老年冠心病、脑梗死患者血清同型半胱氨酸与血糖、脂蛋白、血尿酸之间的关系

目的探讨老年冠心病、脑梗死患者血清同型半胱氨酸(Hcy)与空腹血糖(FBG)、甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白-胆固醇(HDL-C)、低密度脂蛋白-胆固醇(LDL-C)、脂蛋白[Lp(a)]、尿酸(UA)的关系。方法测定107例住院老年冠心病和脑梗死患者血清Hcy、FBG、TC、TG、HDL-C、LDL-C、LP(a)、UA等指标,并根据Hcy升高与否分为两组,比较两组FBG、TC、TG、HDL-C、LDL-C、LP(a)、UA的数值。结果Hcy升高组(A组)患者FBG、LP(a)、UA高于Hcy正常组(B组)。A组:FBG(5.51±1.30)mmol/L,TC(4.15±0.71)mmol/L,TG(1.39±1.06)mmol/L,HDL-C(1.08±0.32)mmol/L,LDL-C(2.47±0.73)mmol/L,Lp(a)(34.67±4.08)mg/dl,UA(374.11±9.87)μmol/L。B组:FBG(4.44±0.71)mmol/L,TC(4.03±1.89)mmol/L,TG(1.22±0.76)mmol/L,HDL-C(1.12±0.36)mmol/L,LDL-C(2.35±0.60)mmol/L,LP(a)(24.09±3.93)mg/dl,UA(326.79±11.96)μmol/L。两组间:FBG、LP(a)、UA差异有统计学意义(P<0.05);两组间:TC、TG、HDL-C、LDL-C差异无统计学意义(P>0.05)。结论FBG、LP(a)、UA与血清Hcy密切相关。     

魔芋食品对人体脂质代谢影响的研究

用含极低热能、微量蛋白质、高膳食纤维的魔芋精粉添加制成食品,对110名高血脂者进行研究。实验组加食魔芋食品,对照组食普通食品,实验期45天,实验前、后和停食魔芋食品后45天分别检查血脂一次。结果表明:1.实验组TG、TC、LDL-C水平均比食用前显著降低(P<0.01);HDL-C、apoAI均比食用前显著升高(P<0.01);而对照组各项指标变化无显著意义(P>0.05)。实验组与对照组比较,TG、TC、HDL-C、LDL-C的变化差别显著(P<0.01)。2.魔芋食品对高脂血症者与TG、TC危险临界值者降血脂效应不同,前者TG下降83.8±133.5mg/dl,TC下降42.4±23.4mg/dl;后者TG下降-1.1±23.1mg/dl,TC下降8.3±18.2mg/dl;两者的差异显著(P<0.001)。3.实验期间膳食同日常水平。实验组三大营养素和热能摄入量稍高于对照组,膳食脂肪占总热能35％以上,热能超过供给量1/5以上,但魔芋食品降血脂效果仍显著。     

磷脂与非酒精性脂肪性肝病关系的研究

目的研究磷脂与非酒精性脂肪性肝病(NAFLD)的关系,了解NAFLD患者脂质代谢紊乱的特点。方法采用酶法测定血清磷脂(PL),并以甘油三酯(TG)、胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、极低密度脂蛋白胆固醇(VLDL-C)、空腹血糖(FPG)及肝酶等作为其他观察指标。结果NAFLD组血清磷脂值为(250.23±55.24)mg/dl,对照组为(229.23±39.03)mg/dl,相比较有显著性差异(t=3.12,P<0.01)。NAFLD组TC、TG、VLDL-C、FBS、ALT、AST、GCT明显高于对照组,两组间差异有统计学意义(P<0.01)。NAFLD组AKP高于对照组(P<0.05)。而NAFLD组HDL-C低于对照组,两组间差异有统计学意义(P<0.01)。结论NAFLD患者存在明显的脂质代谢紊乱,磷脂的代谢障碍造成血清磷脂升高。     

慢性三氯化镧暴露对大鼠血糖和血脂水平的影响

目的探讨稀土元素镧的慢性暴露对大鼠血糖、血脂的影响。方法分别以0.1、2和40 mg/kg剂量的三氯化镧(LaC l3)给大鼠经口灌胃,每天1次,90 d后处死;取全血测定糖化血红蛋白(HbA1 c),分离血清测定血糖(G lu)、总胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平。结果与对照组相比,3个LaC l3暴露剂量组大鼠HbA1C、血清G lu、TG和LDL-C水平无统计学意义;0.1和2 mg/kg剂量LaC l3暴露组大鼠血清TC水平分别为(1.38±0.14)mmol/L和(1.37±0.26)mmol/L,与对照组大鼠(1.57±0.14)mmol/L相比有明显降低;0.1 mg/kg剂量LaC l3暴露组大鼠血清HDL-C为(0.79±0.12)mmol/L,比对照组大鼠(0.93±0.10)mmol/L有明显降低。结论0.1~40 mg/kg LaC l3慢性暴露对大鼠血清G lu、TG和LDL-C水平无显著影响;低、中剂量LaC l3慢性暴露可使大鼠血清TC和HDL-C降低。     

1310例体检人群血清脂蛋白胆固醇与年龄、性别及血糖水平的相关性研究

目的探讨成人血清脂蛋白胆固醇与年龄、性别及空腹血糖水平的关系。方法选择1310名体检健康人作为研究对象,根据年龄分为6组,测定其血清脂蛋白胆固醇及空腹血糖,比较各年龄组及性别间脂蛋白胆固醇变化和差异,并行相关分析。结果极低密度脂蛋白胆固醇(VLDL-C)及低密度脂蛋白胆固醇(LDL-C)有随年龄增长而升高的趋势(r=0.19及0.25,均P=0.000),但60岁后男性VLDL-C有所下降。60岁前各年龄段男性VLDL-C结果均显著高于女性(P=0.000),60岁后男女间无差别(P>0.05)。50岁前男性LDL-C水平均高于女性(P<0.05),50岁以后男女间无差别(P>0.05)。高密度脂蛋白胆固醇(HDL-C)随年龄增长变化不明显(P>0.05),但女性各年龄段HDL-C结果均显著高于男性(P=0.000)。相关分析显示随空腹血糖水平升高VLDL-C升高趋势不明显(r=0.08,P=0.004),但LDL-C有所升高(r=0.13,P=0.000)且HDL-C明显降低(r=-0.18,P=0.000)。结论随年龄增长健康人群有发生脂蛋白代谢紊乱的倾向,且男性趋势更明显;空腹血糖增高和脂代谢紊乱有一定的相关性。     

张家港市健康成人血脂参考值初步研究

目的为完善地区性血脂参考值的建立,促进临床对检验指标的更合理应用。方法对张家港市1 009例健康成人的血清胆固醇、甘油三酯、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇,采用国内血脂推荐的Trinder比色法进行测定。结果TC含量随年龄增长而增高,50岁~组男性(4.64±0.81)mmol/L,女性(4.90±0.76)mmol/L显著高于20岁~和30岁~组;TG含量与年龄和性别差异均有显著性;HDL-C女性高于男性;LDL-C年龄间差异有显著性,含量随年龄增加而增加,50岁~组男性(2.88±0.62)mmol/L,女性(2.99±0.62)mmol/L。结论初步得到该市不同年龄及性别的血脂水平概貌,建立了合理的地区性血脂参考范围。     

瑞舒伐他汀对维持性血透心血管疾病发生率的影响

目的探讨瑞舒伐他汀对维持性血透患者心血管疾病发生率的影响。方法 91例患者分成瑞舒伐他汀组及对照组,治疗开始时及30 d、3个月测量血胆固醇、甘油三酯、脂蛋白及高敏C反应蛋白水平并进行比较。结果在瑞舒伐他汀组,各项指标均有显著降低,总胆固醇从(163±53)mg/dl至(142±43)mg/dl(p<0.05);低密度脂蛋白从(90±39)mg/dl到(69±32)mg/dl(p<0.05);非HDL胆固醇从(121±46)mg/dl到(99±39)mg/dl(p<0.05);而高敏C反应蛋白在3个月后也明显降低(p<0.01)。而对照组则无明显变化。结论瑞舒伐他汀在降低维持性血透患者的心血管疾病发生率起着重要作用。     

新生儿血脂水平相关性的研究

目的:探讨新生儿血脂水平的影响因素。方法:测定172例孕妇及其新生儿脐血血清总胆固醇(TC)、甘油三脂(TG)、高密度脂蛋白(HDL-C)和低密度脂蛋白(LDL-C)。结果:妊娠母亲的血脂高于脐血血脂水平(P<0.001),母亲TG水平与新生儿TG水平呈正相关(P<0.001),双亲有高血压家族史组TG水平高于对照组(P<0.05),LDL-C是母系或双亲高血压家族史者高于对照组(P<0.05);不同孕周、不同新生儿体重之间的新生儿血脂均无统计学差异(P>0.05)。结论:新生儿脐血血脂与母亲血脂和高血压家族史密切相关,因此应早期进行血脂筛查和干预。     

产妇和新生儿血清脂类、脂蛋白和锌铜含量及相关关系的研究

本实验对53例正常分娩产妇和61例新生儿血清脂类及脂蛋白和血清锌、镉的含量及其相关关系做了初步的研究。结果表明:产妇血中TG、 TC、 HDL-CLDL-C、 LDL-C/HDL-C及铜均比正常对照组高,但血清锌较低(0.41mg/L)。除LDL-C/HDL-C比值无差异外,各项指标及Zn/Cu比值均有显著差异(P<0.001)。母血中TG、 TC、 HDL-C、 LDL-C、 LDL-C/HDL-C及铜均比脐带血高,且均有显著差异(P<0.001),但Zn和Zn/Cu比值明显低于脐带血(P<0.001),其中HDL-C、AI、LDL-C/HDL-C均有明显相关(P<0.001)。实验结果表明:孕产妇存在高TG、 TC血症;同时,存在血清锌低水平,且与脐带血中HDL-C、AI、LDL-C/HDL-C均有明显正相关。     

婴儿期体格发育与新生儿脐血血脂水平的关系

目的:探讨足月新生儿脐血血脂水平与婴儿期体格发育的关系。方法:选择501例自然经阴道分娩的足月健康新生儿,分别测定脐血总胆固醇(TCH)、甘油三酯(TG)、低密度脂蛋白(LDL-C)和高密度脂蛋白(HDL-C)的水平。追踪随访至婴儿12月龄时,根据营养状况分为肥胖组、标准组及营养不良组,分别评价各组间婴儿出生时的脐血血脂水平。结果:肥胖组TCH为(1.76±0.85)mmol/L,TG为(0.43±0.42)mmol/L,HDL-C为(1.15±0.53)mmol/L;标准组TCH为(1.56±0.71)mmol/L,TG为(0.38±0.38)mmol/L,LDL-C为(0.99±0.41)mmol/L,HDL-C为(1.07±0.38)mmol/L,营养不良组TCH为(1.66±0.50)mmol/L,TG为(0.49±0.44)mmol/L,LDL-C为(0.98±0.33)mmol/L,HDL-C为(1.19±0.55)mml/L。LDL-C为(0.88±0.42)三组婴儿出生时脐血血脂值均无明显差异(P>0.05)。结论:脐血血脂水平与婴儿期体格发育无明显关系。     

鲨烯、苔条、紫菜、花菜对大鼠血清胆固醇的作用

通过喂养试验,观察了11种食物和1种食物提取物(鲨烯),对大鼠血清胆固醇浓度的作用。结果发现,鲨烯、苔条、紫菜、花菜均有降低血清T-C的作用,其中鲨烯和苔条还能促进HDL-C的增高。与对照组相比,鲨烯组大鼠血清T-C,LDL-C和VLDL-C分别下降50.5％、60.8％和53.7％,而HDL-C则增高56.5％。苔条组大鼠血清T-C,LDL-C和VLDL-C分別下降34.9％,42.7％、和31.4％,而HDL-C增高58.3％。紫菜组和花菜组大鼠血清T-C则分别下降29.4％和36.7％。     

中老年人群血清胆固醇水平及其相关因素的研究

目的　探讨中老年“健康”人群血清总胆固醇 (TC)、高密度脂蛋白—胆固醇 (HDL- C)、低密度脂蛋白—胆固醇 (L DL- C)水平及与相关个体因素的关系。方法　随机抽取 340人 ,横断面调查方法进行问卷调查、体格检查和血脂水平测定。结果　 4 5岁以上的 340人 (男 183人、女 15 7人 )血清胆固醇水平均在正常范围内 ;女性 TC、HDL- C及 L DL- C水平均显著高于男性 (P<0 .0 5 ) ;70岁以上老人 HDL- C水平均显著高于其它年龄组。逐步回归分析显示 :显著影响 TC水平的个体因素为年龄、性别 ,影响 L DL- C的因素为年龄、性别和体重指数 (BMI) ,影响 HDL- C水平的因素为年龄、饮酒、BMI。结论　超重和肥胖、经常大量饮酒是升高血胆固醇的重要因素。健康教育和行为干预过程中应强调良好的生活方式和维持适当的体重。     

Secular trends in cardiovascular risk factors among school-aged boys from Crete, Greece, 1982-2002

OBJECTIVE: The aim of the present study was to examine secular trends in major cardiovascular disease (CVD) risk factors, that is, obesity and dyslipidaemia, among Cretan children during 1982-2002. DESIGN: Epidemiological survey. SETTING AND SUBJECTS: A total of 528 boys in 1982 and 620 boys in 2002, aged 12.1+/-0.1 y, were randomly selected from urban and rural regions throughout the county of Iraklio, Crete, Greece. Care was taken so that all procedures in 2002 closely matched those in 1982. RESULTS: Mean height, weight, and body mass index (BMI) were 1.1, 9.6, and 8.4% higher, respectively, in 2002 vs 1982 (P<0.001). The prevalence of overweight and obesity has risen by 63 and 202%, respectively (P<0.001). Contemporary children were found to have 3.6% higher total cholesterol (TC), 24.9% lower high-density lipoprotein-cholesterol (HDL-C), 25.3% higher low-density lipoprotein-cholesterol (LDL-C), 19.4% higher triacylglycerol, 36.6% higher TC/HDL-C ratio, and 60.3% higher LDL-C/HDL-C ratio compared with their peers in 1982 (P<0.003). These differences persisted even when adjusting for BMI (P<0.02). The proportion of children having abnormal lipid values was much greater nowadays than in the 1980s, yielding odds ratios of 1.4-8.8 (P<0.005). CONCLUSIONS: Results are indicative of a largely deteriorated CVD risk profile in Cretan children since 1982, and predict an unfavourable CVD morbidity and mortality for this population in the foreseeable future.     

Influence of fish consumption on the distribution of serum cholesterol in lipoprotein fractions: comparative study among fish-consuming and non-fish-consuming populations

The objective of this study was to investigate serum lipoprotein levels in order to assess cardiovascular disease (CVD) risk factors between fish-consuming populations and non-fish-consuming populations, as it has been speculated that fish intake reduces CVD risk. A representative sample of one thousand subjects (529 men and 471 women) were selected, with ages ranging from 20 to 70 years, from 40 villages belonging to fish-consuming (500) or non-fish-consuming (500) populations. Serum lipoprotein lipids such as total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were analysed biochemically using standard procedures. The ratios of TC: HDL-C and LDL-C: HDL-C were computed. Mean values of serum LDL-C and the ratios of LDL-C: HDL-C and TC: HDL-C were significantly lower and HDL-C levels were higher in fish-consumers than in non-fish-consumers. The concentrations of HDL-C decreased with increasing age, while the reverse was true for LDL-C and for the LDL-C: HDL-C and TC: HDL-C ratios. There were significant sex differences for certain age groups in both of the population groups. The 5th, 50th and 95th percentile cut-off values for these parameters were lower in fish-consumers than in non-fish-consumers. The prevalence of individuals at risk of CVD because of low HDL-C (<35 mg/dL), high LDL-C (>130 mg/dL) and their atherogenic ratios (LDL-C: HDL-C >3.5 and TC: HDL-C>4.5) was significantly greater in non-fish-consumers. This study highlights that the fish-consuming population had a lower atherogenic risk than the non-fish-consuming population. The intake of fish may have substantial implications for public health and health economy by decreasing the risk of CVD. However, more studies are warranted to better define the mechanisms of cardioprotection by dietary fish and fish oils.     

Dietary vitamin A may be a cardiovascular risk factor in a Saudi population

Traditional risk factors do not appear to explain fully the variation in the incidence of the cardiovascular diseases (CVD). Epidemiological studies have not been entirely consistent with regard to the relationship between antioxidant vitamin intake and CVD and there appears to be little data on this relationship in non-Caucasian populations. This study aimed to investigate the dietary intake of vitamin A, C, and vitamin E, and carotenoids, serum concentrations of vitamin E and A and indices of lipid peroxidation were measured in male Saudi patients with established CVD and age-matched controls. We assessed the dietary intakes of vitamins A, C, and E and carotenoids, by a food frequency questionnaire. Serum vitamins A and E concentrations were measured by HPLC, in 130 Saudi male subjects with established CVD, and 130 age-matched controls. We also determined serum lipid profiles (total cholesterol, triglycerides, HDL-C, LDL-C), lipoprotein (a), oxidized LDL, and serum lipid peroxide concentrations. Diabetes mellitus (P<0.0001), a positive smoking habit (P<0.0001) and hypertension (P<0.05) were more prevalent among CVD patients. Levels of dietary vitamin E and A were also significantly higher among cases. In conditional logistic regression analysis, the most significant characteristics differentiating CVD patients from controls were diabetes mellitus (Odds ratio 2.49, CI 1.42-4.37, P<0.001), total fat intake (Odds ratio 1.02, CI 1.01-1.03, P<0.01), serum vitamin A (Odds ratio 0.72, CI 0.53-0.99, P<0.05), and the vitamin A/total fat intake ratio (Odds ratio 1.04, CI 1.01-1.06, P<0.01). In a Saudi population, smoking habit and hypertension were significantly more common among patients with CVD. Multivariate analysis showed that dietary total fat and vitamin A and the presence of diabetes mellitus were independent coronary risk factors. This is the first report of a potentially deleterious effect of dietary vitamin A in a non-Caucasian population. However it is possible that unidentified residual confounding factors may account for this finding.     

A macadamia nut-rich diet reduces total and LDL-cholesterol in mildly hypercholesterolemic men and women

Epidemiologic studies and clinical trials have demonstrated that the unique fatty acid profile of nuts beneficially affects serum lipids/lipoproteins, reducing cardiovascular disease (CVD) risk. Nuts are low in SFA and high in PUFA and monounsaturated fatty acids (MUFA). Macadamia nuts are a rich source of MUFA. A randomized, crossover, controlled feeding study (5-wk diet periods) compared a Macadamia nut-rich diet [42.5 g (1.5 ounces)/8.79 MJ (2100 kcal)] [MAC; 33% total fat (7% SFA, 18% MUFA, 5% PUFA)] vs. an average American diet [AAD; 33% total fat (13% SFA, 11% MUFA, 5% PUFA)] on the lipid/lipoprotein profile of mildly hypercholesterolemic (n = 25; 15 female, 10 male) subjects. Serum concentrations of total cholesterol (TC) and LDL cholesterol (LDL-C) following the MAC (4.94 +/- 0.17 mmol/L, 3.14 +/- 0.14 mmol/L) were lower than the AAD (5.45 +/- 0.17 mmol/L, 3.44 +/- 0.14 mmol/L; P < 0.05). The serum non-HDL cholesterol (HDL-C) concentration and the ratios of TC:HDL-C and LDL-C:HDL-C were reduced following consumption of the MAC diet (3.83 +/- 0.17, 4.60 +/- 0.24, and 2.91 +/- 0.17, respectively) compared with the AAD (4.26 +/- 0.17, 4.89 +/- 0.24, and 3.09 +/- 0.18, respectively; P < 0.05). There was no change in serum triglyceride concentration. Thus, macadamia nuts can be included in a heart-healthy dietary pattern that reduces lipid/lipoprotein CVD risk factors. Nuts as an isocaloric substitute for high SFA foods increase the proportion of unsaturated fatty acids and decrease SFA, thereby lowering CVD risk.     

平顶山市256名8岁～16岁中小学生血脂水平与体重指数相关性研究

目的了解平顶山市儿童血脂谱水平,研究体重指数（BM I）对血脂的影响,为从儿童期开始进行心、脑血管疾病的早期预防提供基础资料。方法2006年3月对平顶山市256名8岁-16岁中小学生进行体格检查与血总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）和低密度脂蛋白胆固醇（LDL-C）的水平监测。结果检测256人,TC为（3.511±0.770）mmol/L;TG为（0.962±0.321）mmol/L;HDL-C为（1.146±0.244）mmol/L;LDL-C为（1.757±0.622））mmol/L。4项指标均为女性高于男性（P〈0.05）。TC、HDL-C水平与年龄呈负相关（r=-0.184、-0.267,P〈0.01）,TG、LDL-C水平与年龄呈正相关（r=0.213、0.232,P〈0.01）TG水平,超重组、肥胖组均高于正常组,肥胖组高于超重组（P〈0.01）;HDL-C水平,超重组低于正常组P〈0.01）。腰臀比（WHR）与男性的TC水平呈正相关（r=0.202）,与女性的HDL-C水平呈负相关（r=-0.223）,相关均有统计学意义（P〈0.05）。结论平顶山市中小学生血脂谱水平略低于其他城市;性别、年龄、体重指数、腰臀比是影响儿童血脂谱的主要因素。     

Cardiovascular Disease Risk Factors are Lower in African-American Vegans Compared to Lacto-Ovo-vegetarians

Objective: This study was undertaken to determine if African-American strict vegetarians (vegans) exhibit lower blood pressure (BP) and a more favorable serum lipid profile than their lacto-ovo vegetarian (LOV) counterparts, and if plasma ascorbic acid (AA) concentrations could explain any group differences in these cardiovascular disease (CVD) risk factors.

Methods: Habitual dietary intake, anthropometric characteristics, blood pressure, and blood lipids and ascorbic acid concentrations were determined in African-American study participants (male vegans, n=14, age=45.6 years; male LOV, n=49, age=49.8; female vegans, n=31, age=51.1, female LOV, n=94, age=52.1) recruited from Seventh-Day Adventist Churches in several cities in the northeastern United States.

Results: Body mass index (BMI) was significantly lower in the vegans (24.7±1.9 kg/m²) compared to LOV (26.4±0.45 kg/m²). There were no diet or gender differences in BP. Serum total cholesterol (3.75±0.12 vs. 4.51±0.10 mmol/L), LDL-cholesterol (2.06±0.13 vs. 2.65±0.09 mmol/l), and triglycerides (0.94±0.07 vs. 1.17±0.04 mmol/L) were significantly (p<0.05) lower in vegans compared to LOV, but there were no dietary group differences in HDL-C. The ratio of total to HDL-cholesterol was significantly lower in vegans than in LOV (3.0±0.13 vs. 3.7±0.13). There were no dietary group differences in plasma AA concentrations. However, in the entire sample, plasma AA was inversely associated with BP (SBP: r=?0.46, p<0.001, DBP: r=?0.32, p<0.001), but unrelated to the serum lipid concentrations.

Conclusion: African-American vegans exhibit a more favorable serum lipid profile than lacto-ovovegetarians and plasma AA is inversely related to BP in African-American vegetarians but does not explain any of the differences in CVD risk factors between vegans and lacto-ovo vegetarians.     

绝经后妇女冠心病患者性激素水平与脂质代谢的临床观察

目的:观察绝经后妇女冠心病(CHD)患者血清性激素水平与脂质代谢关系。方法:58例绝经后妇女CHD患者作为观察组,58例绝经后健康妇女作为对照组,测定两组性激素相关指标(血清雌二醇(E2)、孕酮(P)、睾酮(T)、催乳素(PRL)、黄体生成素(LH)、促卵泡激素(FSH)、E/T)及脂质代谢相关指标(总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白B(ApoB)、HDL-C/LDL-C、HDL-C/TC)水平,并进行相关性分析。结果:观察组患者E2、HDL-C、E/T、HDL-C/LDL-C、HDL-C/TC水平明显低于对照组,TC、TG、LDL-C、ApoB水平均明显高于对照组,差异有统计学意义(P<0.01或P<0.05);经多元回归分析观察组患者E2、E/T与TC、TG、LDL-C、ApoB水平呈负相关。结论:绝经后妇女CHD患者血脂异常与性激素下降密切相关,且共同参与CHD发生、发展。     

血清脱氢表雄酮水平与男性冠心病冠状动脉病变程度相关性分析

目的:观察血清脱氢表雄酮(DHEA)水平与男性冠心病冠状动脉病变程度的关系。方法:采用酶联免疫吸附试验检测血清脱氢表雄酮。并检测空腹血糖、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、尿酸等生化指标。结果:冠心病患者组血清脱氢表雄酮水平显著低于无冠心病组,P<0.001。多元logistic回归分析显示,血清脱氢表雄酮为冠心病独立危险因素(OR=0.526;95%C I:0.361~0.768;P=0.001),血清脱氢表雄酮水平与冠心病冠状动脉狭窄程度呈负相关(t=3.424,P=0.001,r=-0.415)。控制其他冠心病危险因素后,血清脱氢表雄酮仍然与冠心病冠状动脉病变程度呈负相关(t=3.424,P=0.001,r=-0.415)。结论:血清DHEA水平的降低可能是导致男性冠心病发病率升高的重要因素,监测血清DHEA水平有助于判断冠心病病变的程度。