塔拉萨敏并环衍生物的合成

目的 制备二萜生物碱塔拉萨敏的并环衍生物.方法 以塔拉萨敏为原料,通过Jones氧化、Baeyer-Villiger内酯化、Grob裂解及[3+2]环加成等4步反应制备了相应的衍生物.结果与结论 所得产物的结构经MS及NMR进行确证,4步反应的总收率为55％.     

白花瓜叶乌头中生物碱成份的研究

目的：研究白花瓜叶乌头（Aconitum hemsleyanum Pritz vor.laueanthus P.Guo et.M.R.Jia)根中生物碱成份。方法：pH与溶剂极性梯度萃取及硅胶层析。结果：从中分得7个已知去甲二萜生物碱,由光谱法分别鉴定为大渡乌碱1;13,15－dideoxyaconitine 2;indaconitine 3;crassicaudine4;塔拉萨敏5;查斯曼宁6;ezochasmanine 7。结论：这些化合物均首次从该植物中分离得到。     

外消旋药喇叭酸甲酯的制备

目的制备外消旋药喇叭酸甲酯。方法以廉价易得的1,10-癸二醇为原料,经单苄醚化、溴代、格氏反应、乙酰化、氢解脱苄、Jone’s氧化和甲酯化等7步反应,制得外消旋药喇叭酸甲酯。结果以总收率7.2%合成了目标化合物,并经1HNMR1、3CNMR和MS确证其结构。结论所用方法成本低廉,反应条件温和,适于外消旋药喇叭酸甲酯的大量合成。     

去甲二萜生物碱的药理活性

归纳总结了1984年以来所发表的有关去甲二萜生物碱的药理作用。     

毛苞瓜叶乌头生物碱成分的研究

目的 研究毛苞瓜叶乌头根中的生物碱化学成分.方法 酸提碱沉提取总碱,硅胶层析法分离,波谱法鉴定结构.结果 分离到6个已知的去用二萜生物碱,分别为滇乌碱(yunaconitine)、塔拉萨敏(talasamine)、瓜乌定(hemsleyadine)、拳乌宁乙(circinanine B)、黄草乌碱丁(schaconitine)和senbusine A.结论 应用光谱法和与已知物TLC对照的方法鉴定了所有化合物的结构.     

异雷公藤内酯四醇的半合成研究（Ⅰ）

以雷公藤内酯酮为原料,经烯丙位烃基氧化、亲核酰化和还原反应,合成了异雷公藤内酯四醇,其结构经红外光谱、核磁共振光谱、质谱确证。     

基于C-H胺化策略构建arcutine类二萜生物碱的二氢吡咯环系的合成

目的 设计并完成一种基于C-H胺化策略构建arcutine类二萜生物碱二氢吡咯环系的合成路线.方法 由异长叶烷酮为原料,经羟胺缩合、还原、上Ts基团、Hofmann-L?ffler-Freytag(HLF)反应、还原脱Ts、氧化等步骤得到目标二氢吡咯环化合物.结果 与结论 该路线以6步、32％的总收率成功构建了二氢吡咯...     

竹柏属(Podocarpus)植物中去甲二萜双内酯的抗癌活性:体外对Yoshida肉瘤细胞毒作用的构-效关系

迄今从竹柏属植物中已分离出约40个去甲及二去甲二萜双内酯成分,它们显示强而广泛的生物活性,如抗癌活性、植物生长调节作用、杀灭白蚁活性及对某些昆虫幼虫毒性作用。本文报道15个天然二萜内酯及     

雷酚酮内酯的半合成研究

以雷酚内酯为原料，经甲基化。氧化和去甲基化三步反应合成了雷酚酮内酯，它是新一代抗白血病药物一雷公藤甲素全合成的重要中间体。     

直缘乌头根中生物碱成分的研究

目的：研究直缘乌头（Aconitum transsectum Diels.）根中的生物碱成分。方法：采用pH梯度、中压柱层析、常压硅胶柱层析及离心薄层层析法。结果：分得11个已知二萜生物碱，由光谱法分别鉴定为：滇乌碱（yunaconitine）、印乌碱（indaconitine）、黄草乌碱甲（vilmorrianine A）、黄草乌碱丙（vilmorrianine C）、草乌甲素(crassialine A)、膝乌碱（geniconitine）、查斯曼宁（chasmanine）、８－去乙酰滇乌碱（8-deacetylyunaconitine）、塔拉萨敏（talatisamine）、14-乙酰塔拉萨敏（14-acetyltalatisamine）和chasmaconitine。结论：黄草乌碱甲和chasmaconitine是首次从该植物中分离得到。     

Biomimetic conversion of aconitine-type C19-diterpenoid alkaloids to lactone-type alkaloids

The first biomimetic conversion from the aconitine-type C(19)-diterpenoid alkaloids to the corresponding alkaloids of lactone-type C(19)-diterpenoid alkaloid has been achieved. Chasmanine was used as starting material with Baeyer-Villiger oxidation as a key reaction. It was also observed that the oxygenated group at C-16 did not change the relative migration tendencies of C-13 and C-9 during the oxidation. Meantime, a novel D-ring fragmented compound was obtained during the course of the present investigation. The plausible mechanism of the formation of this compound was also proposed.     

Biomimetic conversion of aconitine-type C19-diterpenoid alkaloids to lactone-type alkaloids

The first biomimetic conversion from the aconitine-type C₁₉-diterpenoid alkaloids to the corresponding alkaloids of lactone-type C₁₉-diterpenoid alkaloid has been achieved. Chasmanine was used as starting material with Baeyer–Villiger oxidation as a key reaction. It was also observed that the oxygenated group at C-16 did not change the relative migration tendencies of C-13 and C-9 during the oxidation. Meantime, a novel D-ring fragmented compound was obtained during the course of the present investigation. The plausible mechanism of the formation of this compound was also proposed.     

Two new norditerpenoid alkaloids from Delphinium potaninii

Further studies on the chemical constituents of Delphinium potaninii roots led to the isolation of two new lycoctonine-type norditerpenoid alkaloids, potanisines A (1) and B (3). The structures of these compounds were determined by interpretation of the spectroscopic data. They are the first examples of naturally occurring lycoctonine-type norditerpenoid alkaloids possessing an N-formyl moiety.     

聚伞翠雀生物碱成分的研究

目的研究聚伞翠雀根中生物碱成分。方法采用pH梯度洗脱及硅胶柱层析分离,应用光谱方法鉴定结构。结果从根中分得5个已知二萜生物碱:氨茴酰牛扁碱、牛扁碱、德尔塔生、DelsemineA和DelsemineB。结论5个化合物是首次从该植物中分离得到。     

黑水翠雀中生物碱成份的研究

目的：研究黑水翠雀（Delphinium potaninii)根中生物碱成分,方法：采用PH梯度洗脱及硅胶柱层析。结果：从根中分得10个已知二萜生物碱,由光谱法分别鉴定为牛扁碱（lycoctonine)1、氨茴牛扁碱（anthranoylycoctonine)2、methyllycaconitine3、德尔塔生（deltatsine)4、delectine5、delsoline6、德尔色明甲(delsemineA)7、德尔色明乙（delsemineB)8、德拉瓦印甲和乙（delavaineA and B)9 10。结论这些化合物是首次从该植物中分离得到。     

Two norditerpenoid ester alkaloids from Aconitum bulleyanum

Two new norditerpenoid alkaloids, 8-acetyl-14-p-methoxybenzoate of talatisamine (1) and 14-p-methoxybenzoate of talatisamine (2), were isolated from Aconitum bulleyanum Diels. The structures were elucidated on the basis of spectroscopic and chemical studies.     

New norditerpenoid alkaloids from Aconitum hemsley anum var. pengzhouense

Two new norditerpenoid alkaloids, 13-deoxyludaconitine (1) and 8-deacetylsungpaconitine (3), were isolated from the roots of Aconitum hemsleyanum Pritz var. pengzhouense and their structures were elucidated by spectral data.     

Five new norditerpenoid alkaloids from Aconitum sinomontanum

From the roots of Aconitum sinomontanum, five new norditerpenoid alkaloids, sinomontanitines A (1) and B (2), sinomontanines A (3), B (4) and C (5), were isolated together with the known alkaloids lappaconitine (6) and ranaconitine (7), The structures of the new alkaloids were determined by spectral analysis.