口腔扁平苔藓患者血硒水平的测定及初步研究

目的探索口腔扁平苔藓与必需微量元素硒的关系。方法30例口腔扁平苔藓实验组与30例健康对照组,采用原子吸收分光光度法测定红细胞及血清硒水平。结果实验组红细胞及血清硒水平均低于健康对照组（P＜0.05）。结论硒水平低下可能是口腔扁平苔藓发病原因之一。     

硒治疗口腔扁平苔藓的初步报告

目的探讨硒元素对口腔扁平苔藓患者免疫状况的影响。方法对30例口腔扁平苔藓患者采用硒治疗,观察患者治疗前、后T淋巴细胞亚群的变化及临床症状。结果患者治疗前CD3+,CD4+以及CD4+/CD8+比率显著低于健康者(P<0.05),硒治疗后患者CD3+、CD4+,以及CD4+/CD8+比率显著提高(P<0.05)。CD4+/CD8+比率恢复正常。临床症状有所缓解,局部病损基本愈合。结论硒对口腔扁平苔藓患者外周血CD3+、CD4+,以及CD4+/CD8+比率具有调节作用。     

口腔扁平苔藓患者血浆一氧化氮含量的检测

目的 观察一氧化氮在口腔扁平苔发病机理中的作用。方法 采用Ｇｒｅｉｓｓ方法测定了３０例口腔扁平苔藓患者及３０例正常对照者血浆中一氧化氮的稳定代谢产物亚硝酸基／硝基（ＮＯ２／ＮＯ３）的含量。结果 口腔扁平苔藓患者与正常对照相比血浆ＮＯ２／ＮＯ３水平明显升高,结论 一氧化氮在口腔扁平苔藓的免疫防御方面具有重要作用,在口腔扁平苔鲜的免疫发病机理中也有重要意义 。     

口腔扁平苔藓癌变

病例报告例1 喻某某,女,39岁,门诊号24295,住院号18912,因左舌缘溃疡伴白色损害于1979年来我院粘膜病专科门诊就诊。在就诊前2月参加普查时发现舌左缘中份有一小“溃疡”,疼痛明显,进食刺激性食物时疼痛加剧,周围有白色损害。患者认为“溃疡”与月经周期有关。尤其在行经前半月溃疡扩大,疼痛加重。就诊时查:舌左舌缘后份有—1×2cm大小的白色损害区,呈条纹状,粗糙,粘膜充血明显,局部糜烂,压痛,但质软,无硬结,舌质红、舌苔白,脉弦细数。临床诊断:口腔     

趋化因子和口腔扁平苔藓的研究进展

口腔扁平苔藓(OLP)是慢性炎症性口腔黏膜病,趋化因子是一种炎症的关键调节物,在OLP中炎症的发生发展、T细胞的再循环、细胞粘附以及宿主防御等方面起重要作用。笔者就趋化因子与OLP的相关性作一综述。     

与月经周期有关的女性口腔扁平苔藓患血血清孕酮含量变化及其 …

应用放射免疫方法检测２０例与月经周期有关的女性口腔扁平苔藓黄体中期血清孕酮含量。并与２０名正常女性对照。结果显示，患病组的检测值低于下沉组，判别具有显著性（Ｐ〈０．０５）。通过孕酮补充治疗，患者口腔损害缓解，表明本组患者的发病与血清孕酮水平低下有关。     

口腔扁平苔藓癌变的临床研究

口腔扁平苔藓（ＯＬＰ）的癌变问题一直争论很大。作者从１９８５年来对收治的５９６例ＯＬＰ患者进行了为期１０年的追踪随访观察,平均随访时间为７年,这些ＯＬＰ患者均在病理上有“符合扁平苔藓”的诊断,且均有２－３次活检,至少每年随访一次。在这１０年中,发现ＯＬＰ癌变的病例７例,从这７例ＯＬＰ癌变的病例分析中发现,癌变与不适当的治疗和对外界致癌因素敏感有关。     

中药治疗口腔扁平苔藓的临床观察

在中医辨证施治原则指导下,应用中药对治疗口腔扁平苔藓患者进行探索,在２３例患者中,痊愈４例,显效５例,好转１１例,明显高于服用磷酸氯喹的对照组。提示中药治疗口腔扁平苔藓作用是肯定的。     

念珠菌与口腔扁平苔藓

口腔扁平苔藓 (OLP)是常见的慢性炎症性皮肤黏膜疾病 ,其病因尚不完全清楚 ,念珠菌感染在OLP中的作用尚无定论。本文从念珠菌与OLP的关系受到关注的原因、OLP患者念珠菌的检出情况等方面对历年的研究作了全面的总结 ,并提出应当进一步对念珠菌与OLP关系进行深入研究     

口腔扁平苔藓416例治疗分析

口腔扁平苔藓(OLP)是口腔粘膜病中最普遍的常见病,它可能产生恶变,而治疗尚有困难。我们于1978年起先后采用中医药及西药单一或联合治疗OLP16例取得一定疗效,现报告如下。 临床资料 一、性别与年龄:本组416例中男197例(47.4％),     

Arterial blood pressure in patients with oral lichen planus.

The arterial blood pressure of 121 patients with oral lichen planus was determined using the auscultatory method. These values were then compared with those previously found in a general adult population. No significant difference was found betwween the values of the lichen planus patients and those of the general population. The present investigation does not support the hypothesis of a relationship between lichen planus and hypertension.     

Salivary gland function and changes in patients with oral lichen planus

Abstract – Saliva analysis, sialography and histopathologic examination of labial salivary glands were performed on patients with oral lichen planus. Diseases connected with salivary gland function were also recorded. Saliva analysis regarding secrection rate, pH and buffer capacity in unstimulated and stimulated saliva was permormed on 39 patients. 87% of the patients exhibired a low or very low unstimulated secretion rate, the mean value being 0.14 ml/min. The rate of stimulated saliva, pH and buffer capicity did not deviate from normal reference values. Sialographic examination was performed on 18 patients, corresponding to 36 major salivary glands. Radiologic changes were seen in 89% patients. Histopathologic examination was performed on 15 patients. Lymphocytic infiltration, acinar atrophy, fibrosis, fatty degeneration or ducral changes were observed in the minor glands of all patients. Different degrees of acinar atrophy were present in 93% of the patients. Lymphorytic infiltration was seen in 12 patients (80%) of whom three exhibited focal accumulation as in Sjögren's syndrome. Since decreased salivary secretion and symptoms of joint diseases and keratoconjunctivitis sicca were frequently present, over a third of the patients showed clinical signs comparable to those of Sjögren's syndrome. A high frequency of gastrointestinal and endocrine diseases was also recorded, which suggests that a general exo and endocrine influence may be present in patients with oral lichen planus.     

Candida in patients with oral lichen planus

The presence of yeasts in oral lichen planus (OLP) lesions was studied in cultivations from 41 OLP patients and by histological examination in 39 of these cases. The histological features of OLP were also recorded. The cultivation results were compared with those of a randomly selected, age- and sex-matched control group without mucosal changes. The extent of growth was recorded as "sparse" (1-10 colonies), "model-rate" (11-40 colonies), or "heavy" (greater than 40 colonies). Yeasts were found to be present on cultures or histologic sections from a total of 19 OLP patients (46%). "Moderate-heavy" growth was obtained in 29% of the OLP cases but in only 7% of the control group. Candida albicans accounted for over 80% of the yeasts. The histological examination revealed only 3 cases of invasive fungal growth. Regarding the criteria of OLP, hyperortho- or hyperparakeratosis and a band-shaped subepithelial infiltration of lymphocytes were present in all specimens, basilar liquefaction degeneration in 87% and an eosinophilic zone in 77%. Local treatment with amphotericin B (Fungizone) in 18 OLP patients with positive findings resulted in subjective relief of symptoms in 89% of the patients. Clinical improvement was seen in 94%. The presence of Candida was significantly correlated to low secretion rate in unstimulated saliva.     

Basement membrane changes in oral lichen planus

In recent years ultrastructural morphological alterations in the basement membrane have been observed in a number of mucocutaneous diseases. Varying degrees of fragmentation and branching are seen, but such changes are not specific to any disease. In this respect, oral lichen planus has been studied extensively and clear correlations observed between the clinical type of lesion and type of basement membrane change. The nature of these changes has been studied using different immunohistochemical methods, including immunoelectron microscopy, and immunoreactivity to various basement membrane components has been noted even in the branches of the subbasal basement membrane. Thus these changes probably reflect various proliferative or degenerative changes in basal cells. Using the same technique the topographical distribution of T cell subsets and their relationship to the basement membrane pathology have been studied. Inflammation topography, analysis of lymphocyte differentiation markers, signs of CD8+ cell activation and association of CD8+ cells with mononuclear phagocytes all suggest that the local inflammatory cells are active participants in the local pathogenetic process.     

Oral and serum IL-6 levels in oral lichen planus patients

OBJECTIVE: The purpose of this study was to compare IL-6 levels in oral exfoliated mucosal cell samples and in serum in subjects with oral lichen planus versus controls.Study design Ten patients with ulcerative OLP, 10 with reticular OLP, and 10 control subjects were recruited at a University Oral Medicine Clinic. Using smear tissue culture brushes, oral samples were collected from lesional sites for OLP patients and from buccal mucosa for controls into vials with 300 muL PBS. After centrifugation, the supernatants were aspirated for cytokine ELISA assay and protein assay. Venous blood was processed to serum for ELISA assay. Oral IL-6 was expressed as both pg/mL and pg/mug protein, and serum IL-6 was expressed as pg/mL. RESULTS: The mean oral IL-6 levels were higher in the ulcerative OLP group (11.19 +/- 5.34 pg/mL) than in the reticular OLP (1.05 +/- 0.34 pg/mL) and control (0.52 +/- 0.29 pg/mL) groups. There were significant differences between ulcerative OLP and reticular OLP groups (P < .039), and between ulcerative OLP and control groups (P < .009). After the standardization of IL-6 concentration by protein, a significant difference in IL-6 concentration was shown only between the ulcerative OLP (0.0245 +/- 0.0121 pg/mug protein) and control (0.0023 +/- 0.0012 pg/mug protein) groups (P < .029). Similarly, the ulcerative OLP group showed a significantly higher serum IL-6 level than the control group (P < .021). CONCLUSION: Both oral and serum IL-6 levels were higher in patients with ulcerative OLP. An oral exfoliated cell technique may be a useful and sensitive method to measure IL-6 in patients with OLP as it provided results consistent with those found in peripheral blood.     

Psychiatric disturbance in patients with oral lichen planus

The degree of mental disturbance in 56 patients with clinically and histologically verified oral lichen planus (OLP) and in 44 non-OLP patients was investigated by means of the Cornell Medical Index psychological questionnaire. A statistically significant difference in mental disturbance between OLP patients and non-OLP patients was found, the OLP patients being more disturbed (p less than 0.01). The mental health of the non-OLP patients was equal to that of the general Finnish population. Of the OLP patients, 48.2% were mentally healthy, 21.4% had a mild mental disturbance, 5.4% had a moderate mental disturbance, and 25.0% had a severe mental disorder. The corresponding figures for the non-OLP patients were 72.7%, 9.1%, 11.4%, and 6.8%. Of the 56 OLP patients, 21 were randomly selected and referred for a psychiatric consultation. Five patients refused the psychiatric interview. Of the sixteen patients who were examined, five had a moderate psychiatric disorder, seven had a mild psychiatric disorder, one had signs of neurosis, and three were mentally healthy. Most of the patients had the subjective feeling that the clinical appearance of OLP, including discomfort, became worse during times of mental stress. None of the patients, however, had a subjective feeling of mental disturbance; nor did any of them feel any need for psychiatric treatment, except in one case.