitrile (Tc-99m MIBI) with technetium-99m methylene diphosphonate (Tc-99m MDP) to determine whether Tc-99m MIBI could distinguish vertebral metastases from traumatic vertebral fractures. Twenty patients with traumatic vertebral fracture (and no malignant disease) and 14 patients with metastatic vertebral lesions were evaluated. Three to 4 hours after intravenous injection of Tc-99m MDP, images of the vertebrae in all patients were obtained. Corresponding Tc-99m MIBI images were acquired within 4 days after the Tc-99m MDP bone images were obtained. Computed tomography and magnetic resonance imaging demonstrated 24 vertebral traumatic fractures and 44 vertebral metastases. On conventional bone scans, Tc-99m MDP activity was increased in 92% of vertebral fractures and in 100% of vertebral metastases. However, on MIBI scans, no abnormal findings were observed in the vertebrae with fracture, although increased activity was seen in 73% of vertebral metastases. In this study, traumatic vertebral fractures tended to display no pathologic increases in Tc-99m MIBI uptake, whereas bone metastases usually appeared with high uptake. In light of the excellent specificity of Tc-99m MIBI scans compared with Tc-99m MDP bone scans, imaging studies that use Tc-99m MIBI scans may play an important complementary role in differentiating vertebral metastases from traumatic vertebral fractures.     

Clinical use of renal perfusion imaging by means of harmonic sonography with a microbubble contrast agent in patients after renal transplantation: preliminary study.

OBJECTIVE: The purpose of this research was to determine the feasibility of renal perfusion imaging by means of harmonic sonography with a microbubble contrast agent for the evaluation of renal perfusion after renal transplantation compared with technetium Tc 99m diethylenetriamine pentaacetic acid ((99m)Tc-DTPA) scans. METHODS: During a 10-month period, 100 patients with renal transplantation that included normal perfusion (n=68) and delayed perfusion including chronic rejection (n=19), acute rejection (n=9), arterial stenosis (n=2), and urinary stricture (n=2) underwent sonographic renal perfusion imaging and (99m)Tc-DTPA scans. Sonographic images were obtained every 3 seconds for a total of 3 minutes after administration of a bolus injection of 4 g of the microbubble contrast agent at a concentration of 300 mg/mL. Sonographic renal perfusion images were converted into a renal perfusion curve, and the calculated time at the peak of the curve (T(peak)) was compared with that of the (99m)Tc-DTPA scan. RESULTS: The T(peak) with the (99m)Tc-DTPA scan was 14.9 seconds in the normal group and 33 seconds in the delayed perfusion group. The T(peak) on sonographic renal perfusion images was 25 seconds in the normal group and 44.8 seconds in the delayed perfusion group. Sonographic renal perfusion images showed good correlation with the (99m)Tc-DTPA scan (r=0.74; P=.0001). The cutoff value of the T(peak) on sonographic renal perfusion images was 35 seconds (sensitivity=85%; specificity=90%). CONCLUSIONS: The renal perfusion images obtained by means of harmonic sonography with a microbubble contrast agent constitute an effective sonographic technique for the evaluation of renal perfusion abnormalities after renal transplantation compared with a (99m)Tc-DTPA scan.     

Sensitivity of New-generation Computed Tomography in Subarachnoid Hemorrhage

Objective: To determine the sensitivity of the initial new-generation CT (NGCT) scan interpretation for detection of acute nontraumatic subarachnoid hemorrhage (SAH) and to decide whether lumbar puncture (LP) should follow a "normal" NGCT scan.
Methods: A retrospective chart review was performed of patients admitted between March 1988 and July 1994 with proven SAH. Exclusion criteria were age <2 years, diagnosis other than acute SAH, history of head trauma within 24 hours before symptom onset, NGCT scan not done before diagnosis, and records not available. Patients were placed into two groups: symptom duration <24 hours (group 1) and >24 hours (group 2) prior to CT scan. The resolution of each NGCT scanner was recorded. An NGCT sceinner was defined as a third-generation scanner or more recent.
Results: Of 349 SAH patients, 181 met inclusion criteria. The sensitivity of NGCT scans for SAH was 93.1% for the group 1 patients ( n = 144) and 83.8% for the group 2 patients ( n = 37). The overall sensitivity was 91.2%. All the patients who had SAH not detected by NGCT scans were diagnosed by LP. There was no significant relationship between NGCT scanner resolution and sensitivity for SAH.
Conclusion: Initial interpretation of NGCT scans to detect SAH does not approach 100% sensitivity. A "normal" NGCT scan does not reliably exclude the need for LP in patients who have symptoms suggestive of SAH.     

Na18F用于肿瘤骨转移病灶显像及其诊断效能

目的介绍骨转移瘤的Na18F PET/CT显像,并比较其与Na18F PET和99Tcm-亚甲基二膦酸盐(MDP)ECT显像对骨转移病灶的诊断效能。方法对临床15例多发性骨转移瘤患者,分别行Na18F PET/CT、Na18F PET和99Tcm-MDP ECT显像,将肉眼可见的骨骼热区记为转移、无法定性和非转移病灶,通过临床随访最终定性诊断为转移病灶、非转移病灶,比较3种检查方法探测骨转移灶的灵敏度、特异度和准确率。结果 Na18F PET/CT和Na18F PET均检出全部168处病灶,99Tcm-MDP ECT探测到全部病灶的64.88%(109/168)。当无法定性的病灶被计入转移病灶时,Na18F PET/CT、Na18F PET和99Tcm-MDP ECT的灵敏度、特异度分别为100%、100%;99.17%、72.92%;66.67%、39.58%。前两者与后者之间差异均有统计学意义(χ2=17.8、χ2=8.2、χ2=18.0、χ2=25.4,P均<0.05)。当无法定性的病灶被计入非转移病灶时,Na18F PET/CT、Na18F PET和99Tcm-MDP ECT的灵敏度、特异度分别为100%、93.75%;93.33%、79.17%;57.50%、81.25%。PET/CT、PET较ECT灵敏度差异均有统计学意义(χ2=26.1、χ2=22.5,P均<0.05),而特异度差异均无统计学意义(χ2=4.8、χ2=0.44,P均>0.05)。结论 Na18F PET/CT用于骨转移瘤显像具有高灵敏度、高特异度兼备的优势。