双探头符合线路SPECT正电子显像衰减校正实验研究

目的 用Jaszczak模型及心肌模型检测及评价SPECT和正电子符合探测显像衰减校正在肿瘤和心肌显像中的应用效果.方法 用Jaszczak模型充满18F-脱氧葡萄糖(FDG)溶液,充分混匀,分别在Vertex Plus机型和Hawkeye机型上做模型图像的采集并进行图像重建.结果 Vertex Plus衰减校正后的图像质量明显改善,周边和深部的计数之差减少,深部的计数得到补偿.校正后的图像可以发现直径为9 mm的"冷"区,而7 mm的"冷"区则难以辨认,"热"区可以分辨到6 mm.Hawkeye衰减校正后的圆形"冷"区有较大的改善,校正前对直径在12 mm以下的"冷"区都无法显示,中央的"冷"区几乎与本底相似,难以分辨,周边的放射性与中央部分的放射性计数差距较大.校正后的图像可以发现5个"冷"区,而7 mm的"冷"区则难以辨认.结论 衰减校正的模型实验显示用137CS作为穿透射线方法的校正效果优于Hawkeye X线球管,不仅明显改变图像质量,而且可以明显改善空间分辨率,在"冷"区可以显示到直径9 mm,而"热"区则可以显示到6 mm.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

双探头符合线路SPECT正电子显像衰减校正实验研究

Objective The photons from the body would be attenuated in their intensity by the soft tissue before they reach the detectors. Some of them lost more intensity than others when coming from the deeper body. Attenuation of the photons would distort the image, affect the image quality, and may lead to misdiagnosis. In this research the X-ray and γ-ray were used as transmission resources for accurate assess-ment of attenuation in each part of the body. The transmission data was used to correct the emission data from the body. Iteration algorithm was used for the reconstruction of attenuation corrected tomography ima-ges. Evaluate the efficacy of attenuation correction in duel head hybrid SPECT/coincidence PET systems (SPECT/PET) and SPECT using both the Jaszczak and the myocardial phantoms. Methods For PET phantom study, the Jaszczak phantom was filled with the aqueous solution of 18F-fluorodeoxyglucose (FDG) and was scanned with two hybrid SPECT/coincidence PET systems respectively (Vertex Plus, Netherlands Philips ADAC Company and Hawkeye, USA GE Company). The PET images were acquired and reconstruc-ted. Results The "cold" lesion, which the diameter was less than 12 mm of uncorrected image, could not be identified. But it, after correction, diameter 9 mm, would be recognized clearly, less than 7 mm would not be distinguished. Noncorrected image could only identify "hot" lesions which the diameter were 9, 12, 14, 18, 22 and 38 mm, while in the corrected image, not only it was much better, but also the "hot" le-sion of 6 mm was distinguished. In Hawkeye, the same situation, the corrected image of was improved obvi-ously; the disparity of counts between surrounding and deep center less, and the counts in deep center were compensated. There were only 3 round " cold" lesions could be recognized, the diameter: 14, 18 and 20 mm; all of them which diameter were less than 12 mm could not be distinguished. One in the center was al-most as background, and could not be identified. The radioactive accounts of surrounding and center were quite different. The corrected image 5 "cold" lesions could be found, 9, 12, 14, 18 and 20 mm, but7 mm could not be found. The noncorrected image, only 12, 14, 18, 22 and 38 mm " hot" lesions could be found, and by the surrounding, there was an arc shape "hot" lesion. But it could distinguish 9, 12, 14, 18, 22 and 38 mm "hot" lesions on the corrected image, and the image was much better than noncorrected one. Conclusions The corrected image of Vertex Plus was improved obviously with the disparity of counts between surrounding and deep center less, and the counts in deep center was compensated. The result of at-tenuation with phantom showed that 137Cs was better than CT in both image quality and spatial resolution.     

部分容积效应对单光子与符合线路显像中病灶/本底比值影响的模型研究

目的 评价部分容积效应对单光子与符合线路显像中病灶/本底比值(L/B值)的影响.方法 使用简易Jaszczak模型,内有6个高为7.0.cm,底面直径分别为2.8,1.8,1.3,0.8,0.8和0.8 cm的圆柱体作为病灶,分别用99TcmO4和18F-脱氧葡萄糖(FDG)进行2组对比度的实验.测量3种L/B值:L/B1为最大计数比值,L/B2为以病灶直径为感兴趣区(ROI)直径的平均计数比值,L/B3为以6个像素为ROI的平均计数比值.本底均为平均计数.比较3种L/B值与对比度的关系.采用SPSS 11.0软件进行配对t检验和直线相关、回归分析.结果 单光子显像对比度为2:1和符合线路显像对比度为2:1及2.5:1时,直径0.8 cm病灶显示不清.除符合线路显像直径2.8 cm病灶的L/B值与对比度的差异无统计学意义外,其余病灶的L/B值均低于对比度;病灶直径越小,L/B值被低估的程度越明显,二者呈显著正相关,其回归方程分别为:单光子显像时Y2.8=0.086+0.689 X对比度、Y1.8=0.350+0.436X对比度、Y1.3=0.837+0.307 X对比度及Y0.8=0.564+0.199 X对比度符合线路显像时Y208=0.221+0.941 X对比度、Y1.8=0.426+0.647 X对比度H、Y<1.3>3=0.484+0.528X对比度H及Y0.8=0.429+0.318 X对比度.L/B1值最接近对比度.结论 部分容积效应对单光子和符合线路的L/B值测量都有重要影响,对前者的影响更显著,可以用回归方程校正,用病灶最大计数计算L/B值更实用.     

用钡造影剂模型研究18F-FDG符合线路显像中基于CT的过度衰减校正

目的通过模型实验探讨钡造影剂（简称钡剂）在基于CT衰减校正（AC）技术的^18F-脱氧葡萄糖（FDG）符合线路显像中产生伪影的规律。方法将不同质量浓度（0．05、0．1、0．2、0．3、0．4、0．5、1．0、2．0、3．0kg／L）、相同体积（2．5m1）和相同质量浓度（0．5kg／L）、不同体积（0．5、1．0、1．5、2．0、2．5m1）的钡剂灌人乳胶指套并浸于含^18F—FDG水溶液（3．7kBq／m1）的圆柱体模型中。按常规行符合线路数据采集和重建，观察图像并作定量分析。结果模型中均匀液体部分的AC图像放射性分布均匀，非衰减校正（NAC）图像放射性分布呈中央低周边高的不均匀状态。钡剂部位在NAC图像中低于周围液体计数形成“冷区”，在AC图像中高于周围计数呈“热区”。质量浓度≥0．1kg／L的钡剂以及直径〉10mm（V银剂=0．5ml）的乳胶指套在AC图像上产生了“热区”伪影。结论基于CT的AC技术改善了^18F—FDG符合线路显像的图像质量，但钡剂的存在可能造成衰减的过度校正，形成“热区”伪影。对体内残留钡剂的患者，通过仔细阅读CT图像、AC及NAC图像，能够鉴别放 射性浓聚区是否为伪影。