便携式脑电图机的设计

设计实现了USB接口、模拟放大、采样一体化的便携式脑电图机.采用AN2131进行A/D转换控制和PC的USB通讯等工作.通过数字光耦完成电路的隔离,为减少光耦的数量采用了软件模拟的SPI接口通讯.设计的脑电图机可以在恶劣的电磁环境下完成常规脑电图的检查.     

便携式脑电图机的设计

本设计实现了USB接口的，模拟放大、采样一体化的便携式脑电图机。采用＆N2131进行A／D转换控制和PC的USB通讯等工作。通过数字光耦完成电路的隔离。为减少光耦的数量采用了软件模拟的SPI接口通讯。设计的脑电图机可以在恶劣的电磁环境下完成常规脑电图的检查。     

基于EZ-USB系列单片机的USB接口设计与实现

目的：设计一种高速便捷的USB接口,用于面向社区的医疗监护系统。方法：利用Cypress公司提供的EZ-USB-FX2系列单片机CY7C68013a开发实现PC与监护系统的高速数据传输,包括USB接口的硬件电路设计、固件程序开发、驱动程序与固件装载驱动程序的制作、上位机程序的编写等4个部分。结果：完成了基于EZ-USB-FX2系列单片机CY7C68013a的USB接口设计,提供了一个用于社区医疗监护系统的高速数据传输接口方案,实现了社区医疗监护系统的低成本化和便捷化。结论：该接口可以很方便地运用到社区医疗监护系统中。     

主机与嵌入式医疗设备USB通讯的C++实现

USB是一种新型的计算机接口规范，USB通讯有着传输速度快、可靠性高、易于连接等优点，被广泛应用于目前的PC外围设备中。介绍了USB总线接口芯片CH375，并在此基础上实现了PC与嵌入式医疗设备的USB通讯，给出了相关的程序代码。     

通讯与网络技术在医学仪器设计中的应用

主要介绍常见有线通讯技术和无线通讯技术以及网络技术在医疗仪器设计中的应用。主要介绍了串行通讯、并行通讯、USB接口以及蓝牙技术、HomeRF技术、无线网络通讯、GPRS技术等的原理和其在医学仪器设计的应用。     

基于ARM处理器的心电血压监护仪的研制

介绍一种基于ARM处理器的心电血压监护仪的硬件电路的实现方法 ,内容包括ARM7TDMI核的S3C44B0X芯片、心电检测和血压检测等模拟电路的设计以及存储系统、A/D转换器、LCD模块、USB通讯口等接口模块的设计。     

X线机高压测量分析仪信号采集系统的研制

目的：设计与研制X线机高压测量分析仪信号采集系统。方法：系统由线性放大电路、数据采集、USB接口和计算机等4部分组成。通过高压分压箱得到X线机高压发生器的分压信号,经A/D转换把信号转换成数据,通过USB接口输入计算机,实现信号的实时显示、存储、分析和参数计算。结果：使用USB接口不仅能够实现快捷、实时的数据传输,而且使得整个系统体积更小,更便于安装和使用。结论：该数据采集系统完全能够满足X线机高压发生器次级数据的显示、分析和计算,使用该课题设计制作的高压分析仪分析次级电压,可以改进X线机的设计,提高X线机的性能。     

利用USB/UART桥接芯片进行USB接口的设计

近几年来，USB接口得到了日益普遍的应用，针对USB接口的开发方法也随之日益丰富完善起来。利用USB／UART桥接芯片开发USB接口是一种较为简便易行的设计方法，这种方法可以适合大多数的USB小型系统的应用。本文以FTDI公司的bTSU232BM为例，对这种USB接口的设计方法进行了阐述。     

多功能心脏电生理刺激记录仪的设计及实现

设计了一种多功能心脏电生理刺激记录仪,该设备以嵌入式系统为核心,前端电路包含除颤电压保护电路和静电防护电路,高压电路采用变压器耦合单端他激式MOS开关升压电路及高压稳压电路,用达林顿光耦开关进行脉冲控制,保证了脉冲输出波形的平稳。该设备可通过USB接口与计算机联机,同步实时采集并显示、存储体表十二导联及食管导联心电图;还集成了临床医师惯用的众多操作分析功能,有效优化了心脏电生理检查及记录工作流程。     

便携式低功耗12导联数字心电图机的设计

设计了一种基于数字信号处理器TMS320C5515和模拟采集前端ADS1298的便携式低功耗12导联数字心电图机。心电信号由模拟前端采集后送入TMS320C5515进行预处理并通过液晶模块实时显示。同时系统配置了大容量闪存芯片,可以长时间无压缩存储心电数据,也可以通过USB接口将心电数据传送至上位机,进行信号的离线分析和诊断。系统体积小．功耗低．精度高。     

Isocyanate induced allergic contact dermatitis in a university undergraduate student: An occupational dermatitis case report,review of laboratory safety regulations,and implications for campus research

A 19-year-old female college undergraduate developed an intensely swollen, erythematous and pruritic rash on the face and hands while working in an optical fabrication lab producing photosensitive polymers. She had no respiratory symptoms. The rash was consistent with contact dermatitis and there was no clinical evidence of respiratory involvement with normal spirometry. A review of the safety data sheets of chemicals used in the laboratory revealed several known sensitizers, including 6-hexamethylene diisocyanate (HDI), dibutyl phthalate, and 2,4,6-tribromophenyl acrylate. Patch testing confirmed the patient's sensitization to HDI. A subsequent worksite visit identified several hazardous chemicals that were used without appropriate hazard communication, training, standard operating procedures, or personal protective equipment. Simple exposure controls were recommended and instituted, and the patient was able to return to work in the laboratory without the recurrence of symptoms. This case demonstrates the importance of hazard identification, communication, and safety training in academic laboratories, for students and workers. A medical evaluation can identify hazards as well as lead to improvements in exposure controls and safe return to research.     

Photosensitive epilepsy beyond adolescence: is freedom from photosensitivity age-dependent?

Patients with photosensitive epilepsy (PSE) are said to lose photosensitivity with age. That is, they do not suffer from photosensitive epileptic seizures after the third decade of life. This claim seems to be an over generalised statement and does not take into account all other important confounding factors that determine the duration and process of neurological illnesses. Hence, there are contradictions pertaining to age of freedom of photosensitivity in epilepsy and in epilepsy with photosensitivity. Often patients are declared free from epileptic activity; however, some of these patients are still found to have seizures a few years later. This paper assesses the freedom photosensitivity in 58 PSE patients to ascertain validity of the claim that patients lose their photosensitivity with age. Thirty-nine of the 58 patients (67%) were female whilst (33%) were male, giving a female/male ratio of 3:1. The average age of onset of photosensitivity was 7 years. Of all the cases studied forty-one (71%) had a family history of photosensitive epilepsy, while seventeen (29%) had no family history of photosensitive epilepsy. Proof of photosensitivity in all the patients was determined by persistent EEG abnormalities including occipital spike and wave discharges. Results show that photosensitivity persisted beyond adolescence; hence, there was no specific age limit of freedom from photosensitivity in patients, especially in those with family history of photosensitive epilepsy. However, those patients who were having regular antiepileptic medication and/or were taking adequate preventive measures had a temporary period of freedom from sensitivity which lasted 1-4 years. These findings suggest that freedom from photosensitivity is not age-dependent, especially in those patients with family history of photosensitive epilepsy.     

早期肺癌荧光诊断仪光机系统设计

本文从激光诱发特定光敏药物荧光探测癌瘤组织的原理出发，通过理论分析和计算，确定了小肺癌荧光诊断仪的设计方案和光机系统的一个实用结果。经实验测试表明，该系统有良好的性能，可检测并定位早期肺恶性肿瘤。     

A study of the necessity of cooling of charge-coupled devices in x-ray imaging systems

The goal of this work was to study one of the widely used X-ray imaging systems: luminescent screen-optical system-matrix of photosensitive charge-coupled device (CCD)-amplifier-analog-to-digital converter. Experimental and theoretical studies were performed to substantiate the necessity of cooling of charge-coupled devices for improvement of X-ray image characteristics. The obtained results reveal the necessity of cooling of CCD-matrix crystals in the X-ray imaging system under consideration.     

X线影像增强电视系统点片条件的设定

根据感光效应原理和影像增强电视系统的性能，在一定的焦－片距下，透视mA与kV相匹配，图像质量满意；而在相同的焦－片距下，点片用稀土增感屏，则点片mAs与kV相区配也能得到图像质量良好的X光片。那么用相同的kV而找到mA对应的mAs,则点片条件的设定有了参照，此方法明显优越于经验点片，且在特殊部位点片更显优越。     

Physiological and pathophysiological role of the circadian clock system

It has been well known for ages that in living organisms the rhythmicity of biological processes is linked to the ~ 24-hour light-dark cycle. However, the exact function of the circadian clock system has been explored only in the past decades. It came to light that the photosensitive primary "master clock" is situated in the suprachiasmatic photosensitive nuclei of the special hypothalamic region, and that it is working according to ~24-hour changes of light and darkness. The master clock sends its messages to the peripheral "slave clocks". In many organs, like pancreatic β-cells, the slave clocks have autonomic functions as well. Two essential components of the clock system are proteins encoded by the CLOCK and BMAL1 genes. CLOCK genes are in interaction with endonuclear receptors such as peroxisoma-proliferator activated receptors and Rev-erb-α, as well as with the hypothalamic-pituitary-adrenal axis, regulating the adaptation to stressors, energy supply, metabolic processes and cardiovascular system. Melatonin, the product of corpus pineale has a significant role in the functions of the clock system. The detailed discovery of the clock system has changed our previous knowledge about the development of many diseases. The most explored fields are hypertension, cardiovascular diseases, metabolic processes, mental disorders, cancers, sleep apnoe and joint disorders. CLOCK genes influence ageing as well. The recognition of the periodicity of biological processes makes the optimal dosing of certain drugs feasible. The more detailed discovery of the interaction of the clock system might further improve treatment and prevention of many disorders.     

尿液分析仪的设计

本文设计的尿液分析仪是采用光学、电子、计算机等技术,用于尿液临床检测的高精度智能化仪器。光学部分采用低功耗、高亮度、长寿命的LED发光管作为发光源,以光谱响应范围宽、转换效率高、线性响应好的硅光电池作为光敏接收器件。电子及计算机部分采用8位高速单片机C8051F020,仪器由液晶显示器以中英文方式显示人机对话窗口,并能保存测试结果以供查询,仪器具有自动探测有无试纸、自动启动测试及自动卸条功能。     

Dermatologische Verträglichkeit von UV-Filtern, Duftstoffen und Konservierungsmitteln in Sonnenschutzpräparaten

Active sunscreens constituents are of two basic types: chemical agents that absorb ultraviolet radiation (UVR) und micropigments that act as physical barrier to UVR. Whereas micronized zinc oxide and titanium dioxide are well tolerated, UV absorbers can elicit allergic and photoallergic contact dermatitis. As photopatch testing is necessary to detect photoallergic reactions to UV filters and occasionally to perfume components, this important diagnostic tool is presented. Like many other cosmetics for skin care, sunscreen products can in addition contain perfume components, preservatives and emulsifiers that may cause allergic contact dermatitis. Now, that complete ingredient labeling according to INCI has become mandatory in the EU, the patient can avoid the (photo)allergenic ingredient in cosmetics provided he knows the INCI designation. Special sunscreen products for sensitive und photosensitive individuals are presented.     

Immunological and molecular mechanisms of photoallergic contact dermatitis

Photocontact dermatitis is one of the major occupational skin diseases and an undesirable adverse effect produced by chemicals and drugs in our environment. This dermatitis is caused by skin application of photosensitive agents plus ultraviolet light irradiation. There exist both primary irritant and allergic mechanisms in this dermatosis. While the former is induced by the phototoxic reactions, the latter allergic type is mediated by Langerhans cells, T cells, various cytokines and chemokines, and thus occurs via a well-orchestrated and well-elucidated immunological mechanism. The photoallergic type has a higher incidence and more severe skin eruptions than the primary irritation. Photoconjugation of epidermal cells with a photohaptenic halogenated chemical is the initial step, and Langerhans cells serve as antigen-presenting cells. Causative photohaptens are bound to MHC class II molecules/self peptide on Langerhans cells upon exposure to UVA. The photomodified Langerhans cells sensitize and elicit antigen-specific T cells that mediate photoallergy. Thus, this photoallergy is induced by well-orchestrated photochemical and immunological mechanisms.