糖尿病患者的眼动脉和视网膜中央动脉血流动力学改变

目的应用彩色多普勒显像(CDFI)检测探讨糖尿病患者的眼动脉和视网膜中央动脉血流动力学变化。方法应用CDFI检测30例糖尿病患者和50例正常对照组的眼动脉(OA)、视网膜中央动脉(CRA)的收缩期血流峰速(Vs)、舒张末期流速(Vd)平均流速(Vm)、血管阻力指数(R I)和搏动指数(PI)。结果与对照组比较,糖尿病组OA和CRA的的Vs、Vd降低、R I增加。结论糖尿病患者的OA和CRA血流速度降低,视网膜循环阻力升高,视网膜血液供应不良。     

糖尿病人眼动脉和视网膜中央动脉血流动力学改变

目的：应用彩色多谱勒显像（color Doppler flow imaging,CDFI）检测糖尿病患者,以探讨其血液动力学变化,提供有参考价值的数据。方法：应用CDFI检测了30例糖尿病患者和50例正常对照组的眼动脉（ophthalmic artery,OA）视网膜中央动脉（central retinal artery,CRA）的收缩期血流峰速(peak systolic velocity,Vs）,舒张末期流速（end diastolic velocity,Vd）,平均流速（mean envelopet velocity,Vm）,血管阻力指数（resitance index,RI）和搏动指数（pulse index,PI）。结果：与对照组比较有或无糖尿病视网膜病变（diabeetic retinopathy,DR）糖尿病组OA和CRA的Vs、Vd降低（p＜0.05）RI增加（p＜0.05）。结论：糖尿病患者的OA和CRA血流速度降低,视网膜循环阻力升高,视网膜血液供应不良。     

糠尿病患者的眼动脉和视网膜中央动脉血流动力学改变

目的 :应用彩色多普勒显像 (colorDopplerflowimaging ,CDFI)检测糖尿病患者 ,以探讨其血液动力学变化 ,提供有参考价值的数据。方法 :应用CDFI检测了 3 0例糖尿病患者和 50例正常对照组的眼动脉、视网膜中央动脉的收缩期血流峰速、舒张末期流速、平均流速、血管阻力指数和搏动指数。结果 :糖尿病组与对照组比较有 /或无糖尿病视网膜病变 (diabeticretinopathy ,DR)OA和CRA的Vs、Vd降低 (P <0 0 5)、RI增加 (P <0 0 5)。结论 :糖尿病患者的OA和CRA血流速度降低 ,视网膜循环阻力升高 ,视网膜血液供应不良。     

糖尿病视网膜病变视网膜血流动力学变化的超声观察

目的观察糖尿病视网膜病变（diabetic retinopathy，DR）时视网膜中央动脉（central retinal artery，CRA）和视网膜中央静脉（central retinal vein，CRV）血流动力学变化，探讨DR与视网膜血流动力学变化之间的关系。方法应用彩色多普勒超声诊断（color Doppler ultrasoundgraph，CDI）术，对20例34眼正常人（NDR组）与42例60眼DR眼患者（DR组）的CRA和CRV的血流动力学指标进行检测。结果DR组与NDR组相比，CRA的最大收缩期血流速度、舒张末期血流速度和总平均速度、博动指数均降低（P〈0.05），阻力指数增高（P〈0.05）；CRV的最高流速、最低流速和平均血流速度均增高（P〈0.05）。结论CDI是评价DR时视网膜血流动力学变化的有效方法。     

国人糖尿病性视网膜病变眼和视网膜中央动脉血流改变的Meta分析

目的:综合评价糖尿病视网膜中央动脉(CRA)和眼动脉(OA)血流动力学改变对糖尿病性视网膜病变(DR)的诊断意义.方法:计算机网上检索中国期刊全文数据库1994～2006年来有关CRA和OA彩色超声多普勒血流动力学测定的DR病例-对照研究文献33篇对CRA和OA血流参数进行同质性检验和合并效应量的检验.结果:合并分析后有统计学意义的同质性研究结果为糖尿病患者的OA平均血流速度比正常人低0.26～0.31标准差;DR出现前,OA收缩期峰值血流速度比正常人低0.24～0.3标准差,OA舒张末期血流速度比正常人低0.31～0.37标准差;单纯型DR的OA舒张末期血流速度比正常人低0.94～1.01标准差,也比DR出现前糖尿病患者低0.56～0.67标准差;增殖型DR的CRA平均血流速度比正常人低2.98～3.21标准差,也比单纯型DR者低0.49～2.43标准差.结论:糖尿病患者表现早期OA的血流速度降低,DR增殖期CRA的平均血流速度降低.血流动力学改变早于DR肉眼可见的视网膜形态学改变.     

激光治疗对糖尿病视网膜病变患者视网膜血流动力学的影响

目的以彩色多普勒成像(colorDopplerimaging,CDI)技术探讨激光治疗对糖尿病视网膜病变(diabeticretinopathy,DR)患者视网膜血流动力学的影响。方法用CDI技术检测激光治疗前后DR患者视网膜中央动脉的收缩期峰值流速、舒张末期血流速度与阻力指数,以及激光治疗前后视力的改变,并作对照比较。结果激光治疗后DR患者视网膜中央动脉的收缩期峰值流速、舒张末期血流速度均有所增加,阻力指数稍下降,视力不同程度提高或保持不变。结论激光治疗能改善DR患者视网膜的血流灌注,对视力提高及保持原有视力有很好的临床价值。     

缺血性眼病眼部动脉血流改变的临床对比观察

目的通过对缺血性跟病（IOP）患者患眼进行荧光素眼底血管造影（FFA）及彩色多普勒超声诊断仪等检查,观察患眼眼部血流改变情况。方法将我院眼科中心3年间临床确诊的IOP患者53例纳入研究,并将对侧健眼作为对照组进行对照研究,双眼同时行FFA及彩色多普勒超声检查,观察臂-视网膜（A—RCT）、眼动脉（OA）、视网膜中央动脉（CRA）、睫状后短动脉（PCA）收缩期血流峰值速度（PSV）、舒张末期血流速度（EDV）、阻力指数（RI）等变化,采用统计学方法对检查结果进行分析。结果IOP患者患眼与其对侧健眼以下项目比较存在统计学差异：IOP患者患眼A-RCT较对侧健眼延长,OA、CRA、PSV血流速度降低,RI增高。结论IOP患眼眼部各动脉血流速度、血流量均较低,阻力增大,循环时间延长,进一步导致球眼内血流量下降,致IOP患者患眼均存在血流量不足。     

糖尿病患者的眼动脉和视网膜中央动脉血流动力学改变

目的：应用彩色多普勒显像（ｃｏｌｏｒＤｏｐｐｌｅｒ ｆｌｏｗ ｉｍａｇｉｎｇ,ＣＤＦＩ）检测糖尿病患者,以探讨其血液动力学变化,提供有参考价值的数据。方法：应用ＣＤＦＩ检测了３０例糖尿病患者和５０例正常对照组的眼动脉、视网膜中央动脉的收缩期血流峰速、舒张末期流速、平均流速、血管阻力指数和搏动指数。结果：糖尿病组与对照组比较有／或无糖尿病视网膜病变（ｄｉａｂｅｔｉｃ ｒｅｔｉｎｏｐａｔｈｙ,ＤＲ）Ｏ     

国人青光眼视网膜中央动脉和眼动脉血流改变的Meta分析

目的:综合评价青光眼视网膜中央动脉(CRA)和眼动脉(OA)血流动力学改变的诊断意义和临床应用.方法:计算机网上检索中国期刊全文数据库1994/2006有关CRA和OA彩色超声多普勒血流动力学测定的青光眼病例-对照研究文献40篇,对CRA和OA血流参数进行同质性检验和合并效应量的检验.结果:合并分析后有统计学意义的同质性研究结果为青光眼对侧未损害眼的OA与CRA收缩期峰值血流速度比正常人分别降低0.55～0.68和0.41～0.51个标准差,舒张末期血流速度比正常人降低0.22～2.52和0.69～0.79个标准差,OA和CRA阻力指数分别高于正常人1.13～1.29和0.51～0.61个标准差.抗青光眼术后OA平均血流速度比正常低0.23～0.32个标准差,CRA阻力指数比正常高0.04～1.51个标准差.正常眼压性青光眼(NTG)的CRA的收缩期峰值和舒张末期血流速度比正常人分别低0.71～0.79和0.68～0.77个标准差,却比原发性开角型青光眼(POAG)患者高0.03～0.12和0.04～0.13个标准差.闭角型青光眼的CRA搏动指数比正常人和POAG患者分别降低0.04～0.11和0.33～0.40个标准差.高眼压组的OA舒张末期血流速度分别比低眼压组降低1.61～1.82,1.01～126,0.47～0.79个标准差,阻力指数分别比低眼压组增加0.57～0.73,0.82～1.06,0.03～0.34个标准差.合并分析后有统计学意义的结果是慢性闭角型青光眼(CCAG)的OA平均血流速度和CRA收缩期峰值血流速度比正常人分别降低0.06～2.25和0.34～3.81个标准差.结论:各型原发性青光眼缺血性改变最明显的是POAG,其次为NTG,CCAG.NTG的CRA收缩期峰值和舒张末期血流速度下降明显;CCAG的OA平均血流速度和CRA收缩期峰值血流速度下降明显;POAG的CRA阻力指数增加明显.抗青光眼术后彩色超声多普勒检测OA和CRA血流动力学参数,发现其缺血性改变程度,是重要的疗效评价方法和指标.     

彩色多普勒血流显像在前部缺血性视神经病变针刺效应评估中的应用研究

目的应用彩色多普勒血流显像检测前部缺血性视神经病变(anterior ischemic optic neuropathy,AION)针刺治疗前后的血流参数,评价其临床应用价值。方法对39例(51眼)AION患者分别于针刺前5min、针刺后5min检测视网膜中央动脉、睫状后短动脉及眼动脉的血流参数。结果与针刺前比较,针刺后5min睫状后动脉的收缩期峰速、舒张末期流速明显增高,差异有显著统计学意义(t=4.6227,P<0.001;t=6.0248,P<0.001),阻力指数明显降低(t=2.5210,P<0.05);视网膜中央动脉和眼动脉的收缩期峰速、舒张末期流速以及阻力指数针刺前后差异无统计学意义(P>0.05)。结论彩色多普勒血流显像对AION的诊断及疗效评估具有重要的应用价值。     

青光眼小梁切除术前后眼部血流动力学变化的研究

目的:比较青光眼32眼小梁切除术前后的血流动力学变化。方法:利用彩色多普勒成像技术(CDI)分别检测正常对照组与青光眼组术前、术后2,12wk的眼部血流情况,包括眼动脉(OA)、睫状后短动脉(SPCA)和视网膜中央动脉(CRA)的收缩期峰值血流速度(PSV)、舒张末期血流速度(EDV)和阻力指数(RI)。结果:(1)青光眼组手术前后比较:青光眼组在小梁切除术后血流灌注明显好转,表现为PSV,EDV增高,RI下降;(2)青光眼术后组之间比较:PSV,EDV,RI有改变,但差异无统计学意义;(3)青光眼组术后与正常对照组比较:青光眼组在小梁切除术后眼压降至正常范围时OA,SPCA,CRA的PSV,EDV和RI仍不及正常人(P<0.05);(4)青光眼组术前与正常对照组比较:OA,SPCA,CRA均表现为PSV,EDV下降,RI增高(P<0.01)。结论:(1)青光眼患者与正常人相比较存在明显的血流灌注不足,小梁切除术可以有效的改善眼部血流灌注情况;(2)CDI可长期用于监测和评价青光眼小梁切除术的治疗效果。     

复方血栓通对NPDR激光光凝术后的视网膜血流动力学影响

目的：观察复方血栓通对非增生性糖尿病性视网膜病变（ nonproliferative diabetic retinopathy,NPDR）激光光凝术后的视网膜血流动力学的影响。 方法：选取已行激光光凝术后的NPDR患者41例72眼,给予复方血栓通治疗,于治疗前后,采用彩色多普勒血流检测仪检测视网膜血流动力学情况。 结果：治疗后患眼视网膜血流灌注有明显改善,视网膜中央动脉的收缩期峰值血流速度（ PSV）、舒张末期血流速度（ EDV）和平均血流速度（ Vm）均增高,而阻力指数（ RI）降低,差异有统计学意义（P〈0.05）。治疗后61眼视力改善,总有效率85%。治疗后视力提高值和患眼的PSV,Vm和RI的变化差值呈明显的相关性。 结论：复方血栓通对NPDR激光光凝术后患者的视网膜血流灌注有明显改善,并且这种改善和患者视力预后的改善密切相关。     

The Effects of Darkness on Retrobulbar Hemodynamics in Patients with Early Stages Retinitis Pigmentosa

PURPOSE: To investigate the retrobulbar hemodynamic changes occurring in light and darkness in patients with early stages retinitis pigmentosa (RP). METHODS: Eleven early stages RP patients were enrolled in the study. The peak systolic velocity (PSV), end-diastolic velocity (EDV), pulsatility index (PI) and resistivity index (RI) of the ophthalmic artery (OA) and central retinal artery (CRA) were measured by color Doppler imaging in light and darkness. The results were compared with that of 10 age-matched normal subjects. RESULTS: PSV and EDV of the OA did not show significant differences in both groups. However, PSV and EDV of the CRA in RP patients decreased significantly in darkness (p = 0.001, p < 0.001, respectively). In addition, we found a significant increase in RI of the CRA in RP patients in darkness (p = 0.003). On the contrary, PSV and EDV of the CRA in control subjects showed a significant increase (p = 0.002, p < 0.001, respectively) and RI showed a significant decrease in darkness (p = 0.004). CONCLUSIONS: Darkness causes a decreased blood flow in the CRA in early stages of RP.     

Colour Doppler imaging in normal pressure glaucoma patients

AIM: Ocular hemodynamics is of great interest in glaucoma, especially since vascular disturbances may play a pathogenetic role in disease development. To investigate the hemodynamic differences between normal pressure glaucoma patients and normal volunteers, flow velocities of the retrobulbar vessels were measured by colour Doppler imaging. METHOD: 15 patients with normal pressure glaucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging (CDI) of the retrobulbar vessels. The patients and the volunteers were especially gender- and age-matched. Peak systolic velocities (PSV), end-diastolic velocities (EDV), and resistive indices (RI) of the ophthalmic artery and central retinal artery were obtained. RESULTS: In NPG patients, PSV and EDV in the central retinal artery were significantly decreased, whereas RI was increased in central retinal artery and the ophthalmic artery. CONCLUSION: Colour Doppler imaging is a non-invasive technique that allows further estimation of the ocular circulatory status. Particularly in the group of patients with disturbed hemodynamics, like NPG patients, it was able to show a reduction of the retrobulbar hemodynamics.     

Colour Doppler imaging and fluorescein filling defects of the optic disc in normal tension glaucoma

AIM: To investigate the relation between blood flow parameters of the retrobulbar vessels measured by means of colour Doppler imaging (CDI) and fluorescein filling defects of the optic nerve head in patients with normal tension glaucoma (NTG) and control subjects. METHODS: 29 patients with NTG and 29 age and sex matched control subjects were included in this study. Blood flow velocities-peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive indices (RI) of the ophthalmic artery (OA), the central retinal artery (CRA), and of the temporal and nasal short posterior ciliary arteries (TPCA, NPCA)-were measured with CDI. Fluorescein angiograms were performed with a scanning laser ophthalmoscope. The extent of absolute fluorescein filling defects of the optic nerve head in relation to the optic nerve head was assessed. RESULTS: The PSV of the OA, the PSV and EDV of the CRA, and of the TPCA and NPCA were significantly reduced in NTG (p<0.05). The RI of the CRA, the TPCA and NPCA were significantly increased in NTG (p<0.01). The optic nerve head fluorescein filling defects were significantly larger in NTG (p<0.01). The filling defects were significantly negatively correlated (p<0.05) with the PSV and EDV of the CRA (PSV(CRA): r = -0.41; EDV(CRA): r = -0.34), with the PSV and EDV of the NPCA (PSV(NPCA): r = -0.34; EDV(NPCA): r = -0.38), and with the EDV of the TPCA (r = -0.29). A significant positive correlation (p<0.05) was found with the RI of both PCAs (RI(NPCA): r = 0.28; RI(TPCA): r = 0.29). CONCLUSION: Patients with NTG had reduced blood flow velocities and higher resistive indices in most retrobulbar vessels. Optic nerve head fluorescein filling defects were larger compared to controls. The filling defects were correlated with end diastolic velocities and resistive indices of the PCAs and with blood flow velocities of the CRA. Capillary loss of the optic nerve head may be related to higher downstream resistance and reduced blood flow velocities of the retrobulbar vessels.     

Comparison of colour Doppler imaging and retinal scanning laser fluorescein angiography in healthy volunteers and normal pressure glaucoma patients

PURPOSE: To correlate retinal circulatory measurements using scanning laser fluorescein angiography and flow velocities of retrobulbar vessels measured by means of colour Doppler imaging. METHODS: Fifteen patients with normal pressure glaucoma (NPG) and 15 healthy volunteers underwent colour Doppler imaging and fluorescein angiographic studies. Peak systolic velocities (PSVs), end-diastolic velocities (EDVs) and resistive indices (RIs) of the ophthalmic artery (OA) and central retinal artery were obtained. In the fluorescein angiograms arteriovenous passage time (AVP) was quantified by means of digital dye dilution curve analysis. RESULTS: Arteriovenous passage time was significantly prolonged in NPG patients compared to healthy subjects (p = 0.0026). In the central retinal artery PSV (p = 0.023) and EDV (p < 0.0001) were significantly decreased and RI was increased (p < 0.0001) in patients with NPG. The EDV of the central retinal artery showed a significant correlation with AVP (EDV: r = - 0.53, p = 0.0023). The RI of the central retinal artery correlated significantly to AVP (RI: r = 0.63, p < 0.0001). The AVP did not correlate to EDV or PSV, nor to the RI measured in the ophthalmic artery. CONCLUSION: Arteriovenous passage time, which represents blood flow in a vascular segment of artery, capillary bed and corresponding vein, was found to be correlated to the EDV and the RI of the central retinal artery. The combination of different techniques allows further interpretation of ocular circulatory responses.     

玻璃体切割联合眼内全视网膜光凝对PDR合并虹膜新生血管的视网膜供血影响

目的：探讨玻璃体切割联合眼内全视网膜光凝对增殖性糖尿病视网膜病变( proliferative diabetic retinopathy,PDR)合并虹膜新生血管( iris neovascularization,NVI)患者视网膜供血的影响及其临床价值。
　　方法：采用彩色多普勒超声血流显像技术( color doppler flow imaging,CDFI)检测21例21眼PDR合并NVI患者行玻璃体切割联合眼内光凝术前、术后3 mo视网膜中央动脉( central retinal artery, CRA )、睫状后短动脉( shot posterior ciliary artery, sPCA )、眼动脉( ophthalmic artery, OA)的收缩期峰值流速( peak systolic velocity,PSV)、舒张末期血流速度( end diastolic velocity, EDV )、阻力指数( resistance index,RI)的变化。
　　结果：玻璃体切割联合眼内全视网膜光凝术后3 mo CRA的PSV、EDV较术前明显升高,而RI值下降,有统计学差异( P<0.05)。 sPCA及OA各项血流参数手术前后改变无统计学差异(P>0.05)。
　　结论：玻璃体切割联合眼内光凝可以提高PDR合并NVI患者术后CRA的血流速度,降低远端视网膜血管的RI,改善眼视网膜的血液供应,延缓或阻止患者向新生血管性青光眼( NVG)的发展与发生。     

Color Doppler Imaging of the Orbital Vessels in Ankylosing Spondylitis

Abstract

Purpose: To analyze the hemodynamic features of orbital blood flow velocities using Doppler ultrasonography in ankylosing spondiylitis (AS) patients, as well as to compare these results with those of healthy controls. Methods: 33 AS patients and 32 healthy controls were consecutively included in the study groups. The same radiologist performed ocular blood flow measurements. Peak systolic velocity (PSV), end diastolic velocity (EDV), and resistive index (RI) were measured in the central retinal artery (CRA), posterior ciliary arteries (PCAs), and ophthalmic artery (OA). Resistive index was used to assess arterial resistance; it was automatically calculated as RI [(PSV–EDV)/PSV]. Results: There were no significant differences in the PSV, EDV, and RI of the OA, CRA, and PCAs between AS patients and controls. Conclusion: This result suggests no possible contributory role of vascular structures in formation of uveitis in AS. We believe that our preliminary results need to be complemented with further studies, particularly including AS patients with uveitis and rheumatic diseases with other ocular involvement.     

彩色多普勒超声对缺血性眼病的临床诊断意义

目的:探讨彩色多普勒超声对缺血性眼病的临床诊断意义。方法:采用IU22型超声诊断仪对40例已确诊的单眼缺血性眼病患者40眼,对照组采用患者的另一相对健康眼40眼及正常人40例40眼,进行颈内动脉、眼动脉、视网膜中央动脉检查。结果:缺血性眼病患者的患眼的眼动脉、视网膜中央动脉的收缩期血流峰值速度(peak systolic velocities,PSV)、舒张末期血流速度(end diustolic velocities,EDV)、血管内径(blood vessel diameter,BVD)明显低于患者的健康眼及正常人的眼(P<0.05);阻力指数(resistance index,RI)则明显增加(P<0.05);三组比较,颈内动脉测量结果,患者患眼及健康眼较正常人组仅阻力指数明显增加(P<0.05),其它检测结果无统计意义。结论:缺血性眼病患者患眼眼动脉,视网膜中央动脉PSV,EDV,BVD均下降,RI增加。彩色多普勒对缺血性眼病是一种比较敏感的检测手段。     

Color Doppler Imaging in the Study of Retrobulbar Hemodynamic Changes of Primary Angle—closure Glaucoma

Purpose: To investigate the hemodynamic changes of ophthalmic and central retinal artery (OA,CRA) in Primary Angle-closure Glaucoma (PACG) and the effects of intraocular pressure (TOP) on the retrobulbar hemodynamics.Methods: The hemodynamic changes of OA, CRA in PACG were explored with color Doppler imaging (CDI) technique. Peak systolic blood flow velocity (PSV), end-diastolic blood flow velocity (EDV),pulsatile and resistive indices (PI,RI) were recorded and compared with those of the normal subjects. There were 20 patients (40 eyes) with PACG who were divided into two groups according to their IOP levels; ocular hypertension (15 eyes) and normal tension (25 eyes) .Results : Compared with the normal subjects, the hypertension group of PACG showed significant reduction in the EDV and increases in PI, RI of CRA; normal tension group of PACG also showed remarkable increase in RI of CRA. The ocular hypertension was significantly correlated with the RI and not with the EDV by the analysis of multiple line