前交叉韧带重建术后早期应用中医推拿手法的康复疗效

目的探讨前交叉韧带重建术后早期应用中医推拿手法的康复疗效。方法自2018年1月我院收治行单纯前交叉韧带重建术的患者30例随机分成两组,对照组15例行标准前交叉韧带重建术后康复治疗,包括肌肉锻炼与活动度练习;中医推拿组15例在标准的前交叉韧带重建术后康复治疗的基础上增加中医推拿手法,推拿手法自术后1周开始,持续四周;分别于术后1、3、6个月测量患肢膝关节活动度与大腿周径,术前与术后6个月采用Lysholm评分标准对患者膝关节功能进行评估,并对结果进行统计学分析。结果两组患者术前术后Lysholm评分均有明显提升(P0.05),但二组之间无明显统计学差异(P0.05);中医推拿组术后1个月的患肢膝关节活动度与大腿周径均比对照组高,有明显统计学差异(P0.05),术后3、6个月患肢膝关节活动度与大腿周径无明显统计学差异(P0.05)。结论前交叉韧带重建术后早期应用中医推拿手法可以有效的降低膝关节粘连的发生率,提升肌肉力量,加速前交叉韧带重建术后的康复过程。     

动态关节松动术对ACL重建术后功能恢复的效果研究

前交叉韧带损伤后进行重建的患者临床上较为多见,如何在恢复期较好的康复治疗尤其重要,但较少将动态关节松动术应用于前交叉韧带重建术后的恢复期.目的:观察动态关节松动术对前交叉韧带重建术后患者膝关节功能恢复的康复效果.方法:首次ACL断裂重建术后患者39例,随机分为治疗组20例与对照组19例.治疗组使用动态关节松动术进行康复治疗;对照组使用传统关节松动术进行康复治疗.治疗时间共3周,每周5次,每日1次,每次1.5-2小时.治疗前后用膝关节主动关节活动度、Lysholm膝关节评分对两组疗效进行评价.结果与结论:经过3周康复治疗,2组膝关节主动关节活动度均显著增加(P<0.01),且治疗组增加幅度大于对照组(P<0.05);2组Lysholm膝关节评分与治疗前相比均显著提高(P<0.05),且治疗组增加幅度大于对照组(P<0.05).动态关节松动术能有效改善前交叉韧带重建术后患者膝关节主动关节活动度和运动功能.     

自体腘绳肌腱重建前交叉韧带术后两种康复方案效果的比较

目的：观察自体腘绳肌腱重建前交叉韧带术后两种不同康复方案的临床效果,为前交叉韧带重建术后康复方案的选择提供理论依据。方法：收集单侧自体腘绳肌腱重建膝关节前交叉韧带手术的患者32例,其中,车祸20例,运动损伤12例。采用保守康复方案16例,采用积极康复方案16例。术后6个月时比较关节活动度、髌上10em处双侧大腿周径差值、Lysholm评分、IKDC评分、关节稳定性。结果：两组术后6个月比较,膝关节活动度存在明显差异;髌上10em处双侧大腿周径差值无明显差异;Lysholm评分存在明显差异;IKDC评分有明显差异;关节稳定性检查均为阴性。结论：自体腘绳肌腱重建膝关节前交叉韧带术后早期积极康复可以明显改善膝关节功能,增加关节活动度．缩短康复时间．但远期效果还有待研究。     

前交叉韧带重建术后康复治疗中开链与闭链运动的效果观察

目的:比较前交叉韧带重建术后行开链与闭链运动的康复效果,并为前交叉韧带重建术后康复方案的选择提供依据? 方法:从2010年1月~2012年6月符合纳入标准的接受自体肌腱单束解剖重建前交叉韧带手术的患者97例,通过随机数字表将其分为两组,分别采用开链运动康复方案(45例)和闭链运动康复方案(52例)?两组术前Lysholm膝关节评分?IKDC评分及KT-1000值均无明显差异?比较术后3?6?12个月时两组患者的Lysholm膝关节评分?IKDC评分?KT-1000值及主动?被动关节活动度的差值?结果:术后3个月开链运动组与闭链运动组Lysholm膝关节评分?IKDC评分和被动关节活动度差值的差异无统计学意义,而主动关节活动度差值?KT-1000值有明显差异;术后6个月两组Lysholm膝关节评分?IKDC评分和主?被动关节活动度差值的差异无统计学意义,KT-1000值有明显差异?术后12个月两组Lysholm膝关节评分?IKDC评分?KT-1000值和主动?被动关节活动度差值的差异均无统计学意义?结论:前交叉韧带重建术后行开链运动与闭链运动康复训练,膝关节的肌力及活动度最终均能恢复到较为满意的结果,且无明显差异,但闭链运动较开链运动恢复得更早?康复早期,闭链运动更有利于保护重建韧带,防止术后再损伤?     

基于关节镜下ACL损伤重建术应用快速康复的疗效观察

目的观察快速康复及传统康复两种方案对前交叉韧带重建术后患者膝关节功能康复的效果差异。方法将28例行前交叉韧带重建术后的患者分为对照组及研究组,各14例,分别给予传统康复方案及快速康复方案。术后1个月、3个月、6个月时分别采用VAS视觉评分表、膝关节Lysholm评分表、测量大腿周径及被动关节活动度以评估患者膝关节功能恢复情况。结果术后1个月、3个月、6个月对患者进行膝关节功能评分,术后1个月、3个月时研究组评分明显高于对照组,差异具有显著统计学意义(P0.05)。结论通过快速康复方案进行系统康复治疗可使膝关节前交叉韧带重建术后的患者缩短康复时间,并能在较短时间内达到运动水平。     

快速康复理念对关节镜下前交叉韧带重建术后膝关节功能的影响

目的:探讨快速康复理念对关节镜下前交叉韧带重建术后膝关节功能的影响。方法:收集本院行关节镜下前交叉韧带重建术的患者85例,随机分为研究组和常规组,其中常规组患者42例采用常规临床术后干预,研究组43例根据快速康复外科理念对患者进行术后康复干预。比较两组患者膝关节功能及膝关节活动度恢复情况。结果:干预6个月后研究组Lysholm膝关节活动评分高于常规组(P <0. 05);研究组屈曲及伸展受限角度低于常规组(P <0. 05)。结论:快速康复理念应用于关节镜下前交叉韧带重建术后患者,可有效提高膝关节活动度及膝关节功能。     

手法配合中药熏洗在膝关节前交叉韧带重建术后康复中应用价值研究

目的:探讨手法配合中药熏洗在膝关节前交叉韧带重建术后康复中的应用价值。方法:选择2014年1月—2015年1月间我院收治的56例接受前交叉韧带重建术治疗的前交叉韧带损伤患者,随机分为两组,观察组与对照组每组各28例,对照组术后予常规康复训练治疗,观察组在此基础上加用手法及中药熏洗治疗,观察术后两组患者关节腔积液及膝关节活动度、功能恢复情况。结果:观察组患者术后3 d、7 d及14 d患侧膝关节积液量均明显少于对照组,差异有统计学意义(P0.05);两组患者术前VAS评分、关节活动度及Lysholm评分比较差异无统计学意义(P0.05);术后3个月,两组患者VAS评分均较术前明显下降,关节活动度及Lysholm评分均明显提高,差异有统计学意义(P0.05);观察组患者VAS评分低于对照组,关节活动度及Lysholm评分明显高于对照组,差异有统计学意义(P0.05)。结论:对于膝关节前交叉韧带重建术后患者,在常规康复训练的基础上加用手法及中药熏洗治疗可有效减轻术后膝关节肿胀,减轻患者疼痛感觉,改善膝关节活动度及功能。     

阶段性系统康复锻炼在膝关节前交叉韧带损伤重建术后的应用效果

目的探讨阶段性系统康复锻炼对关节镜下前交叉韧带重建术后的应用效果。方法将81例膝关节前交叉韧带损伤患者随机分为观察组42例和对照组39例。对照组给予常规护理,观察组在对照组护理的基础上,给予阶段性系统康复锻炼指导,采用Lysholm评分和HSS评分以及患膝关节伸屈活动度评价两组患者患膝术前、术后不同时段膝关节功能,采用简明健康调查量表(SF-36)测评两组患者生活质量。结果两组患者术前各项评分无显著性差异(P>0.01);术后1月、5月和1年随访,观察组各阶段膝关节功能恢复的有效率明显优于对照组,Lysholm评分和HSS评分与对照组比较,差异均有统计学意义(P<0.01);膝关节伸屈活动度差异有统计学意义(P<0.01);观察组患者术后SF-36评分高于对照组,差异有统计学意义(P<0.01)。结论阶段性系统康复锻炼护理干预对关节镜下前交叉韧带重建术后手术疗效的巩固、促进患者膝关节功能的恢复以及提高患者的生活质量均有显著的影响。     

膝关节前交叉韧带损伤重建术后系统康复锻炼的效果观察

目的探讨阶段性系统康复锻炼对关节镜下前交叉韧带重建术后的应用效果。方法将81例膝关节前交叉韧带损伤患者随机分为观察组和对照组。对照组给予常规护理,观察组在对照组护理的基础上,给予阶段性系统康复锻炼指导,采用Lysholm评分和HSS评分以及患膝关节伸屈活动度评价两组患者患膝术前、术后不同时段膝关节功能,采用简明健康调查量表(SF-36)测评两组患者生活质量。结果两组患者术前各项评分无显著性差异(P0.01);术后1个月、5个月和1年随访,观察组各阶段膝关节功能恢复的有效率明显优于对照组,Lysholm评分和HSS评分与对照组比较,差异均有统计学意义(P0.01);膝关节伸屈活动度差异有统计学意义(P0.01);观察组患者术后SF-36评分高于对照组,差异有统计学意义(P0.01)。结论阶段性系统康复锻炼护理干预对关节镜下前交叉韧带重建术后手术疗效的巩固、促进患者膝关节功能的恢复以及提高患者的生活质量有显著的影响     

交叉韧带重建术后实施系统康复治疗对促进患者膝关节功能恢复的作用

目的:分析与探讨实施系统康复治疗对交叉韧带重建术后患者膝关节功能的影响。方法:选择经本院临床确诊后进行交叉韧带重建术的40例患者为临床研究对象,根据就诊顺序编号并按单双号分为两组,对照组(单号)20例给予传统康复治疗,试验组(双号)20例实施系统康复治疗。比较两组患者的Lysholm评分、IKDC评分、回访优良率及膝关节活动度。结果:试验组患者Lysholm评分、IKDC评分、回访优良率及膝关节活动度均优于对照组,差异均有统计学意义(P0.05)。结论:将系统康复治疗应用于交叉韧带重建术后患者,疗效显著,回访优良率较高,有助于改善患者膝关节功能,增强其稳定性及活动度,促进其恢复。     

Value of D-Dimers in patients with acute aortic dissection

Objective: To evaluatel the value of D-dimers in patients with acute aortic dissection (AAD). Methods: This study consisted of 16 patients with AAD and 27 non-AAD patients. Serum D-dimets were measured by Sta-Liatest D-DI immunoturbidimetric assay. Results: D-dimer level was higher (P ＜ 0.001) in patients with AAD(7.91 ± 5.52 μg/ml) than that in non- AAD group(1.57±1.24 μg/ml). D-dimer was positive (＞0.4 μg/ml) in all patients with AAD and in 10 control group patients (37%). Among patients with acute AAD, D-dimers tended to be higher in Stanford A than in Stanford B (8.67 ± 4.31 μg/ml vs. 3.24±1.27 μg/ml, P ＜0.01). D-dimer values tended to be higher in more extended disease(3.84 ± 1.65 μg/ml, 8.57 ± 3.58 μg/ml and 11.87 ± 5.69 μg/ml in thoracic aorta, thoracic and abdominal aorta, thoracic and abdominal aorta and iliacal arteries, respectively, P ＜ 0.05 for both 8.57 ± 3.58 and 11.87 ± 5.69 vs. 3.84 ± 1.65 ). Including the control group into the analysis, we found a sensitivity of 100%, a negative predictive value of 100%, and a specificity of 66% and a positive predictive value of 64% for D-dimer in diagnosis of AAD in our patients with suspected AAD. Conclusion: D-dimer was elevated in patients with AAD. A negative D-dimer test result could be useful in excluding AAD.     

Research of combined liver-kidney transplantation model in rats

Objective： To set up a simple and reliable rat model of combined liver-kidney transplantation. Methods： SD rats served as both donors and recipients. 4℃ sodium lactate Ringer＇s was infused from portal veins to donated livers,and from abdominal aorta to donated kidneys, respectively. Anastomosis of the portal vein and the inferior vena cava （IVC） inferior to the right kidney between the graft and the recipient was performed by a double cuff method, then the superior hepatic vena cava with suture. A patch of donated renal artery was anastomosed to the recipient abdominal aorta. The urethra and bile duct were reconstructed with a simple inside bracket. Results： Among 65 cases of combined liver-kidney transplantation, the success rate in the late 40 cases was 77.5%. The function of the grafted liver and kidney remained normal. Conclusion： This rat model of combined liver-kidney transplantation can be established in common laboratory conditions with high success rate and meet the needs of renal transplantation experiment.     

BLOOD PRESSURE CHANGE WITH AGE IN SALT-SENSITIVE TEENAGERS

Objective To observe blood pressure change with age in salt-sensitive teenagers whose salt sensitivity were determined by repeated testing.Methods Salt sensitivity was determined through intravenous infusion of normal saline combined with volume-depletion by oral diuretic furosemide in 55 teenagers. After five years, salt sensitivity was re-examined and subject blood pressure was followed up. Blood pressure changes in salt-sensitive teenagers were compared to that of non-salt sensitive teenagers over five years.Results After 5 years, the repetition rate of salt sensitivity determined by intravenous saline loading is 92.7%. In teenagers with salt sensitivity on the baseline, both the systolic blood pressure increments and increment rates were much higher than non-salt sensitive teenagers (12.7±12.1 mmHg vs. 2.8±5.2 mmHg, P＜ 0.01; 12.2%± 12.0% vs. 2.5% ±4.4%, P＜ 0.001,respectively). There was a similar trend for diastolic blood pressure (8.4 ± 6.4 mmHg vs. 3.7 ± 6.4 mmHg, P = 0.052; 13.2% ±10.6 % vs. 6.8%± 10.1%, P = 0.053, respectively).Conclusions Salt sensitivity determined by intravenous saline loading showed good reproducibility. Blood pressure increments with age were much higher in salt-sensitive teenagers than non-salt sensitive teenagers, especially in terms of systolic blood pressure.     

安心颗粒对急诊经皮冠状动脉介入术后生活质量影响的研究

目的：评价使用安心颗粒对急诊经皮冠状动脉介入术（PPCI）术后生活质量的影响.方法：将160例接受PPCI的急性ST段抬高型心肌梗死患者随机分为安心颗粒组（术前顿服安心颗粒8.8g,术后安心颗粒4.4 g/次,每日2次）和对照组（仅接受基础药物治疗）.所有患者均服用阿司匹林、氯吡格雷和阿托伐他汀.分别在入院时、出院前1d、出院后180 d时,应用心肌梗死多维度量表（MIDAS）、中文版SF-36评价量表对患者生活质量评分.并观察术后30 d以内的出血并发症、血小板减少症发生情况.结果：入院时和出院前1d,两组患者的心肌梗死MIDAS、SF-36量表评分比较无差异（P＞0.05）;出院后180 d时,与对照组比较,安心颗粒组MIDAS、SF-36评分明显减低（P＜0.05）;组内与入院时比较,两组出院前1d、出院后180 d时,MIDAS、SF-36评分均降低（P＜0.05）.两组患者在随访期间均无大量出血、少量出血、重度和极重度血小板减少症发生,安心颗粒组有4例、对照组有7例发生不明显出血（P＞0.05）.两组发生轻度血小板减少症的患者数比较无差异（P＞0.05）.结论：PPCI使用安心颗粒,能改善急性ST段抬高型心肌梗死患者的生活质量,且不增加出血风险.     

The comparative studies of the influences of Urapidil and Nicardipine on sino-atrial node function, atrio-ventricular node function and hemodynamics

Objective:To investigate the influences of urapidil and nicardipine on rabbit sinus function,atrio-ventricular node function and hemodynamics.Methods:Thirty-two Angora's rabbits were selected and randomly divided into four groups.U1 group:urapidil 0.25 mg/kg;U2 group:urapidil 0.5 mg/kg;N1 group:nicardipine 10 μg/kg;N2 group:nicardipine 20 μg/kg.All these medicine were administrated within 30 seconds.Measurements were taken before and after the administration of urapidil or nicardipine for the following data:mean blood pressure(MAP),heart rate(HR),sino-atrial conduction time(SACT),maximal sinoatrial recovery time(SNRTmax)corrected sinus node recovery time(CSNRT),index of sinus node recovery time(SNRTI),Wenckebach A-V conduction frequency (WB),and P-R interval.Results:Significant MAP and HR changes were identified in all of the four groups before and after administration of both urapidil and nicardipine.No significant changes could be found in the rest of the parameters.Intergroup analysis showed that SACT and CSNRT of N1 and N2 groups were shorter than those of the U2 group(P＜0.01);the MAP decreased(P＜0.01)and the HR increased drastically(P＜0.01).Conclusions:Neither urapidil(0.25 mg/kg,0.5 mg/kg)nor nicardipine(10μg/kg,20μg/kg)has any significant influence on rabbit sinus function or rabbit atrio-ventricular node function.Nicardipine could be a better choice than urapidil for parafunctional sinus node patients.     

Expression of OPGmRNA and ODFmRNA in the patients of hip fracture due to osteoporosis

Objective：To investigate the gene expression of osteoprotegerin（OPG） and osteoclast differentiation factor（ODF） in the bone tissue of patients with hip fracture due to osteoporosis. Methods：OPGmRNA and ODFmRNA in the bone tissue in 50 cases of osteoporosis sufferers（over 50 years old） with hip fracture（Observer Group） and 30 cases of hip facture sufferers with no osteoporosis（Control group） were analyzed with the Semi-Quantitative RT-PCR method. Results：The mRNA expressed of ODF, OPG were both high in the patients with hip fracture. In the control group, the expression of OPG mRNA was observed, while the expression of ODF mRNA was very slight. Conclusion：Aged patients contained all signals including OPG, ODF that are essential for inducing osteoclastogenesis and promoting bone resorption.     

Dynamic Changes in Serum Estradiol and Progesterone levels in Patients of Premenstrual Syndrome with Adverse Flow of Liver-qi

Objective:To probe into the influence of changes of ovarian hormones on the pathogenesis of the specific sub-type premenstrual syndrome(PMS)and reveal partial microcosmic mechanisms of adverse flow of liver-qi.Methods:Estradiol(E2)and progesterone(P)levels in serum were determined at different phases of menstrual cycle by radioimmunoassay.Results:In the group of PMS with adverse flow of liver-qi.the secretive peak value Of E2 and P at the follicular phase significantly decreased,and the secretive peak value at the luteal phase did not come into being.Conclusions:Low E2 and P secretive peak at the follicular phase and absence of secretive peak at the luteal phase is one of the microcosmic mechanisms of PMS with adverse flow of liver-qi.One of the pathophysiologic mechanisms of specific sub-type PMS is probably the continuous low level of E2and P.     

Real-time Three-dimensional Echocardiography in Assessment of Left Ventricular and Right Ventricular Volumes

Real-time three-dimensional echocardiography (RT3DE)is a new ultrasound technique that enables dynamic threedimensional visualization and quantification of the heart in real time. Investigation of feasibility and methodology of RT3DE in determining left ventricular (LV) and right ventricular (RV) volumes, RT3DE was performed in 35 normal adults using Philips SONOS 7500 system with a 2-4 MHz matrix array transducer. The 60°×60° "pyramid" volume database was obtained and analyzed on a TomTec echo workstation. Both LV and RV volumes were calculated with four 3DE methods (i.e. apical 2, 4, 8, and 16-plane) through manually tracing ventricular endocardial borders in end diastole and end systole. Stroke volumes were then calculated. LV volume was also measured by 2DE Simpson's rule using GE VIVID 7 ultrasound machine.     

SCREENING FOR A 21-CHROMOSOME ABNORMALITY IN PREIMPLANTED EMBRYOS OF ELDERLY WOMEN

Increasing maternal age is the only etiological factor unequivocally linked to Down's syndrome in humans. The occurrence rate of newborns with Down's syndrome is about 1/220 in women over 35 years old. However, the occurrence rate in embryos fertilized in vitro, of the elder woman is unclear. Using FISH we screened the number of chromosome 21 in preimplanted embryos of 5 elderly women (average age, 38.4 years) to study the feasibility and necessity of screening trisomy 21 in embryos in patients over 35 years old at the in vitro fertilization (IVF) center.     

Scientific principles and rigorous processes should be followed in developing clinical guidelines for therapeutic interventions of integrative medicine

A clinical guideline for the therapeutic interventions of integrative medicine may be defined as a written document which states a series of recommendations on therapeutic interventions of integrative medicine for a special disease or condition. The guideline may provide assistance to medical professionals in making clinical decisions aimed at improving the clinical outcome of patients and reducing the costs of medical care（~＇4~. Recommendations issued by a guideline should be based on the best available evidence in both Western and Chinese medicine. For fulfilling this purpose, the development of clinical guidelines for therapeutic interventions in the field of integrative medicine should follow scientific principles and undergo a rigorous processes.