联合国健康相关SDG指标及中国现状

目的通过对健康相关可持续发展目标(Sustainable Development Goals,SDG)指标进行分析,明确中国健康发展的基线情况,为中国顺利实现SDG目标提供数据参考。方法基于IHME的研究,对比分析全球与中国健康相关SDG指标得分,反映2015年全球与中国SDG的基线水平。结果 2015年全球188个国家或地区的健康相关SDG指标得分为59.3分,中国为60分(全球排名第92位)。在中国健康相关SDG指标中,战争所致死亡率、疟疾发病率、营养不良、亲密伴侣暴力、安全接生等SDG指标得分较高,均在90分以上;灾难、道路伤害、空气污染、中毒等所致死亡率,乙肝、结核、艾滋病等发病率,以及PM2.5、不良卫生习惯、职业风险、不安全饮用水、吸烟等危险因素指标的得分较低,其中PM2.5、艾滋病等指标得分呈逐年下降趋势;虽然儿童超重和有害饮酒得分尚可,但亦呈逐年下降趋势;结论中国健康相关SDG指标得分略高于全球平均水平,为了顺利实现联合国SDG 2030目标,中国仍面临着许多挑战,需全社会共同努力,以健康为中心,全方位全生命周期落实国家大健康战略。     

National practice guidelines for mental health care: a comparative policy analysis of the United kingdom and the United States

Mental disorders are the leading cause of disability worldwide, according to the World Health Organization (WHO, 1996). In a report on health indicators of premature death and disability, the World Bank concluded that mental health problems account for 8.1% of the global burden of disease (GBD). Industrialized nations have taken different approaches in applying innovations to mental health care and mental health care policy. This paper uses the K. McInnis-Dittrich model of policy analysis (Ginsberg, 1994) to analyze the approaches of the United Kingdom (U.K.) and the United States (U.S.) to mental health treatment, specifically examining the effects of the U.K.'s national practice guidelines and the U.S.'s lack of similar guidelines. Recommendations for changes in current U.S. mental health policy are presented.     

Long-term health implications of the Chernobyl accident and relevant projects of the World Health Organization

The past two decades have witnessed dramatic changes in public health governance and international cooperation on the Chernobyl Nuclear Power Plant accident, especially after the end of the Cold War. The World Health Organization (WHO) has committed itself deeply to the public health issues around Chernobyl and has participated in various health projects such as health monitoring and cancer screening. WHO has also been engaged in research activities such as the Chernobyl Tissue Bank, in close collaboration with the Ministries of Health in Belarus, Russia, and Ukraine. In addition to the official report of the Chernobyl Forum "Health Expert Groups" in 2005, the task of WHO is to not only analyze and clarify the global burden of Chernobyl-related illness, but also to promote the well-being of the local residents who suffered chronic low-level radiation exposure from radiation fallout.     

联合国后千年发展议程的形成及健康相关目标

目的:探究联合国2015年后发展议程的形成过程,以及与健康相关的目标和指标,了解其与"千年发展目标(MDGs)"的异同,方法:从相关国际组织官方网站(联合国、WHO等),以及Pub Med等数据库中查阅相关官方文件、文献,进行归纳总结。结果:联合国在2010年开始着手对2015年后发展议程制定的准备工作,通过不同组织部门之间的调研、讨论,并发布一系列报告,为最终的后2015发展日程形成奠定基础,2015年后发展日程中有1项总目标,包括13项具体目标涉及公共卫生领域。结论:2015年后发展议程中公共卫生相关目标结合了"千年发展目标"指标和新增挑战,其具体目标的覆盖面也更为广泛、具体。     

Dietary Exposure to Polychlorinated Biphenyls and Dioxins and Its Relationship to Telomere Length in Subjects Older Than 55 Years from the SUN Project

Exposure to persistent organic pollutants (POPs) may influence telomere length (TL), which is considered as a marker of biological age associated with the risk of chronic disease. We hypothesized that dietary exposure to polychlorinated biphenyls (PCBs) and dioxins could affect TL. Our aim was to evaluate the association of dietary exposure to PCBs and dioxins with TL. In this cross-sectional study of 886 subjects older than 55 y (mean age: 67.7; standard deviation (SD): 6.1; 27% women) from the “Seguimiento Universidad de Navarra” (SUN) project. TL was determined by real-time quantitative polymerase chain reaction and dietary PCBs and dioxins exposure was collected using a validated 136-item Food Frequency Questionnaire. Multivariable linear regression models were used to control for potential confounding factors. Shorter TL was associated with dietary total PCBs (SD of T/S ratio/(ng/day) = −0.30 × 10⁻⁷; 95% CI, −0.55 × 10⁻⁷ to −0.06 × 10⁻⁷), dioxin-like PCBs (DL-PCBs) (SD of T/S ratio/(pg WHO TEQ (Toxic Equivalents)/day) = −6.17 × 10⁻⁷; 95% CI, −11.30 × 10⁻⁷ to −1.03 × 10⁻⁷), and total TEQ exposure (SD of T/S ratio/(pg WHO TEQ/day) = −5.02 × 10⁻⁷; 95% CI, −9.44 × 10⁻⁷ to −0.61 × 10⁻⁷), but not with dioxins (SD of T/S ratio/(pg WHO TEQ/day) = −13.90 × 10⁻⁷; 95% CI, −37.70 × 10⁻⁷ to 9.79 × 10⁻⁷). In this sample of middle-aged and older Spanish adults, dietary exposure to total PCBs and DL-PCBs alone and together with dioxins was associated with shorter TL. Further longitudinal studies, preferably with POPs measured in biological samples, are needed to confirm this finding.     

DALY和DALE:两种健康衡量指标内在关系探索

伤残调整的生命年（DALY）和伤残调整的预期寿命（DALE）是世界组织和世界银行在对全球疾病负担的研究中，使用的两个综合性衡量人口健康状况的指标。其中，DALY用于表示人口健康状况的有效指标。两个指标都是通过分析疾病、残疾等对健康寿命造成的损失，来衡量各类疾病对人口健康的影响，因而可作为政府在权衡、分配卫生资源时的依据。     

Non-communicable diseases and global health governance: enhancing global processes to improve health development

This paper assesses progress in the development of a global framework for responding to non-communicable diseases, as reflected in the policies and initiatives of the World Health Organization (WHO), World Bank and the UN: the institutions most capable of shaping a coherent global policy. Responding to the global burden of chronic disease requires a strategic assessment of the global processes that are likely to be most effective in generating commitment to policy change at country level, and in influencing industry behaviour. WHO has adopted a legal process with tobacco (the WHO Framework Convention on Tobacco Control), but a non-legal, advocacy-based approach with diet and physical activity (the Global Strategy on Diet, Physical Activity and Health).     

COVID-19 in WHO African Region: Account and Correlation of Epidemiological Indices with Some Selected Health-related Metrics

BackgroundThe coronavirus disease 2019 (COVID-19) is a highly contagious and pathogenic viral disease caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). Since it was first reported in Wuhan, China, it has spread across the continents. The study is aimed at describing epidemiological indices of COVID-19 as reported by the World Health Organization and to examine correlations with some country specific measures of general health status.MethodsData from the WHO African region were extracted from World Health Organization, Global Health Security Index, Worldometer and World Bank databases, as at September 8, 2020. Other epidemiological indices were computed for the various countries. Epidemiological indices of COVID-19 were correlated with some selected health related metrics: Global Health Security index (GHSI) and current health expenditure (CHE). Pearson correlation was used to access the relationship between the health-related metrics and epidemiological indices.ResultsForty-seven (47) countries belonging to the WHO African region were evaluated. A total of 1,086,499 confirmed cases and 23,213 deaths were recorded giving a fatality rate of 2.1%. South Africa recorded the highest cumulative confirmed cases as well as deaths (Cases: 639,362; Deaths: 15,004) while Seychelles (Cases:135) and Eritrea/Seychelles (Deaths:0) had the least cumulative cases and deaths (135;0 and 330;0), respectively. South Africa recorded the highest attack rate (1127.67/100,000) while Republic of Tanzania recorded the least attack rate (0.78/100,000). The highest case fatality rate/ratio was observed in Chad (7.60%) while the least value was observed in Seychelles (0.0%). France was the most common country involved in travel history of index cases. Sporadic transmission was recorded in 3 countries, 9 countries had cluster of cases while the rest had community transmission. The first WHO African region country to record COVID-19 case was Algeria, while Comoros was the last. Significant positive correlation was found between COVID-19 case number/deaths and Global Health Security Index.ConclusionThe WHO African region has had its own share of the pandemic with all the countries being affected. The trio of cluster cases, sporadic and community transmission were recorded with majority being community transmission.     

Changes in government spending on healthcare and population mortality in the European union, 1995–2010: a cross-sectional ecological study

Objective

Economic measures such as unemployment and gross domestic product are correlated with changes in health outcomes. We aimed to examine the effects of changes in government healthcare spending, an increasingly important measure given constrained government budgets in several European Union countries.

Design

Multivariate regression analysis was used to assess the effect of changes in healthcare spending as a proportion of total government expenditure, government healthcare spending as a proportion of gross domestic product and government healthcare spending measured in purchasing power parity per capita, on five mortality indicators. Additional variables were controlled for to ensure robustness of data. One to five year lag analyses were conducted.

Setting and Participants

European Union countries 1995–2010.

Main outcome measures

Neonatal mortality, postneonatal mortality, one to five years of age mortality, under five years of age mortality, adult male mortality, adult female mortality.

Results

A 1% decrease in government healthcare spending was associated with significant increase in all mortality metrics: neonatal mortality (coefficient −0.1217, p = 0.0001), postneonatal mortality (coefficient −0.0499, p = 0.0018), one to five years of age mortality (coefficient −0.0185, p = 0.0002), under five years of age mortality (coefficient −0.1897, p = 0.0003), adult male mortality (coefficient −2.5398, p = 0.0000) and adult female mortality (coefficient −1.4492, p = 0.0000). One per cent decrease in healthcare spending, measured as a proportion of gross domestic product and in purchasing power parity, was both associated with significant increases (p < 0.05) in all metrics. Five years after the 1% decrease in healthcare spending, significant increases (p < 0.05) continued to be observed in all mortality metrics.

Conclusions

Decreased government healthcare spending is associated with increased population mortality in the short and long term. Policy interventions implemented in response to the financial crisis may be associated with worsening population health.     

Tobacco industry attempts to counter the World Bank report Curbing the Epidemic and obstruct the WHO framework convention on tobacco control

In 1999 the World Bank published a landmark study on the economics of tobacco control, Curbing the Epidemic: Governments and the Economics of Tobacco Control (CTE), which concluded that tobacco control brings unprecedented health benefits without harming economies, threatening the transnational tobacco companies' ability to use economic arguments to dissuade governments from enacting tobacco control policies and supporting the WHO Framework Convention on Tobacco Control (FCTC). We used tobacco industry documents to analyze how tobacco companies worked to discredit CTE. They hired public relations firms, had academics critique CTE, hired consultants to produce "independent" estimates of the importance of tobacco to national economies, and worked through front groups, particularly the International Tobacco Growers' Association, to question CTE's findings. These efforts failed, and the report remains an authoritative economic analysis of global tobacco control during the ongoing FCTC negotiations. The industry's failure suggests that the World Bank should continue their analytic work on the economics of tobacco control and make tobacco control part of its development agenda.     

Mycobacteria: laboratory methods for testing drug sensitivity and resistance

In its seventh report, published in 1960, the WHO Expert Committee on Tuberculosis “noted the need for international standards for the definition and determination of drug resistance which will permit comparisons to be made from one area to another, and recommended that the World Health Organization take appropriate steps to establish such standards”.¹⁰ Acting on this recommendation, WHO took the first step towards standardization by convening in Geneva, in December 1961, an informal international meeting of specialists in the bacteriology of tuberculosis. At this meeting an attempt was made to formulate prerequisites for reliable sensitivity tests and to specify the technical procedures for them.     

Cutaneous malignant melanoma incidence is strongly associated with European depigmented skin type regardless of ambient ultraviolet radiation levels: evidence from Worldwide population-based data

Current public health advice is that high ultraviolet radiation (UVR) exposure is the primary cause of Malignant Melanoma of skin (CMM), however, despite the use of sun-blocking products incidence of melanoma is increasing. To investigate the UVR influence on CMM incidence worldwide WHO, United Nations, World Bank databases and literature provided 182 country-specific melanoma incidence estimates, daily UVR levels, skin colour (EEL), socioeconomic status (GDP PPP), magnitude of reduced natural selection (Ibs), ageing, urbanization, percentage of European descendants (Eu%), and depigmentation (blonde hair colour), for parametric and non-parametric correlations, multivariate regressions and analyses of variance. Worldwide, UVR levels showed negative correlation with melanoma incidence (“rho” = −0.515, p < 0.001), remaining significant and negative in parametric partial correlation (r = −0.513, p < 0.001) with other variables kept constant. After standardising melanoma incidence for Eu%, melanoma correlation with UVR disappeared completely (“rho” = 0.004, p = 0.967, n = 127). The results question classical views that UVR causes melanoma. No correlation between UVR level and melanoma incidence was present when Eu% (depigmented or light skin type) was kept statistically constant, even after adjusting for other known variables. Countries with lower UVR levels and more Eu% (depigmented or light skin people) have higher melanoma incidence. Critically, this means that individual genetic low skin pigmentation factors predict melanoma risk regardless of UVR exposure levels, and even at low-UVR levels.     

Legal strategies to improve physical activity in populations

The World Health Assembly has adopted the World Health Organization’s (WHO) recommended target of achieving a 15% reduction in physical inactivity by 2030. The WHO Global Action Plan on Physical Activity provides a framework for countries to achieve this, using a systems-based approach to address the social and environmental determinants of physical inactivity. Lack of progress in many countries indicates a need to identify new ways of addressing this public health priority. WHO continues to highlight the importance of legislative and regulatory measures within the multicomponent and multisectoral action needed to reduce physical inactivity. Yet research into the role of law for addressing physical inactivity has been limited, in contrast to the legal approaches to other major noncommunicable disease risk factors such as smoking and alcohol use. Conceptual frameworks for public health law offer a method for mapping and understanding the determinants, mechanisms and outcomes of law-making for the promotion of physical activity within populations. We describe the development and application of a framework that aligns legal strategies with the WHO Global Plan policy objectives. This new framework – the Regulatory Approaches to Movement, Physical Activity, Recreation, Transport and Sport – can help policy-makers to use the untapped potential of legal interventions to support or strengthen a whole-system response for promoting physical activity. The framework illustrates the role of legal interventions to improve physical activity and identifies opportunities for research to advance understanding, implementation and evaluation of legal responses to this issue.     

A Randomized Pilot Study of DASH Patterned Groceries on Serum Urate in Individuals with Gout

The Dietary Approaches to Stop Hypertension (DASH) diet reduces serum urate (SU); however, the impact of the DASH diet has not been previously evaluated among patients with gout. We conducted a randomized, controlled, crossover pilot study to test the effects of ~$105/week ($15/day) of dietitian-directed groceries (DDG), patterned after the DASH diet, on SU, compared with self-directed grocery shopping (SDG). Participants had gout and were not taking urate lowering therapy. Each intervention period lasted 4 weeks; crossover occurred without a washout period. The primary endpoint was SU. Compliance was assessed by end-of-period fasting spot urine potassium and sodium measurements and self-reported consumption of daily servings of fruit and vegetables. We randomized 43 participants (19% women, 49% black, mean age 59 years) with 100% follow-up. Mean baseline SU was 8.1 mg/dL (SD, 0.8). During Period 1, DDG lowered SU by 0.55 mg/dL (95% CI: 0.07, 1.04) compared to SDG by 0.0 mg/dL (95% CI: −0.44, 0.44). However, after crossover (Period 2), the SU difference between groups was the opposite: SDG reduced SU by −0.48 mg/dL (95% CI: −0.98, 0.01) compared to DDG by −0.05 mg/dL (95% CI: −0.48, 0.38; P for interaction by period = 0.11). Nevertheless, DDG improved self-reported intake of fruit and vegetables (3.1 servings/day; 95% CI: 1.5, 4.8) and significantly reduced total spot urine sodium excretion by 22 percentage points (95% CI: −34.0, −8.6). Though relatively small in scale, this pilot study suggests that dietitian-directed, DASH-patterned groceries may lower SU among gout patients not on urate-lowering drugs. However, behavior intervention crossover trials without a washout period are likely vulnerable to strong carryover effects. Definitive evaluation of the DASH diet as a treatment for gout will require a controlled feeding trial, ideally with a parallel-design.     

Crises as Catalyst: A New Social Contract Grounded in Worker Rights

Three crises—climate change, the COVID-19 pandemic, and extreme economic and social inequality—intersect and have had devastating impacts on workers’ rights to health, as well as the right to decent work, an underlying determinant of health. Yet these crises may act as catalysts, as responses present opportunities for transformation. Indeed, multiple international governance institutions and nongovernmental organizations have proposed new social contracts that aim to address the multiple challenges facing workers today. These initiatives promise to transform society to make workers and their families healthier and the planet more sustainable. They join and supplement earlier efforts at transformation, such as the 2030 Agenda for Sustainable Development. This article critiques (1) the market-fundamentalist neoliberal social contract, which gave rise to, or exacerbated, the three crises, and (2) the 2030 agenda and recent International Labour Organization proposals, which are all built on this neoliberal platform. Finally, the article argues for a social contract that is grounded in human rights—specifically worker rights—to address these crises and ensure greater protection of the health     

Backstage: the relationship between the Rockefeller Foundation and the World Health Organization,Part I: 1940s–1960s

In recent years, there has been a growing debate about what role foundations should play in global health governance generally, and particularly vis-à-vis the World Health Organization (WHO). Much of this discussion revolves around today's gargantuan philanthropy, the Bill and Melinda Gates Foundation, and its sway over the agenda and modus operandi of global health. Yet such pre-occupations are not new. The Rockefeller Foundation (RF), the unparalleled 20th century health philanthropy heavyweight, both profoundly shaped WHO and maintained long and complex relations with it, even as both institutions changed over time. This article examines the WHO–RF relationship from the 1940s to the 1960s, tracing its ebbs and flows, key moments, challenges, and quandaries, concluding with a reflection on the role of the Cold War in both fully institutionalizing the RF's dominant disease-control approach and limiting its smaller social medicine efforts, even as the RF's quotidian influence at WHO diminished.     

Developing Industrial-Governmental-Academic Partnerships to Address Micronutrient Malnutrition

Micronutrient malnutrition affects approximately 2 billion people and has a significant impact on mortality, morbidity, reproductive health, individual growth and development, and economic productivity. The World Bank has suggested that micronutrient interventions are among the most cost-effective of all health interventions. Therefore, greatly increased collaborative efforts are needed to bring about further reductions in micronutrient malnutrition. At the FAO/WHO International Conference on Nutrition, the importance of various partners in improving nutrition was recognized in the World Declaration on Nutrition and adopted unanimously by 159 governments: "Governments, academic institutions and industry should support the development of fundamental and applied research directed towards improving the scientific and technological knowledge base" for addressing malnutrition, including micronutrient malnutrition. Foodbased strategies, including fortification, provide a good example.     

Health worker remuneration in WHO Member States

Objective

To present the available data on the money spent by Member States of the World Health Organization (WHO) on remunerating health workers in the public and private sectors.

Methods

Data on government and total expenditure on health worker remuneration were obtained through a review of official documents in WHO’s Global Health Expenditure Database and directly from country officials and country official web sites. Such data are presented in this paper, by World Bank country income groups, in millions of national currency units per calendar year for salaried and non-salaried health workers. They are presented as a share of gross domestic product (GDP), total health expenditure and general government health expenditure. The average yearly change in remuneration (i.e. compound annual growth rate) between 2000 and 2012 as a function of these parameters was also assessed.

Findings

On average, payments to health workers of all types accounted for more than one third of total health expenditure across countries. Such payments have grown faster than countries’ GDPs but less rapidly than total health expenditure and general government health expenditure. Remuneration of health workers, on the other hand, has grown faster than that of other types of workers.

Conclusion

As they seek to attain universal health coverage (UHC), countries will need to devote an increasing proportion of their GDPs to health and health worker remuneration. However, the fraction of total health expenditure devoted to paying health workers seems to be declining, partly because the pursuit of UHC calls for strengthening the health system as a whole.     

“一带一路”沿线国家非传染性疾病的现状与预测研究

目的 对与中国签订“一带一路”倡议国家的可持续发展目标（SDG）中,非传染性疾病（NCD）的情况进行评价和预测。方法 利用全球疾病负担开放数据,获得“一带一路”沿线126个国家（含中国）1990－2017年每年分国别的四大慢性病早死率和自杀死亡率,使用百分数缩放法计算指标得分（0~100分）、几何平均数法计算NCD总得分,对2017年126个国家四大慢性病和自杀得分,以及NCD总得分进行比较。结合社会人口学指数（SDI）进行相关性分析。使用1990－2015年年均变化率对联合国提出的2030年SDG慢性病早死率和自杀死亡率各国实现情况进行预测。结果 2017年126个国家NCD指标总得分中位数为82.7分,其中中国得分87.6分,排名第33位。排名前3位的国家分别为科威特（98.1分）、秘鲁（97.5分）和意大利（96.0分）,排名最低的是巴布亚新几内亚,仅为28.9分,其次为瓦努阿图（54.7分）和乌克兰（58.0分）。NCD指标总得分与SDI值相关性r=0.33（慢性病早死率0.45,自杀死亡率0.09）。预计到2030年,能够实现SDG慢性病早死率目标的国家有15个,中国则要在2038年实现;能够实现SDG自杀死亡率目标的国家有15个,中国将于2024年提前实现。结论 “一带一路”沿线国家在NCD指标上表现存在差异,中国实现SDG慢性病早死率目标形势严峻。国家间应加强多边合作,优势互补,降低沿线国家人民慢性病早死率和自杀死亡率,提升沿线各国人民的健康水平。     

Collect Once,Use Many Times: Attaining Unified Metrics for Tuberculosis Preventive Treatment for People Living With HIV

The World Health Organization (WHO) recommends providing tuberculosis preventive treatment (TPT) to all persons living with HIV and to all household contacts of persons with bacteriologically confirmed pulmonary tuberculosis disease. Regrettably, the absence of a harmonized data collection and management approach to TPT indicators has contributed to programmatic challenges at local, national, and global levels. However, in April 2020, the WHO launched the Consolidated HIV Strategic Information Guidelines, with an updated set of priority indicators. These guidelines recommend that Ministries of Health collect, report, and use data on TPT completion in addition to TPT initiation. Both indicators are reflected in the WHO’s list of 15 core indicators for program management and are also required by the US President’s Emergency Plan for AIDS Relief’s Monitoring, Evaluation, and Reporting (MER) guidance. Although not perfectly harmonized, both frameworks now share essential indicator characteristics. Aligned indicators are necessary for robust strategic and operational planning, resource allocation, and data communication. “Collect once, use many times” is a best practice for strategic information management. Building harmonized and sustainable health systems will enable countries to successfully maintain essential HIV, tuberculosis, and other health services while combatting new health threats.