Vitamin D status in patients with rosacea

Background: Rosacea is a common chronic skin condition affecting the face. In recent years, significant evidence shows that vitamin D plays an important role in modulating the immune system. Vitamin D and its analogues via these mechanisms are playing an increasing role in the management of atopic dermatitis, psoriasis, vitiligo, acne and rosacea.

Objectives: In our study, we aimed to investigate the relationship between serum vitamin D levels in patients with rosacea and analyze the association of vitamin D with clinical features.

Methods: Forty-four rosacea patients and 32 healthy control subjects were included into the study. 25-hydroxyvitamin D (25(OH)D), calcium and intact parathyroid hormone were measured. Deficiency of vitamin D is defined as the level of 25(OH)D being less than 20?ng/ml.

Results: Thirty-three female and 11 male patients were included in the study. The mean age of patients was 48.6?±?11.5. The mean levels of vitamin D levels were found as 21.4?±?9.9 and 17.1?±?7.9 in patients and controls, respectively. The difference was statistically significant (p?=?0.04). The prevalence of vitamin D deficiency in patients with rosacea was 38.6% and 28.1% in healthy controls (p?=?0.34).

Conclusions: To the best of our knowledge, our study is the first study for evaluating serum vitamin D levels of patients with rosacea in the literature. Patients with rosacea have relatively high serum vitamin D levels compared to control groups. The result of our study suggests that increased vitamin D levels may lead to the development of rosacea. To confirm status of vitamin D levels in patients with rosacea, larger epidemiological studies are needed.     

Vitamin D levels in children affected by vernal keratoconjunctivitis

Background: Vernal keratoconjunctivitis (VKC) is a chronic and often severe bilateral conjunctivitis. VKC etiology still remains unclear although endocrine, genetic, neurogenic and environmental factors have been implicated. Vitamin D is a fat-soluble prohormone whose main function is the regulation of calcium and phosphate metabolism. The aim of this study was to evaluate serum vitamin D in children affected by VKC compared to the healthy children and investigate the relationship between its levels and disease severity.

Methods: A total of 110 children, 47 affected by VKC, aged between 5 and 12 years were enrolled at the Department of Pediatrics, Division of Allergy and Immunology, “Sapienza” University of Rome. Used as controls were 63 healthy children with negative skin prick test (SPT), without allergic, ocular and systemic disease. Serum samples were obtained in April from all the children included in the study. Vitamin D dosage was repeated in October in 20 patients after therapy and in 20 controls. A conjunctival scraping was performed in all children affected by VKC.

Results: Children affected by VKC had lower vitamin D levels compared to healthy controls and we found an increase in vitamin D levels after therapy with cyclosporine eye drops 1% although this increase was lower than that of healthy controls. Moreover we found significant correlations between vitamin D level and the severity of the disease.

Conclusions: The study shows that children affected by VKC have lower vitamin D levels when compared to healthy controls and highlights a significant correlation between its levels and disease severity.     

代谢综合征患者的高敏C反应蛋白及靶器官损害

目的探讨高敏C反应蛋白(hs-CRP)与代谢综合征组分及其靶器官损害的关系。方法389例老年高血压、糖尿病或代谢综合征患者用乳胶免疫增强比浊法检测血清hs-CRP,分析hs-CRP与血脂、血糖、血压、腹围的关系;同时测定了289例患者颈动脉内-中膜厚度(IMT)、267例左室质量指数(LVMI)和343例尿蛋白排泄率(UAER)作为判断是否存在代谢综合征靶器官损害的指标,分析hs-CRP与IMT、LVMI和UAER的关系。结果血清hs-CRP水平随着代谢综合征组分成分数量的增加而升高,当其组成成分≥3个时,hs-CRP水平明显升高。相关分析表明hs-CRP浓度与甘油三酯、腹围、收缩压、舒张压、空腹血糖呈正相关,与高密度脂蛋白胆固醇呈负相关;血清hs-CRP水平与IMT、LVMI和UAER呈正相关关系,当hs-CRP水平升高时,可增加代谢综合征靶器官损害的程度和范围。结论血清hs-CRP水平不仅与代谢综合征组成成分相关,而且与其靶器官损害程度密切联系。     

1,25-dihydroxyvitamin D3 and dexamethasone increase interleukin-10 production in CD4+ T cells from patients with Crohn's disease

BACKGROUND AND AIM: In Crohn's disease (CD), epidemiological data and animal studies suggest that vitamin D (vitD) has protective immune-modulating properties. 1,25-dihydroxyvitamin D3 and dexamethasone (DEX) induce interleukin (IL)-10 productions in healthy controls (HC) T cells. We studied if 1,25-dihydroxyvitamin D3 with and without DEX could induce IL-10 production, downregulate pro-inflammatory Interferon (IFN)-gamma and Tumor Necrosis Factor (TNF)-alpha production, and influence cell kinetics in peripheral CD4+ T cells from CD patients. METHODS: CD4+ T cells were separated from peripheral blood from CD patients and HC. Cells were activated by anti-CD3 and anti-CD28 in the presence of 1,25-dihydroxyvitamin D3 and/or DEX. Cytokine levels, proliferation, and apoptosis were measured following 7 days of culture. RESULTS: In T cells from CD patients, 1,25-dihydroxyvitamin D3 and DEX increased IL-10 production from a median of 0.08 ng/ml to 0.2 ng/ml (p<0.01) and downregulated IFN-gamma production from 8.3 ng/ml to 3.1 ng/ml (p<0.01). The induced IL-10 increase in cultures from HC (0.2 ng/ml to 1.0 ng/ml, p<0.01) was significantly higher than in CD patients (p<0.05). In CD cultures, the IL-4 production increased from 0.3 ng/ml to 0.5 ng/ml (p<0.01) and IL-6 production from 2.5 ng/ml to 6.1 ng/ml (p<0.05). Similar changes in cytokine levels were observed with 1,25-dihydroxyvitamin D3 independently of DEX. In addition, 1,25-dihydroxyvitamin D3 and DEX decreased proliferation and reduced viability of T cells. CONCLUSION: We found that 1,25-dihydroxyvitamin D3 with and without DEX stimulation increased IL-10 and reduced IFN-gamma production. These findings suggest that vitD may play a therapeutic role in CD.     

3C疗法治疗1型糖尿病儿童维生素D水平研究

目的：评估维生素D与1型糖尿病（T1DM）患儿的临床关系,为T1DM的防治提供新的依据。方法：选取我院2017-2018年新诊断及使用3C疗法治疗的T1DM患儿,分析T1DM患儿与健康体检患儿血清25-羟维生素D［25(OH)D］水平。根据25(OH) D水平,将T1DM患儿分为3组（缺乏组、不足组及充足组）,比较三个亚组的性别、年龄、居住地、体质量指数（BMI）、空腹C肽、空腹血糖及胰岛素用量等情况,探讨不同tanner分期、性别、季节、有无合并糖尿病酮症酸中毒（DKA）与血清维生素D水平的关系。结果：T1DM组患儿血清25(OH)D水平为（42.31±22.01）nmol/L,较健康对照组的（50.37±22.28）nmol/L低,差异有统计学意义（P<0.05）。T1DM组患儿中,维生素D充足组的空腹C肽水平高于维生素D不足组及维生素D缺乏组（P<0.05）;维生素D缺乏组空腹血糖水平及单位体质量胰岛素用量高于维生素D充足组（P<0.05）。按血清25(OH)D水平测定时间不同分A组（1-3月、10-12月）和B组（4-9月）,A组25(OH)D水平低于B组（P<0.05）;合并DKA组25(OH)D水平低于无DKA组（P<0.05）。结论：T1DM患儿普遍存在维生素D缺乏,尤其是合并DKA、及1-3月及10-12月的患儿;维生素D充足的T1DM患儿可减少胰岛素用量。临床上要加强T1DM患儿的维生素D的监测以及补充。     

维生素A、D、E与抽动障碍的相关性研究

目的：探讨抽动障碍（TD）患儿血清中维生素A（VA）、维生素D（VD）、维生素E（VE）水平及其与抽动障碍的临床亚型、抽动症状严重程度的相关性,为临床更好地防治TD提供参考。方法：选取2018年1月至2020年7月泰州市中医院儿科门诊收治的TD患儿198例为TD组,同期就诊的健康儿童50例为对照组,检测VA、VD、VE水平并分析其与抽动症状的持续时间、严重程度的相关性。结果：TD组患儿VA、VD水平均低于对照组,VA、VD缺乏或不足比例均高于对照组（P均<0.05）;TD组患儿VE水平与对照组比较差异无统计学意义,VE缺乏或不足比例与对照组比较差异无统计学意义（P均>0.05）。根据病程及抽动形式,TD可分为抽动秽语综合征（TS）、慢性抽动障碍（CTD）、短暂性抽动障碍（TTD）3个临床亚型。TS组患儿VA水平低于CTD组及TTD组;TS组及CTD组患儿VD水平低于TTD组患儿;不同组间VE水平比较差异无统计学意义（P>0.05）。根据耶鲁综合抽动严重程度量表（YGTSS）,将TD组患儿分为轻度TD组和中重度TD组。轻度TD组、中重度TD组与对照组VA、VD水平比较差异有统计学意义（P<0.05）;中重度TD组VA、VD水平低于轻度TD组和对照组（P<0.05）;轻度TD组、中重度TD组与对照组VE水平比较差异无统计学意义（P>0.05）。TD患儿VA、VD水平与抽动症状严重程度呈负相关（P<0.05）。结论：TD患儿存在VA、VD缺乏或不足,TD患儿血清VA、VD水平与抽动障碍的临床亚型、抽动症状的严重程度具有相关性     

重庆地区0~3岁健康儿童25-羟基维生素D参考值研究

目的:探讨重庆地区0~3岁健康儿童25-羟基维生素D〔25(OH)D〕的参考值。方法:选取代表重庆市不同经济水平不同地域的区/县所在地医院儿保科进行正常体检儿童,按照纳入标准和排除标准,共纳入900例儿童,抽取静脉血,分离血清,采用高效液相色谱-质谱法(LC-MS)检测血清25(OH)D浓度,同时对每个调查对象进行体格检查及问卷调查。结果:重庆市0~3岁儿童外周血25(OH)D参考值范围为(34.99±20.27)ng/mL。女童和男童25(OH)D水平比较差异无统计学意义(u=-1.327,P=0.185);<1岁组儿童25(OH)D水平高于1~3岁组(u=2.062,P=0.040);冬春季25(OH)D水平低于夏秋季(u=-4.299,P=0.000)。结论:重庆地区0~3岁儿童25(OH)D的参考值范围为(34.99±20.27)ng/mL;健康儿童不同年龄、不同季节的25(OH)D水平有一定差异;本研究得出的参考值范围与全球专家共识及美国医学会的推荐值基本一致,可为婴幼儿期维生素D的补充及维生素D缺乏相关疾病的诊断提供参考。     

肺 炎 支 原 体 肺 炎 患 儿 血 清 维 生素 素 D D 水 水 平 及 其 对 免 疫 功 能 的 影

目的:探讨肺炎支原体肺炎(MPP)患儿血清维生素D(Vit D)水平及其对免疫功能的影响。方法:选择2016年1月至2017年1月我院儿科确诊的MPP患儿100例作为MPP组,另选同期体检的健康儿童100例作为对照组,检测两组儿童血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4及T淋巴细胞亚群水平,并按照病情严重程度将MPP组分为轻症组和重症组进行分层分析。结果:MPP组患儿的血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4、CD3^+、CD4^+、CD4^+/CD8^+水平均低于对照组(P均<0.01);两组患儿CD8+水平比较差异无统计学意义(P>0.05)。重症组患儿血清25-(OH)D3、IgM、IgA、IgG、补体C3、补体C4、CD3^+、CD4^+、CD4^+/CD8^+水平均低于轻症组,CD8^+水平高于轻症组(P均<0.01)。结论:MPP患儿的血清25-(OH)D3水平降低,免疫功能指标水平降低,监测血清25-(OH)D3水平及免疫功能水平可为临床治疗提供指导。     

维生素D与儿童孤独症谱系障碍关系的Meta分析

目的:采用Meta分析法评估血清维生素D水平与儿童孤独症谱系障碍(ASD)的相关性.方法:计算机全面检索Medline、EMBase、PubMed、Scopus、the Cochrane Library、EBSCO、Web of Science、中国生物医学文献数据库(CBMdisc)、中国知网(CNKI)、万方数据库...     

Anti-mucus polyclonal antibody production, purification and linkage to the surface of albumin microspheres

This aim of this study was to develop a microparticulate based oral drug delivery system, which could prolong gut transit time by binding via specific interactions to the gut mucus layer. Porcine gastric mucus was semi-purified and used as an antigen to raise a polyclonal antiserum in rabbits. The immunoglobulin fraction of this serum was isolated, purified and tested for homogeneity and cross reactivity. High cross-reactivity was displayed when the antiserum was challenged against types of mucus other than that used as an antigen, but no significant cross-reactivity occurred when challenged against some other common macromolecules. The antibody fraction of this serum was covalently linked to three types of albumin microspheres (MS) using 1-ethyl-3(3-dimethyl aminopropyl) carbodiimide. The MS employed had either a hydrophobic, a hydrophilic or a carboxymethylated surface, and were prepared and characterised as described earlier (MacAdam, A.B., Shafi, Z.B., Martin, G.P. and James, S.L. 1997. Preparation of hydrophobic and hydrophilic MS and determination of surface carboxylic acid and amino residues. Int. J. Pharm. 151, 47-55). Binding of these MS to both radioiodinated mucin in suspension and to isolated gut segments was measured. Hydrophilic and carboxymethylated MS with surface-associated antibody bound significantly more mucin from a suspension than did uncoated controls. Similarly, anti-mucus antibody-coated hydrophilic and carboxymethylated MS bound more strongly to an isolated gut segment than did uncoated controls or controls coated in an antibody specific for albumin. These results suggest anti-mucus antibody coated albumin MS may be a useful model to act as comparators in studies aimed at developing drug delivery systems with delayed gastrointestinal transit.     

不同维生素D预防剂量婴幼儿血清25-羟基维生素D状况研究

目的：了解重庆地区婴幼儿不同维生素D（vitamin D,VD）预防剂量状态下VD营养状况及其影响因素, 为合理补充VD提供参考。方法：选取重庆市不同经济水平地区5所医院健康体检婴幼儿751例（0~3岁）,采用问卷调查,并检测其血清25-羟基维生素D [25(OH)D]水平,根据不同VD预防剂量、年龄、季节、喂养方式等分组,了解以上因素对25(OH)D的影响。结果：0~3岁婴幼儿VD补充率74.6%（560/751）,VD预防剂量30~1 600 IU/d;25(OH)D水平为（35.29±10.39）ng/mL,并随VD补充量的升高呈现先升高、后保持平稳的趋势;未补充组25(OH)D水平为（30.51±11.03）ng/mL,显著低于补充组;未补充组中VD不足及缺乏率达14.7%,高于补充组（P<0.05）;高剂量补充组（>600 IU/d）较其他组VD缺乏和不足的比率明显下降（P<0.05）;不同季节、年龄、喂养方式、预防剂量可影响25(OH)D水平,以冬春季无食物来源儿童25(OH)D水平最低[（18.44±11.91）ng/mL]。结论：重庆地区0~3岁婴幼儿预防性VD补充率高,但补充剂量差异较大。VD预防性补充是维持婴幼儿体内25(OH)D水平的重要措施,季节和喂养方式可显著影响VD营养状态     

维生素D 缺乏与脊柱结核易感性的关系研究

摘要： 目的 研究维生素 D 缺乏对脊柱结核易感性及病理发展的影响。方法 选取 2013 年 6 月—2016 年 5 月于我院行手术治疗的初治脊柱结核患者 163 例 （病例组）, 同期于我院行健康查体人员 170 例为对照组。应用酶联免疫吸附法检测 2 组样本血清 25-羟基维生素 D ［25 （OH） D］ 水平, 分为严重缺乏 （＜25 nmol/L） 和其他情况 （包括缺乏、 不足及充足）。比较 2 组整体和不同季节的 25 （OH） D 水平变化; 病例组根据病理分型分为增生型和干酪样坏死型, 比较 25 （OH） D 的非严重缺乏 （≥25 nmol/L）、 严重缺乏 （＜25 nmol/L） 组中病理分型的分布情况。结果 病例组 25 （OH） D 表达水平 ［23.99 （20.55, 29.54） nmol/L］ 低于对照组 ［42.94 （35.68, 51.04）nmol/L］, 差异有统计学意义 （P＜ 0.01）, 且不同季节病例组 25 （OH） D 表达水平均低于对照组 （P＜0.05）, 而 2 组夏季 25 （OH） D 表达水平均高于春冬季 （P＜0.008 3）; 病例组春冬季 25 （OH） D 严重缺乏者比例较高, 夏季较低, 严重缺乏者在各季节的分布差异有统计学意义 （P＜0.01）, 对照组一年四季 25 （OH） D 缺乏者比例均较高, 但季节的分布差异无统计学意义 （P＞0.05）。病例组干酪样坏死型有 107 例, 增生型有 56 例, 严重缺乏组干酪样坏死型比例 （79.17%, 76/96） 高于非严重缺乏组（46.27%, 31/67）, 差异有统计学意义 （P＜0.01）。结论 排除季节影响, 维生素 D 缺乏与脊柱结核发病风险增加有关, 并与脊柱结核病理分型有关。     

Parameters of altered plasma glucose levels during short intervals in diabetic patients

The percentages of glycosylated proteins or albumin, or glycohemoglobin A1 (HbA1) in sera from patients with noninsulin dependent diabetes mellitus (NIDDM) were measured to elucidate whether such measurements are useful for evaluation of the mean levels of blood glucose during short intervals in these patients. Forty patients with NIDDM and twenty healthy adults were examined. The percentages of glycosylated proteins or albumin were quantitated by a Glyc-Affin system and those of HbA1 were measured by electrophoresis. It was indicated that the percentages of glycosylated proteins or albumin, and HbA1 in sera from patients with NIDDM were significantly higher than those in sera from healthy adults. There was a significant correlation between the percentages of HbA1 in sera and the mean levels of fasting blood sugar (FBS) during short intervals in patients with NIDDM. It was concluded that the measurement of HbA1 is a useful method for evaluation of the mean levels of blood glucose during short intervals in patients with NIDDM compared with those of glycosylated proteins or albumin.     

Quantitation of serum 25(OH)D2 and 25(OH)D3 concentrations by liquid chromatography tandem mass spectrometry in patients with diabetes mellitus

Vitamin D has been considered to regulate calcium and phosphorus homeostasis and to preserve skeletal integrity. Serum 25-hydroxyvitamin D (25(OH)D) is the best indicator of vitamin D levels. The association of serum 25(OH)D deficiency with increased risk of type 1 diabetes (T1DM) and type 2 diabetes (T2DM) is controversial. We investigated serum 25(OH)D₂ and 25(OH)D₃ levels in diabetes patients by using liquid chromatography tandem mass spectrometry (LC-MS/MS). Serum 25(OH)D2 and 25(OH)D3 levels were measured with liquid chromatography tandem mass spectrometry in electrospray ionization positive mode. Chromatograms were separated using an ACE5 C18 column on a gradient of methanol. The total 25(OH)D levels were calculated as the sum of 25(OH)D3 and 25(OH)D2 levels. A total of 56 patients with T1DM and 41 patients with T2DM were enrolled in this study. There were 42 and 28 non-diabetic, age-matched volunteers who participated as the T1DM controls and the T2DM controls, respectively. The total 25(OH)D levels were lowest in the 21–40 age group. The levels of both 25(OH)D3 and the total 25(OH)D were significantly higher in the T1DM and T2DM groups than in the controls (p < 0.01 in T1DM and p < 0.05 in T2DM group, respectively). The 25(OH)D2 levels were only significantly higher in T1DM patients than in the controls. The percentages of vitamin D deficiency (total 25(OH)D less than 20 ng/mL) in the T1DM, T2DM, the T1DM controls and the T2DM controls were 7.1%, 0%, 14.3% and 3.6%, respectively. The percentages of vitamin D insufficiency (total 25(OH)D less than 30 ng/mL) in the T1DM, T2DM, the T1DM controls and the T2DM controls were 26.8%, 7.3%, 54.8% and 17.9%, respectively. The percentages of vitamin D deficiency and insufficiency were significantly lower in the T1DM patients than in the T1DM controls (p < 0.01). In the present study, both type 1 and type 2 diabetes patients had higher serum 25(OH)D levels and lower percentages of vitamin D deficiency/insufficiency.     

不同维生素D注射剂对健康女性血25羟维生素D水平的影响

目的比较维生素D2注射液与维生素D3注射液在治疗健康女性维生素D缺乏或不足时对血25羟维生素D水平的影响。方法选择常住成都市且年龄在40-55岁的健康女性94名,随机将其分为D2组和D3组各47例。D2组给予维生素D2注射液,每次7.5mg（30万U）,每2周注射1次,共注射4次;D3组给予维生素D3注射液,每次7.5mg（30万U）,每2周注射1次,共注射4次。分别于治疗前、最后1次注射后2周采静脉血测定血清25羟维生素D,血清钙、磷、镁,血清甲状旁腺素（PTH）及血清骨源性碱性磷酸酶（BAP）。结果治疗后,D2组和D3组血清25羟D水平明显升高,差异有统计学意义（P〈0.01）;且治疗后D3组25羟D水平高于D2组,差异有统计学意义（P〈0.01）。治疗前后,2组血清磷、血清PTH均降低,差异有统计学意义（P〈0.01）,血清钙、血清镁、血清BAP无明显变化,差异无统计学意义（P〉0.05）。未出现维生素D中毒或药物相关不良反应表现。结论维生素D针剂无论是D2还是D3治疗维生素D缺乏或不足都是有效的,但在相同用法条件下D3比D2升高血清25羟D水平的幅度更大。维生素D注射剂30万U每2周1次共4次治疗维生素D不足或缺乏是安全的。     

妊娠期糖尿病患者血清25-羟维生素D水平及胰岛素抵抗的关系

目的研究妊娠期糖尿病患者血清25-羟维生素D[25（OH）D3]水平及胰岛素抵抗（IR）的关系。方法选取妊娠期在我院妇产科体检正常的40例孕妇为对照组,确诊为糖尿病的40例孕妇为治疗组。采用酶联免疫法测定80例孕妇血清25（OH）D3水平及相关糖脂代谢指标。结果治疗组与对照组TC、HDL-C、TG、LDL-C及FBG等值比较,差异无统计学意义（P〉0.05）;治疗组FINS、25（OH）D3、HOMA-IR均明显高于对照组,差异均具有统计学意义（P〈0.05）,HOMA-IR与血清25（OH）D3呈负相关（r=﹣0.9879,P〈0.05）。结论妊娠期糖尿病患者的血清25（OH）D3水平与IR具有相关性,补充VD可在一定程度对IR产生抑制作用。     

Paricalcitol capsules for the control of secondary hyperparathyroidism in chronic kidney disease

Secondary hyperparathyroidism is a common complication of patients with chronic kidney disease. Treatment with calcitriol, the active form of vitamin D, reduces parathyroid hormone levels, but may result in elevations in serum calcium and phosphorus. New vitamin D analogues have been developed to reduce parathyroid hormone secretion without concomitant hypercalcaemia and hyperphosphataemia. Recent data from studies with paricalcitol capsules, the oral formulation of 19-nor-1,25(OH)₂D₂, show a significant reduction in parathyroid hormone levels with no change in calcium and phosphorus levels when compared with placebo. Paricalcitol also compares favourably to other oral vitamin D analogues, effectively decreasing parathyroid secretion with less hypercalcaemia and hypercalciuria than other agents.     

Striatal dopamine D2 receptors in modulation of pain in humans: a review

We review evidence indicating that the striatum and striatal dopamine D2 receptors are involved in the regulation of pain in humans. Painful stimulation produces an increase in regional cerebral blood flow in the human striatum. Pain is a common symptom in patients with nigrostriatal dopaminergic hypofunction. Positron emission tomography findings show that a low dopamine D2 receptor availability in the striatum of healthy subjects (indicating either a low density of dopamine D2 receptors or a high synaptic concentration of dopamine) is associated with a high cold pain threshold and a low capacity to recruit central pain inhibition by conditioning stimulation. Patients with chronic orofacial pain have higher dopamine D2 receptor availability than their age-matched controls. We propose that the striatal dopamine D2 receptor may be an important target for the diagnosis and treatment of chronic pain.     

肺炎患儿血清维生素D水平研究

目的:探讨肺炎患儿体内维生素D(VitD)水平及其与肺炎的关系。方法:选取88例因肺炎于我院呼吸中心住院治疗的患儿为研究对象,入院时检测其血清VitD水平,同时收集患儿临床资料及电话随访病后1年内呼吸道感染情况。比较肺炎患儿不同性别、年龄、病情轻重间血清VitD水平有无差异,以及病后1年内发生反复呼吸道感染(RRI)组与未发生RRI组间血清VitD水平有无差异。结果:肺炎患儿中不同性别及年龄间血清VitD水平差异无统计学意义(P>0.05);我院肺炎患儿血清VitD水平低于已报道的我国西部地区儿童平均水平;重症肺炎组血清VitD水平低于普通肺炎组(P<0.05);病后1年内发生RRI组血清VitD水平明显低于未发生RRI组(P<0.05)。结论:血清VitD水平与性别、年龄无关;肺炎患儿体内VitD水平普遍低,体内VitD水平高低与肺炎病情轻重及病后再感染风险相关,VitD水平越低,越易发展为重症肺炎,病后再感染风险越高。