医院体检信息系统的设计与应用效果分析

目的构建数字化、网络化的体检信息管理系统,以满足体检中心的业务需要。方法通过将体检软件与医院现有信息系统的集成,实现数据的高度共享,打造具有医院特色的体检系统。结果体检信息系统的应用,实现了医院体检流程的塑造和优化,提高了体检中心的工作效率,为后续医疗工作提供了基础数据。结论功能齐全、人性化的体检信息系统能够满足体检中心和医院未来发展的需要,同时提高医院的效益和知名度。     

人性化服务在健康体检中的应用

随着人们生活水平的不断提高,健康成为人们追求的最高目标;健康体检是保障人们身体健康、预防和发现疾病的有效措施。笔者将人性化服务运用到健康体检的工作中,以满足健康体检者的需求,取得满意效果,现报告如下。     

体检排队系统数学模型的制作

通过制作体检排队数学模型,开发体检排队系统。体检排队根据医院的体检科室和体检时间需要采用表格模型计算。根据表格计算出体检排队各个组的体检秩序。利用数学模型的制作,开发出雅安市人民医院体检排队系统。数学模型的建立,有助于解决多人多服务台体检时的排队情况。体检分组模型和体检排队模型的建立,可指导系统的设计、开发和维护。     

体检信息系统的实用性

本文从实用性的角度阐述了体检信息系统在医院诸多应用系统的必要性。笔者医院在使用体检信息系统后提高了服务质量,强化了管理,减少了医生的工作量。     

健康体检中人性化护理的应用体会

目的 对在健康体检中实施人性化护理的体会进行深入的探讨以及仔细的研究.方法 坚持树立以＂体检客户为中心＂的科学服务理念、端正工作态度的微笑服务、营造温馨与舒适的体检环境、创建高效便捷的服务流程、建立健康的个人档案,进行跟踪服务治疗,塑造良好的形象.结果 促进护士从根本上改善对工作热情服务的态度,服务质量有所提高,体检者能够更好地满足所需的要求,提升体检者的满意程度,增强医院的竞争力.结论 坚持实施以＂体检客户为中心＂的人性化护理服务理念,是增强体检行业竞争力相对有力的重要举措.     

人性化护理工作在健康体检中的应用

目的探讨实施人性化护理工作在健康体检中的应用效果。方法回顾性总结我医院2009年2月至2011年11月体检前、体检中、体检后的人性化护理服务的资料,并对其进行分析整理。结果健康体检体现以人为本的人性化护理服务理念后用户满意度进一步得到提升,体验工作的效率和质量都有了明显提高。结论倡导人性化工作环境,营造舒适、温馨、安全、舒心的体检环境,大大的满足客户的健康体检服务的需求,赢得了社会的信任,得到了体检者的好评,扩大了医院在社会的知名度。     

健康体检者体检项目漏检的原因与对策

目的研究探讨健康体检者体检项目漏检的原因、对策。方法选取来我院接受健康体检科的受检者10000例作为研究对象,实施人性化管理前后各5000例,并分别将其设为观察组和对照组,比较实施人性化管理前后受检者的项目漏检率和对服务的满意度。结果实施人性化管理前后,受检者的健康体检项目漏诊率为5.46%,对服务的满意度为97.12%,与实施人性化管理前相比有显著提高(漏检率和服务满意度分别为9.02%和84.66%),且两组受检者的比较有统计学差异(P<0.05)。结论在进行健康体检的过程中,可能因医院体检中心的管理存在漏洞、受检者对健康体检的重视程度不够以及医院的环境因素和受检者的心理因素等多方面的原因导致漏检情况的出现,通过制定个性化管理措施,并对医院和受检者实施针对性管理和改革,实现健康体检项目漏检率的降低和整体服务质量的提高。     

运用整体护理程序对体检职工进行健康教育

目的提高职工参加健康体检的意识和愿望,了解掌握自身健康状况,增加预防疾病的保健知识。方法运用整体护理程序对体检的全过程进行护理管理。结果第二次参检职工较第一次增加了17.8%,参加体检职工对自己出现的异常指标有所了解和比较。结论健康体检是早期发现疾病的最有效措施,在体检全过程中科学的运用护理程序实施健康教育,是提高职工防病治病知识和积极参与定期健康体检的有效方法。     

健康体检中放射影像学检查的观察与分析

随着科普知识的普及以及社会的发展,人们的观念不断的在进步,健康开始成为生活的主流,人们开始通过各种各样的途径养生,包括吃养生食品,做养生运动等等。随着人们对健康的重视,健康体检也逐渐受到了大家的认可。通常情况下,都是由单位组织去体检的,所以体检项目也是由于不同的需求而不同。随着科技的进步以及电脑的普及,医院在体检时开始借助影像学的技术,最常用使用的是X线检查。X射线的使用如何才能做到物有所值,物尽其用呢？本文主要通过举例几种健康体检中常用的放射影像学检查,进一步探索该类检查在实际运用中的合理性。     

当前军队医院开拓体检市场应把握的几个问题

当前,随着人们生活水平的不断提高,健康体检工作越来越受到社会的重视。全国医疗体检市场竞争形势日趋激烈,给军队医院健康体检带来新的挑战和发展机遇。本文主要强调了军队医院在对外服务中,需要把握好的几个问题,切实保证军队医院对外体检工作健康有序地开展。     

Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat

1. The pharmacokinetics of the antimalarial compound artemisinin were compared in the male and female Sprague-Dawley rat after single dose i.v. (20 mg.kg) or i.p. (50 mg.kg) administration of an emulsion formulation. 2. Plasma clearance of artemisinin was 12.0 (95% confidence interval: 10.4, 13.0) l.h. kg in the male rat and 10.6 (95% CI: 7.5, 15.0) l.h. kg in the female rat suggesting high hepatic extraction in combination with erythrocyte uptake or clearance. Artemisinin half-life was 0.5 h after both routes of administration in both sexes. Values for plasma clearance and half-lives did not statistically differ between the sexes. 3. After i.p. administration artemisinin AUCs were 2-fold higher in the female compared with male rat (p 0.001). Artemisinin disappearance was 3.9-fold greater in microsomes from male compared with female livers and it was inhibited in male microsomes by goat or rabbit serum containing antibodies against CYP2C11 and CYP3A2 but not CYP2B1 or CYP2E1. 4. The unbound fraction of artemisinin in plasma was lower (p 0.001) in plasma obtained from the male (8.8 2.0%) compared with the female rat (11.7 2.2%). 5. The possibility of a marked sex difference, dependent on the route of administration, has to be taken into account in the design and interpretation of toxicological studies of artemisinin in this species.     

Quantitative in vivo and in vitro sex differences in artemisinin metabolism in rat

1. The pharmacokinetics of the antimalarial compound artemisinin were compared in the male and female Sprague-Dawley rat after single dose i.v. (20 mg x kg(-1)) or i.p. (50 mg x kg(-1)) administration of an emulsion formulation. 2. Plasma clearance of artemisinin was 12.0 (95% confidence interval: 10.4, 13.0) 1 x h(-1) x kg(-1) in the male rat and 10.6 (95% CI: 7.5, 15.0) 1 x h(-1) x kg(-1) in the female rat suggesting high hepatic extraction in combination with erythrocyte uptake or clearance. Artemisinin half-life was approximately 0.5 h after both routes of administration in both sexes. Values for plasma clearance and half-lives did not statistically differ between the sexes. 3. After i.p. administration artemisinin AUCs were 2-fold higher in the female compared with male rat (p < 0.001). Artemisinin disappearance was 3.9-fold greater in microsomes from male compared with female livers and it was inhibited in male microsomes by goat or rabbit serum containing antibodies against CYP2C11 and CYP3A2 but not CYP2B1 or CYP2E1. 4. The unbound fraction of artemisinin in plasma was lower (p < 0.001) in plasma obtained from the male (8.8 +/- 2.0%) compared with the female rat (11.7 +/- 2.2%). 5. The possibility of a marked sex difference, dependent on the route of administration, has to be taken into account in the design and interpretation of toxicological studies of artemisinin in this species.     

Interindividual variability in metabolic activation in humans in vivo

In assessing interindividual variability in metabolic activation, the toxic metabolite is often too unstable for conventional analysis. Possible alternatives include a stable product of the reactive metabolite e.g. cysteinyl derivatives of N-acetyl-4-benzoquinoneimine, the toxic metabolite of paracetamol, adducts with DNA or protein, and indirect measurement of the activity of the enzyme(s) producing the active metabolite. An example of the last approach is the use of furafylline, a highly specific inhibitor of human CYP1A2, to determine the extent of the metabolic activation of the cooked food mutagens PhIP and MeIQx. The extent of inhibition, determined from levels of unchanged amine in urine, is an indirect measure of the activity of the activation pathway. Further refinement of this approach, allied to improved measures of the biological process of interest should prove of value in evaluating interindividual variability and its role in the risk assessment process.     

Theophylline kinetics in peripheral tissues in vivo in humans

Several biochemical and cellular effects have been described for methylxanthines under in vitro conditions. However, it is unknown, whether threshold concentrations required to exert these effects are attained in target tissues in vivo. We therefore employed the microdialysis technique for measuring theophylline concentrations in peripheral tissues under in vivo conditions.Following in vitro and in vivo calibration, microdialysis probes were inserted into the medial vastus muscle and into the periumbilical subcutaneous adipose layer of healthy volunteers. Following single oral dose administration of 300 mg or i.v. infusion of 240 mg theophylline, in vivo time courses of theophylline concentrations were monitored in tissues and plasma. Major pharmacokinetic parameters (c_max, t_max, AUC) were calculated for plasma and tissue time courses. The mean AUC_tissue /AUC_plasma-ratio was 0.56 (p.o.) and 0.55 (i.v.) for muscle and 0.55 (p.o.) and 0.72 (i.v.) for subcutaneous adipose tissue.We conclude that microdialysis provides important information on the distribution and the tissue pharmacokinetics of theophylline.Abbreviations FPIA Fluorescence polarisation immuno assay - AUC Area under the curve - t_max Time to peak concentration - c_max Peak concentration     

休克时血中氧自由基的变化

本实验测定10名休克患者血浆和红细胞的丙二醛(MDA)、血浆总抗的氧化活性(AOA)的含量。结果表明:休克病人红细胞膜和血浆 MDA 含量(4.298±0.722;5.348±0.834)与对照组(3.235±0.682;4.356±1.081)比较明显增高(P<0.05);血浆 AOA(39.65±7.858)与对照组(48.21±10.81)比较明显降低(P<0.01)。提示:休克时,患者机体内自由基反应增强是引起组织细胞损伤的原因之一。     

Changes in angiopoietin expression in glomeruli involved in glomerulosclerosis in rats with daunorubicin-induced nephrosis

AIM: To study the potential pathological role of endogenous angiopoietins in daunorubicin-induced progressive glomerulosclerosis in rats. METHODS: Seventy male Wistar rats were allocated randomly into a daunorubicin group (DRB; n=40) or a control group (n=30). The rats in the DRB group were injected with DRB (15 mg/kg), in their tails. Subsequently, at intervals of 1, 2, 4, 6, 8, and 12 weeks, 5 male Wistar rats in each group were chosen randomly for 24 h urinary protein quantitative measurements (24 h UPQM), and determination of plasma tumor necrosis factor alpha (TNF-alpha), angiopoietin-1 (Ang1), and angiopoietin-2 (Ang2) levels. Kidney sections were examined by electron microscopy, Periodic Acid Schiff (PAS) staining, immunohistochemical staining and in situ hybridization histochemistry. RESULTS: As glomerulosclerosis progressed in the DRB group, expression of Ang1 mRNA and protein in glomeruli decreased and expression of TNF-alpha protein, Ang2 mRNA and protein in glomeruli increased. Expression of Ang1 mRNA and protein in glomeruli were negatively correlated with 24 h UPQM, Fn protein expression, and mean area of extracellular matrix (MAECM). In comparison, expression of Ang2 mRNA and protein in glomeruli were positively correlated with 24 h UPQM, Fn protein expression and MAECM; furthermore, there was a positive correlation between plasma Ang2 and 24 h UPQM. Plasma TNF-alpha and expression of TNF-alpha in glomeruli were positively correlated with expression of Ang2 mRNA and protein in glomeruli. There was a negative correlation between Ang1 protein expression and Ang2 protein expression in glomeruli. CONCLUSION: During DRB-induced glomerulosclerosis, podocyte injury led to a shift in the balance of Ang1 and Ang2 in glomeruli. Increased TNF-alpha in plasma and glomeruli may upregulate Ang2 expression in glomeruli. Elevated Ang2 in both plasma and glomeruli may mediate protein permeability through the glomerular filtration barrier. Moreover, local expression of Ang2 may facilitate the progress of glomerulosclerosis by upregulating a component expression of extracellular matrix.     

Trichinellosis in immigrants in Switzerland

We describe a case of trichinellosis diagnosed at the Division of Infectious Diseases, Hospital of Lugano, in January 2009. This case was associated with a cluster of cases and was traced to the consumption of contaminated meat after a wild boar hunt in Bosnia.