帕利哌酮缓释片与奥氮平片治疗精神分裂症疗效对照观察

目的探讨新型抗精神病药帕利哌酮缓释片对精神分裂症的疗效和副作用。方法以30例用帕利哌酮缓释片治疗的精神分裂症患者和用奥氮平治疗的30例患者作对照,用简明精神症状评定量表(BPRS))、副反应量表(TESS)每周评定1次。结果 BPRS量表评定:两组治疗前后比较均有显著差异(P均<0.01),但两组之间比较显效率(χ2=0.847,P>0.05),两组有效率(χ2=0.775,P>0.05)均无显著性差异。TESS量表评定:两组比较无显著差异,但两组的副反应各有所不同。结论帕利哌酮缓释片和奥氮平对精神分裂症阳性症状和阴性症状疗效相当。     

双黄连水提醇沉、干燥工艺的研究

目的通过实验,对双黄连中金银花和连翘水提液醇沉工艺及干燥工艺进行研究,优选出最佳精制方法和干燥条件。方法黄芩的提取精制方法按照药典方法进行,本实验考察比较金银花和连翘提取液一次醇沉和二次醇沉后所测得的浸膏得量和有效成分的含量,从而确定最优的提取精制工艺。在此基础上,对减压干燥法和微波干燥法进行了比较,优选出最佳干燥条件。结果通过两种方法的比较显示：二次醇沉的提取精制方法出膏率更低且含量高;微波干燥大大减少了干燥时间。结论优选所得醇沉工艺和干燥工艺科学合理。     

复明片与沃丽汀中西联合治疗玻璃体混浊的临床研究

目的：观察并评价口服复明片及沃丽汀联合治疗玻璃体混浊的临床疗效。方法将符合诊断标准的90名患者随机分为治疗组30例(44眼)和对照组1有30例(42眼),对照组2有30例(44眼)。治疗组口服复明片及沃丽汀联合用药,对照组1口服复明片,对照组2口服沃丽汀,对比疗效。结果治疗8w后,观察组的症状及视力较两对照组有明显改善(P<0.05),差异具有统计学意义。结论口服复明片及沃丽汀中西联合治疗玻璃体混浊,疗效优于两者各单独使用,且患者依从性仍很高。     

赖氨匹林片解热作用的研究

目的评价赖氨匹林片的解热作用.方法采用伤寒-副伤寒甲、乙三联菌苗及2,4-二硝基酚致家兔发热模型.结果赖氨匹林片300mg、150mg*kg-1能明显降低三联菌苗和2,4-二硝基酚所致发热家兔的体温升高.结论赖氨匹林片具有明显的解热作用.     

HPLC法测定对乙酰氨基酚片的含量

目的 建立HPLC法测定对乙酰氨基酚片的含量。方法 色谱柱为Agilent Eclipse XDB-C18柱（4.6 mm×150 mm,5 μm）;流动相为甲醇-水（20∶80）,流速为1.0 ml/min,检测波长为244 nm,柱温30 ℃。结果 对乙酰氨基酚浓度在10.16~30.48 μg/ml范围内线性关系良好,r=0.9998（n=5）;平均加样回收率为100.04%,RSD=0.95%（n=6）。结论 HPLC法操作简便、结果准确、重复性好、专属性强,适用于测定对乙酰氨基酚片中对乙酰氨基酚的含量。     

Terbutaline Depot Tablets in Asthma

A sustained release preparation of terbutaline sulphate has been formulated (Bricanyl® depot tablets) in order to extend the duration and accordingly change the dosage regimen to twice a day. This presentation gives a summary of a clinical trial performed in order to study effect and side effects of terbutaline depot tablets 7.5 mg twice a day compared to terbutaline tablets 5 mg three times a day.
Patients suffering from perennial asthma and with daily requirement of asthma medicine were accepted for the study. The trial was a double-blind cross-over, double dummy and randomized. The tablets were given in two consecutive periods of 7 day's duration each. The effect of terbutaline depot tablets was equal to the effect of the ordinary terbutaline tablets. The indication for using depot tablets in the basic treatment of bronchial asthma is a better patient compliance due to medication twice a day. Furthermore in patients with unstable bronchial asthma and in patients with morning dips in PEF the more stable plasma concentration may perhaps keep the patients in a more steady state.     

克拉霉素片溶出度检测方法分析

目的 优化克拉霉素片溶出度检测方法。方法 采用ZORBAX SB-C18（4.6 mm×150 mm,5 μm）色谱柱,流动相:磷酸盐缓冲液∶乙腈（60∶40）,流速:1.0 ml/min,检测波长:210 nm;柱温:45 ℃,进样量:50 μl。在药典方法基础上去掉稀释步骤,以每批次6片样品分别经溶出仪溶出后直接经高效液相色谱仪测定后按外标法以限度计算溶出度。结果 本法与药典方法相比较,溶出度结果一致,均大于限度80%,符合限度要求。结论 本研究方法可以作为克拉霉素片溶出度的质量控制方法。     

Terbutaline Depot Tablets in Childhood Asthma

Thirty children 8-13 years old, with perennial asthma and with a reversibility of greater than or equal to 20% in lung function (FEV1) were given a sustained-release preparation of terbutaline sulphate 5 mg twice a day and ordinary tablets 2.5 mg three times a day; each treatment lasted 1 week. The design of the study was double-blind, cross-over, with a randomized allocation of the drugs. Both drugs improved the lung function significantly. The children had significantly less coughing during the night when they took depot tablets than when they took ordinary tablets. The side effects were few with both treatments. Most of the patients preferred the depot tablets.     

附桂骨痛片联合艾瑞昔布片及氟比洛芬巴布膏 治疗膝骨关节炎的临床研究

目的 观察附桂骨痛片联合艾瑞昔布片和氟比洛芬巴布膏治疗膝骨关节炎（KOA）的临床疗效和安全性。方法 选取2017年7月~2018年5月在我院就诊的KOA患者284例,按照随机数字表法分为A组和B组,各142例。A组患者给予口服艾瑞昔布片联合外用氟比洛芬巴布膏治疗,B组患者在A组基础上加服附桂骨痛片,两组患者均以8周为1个疗程。比较两组患者治疗前后的临床疗效及西安大略和麦克马斯特大学量表（WOMAC）评分、视觉模拟评分法（VAS）评分、中医证候评分、实验室检查指标、不良反应发生情况。结果 B组治疗总有效率高于A组（90.14% vs 77.46%）,差异有统计学意义（P＜0.05）。治疗后,两组患者WOMAC评分、VAS评分、中医证候积分,以及CRP、ESR、MMP-1、MMP-3水平均低于治疗前,且B组低于A组,差异均有统计学意义（P＜0.05）。治疗中两组患者均无明显不良反应发生。结论 附桂骨痛片联合艾瑞昔布片及氟比洛芬巴布膏可缓解关节疼痛,改善KOA患者临床症状,临床疗效好,且安全性高。     

我国琥珀酸亚铁片与硫酸亚铁片治疗缺铁性贫血疗效的有效性Meta分析

目的 评价硫酸亚铁片与琥珀酸亚铁片治疗缺铁性贫血的临床有效性。方法 利用计算机对文献进行检索,所用数据库包括中国期刊全文数据库（CNKI）、万方数据库（Wan Fang Data）和维普数据库（VIP）,英文数据库Pubmed和Embase。纳入硫酸亚铁片与琥珀酸亚铁片治疗缺铁性贫血的随机对照试验文献,数据由两名评价员进行分别独立提取纳入文献,并对文献质量进行评价,使用RevMan5.0软件对纳入文献进行统计分析,评价二者临床有效性。结果 纳入研究有15篇文献,文章无明显发表偏倚;从随即对照文献的质量评价结果可知,Meta分析稳定、可靠;琥珀酸亚铁组的有效率高于硫酸亚铁组（RR:1.22,95% CI:1.13～1.32:P＜0.00001）。结论 综合分析两种药物治疗缺铁性贫血的临床有效性,表明琥珀酸亚铁片在治疗缺铁性贫血方面较硫酸亚铁片更有效;但在未来研究中应克服相应的方法学缺陷。     

茶碱缓释片的工艺研究

通过对茶碱缓释片不同处方工艺的比较研究,以片面外观、硬度、片重差异及释放度作为主要考察指标,确定其最佳处方工艺.     

新复方大青叶片研究进展

新复方大青叶片是收载于《中华人民共和国卫生部药品标准中药成方制剂》第五册中的中西药结合的复方制剂,其具有抗菌、消炎、解热、镇痛等作用,临床常用来治疗伤风感冒、发热头痛、鼻流清涕、骨节酸痛等。本文根据近年来国内外对于新复方大青叶片的研究,综述其主要处方来源及组成、药理作用、临床应用和不良反应,以期为新复方大青叶片研究提供新的思路。     

Terbutaline Slow-Release Tablets in Children with Asthma

The effects of 5 mg slow-release terbutaline sulphate tablets (Bricanyl Depot) given twice daily were compared with those of ordinary oral beta 2-agonist treatment given three times daily. The study was open, randomized and cross-over and was carried out over 8 weeks in 18 children with bronchial asthma. Compared with ordinary medication, the slow-release tablets obtained higher morning expiratory peak flow values and an improvement in the asthma symptoms during the night and during exercise (P less than 0.05). No differences were found in side effects in spite of a higher total daily dose during the period with terbutaline slow-release tablets. The slow-release tablets were preferred by 15 of 18 children and their families when the effects, side effects and dosage were evaluated.     

舍曲林治疗中学生强迫症临床分析

目的观察舍曲林治疗中学生强迫症的疗效及副作用,为临床工作提供客观依据。方法采用耶鲁-布朗强迫量表YBOCS和副反应量表TESS分别评定疗效和副作用。结果观察治疗4周、8周时YBOCS总均分较治疗前(42.17±11.26)明显减少(21.03±5.28、11.21±3.05),有明显统计学差异(P<0.05,P<0.01);观察治疗8周时临床治愈率86.46%,副反应发生率28.57%。结论舍曲林治疗中学生强迫症疗效显著,副反应少,值得临床推广。     

Efficacy of Emodepside plus Praziquantel Tablets (Profender? Tablets for Dogs) against Mature and Immature Cestode Infections in Dogs

The efficacy of a novel flavoured tablet formulation of emodepside plus praziquantel (Profender? tablets for dogs) against intestinal cestodes was investigated in four randomised, blinded placebocontrolled dose confirmation studies in dogs experimentally infected with Echinococcus granulosus or E. multilocularis and in dogs naturally infected with Dipylidium caninum or Taenia spp. The tablets were used at the minimum recommended dose of 1 mg emodepside and 5 mg praziquantel per kg body weight. The studies demonstrated 100% efficacy against mature and immature E. granulosus and E. multilocularis and mature Taenia spp. and D. caninum. Additionally, one of the studies demonstrated non-interference of emodepside with the efficacy of praziquantel against D. caninum. No side effects of the treatment were observed. It is concluded that emodepside plus praziquantel tablets are safe and effective against mature and immature stages of E. granulosus and E. multilocularis and mature stages of Taenia spp. and D. caninum.     

罗红霉素分散片的人体生物等效性研究

研究两种罗红霉素分散片的人体生物等效性。采用高效液相色谱(HPLC)电化学检测法测定20名健康男性受试者单剂量口服罗红霉素分散片受试制剂和参比制剂后,体内罗红霉素的血药浓度,用DAS药动学程序处理试验数据,并对试验结果进行统计分析。罗红霉素受试制剂和参比制剂的峰浓度(Cmax)分别是10．16±1．46、10．34±1．66μg·ml-1;达峰时间(tmax)分别是2．33±0．61、2．28±0．62 h;药时曲线下面积(AUC0→Tn)分别为143．32±25．80、138．93±22．49μg·h·ml-1,AUC0→∞分别为158．63±26．86、153．77±24．75μg·h·ml-1;半衰期(t1／2)分别是:9．00±1．58、8．68±1．66 h。按罗红霉素血药浓度计算,相对生物利用度为103．63％±14．04％,经统计分析两制剂药动学参数均无显著性差异,表明受试制剂和参比制剂生物等效。     

二甲硅油片在结肠镜检查肠道准备中的应用

目的 观察嚼服二甲基硅油片在常规结肠镜检查肠道准备中的应用价值。方法 选择在我院行常规结肠镜检查患者181例,随机分为研究组84例和对照组97例。对照组口服单瓶磷酸钠盐口服溶液,研究组在口服单瓶磷酸钠盐口服溶液后嚼服二甲基硅油片。观察两组BBPS评分、肠道准备有效率、肠腔气泡评分、肠腔气泡满意率和全结肠息肉检出率。结果 两组各节段及全结肠BBPS评分、肠道准备有效率比较,差异无统计学意义（P＞0.05）。研究组右半结肠、横结肠和全结肠肠腔气泡评分分别为（0.48±0.67）分、（0.36±0.59）分和（0.95±1.35）分,低于对照组的（0.81±0.96）分、（0.61±0.81）分和（1.61±2.03）分,差异具有统计学意义（P＜0.05）。研究组右半结肠和全结肠肠腔气泡满意率分别为90.48%和84.52%,高于对照组的76.29%和71.13%,差异具有统计学意义（P＜0.05）。两组全结肠息肉检出率比较,差异无统计学意义（P＞0.05）。结论 嚼服二甲硅油片在结肠镜检查肠道准备中具有较好的祛泡效果,且不会影响肠道准备质量,但不能提高息肉检出率。     

赛乐特治疗考前焦虑对成绩的影响研究

目的 探索精神类药物（赛乐特,Paroxetine Hydroehloride Tablets,简称PHT）治疗考前焦虑后是否有利于个体正常能力的发挥。方法 以高三学生为被试,观察赛乐特治疗考前焦虑后对他们名次提高的影响。结果 被试考前焦虑的解除反而导致成绩和名次的明显下降。结论 用赛乐特治疗考前焦虑其实不利于个体正常能力的发挥。适量的考前焦虑或许更有利于个体正常能力的发挥。     

Terbutaline Slow-Release Tablets in Children with Bronchial Asthma

The effect of terbutaline sulphate in slow-release (SR) tablets (Bricanyl Depot), 5 mg twice daily, was compared with that of terbutaline sulphate in ordinary tablets (Bricanyl), 2.5 mg three times daily, in a double-blind, randomized, cross-over study during 2 consecutive weeks in 10 asthmatic children. Plasma concentrations and urinary excretion of terbutaline were measured at various times during both treatment periods. The SR tablets produced a higher mean plasma concentration in the morning and a smaller peak-trough variation over the day than the ordinary ones. No differences between the two treatments were observed concerning FEV1 (forced expiratory volume in 1 s). Tremor, measured with an opto-electronic tremorgraph, was about the same for two treatments and not significantly different from tremor seen in healthy children. The reported side effects were less frequent in the SR tablet period.