Er：YAG激光应用于种植体周围炎治疗的临床效果评估

目的：探讨Er：YAG激光( erbium-doped： yttrium aluminium garnet)与机械刮治治疗种植体周围炎的有效性。方法22例种植体周围炎患者,按照单盲随机分组对照原则将种植体分成2组,试验组采用Er：YAG激光照射,激光能量设定为100 mJ/脉冲、频率10 Hz;对照组采用塑料刮治器和0.2%洗必泰抗菌治疗。在基线、3个月和6个月时进行临床牙周指标的检查测定,包括菌斑指数、出血指数、临床附着水平和探诊深度。结果基线时试验组和对照组间各项临床牙周指标的差异无统计学意义(P>0.05)。治疗后3个月(P<0.01)和6个月(P<0.05),试验组出血指数、菌斑指数和对照组比较差异具有统计学意义;2组探诊深度在治疗后3个月和6个月均有降低,且2组探诊深度的差异均有统计学意义(P<0.05);然而2组临床附着水平差异无统计学意义(P>0.05)。结论 Er：YAG激光治疗后能显著改善种植体周围炎炎症水平,控制种植体周围炎的有效性优于机械刮治治疗。     

种植体周围炎与健康种植体黏膜下微生态环境的对照研究

目的 探讨种植体周围炎与健康种植体黏膜下微生物生态环境。方法 选取2017年9月—2019年1月于北京口腔医院治疗种植体周围炎、接受种植术并已随访1年以上的患者,按照是否发生种植体周围炎分为种植体周围炎组(n=43,51颗种植体)与健康组(n=59,63颗种植体)。检测2组患者探诊深度、骨吸收情况、探诊出血情况、改良菌斑指数(modified plaque index,mPLI)、改良出血指数(modified bleeding index,mSBI)。收集2组患者黏膜下菌斑,使用微生物基因提取试剂盒提取细菌DNA,经Illumina公司的MiSeq测序平台测序。采用SPSS 23.0软件包对数据进行统计学分析。结果 种植体周围炎组平均最大探诊深度显著大于健康组(P<0.05);mPLI 2级[56.86%(29/51)]显著高于健康组[0.00%(0/63)](P<0.05);mSBI 2级[60.78%(31/51)]显著高于健康组[0.00%(0/63)](P<0.05)。种植体周围炎组Simpson指数显著高于健康组,Shannon指数显著低于健康组(P<0.05)。种植体周围炎组优势菌属中占比最多的为新月形单胞菌属(16.35%)、依次为假单胞菌属(11.20%)、梭杆菌属(10.05%)、链球菌属(7.63%)、密螺旋体菌属(6.84%)。结论 与健康种植体相比,种植体周围炎黏膜下微生物具有高物种丰度、低物种均匀度,其优势菌属中的假单胞菌属、新月形单胞菌属、梭杆菌属、链球菌属、密螺旋体菌属占比较高。     

激光法治疗种植体周围炎的短期临床效果评估

目的 探讨Er:YAG激光法治疗种植体周围炎临床效果,以期对今后种植体周围炎的临床治疗有所帮助。方法 20名种植体周围炎患者,满足纳入标准和排除标准后随机分为两组,试验组采用Er:YAG激光法治疗,对照组采用碳纤维刮治器和0.2% 洗必泰抗菌治疗。分别记录治疗前（基线水平）、治疗后3个月和6个月时相关的牙周临床指标,包括菌斑指数、探诊后出血指数、龈沟出血指数、探诊深度、临床附着水平。所有的检查均使用牙周探诊器(PCP12)。结果 基线时试验组和对照组间各项临床牙周指标的差异无统计学意义(P＞0.05)。治疗后3个月,与基线水平相比,各项临床牙周指标均有所降低,激光治疗比刮治治疗的降低幅度大,并且这种降低是具有统计学意义的(P＜0.05)。治疗后6个月时,总体来说牙周各项临床指标仍是低于基线水平的,但与3个月时相比,除了出血指数仍然降低以外,其他牙周指数都有略微反弹的趋势。结论 手工刮治和激光治疗都可以改善种植体周围炎患者的各项临床牙周指标,激光治疗可能疗效更为显著,但稳定性稍显不足。这种改善可能只是短期的,长期的疗效还需要依赖大样本长时间的观察随访。     

氯己定联合机械清创对种植体周围炎的治疗效果及对患者SF-36评分的影响

目的：研究氯己定联合机械清创对种植体周围炎的治疗效果及对患者SF-36评分的影响。方法：选取2015年1月—2019年1月浙江省人民医院收治的种植体周围炎患者100例,按照随机数字表法随机分为对照组和联合组各50例。2组患者均采用机械清创术进行治疗,联合组在机械清创术后使用氯己定漱口液含漱。对2组患者治疗前、后菌斑生物膜不同层面平均活性、改良菌斑指数（modified plaque index,mPLI）、探诊后出血指数（bleeding on probing,BOP）、改良龈沟出血指数（modification sulcus bleeding index,mSBI）、探诊深度（probing depth,PPD）、临床附着水平（clinical attachment level,AL）进行评价,并使用SF-36评分量表、VAS视觉疼痛评分法对2组患者生活质量、疼痛程度进行评价,评定治疗效果及统计并发症发生情况。采用SPSS 20.0软件包对数据进行统计学分析。结果：治疗前2组患者菌斑生物膜不同层面平均活性、mPLI、mSBI、AL、PPD、BOP、VAS、SF-36评分比较,无显著差异（P>0.05）;治疗后联合组患者菌斑生物膜不同层面平均活性、mPLI、mSBI、AL、PPD、BOP、VAS评分均低于对照组,SF-36评分高于对照组,治疗总有效率显著高于对照组（P<0.05）。联合组患者治疗过程中并发症发生率显著低于对照组（P<0.05）。结论：氯己定联合机械清创对种植体周围炎患者进行治疗,效果显著,可有效抑制菌斑生物膜活性,抑制菌斑形成,减轻患者疼痛,提高生活质量。     

二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者IL-1β、IL-17F水平的影响

目的 研究二甲胺四环素联合茶多酚对早期种植体周围软组织炎患者白细胞介素1β（interleukin-1 β,IL-1β）、白细胞介素17F（interleukin-17F,IL-17F）水平的影响。方法 选取2016年5月—2018年5月在新疆伊犁哈萨克自治州奎屯医院和新疆医科大学第一附属医院就诊的早期种植体周围软组织炎患者96例,按照随机数字法分为二甲胺四环素组和联合组（每组48例）。二甲胺四环素组患者给予盐酸二甲胺四环素软膏治疗,联合组在二甲胺四环素组的基础上给予茶多酚治疗。检测治疗前后的菌斑指数（plaque index,PLI）、龈沟出血指数（sulcus bleeding index,SBI）、附着丧失（attachment loss,AL）、龈沟液（gingival crevicular fluid,GCF）、探诊深度（probing depth,PD）、IL-1β和IL-17F水平,采用SPSS 20.0软件包对数据进行统计学分析。结果 2组患者治疗后PLI、SBI、AL、GCF、PD指标显著低于治疗前（P<0.05）。联合组患者治疗后,PLI、SBI、AL、GCF、PD指标水平低于二甲胺四环素组治疗后（P<0.05）。2组患者治疗后,IL-1β、IL-17F水平低于2组治疗前（P<0.05）。联合组患者治疗后,IL-1β、IL-17F水平低于二甲胺四环素组治疗后（P<0.05）。联合组患者治疗有效率为93.75%,显著高于二甲胺四环素组的77.08%（P<0.05）。联合组患者不良反应率为6.25%,显著低于二甲胺四环素组的20.83%（P<0.05）。结论 二甲胺四环素联合茶多酚治疗早期种植体周围软组织炎效果显著,能够改善患者的临床症状,降低IL-1β、IL-17F水平,降低不良反应发生率。     

微创拔牙后延期种植与即刻种植的效果评价

目的 探讨和比较微创拔牙后延期种植与即刻种植的临床效果。方法 选择南京同仁医院2013年4月—2018年4月收治的上、下颌单个前牙及前磨牙需要行微创拔牙后种植牙的患者86例,随机分为对照组（40例）和实验组（46例）。对照组微创拔牙后进行延期种植,实验组微创拔牙后进行即刻种植。比较2组患者的种植成功率,记录3个月和永久修复当天患者的种植体稳定性、种植体周围探诊深度、美学效果以及种植体边缘骨水平以及术后满意度。采用SPSS 20.0软件包对数据进行统计学分析。结果 实验组和对照组种植成功率均为100%,差异无统计学意义（P>0.05）;2组在种植体植入3个月后和永久修复当天的ISQ值差异不显著 (P>0.05);实验组种植体周围探诊深度小于对照组,但差异无显著性（P=0.80）;实验组总满意度显著大于对照组（P=0.044）;2组修复后1年,牙龈乳头指数均在1~3级,软组织外形良好,均达到了良好的牙龈美学效果,2组差异无统计学意义（P=0.66）;对照组PES得分7.65±1.32,实验组为8.25±1.19,2组比较差异显著（P<0.05）;2组的近中侧骨吸收量和远中侧骨吸收量相比无显著差异（P>0.05）。结论 微创拔牙后2种植修复方式均能获得良好的临床效果,种植体都具有良好的稳定性,但即刻种植的满意度更高,美学效果更佳,具有良好的临床应用前景。     

2种不同种植体植入对种植体周围软组织的影响

目的: 研究2种种植体对种植体周围软组织的影响。方法: 选择2020年12月—2021年2月普陀区眼病牙病防治所收治的单颗后牙缺失且需行种植修复的患者40例,其中植入骨水平种植体10例,软组织水平种植体30例。在完成种植冠修复当天、3个月、6个月及12个月时比较2组种植体的探诊深度,检测种植体龈沟液中天冬氨酸转氨酶（AST）和碱性磷酸酶（ALP）水平。采用SPSS 17.0软件包对数据进行统计学分析。结果: 修复完成当天、3个月、6个月及12个月,软组织水平种植体的探诊深度和ALP水平均显著低于骨水平种植体（P<0.05）。其中修复完成当天,软组织水平种植体的AST显著低于骨水平种植体（P<0.05）。随着时间增加,骨水平种植体龈沟液中的AST迅速降低,最后与软组织水平种植体接近（P>0.05）。结论: 尽管骨水平种植体和软组织水平种植体均具有良好的临床使用效果,但软组织水平种植体周围的软组织表现出更好的稳定性。     

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目的探讨盐酸二甲胺环素配合治疗种植体周围黏膜炎的临床对照疗效。方法2004年6月至2007年8月在青岛市口腔医院口腔种植中心,将患有种植体周围黏膜炎的患者种植体24颗随机分为试验组和对照组,试验组行碳纤维刮治器洁刮治+抛光喷砂+局部应用盐酸二甲胺四环素软膏;对照组应用碳纤维刮治器洁刮治+抛光喷砂治疗。结果两组治疗后菌斑指数、龈沟出血指数及种植体周围探诊深度较治疗前均明显降低(P<0.05),但两种治疗方法间疗效差异无统计学意义。结论使用机械性洁治和抛光以及有效控制菌斑是治疗种植体周围黏膜炎的有效方法,局部应用盐酸二甲胺四环素软膏短期内有一定疗效。     

种植体周围炎非手术治疗的临床疗效分析

目的：比较两种种植体周围炎非手术治疗的临床疗效。方法：选择44例种植体周围炎患者（44枚种植体），随机分组，分别进行树脂洁治和超声洁治，分别在基线、4周和8周时测龈沟出血指数、探诊深度和最深探诊深度，进行统计学分析。结果：两种治疗方法均可明显改善牙龈出血，但不能改善探诊深度和最深探珍深度。结论：树脂洁治和超声洁治对种植体周围炎的治疗仅为有限效果。     

光动力疗法辅助治疗种植体周围炎疗效的meta分析

目的 系统评价光动力疗法（photodynamic therapy,PDT）联合非手术方法治疗种植体周围炎的疗效。方法 通过计算机检索 The Cochrane Library、PubMed 、Embase、Web of Science、中国知网、万方数据库、维普期刊数据库及中国生物医学文献数据库发表的期刊文献、会议论文和学位论文,收集建库至2018年4月1日公开发表的关于光动力疗法联合非手术治疗对比单纯非手术治疗种植体周围炎的随机对照试验,2名评价员按照文献纳入、排除标准,独立进行文献筛选、数据提取、质量评价并相互核对后,应用Revman 5.3软件进行meta分析。结果 最终有6篇文献符合纳入条件。Meta分析结果显示,PDT联合非手术治疗和单纯非手术治疗相比,3个月后2组附着水平的差异无统计学意义 [WMD=-1.13,95%CI（-3.51,1.25）,P=0.35];3个月后2组的种植体周探诊深度及6个月后2组之间探诊出血指数的差异有统计学意义,分别为[WMD=-0.81,95%CI（-1.52,-0.11）,P=0.02]和[WMD=-5.15, 95%CI（-6.29,-4.01）,P<0.00001]。结论 在种植体周围炎的治疗中,PDT联合非手术治疗相比单纯非手术治疗,可对种植体周探诊深度及探诊出血有更为明显的改善,但两者对附着水平改善效果差别不大。     

Er:YAG激光联合引导骨组织再生术治疗种植体周围炎骨缺损的临床效果

目的 评估Er:YAG激光(erbium-doped:yttrium aluminium garnet)联合引导骨组织再生术(guided bone regeneration,GBR)治疗种植体周围炎骨缺损的临床效果.方法 选择形成环形牙槽骨吸收的种植体周围牙周炎患者15例,共26颗患牙,按照随机照原则分为2组,试验组(14颗)采用Er:YAG激光联合GBR的方式治疗种植体周围骨缺损;对照组(12颗)采用机械刮治联合GBR治疗牙槽骨的缺损.在基线和6个月时进行临床牙周指标的检查测定,包括菌斑指数(plaque index,PI)、龈沟出血指数(sulcus bleeding index,SBI)、牙周探诊深度(probing depth,PD)及临床附着丧失(clinical attachment lost,CAL),并进行比较.结果 2组术后PI、SBI、PD及CAL均较术前有明显改善(P<0.05).术后2组PI均值都维持在一个较低的水平,差异无统计学意义(P>0.05);试验组与对照组的SBI分别为(0.8±0.2)、(1.1±0.2);PD分别为(5.8±0.8)mm、(6.2±0.6)mm;CAL分别为(2.3±0.7)mm、(3.6±0.6)mm.组间比较差异均有统计学意义(P<0.05).结论 Er:YAG激光联合GBR在治疗种植体周炎骨缺损具有较好的临床效果.     

Clinical evaluation of periodontal surgical treatment with an Er:YAG laser: 5-year results

BACKGROUND: The aim of the present study was to evaluate and compare the long-term clinical outcomes of erbium-doped:yttrium, aluminum, and garnet (Er:YAG) laser-assisted periodontal flap surgery versus conventional treatment with the modified Widman flap procedure. METHODS: A total of 146 single-rooted periodontally involved teeth from 25 patients were included in this study. In each patient, left or right maxillary single-rooted teeth were assigned randomly to one of two groups: group A (Er:YAG laser) and group B (modified Widman flap surgery). Er:YAG laser was used to debride the bone pockets, scale the root surface, and trim the periodontal flap. Recession, probing depth (PD), clinical attachment level (CAL), plaque index (PI), gingival index (GI), and bleeding on probing (BOP) scores were recorded at baseline and at 3, 6, 12, 24, 36, 48, and 60 months. RESULTS: Both treatments resulted in decreases in PD, PI, GI, and BOP, increases in gingival recession, and gains in CAL. PD reduction in group A versus group B was statistically significant at 6, 12, 24, and 36 months (P < 0.05). Gains in CAL were significantly greater in group A versus group B at 6, 12, 24, and 36 months. BOP scores were significantly lower in group A versus group B at 3 and 6 months (P < 0.05). All other differences between treatment groups were not statistically significant. CONCLUSIONS: Surgical treatment of single-rooted teeth with chronic periodontitis using the Er:YAG laser yields greater PD reduction and gains in CAL for up to 3 years compared to conventional Widman flap surgery. The short-term results obtained with both treatments can be maintained over 5 years.     

种植体周围疾病发病率及危险因素的研究

目的:明确国人种植体周围疾病发病率并探索种植体周围炎的风险因素。方法:收集北京大学口腔医院第二门诊部种植修复后的736例患者的1612枚种植体复查情况,平均负重时间(22.64±0.92)个月,记录种植体周围菌斑指数、探诊深度(probing depth,PD)、探诊出血指数(bleeding index, BI),角化龈宽度,粘接剂残留、骨吸收情况,记录口内天然牙PD、BI。分析不同种植系统及不同复查时间段种植体周围炎的发病率,Logistic回归分析种植体周围炎的相关风险因素。结果:在个体和植体水平,种植体周围黏膜炎发病率分别为81.90%、83.60%,种植体周围炎发病率分别为4.50%和3.70%。各系统间种植体周围炎发病率无显著差异,在修复后1~5年各时间段组种植体周围炎发病率无显著差异,修复后0.5~1年和5~7年发病率显著低于1~5年各时间段组(P<0.05)。Logistic回归分析显示,在调整性别、年龄、吸烟、粘接剂、角化龈宽度等变量后,口内缺牙数、种植体周围PD、BI是种植体周围炎的风险因素(P<0.01)。结论:种植体周围黏膜炎发病广泛,种植体周围炎的发病率并非随着修复时间的延长而增加,对种植体周围探诊深度和出血的控制是预防种植体周围炎发生的关键。     

Subgingival debridement efficacy of glycine powder air polishing

BACKGROUND: Glycine powder air polishing (GPAP) has been shown to be significantly more effective in reducing the subgingival cultivable microflora in shallow periodontal pockets compared to curets and is safe when applied directly to root surfaces. The purpose of this study was to assess the subgingival debridement efficacy of GPAP in periodontal pockets with various depths. METHODS: In each of 60 patients with severe periodontitis, one tooth with a probing depth (PD) > or =6 mm was randomly assigned to one of the following interventions: GPAP performed in teeth instrumented 3 months earlier (I); GPAP performed in previously non-instrumented teeth (NI); or no treatment (control). GPAP was performed for 5 seconds per surface. After extraction, teeth were stained with 0.5% toluidine blue, and subgingival debridement efficacy was assessed. RESULTS: Overall, median debridement depth was 2.00 mm in I teeth and 1.86 mm in NI teeth, and the median debrided root surface was 49.24% and 45.64%, respectively. In anatomic PDs (APDs) of 2 to 3 mm, relative debridement depth (debridement depth/APD) ranged from 65% to 80% and 60% to 75% in I and NI teeth, respectively; the corresponding values for debrided root surface were 60% to 70% and 50% to 60%. In control teeth, virtually all subgingival root surfaces were stained. Clinical PD measurements were a median of 1.05 mm deeper than APD. CONCLUSION: GPAP for 5 seconds per surface is effective in removing most of the subgingival biofilm in periodontal pockets with an APD < or =3 mm.     

Enamel matrix proteins in the treatment of intra-bony defects. A prospective 24-month clinical trial

BACKGROUND: A growing flow of recent evidence indicates enamel matrix derivative (EMD, Emdogain) as a useful tool for the regeneration of periodontal tissues. This prospective clinical study aimed to evaluate the efficacy of EMD combined with surgical treatment of periodontal intra-bony defects, as compared with surgery alone, up to 24 months of follow-up. METHODS: Twenty-four intra-bony defects were treated in 24 patients in a single clinical centre. Each defect had intra-bony depth (IBD) > or = 4 mm and probing pocket depth (PPD) > or = 6 mm. Patients were randomly assigned to either test or control group. Plaque index (PI), gingival index (GI), PPD and periodontal attachment level (PAL) were assessed at baseline pre-surgical examination at the site to be treated. Full mouth plaque score (FMPS) and full mouth bleeding score (FMBS) were also evaluated. Twelve patients were treated by simplified papilla preservation flap technique (control group), while 12 patients were treated with the same surgical technique plus EMD after ethylenediamine tetraacetic acid root conditioning (test group). Any probing at the involved sites was avoided in the first year post-surgery. Radiographs were taken at baseline, 12 and 24 months after surgery using customized bite blocks. Intra-bony defect depth (IBD) and angle (IBA) were measured from X-rays by a computer-aided technique. At 12 and 24 months post-surgery, FMPS, FMBS, PI, GI, PPD, PAL and radiographic IBD and IBA were assessed. The difference between each follow-up and baseline, and between groups at each follow-up was evaluated for the above parameters by standard statistical methods. RESULTS: In both groups, clinical and radiographic parameters were improved at either 12 or 24 months when compared with baseline. The test group displayed better outcomes when compared with the control group for IBD, PPD, and PAL gain at 12 months, and only for PAL and IBD gain at 24 months. No adverse event related to the use of EMD was reported. CONCLUSIONS: The surgical procedure used in the present study, aiming for maximum preservation of the regenerative potential of periodontal tissues, showed per se excellent results. The use of EMD as an adjunct to periodontal surgery in the treatment of angular defects possibly enhances periodontal regeneration rate.     

The effect of non-surgical periodontal therapy on peroxidase activity in diabetic patients: a case-control pilot study

Objective: To evaluate the effect of periodontal therapy on clinical parameters as well as on total salivary peroxidase (TSP) activity and myeloperoxidase (MPO) activity in the gingival crevicular fluid (GCF) of patients with type 2 diabetes mellitus (DM2) and of systemically healthy individuals.
Material and Methods: Twenty DM2 subjects with inadequate metabolic control (test group) and 20 systemically healthy individuals (control group), both groups with chronic periodontitis, were enrolled. Periodontal clinical parameters, namely periodontal probing depth (PD), clinical attachment level (CAL), visible plaque index (VPI), bleeding on probing (BOP), gingival bleeding index (GBI) and presence of suppuration (SUP), as well as TSP activity and GCF MPO activity, were assessed before and 3 months after non-surgical periodontal therapy.
Results: At baseline and 3 months post-treatment, the test group presented a higher percentage of sites with VPI and BOP ( p <0.01). MPO activity in the GCF presented lower values ( p <0.05) for the test group at both baseline and the post-treatment period. The periodontal treatment resulted in a significant improvement of most clinical and enzymatic parameters for both groups ( p <0.05).
Conclusions: In both groups, the periodontal therapy was effective in improving most clinical parameters and in reducing salivary and GCF enzymatic activity. The diabetic individuals presented lower MPO activity in the GCF.     

Clinical evaluation of an Er:YAG laser for nonsurgical treatment of peri-implantitis: a pilot study

The aim of this controlled, parallel design clinical study was to compare the effectiveness of an Er:YAG laser (ERL) to that of mechanical debridement using plastic curettes and antiseptic therapy for nonsurgical treatment of peri-implantitis. Twenty patients with moderate to advanced peri-implantitis lesions were randomly treated with either (1) an ERL using a cone-shaped glass fiber tip at an energy setting of 100 mJ/pulse and 10 pps (ERL), or (2) mechanical debridement using plastic curettes and antiseptic therapy with chlorhexidine digluconate (0.2%) (C). The following clinical parameters were measured at baseline, 3 and 6 months after treatment by one blinded and calibrated examiner: Plaque index (PI), bleeding on probing (BOP), probing depth (PD), gingival recession (GR) and clinical attachment level (CAL). At the baseline examination, there were no statistically significant differences in any of the investigated parameters. Mean value of BOP decreased in the ERL group from 83% at baseline to 31% after 6 months (P < 0.001) and in the C group from 80% at baseline to 58% after 6 months (P < 0.001). The difference between the two groups was statistically significant (P < 0.001, respectively). The sites treated with ERL demonstrated a mean CAL change from 5.8 +/- 1 mm at baseline to 5.1 +/- 1.1 mm (P < 0.01) after 6 months. The C sites demonstrated a mean CAL change from 6.2 +/- 1.5 mm at baseline to 5.6 +/- 1.6 mm (P < 0.001) after 6 months. After 6 months, the difference between the two groups was statistically not significant (P > 0.05). Within the limits of the present study, it was concluded that (i) at 6 months following treatment both therapies led to significant improvements of the investigated clinical parameters, and (ii) ERL resulted in a statistically significant higher reduction of BOP than C.     

伴糖尿病的慢性牙周炎患者牙周基础治疗效果研究

目的研究牙周基础治疗对伴有糖尿病的慢性牙周炎患者的治疗效果。方法选择伴Ⅱ型糖尿病的老年慢性牙周炎患者(糖尿病组)与不伴糖尿病的老年慢性牙周炎患者(非糖尿病组)各20例行牙周基础治疗,记录并比较两组患者在基线和术后3、6、12个月的菌斑指数、牙龈指数、探诊出血、探诊深度、附着丧失等指标。结果牙周基础治疗对两组患者均有较好的治疗效果,各项指标均明显改善,与基线水平比较差异有统计学意义(P<0.01),而两组间各项牙周指数的改善在术后3、6、12个月差异均无统计学意义(P>0.05)。结论牙周基础治疗对伴有糖尿病的老年慢性牙周炎患者在短期内(12个月)有良好的治疗效果。